Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q3 2016 (← Previous) (Next →)
Filing Date: Nov 14, 2016
Total Value: $11.02B (88.2% shares, 11.8% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seattle Genetics, Inc. | 44,100,294 | $2.382B | 21.6% | $35.08 | — | COM | 812578102 |
| INCY | Incyte Corporation | 23,498,898 | $2.216B | 20.1% | $48.57 | +73.5% | COM | 45337C102 |
| ABBV | AbbVie Inc. | 14,343,358 | $905M | 8.2% | $42.33 | +3.7% | COM | 00287Y109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 25,819,768 | $821M | 7.5% | $16.42 | +106.5% | COM | 004225108 |
| — | Alexion Pharmaceuticals, Inc. | 6,543,295 | $802M | 7.3% | $180.77 | — | COM | 015351109 |
| — | Incyte Corporation Notes 1.25% 11/15/2020 144A | 274,500,000 | $531M | 4.8% | $1.21 | — | NOTE 1.25% 11/15/2020 | 45337CAL6 |
| — | Incyte Corporation Notes 0.375% 11/15/2018 144A | 259,000,000 | $491M | 4.5% | $1.20 | — | NOTE 0.375% 11/15/2018 | 45337CAK8 |
| BMRN | BioMarin Pharmaceutical Inc. | 4,806,483 | $445M | 4.0% | $76.68 | +22.8% | COM | 09061G101 |
| — | Genomic Health, Inc. | 13,770,302 | $398M | 3.6% | $31.71 | — | COM | 37244C101 |
| — | DBV Technologies S.A. | 5,509,560 | $200M | 1.8% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,536,092 | $141M | 1.3% | $13.23 | — | COM | 03842B101 |
| — | BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 | 22,379,000 | $101M | 0.9% | $2.76 | — | NOTE 1.875% 4/23/2017 | 09061GAD3 |
| — | Bellicum Pharmaceuticals, Inc. | 4,865,647 | $96.83M | 0.9% | $22.66 | — | COM | 079481107 |
| CERS | Cerus Corporation | 13,053,275 | $81.06M | 0.7% | $4.68 | +39.7% | COM | 157085101 |
| — | Spark Therapeutics, Inc. | 1,318,341 | $79.18M | 0.7% | $76.38 | — | COM | 84652J103 |
| — | Acorda Therapeutics, Inc. | 3,661,082 | $76.44M | 0.7% | $39.85 | — | COM | 00484M106 |
| — | Clovis Oncology, Inc. 2.5% 9/15/2021 | 72,758,000 | $69.14M | 0.6% | $1.67 | — | NOTE 2.5% 9/15/2021 | 189464AB6 |
| — | Amarin Corporation plc | 20,630,477 | $65.81M | 0.6% | $3.16 | — | SPONSORED ADR NEW | 023111206 |
| EXEL | Exelixis, Inc. | 4,929,494 | $63.05M | 0.6% | $7.37 | +46.7% | COM | 30161Q104 |
| — | Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 | 77,083,000 | $62.83M | 0.6% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| ONC | BeiGene, Ltd. | 1,912,680 | $58.93M | 0.5% | $29.31 | — | SPONSORED ADR | 07725L102 |
| — | Invitae Corporation | 6,554,967 | $57.42M | 0.5% | $16.76 | — | COM | 46185L103 |
| HRTX | Heron Therapeutics, Inc. | 2,857,250 | $49.23M | 0.4% | $13.64 | +36.0% | COM | 427746102 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 10,963,944 | $48.35M | 0.4% | $7.37 | -45.8% | COM | 09058V103 |
| NBIX | Neurocrine Biosciences, Inc. | 895,422 | $45.34M | 0.4% | $28.92 | +72.2% | COM | 64125C109 |
| — | Advanced Accelerator Applications S.A. | 1,029,247 | $39.19M | 0.4% | $32.52 | — | SPONSORED ADR | 00790T100 |
| — | Versartis, Inc. | 2,134,247 | $26.14M | 0.2% | $22.68 | — | COM | 92529L102 |
| — | Progenics Pharmaceuticals, Inc. | 3,650,808 | $23.11M | 0.2% | $4.44 | — | COM | 743187106 |
| — | Foamix Pharmaceuticals Ltd. | 2,466,702 | $22.84M | 0.2% | $7.55 | — | SHS | M46135105 |
| — | Array BioPharma Inc. | 3,310,666 | $22.35M | 0.2% | $6.65 | — | COM | 04269X105 |
| XNCR | Xencor, Inc. | 872,072 | $21.36M | 0.2% | $11.07 | +91.2% | COM | 98401F105 |
| HALO | Halozyme Therapeutics, Inc. | 1,731,057 | $20.91M | 0.2% | $6.50 | +57.2% | COM | 40637H109 |
| — | Achillion Pharmaceuticals, Inc. | 2,475,515 | $20.05M | 0.2% | $8.21 | — | COM | 00448Q201 |
| — | bluebird bio, Inc. | 293,943 | $19.92M | 0.2% | $37.25 | — | COM | 09609G100 |
| — | Merus N.V. | 1,160,014 | $19.43M | 0.2% | $8.27 | — | COM | N5749R100 |
| SGMO | Sangamo BioSciences, Inc. | 4,055,876 | $18.78M | 0.2% | $12.13 | -58.1% | COM | 800677106 |
| NTLA | Intellia Therapeutics, Inc. | 1,062,120 | $18.08M | 0.2% | $26.61 | -27.2% | COM | 45826J105 |
| — | Idera Pharmaceuticals, Inc. | 7,014,015 | $17.96M | 0.2% | $3.05 | — | COM NEW | 45168K306 |
| — | Derma Sciences, Inc. | 3,752,390 | $17.52M | 0.2% | $12.19 | — | COM PAR $.01 | 249827502 |
| — | Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 | 26,517,000 | $17.43M | 0.2% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| GLPG | Galapagos NV | 259,894 | $16.8M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| TGTX | TG Therapeutics, Inc. | 2,003,991 | $15.51M | 0.1% | $4.61 | +39.7% | COM | 88322Q108 |
| — | Mirati Therapeutics, Inc. | 2,269,198 | $15M | 0.1% | $18.66 | — | COM | 60468T105 |
| ASND | Ascendis Pharma A/S | 745,521 | $14.98M | 0.1% | $16.29 | — | SPONSORED ADR | 04351P101 |
| — | BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 | 12,228,000 | $14.63M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| ARWR | Arrowhead Pharmaceuticals, Inc. | 1,856,967 | $13.65M | 0.1% | $5.25 | +23.5% | COM | 04280A100 |
| — | Vitae Pharmaceuticals, Inc. | 637,597 | $13.34M | 0.1% | $8.12 | — | COM | 92847N103 |
| ALKS | Alkermes plc | 250,251 | $11.77M | 0.1% | $70.02 | -32.1% | SHS | G01767105 |
| — | Zogenix, Inc. | 1,000,000 | $11.43M | 0.1% | $13.50 | — | COM NEW | 98978L204 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $11.3M | 0.1% | $17.96 | — | COM | 00771V108 |
| — | Dermira, Inc. | 326,428 | $11.04M | 0.1% | $22.67 | — | COM | 24983L104 |
| AGIO | Agios Pharmaceuticals, Inc. | 207,915 | $10.98M | 0.1% | $37.79 | +15.2% | COM | 00847X104 |
| MGNX | MacroGenics, Inc. | 363,676 | $10.88M | 0.1% | $23.98 | +24.1% | COM | 556099109 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $10.11M | 0.1% | $16.20 | — | COM | 00900T107 |
| — | ContraFect Corporation | 4,045,876 | $10.03M | 0.1% | $2.48 | — | COM | 212326102 |
| — | Dimension Therapeutics, Inc. | 1,251,881 | $10M | 0.1% | $11.23 | — | COM | 25433V105 |
| — | Sage Therapeutics, Inc. | 208,328 | $9.594M | 0.1% | $37.36 | — | COM | 78667J108 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $9.284M | 0.1% | $37.28 | — | COM | 46116X101 |
| — | ImmunoGen, Inc. | 3,015,353 | $8.081M | 0.1% | $11.68 | — | COM | 45253H101 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $7.49M | 0.1% | $41.68 | +76.2% | COM NEW | 53220K504 |
| — | Alder BioPharmaceuticals, Inc. | 217,328 | $7.122M | 0.1% | $24.97 | — | COM | 014339105 |
| RARE | Ultragenyx Pharmaceutical Inc. | 100,000 | $7.094M | 0.1% | $51.09 | +24.9% | COM | 90400D108 |
| — | Inotek Pharmaceuticals Corporation Notes 5.75% 8/1/2021 | 5,000,000 | $6.708M | 0.1% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| — | Trillium Therapeutics Inc. | 413,697 | $6.12M | 0.1% | $13.74 | — | COM NEW | 89620X506 |
| INSM | Insmed Incorporated | 400,000 | $5.808M | 0.1% | $14.37 | -12.9% | COM PAR $.01 | 457669307 |
| — | Alcobra Ltd. | 2,336,359 | $5.771M | 0.1% | $5.61 | — | SHS | M2239P109 |
| PRQR | ProQR Therapeutics N.V. | 860,464 | $5.739M | 0.1% | $14.32 | -61.6% | SHS EURO | N71542109 |
| — | NeuroDerm Ltd. | 305,000 | $5.639M | 0.1% | $15.24 | — | ORD SHS | M74231107 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,102,153 | $5.561M | 0.1% | $2.61 | -65.5% | COM | 14888U101 |
| NTRA | Natera, Inc. | 450,000 | $5M | 0.0% | $13.15 | -14.3% | COM | 632307104 |
| — | Medgenics, Inc. | 880,539 | $4.905M | 0.0% | $5.96 | — | COM NEW | 58436Q203 |
| — | Akari Therapeutics plc | 496,901 | $4.229M | 0.0% | $21.86 | — | SPONSORED ADR | 00972G108 |
| — | Minerva Neurosciences, Inc. | 258,805 | $3.653M | 0.0% | $10.21 | — | COM | 603380106 |
| — | Stemline Therapeutics, Inc. | 333,497 | $3.612M | 0.0% | $23.84 | — | COM | 85858C107 |
| — | Loxo Oncology, Inc. | 137,735 | $3.606M | 0.0% | $17.33 | — | COM | 548862101 |
| — | Ignyta, Inc. | 571,000 | $3.592M | 0.0% | $8.30 | — | COM | 451731103 |
| — | Array BioPharma Inc. Notes 3.0% 6/1/2020 | 3,000,000 | $3.561M | 0.0% | $1.25 | — | NOTE 3.0% 6/1/2020 | 04269XAA3 |
| — | Sunesis Pharmaceuticals, Inc. | 741,665 | $3.241M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Concert Pharmaceuticals, Inc. | 316,976 | $3.205M | 0.0% | $10.71 | — | COM | 206022105 |
| — | Trevena, Inc. | 450,000 | $3.038M | 0.0% | $10.35 | — | COM | 89532E109 |
| — | Syros Pharmaceuticals, Inc. | 204,465 | $2.836M | 0.0% | $18.15 | — | COM | 87184Q107 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $2.833M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Proteon Therapeutics, Inc. | 298,591 | $2.786M | 0.0% | $12.06 | — | COM | 74371L109 |
| — | GlycoMimetics, Inc. | 381,235 | $2.726M | 0.0% | $7.27 | — | COM | 38000Q102 |
| — | InVivo Therapeutics Holdings Corp. | 400,000 | $2.72M | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| — | Endocyte, Inc. | 868,983 | $2.685M | 0.0% | $4.47 | — | COM | 29269A102 |
| — | Aeglea BioTherapeutics, Inc. | 404,230 | $2.591M | 0.0% | $4.86 | — | COM | 00773J103 |
| — | Selecta Biosciences, Inc. | 178,950 | $2.55M | 0.0% | $13.99 | — | COM | 816212104 |
| — | Osiris Therapeutics, Inc. | 499,193 | $2.476M | 0.0% | $16.34 | — | COM | 68827R108 |
| — | Nabriva Therapeutics AG | 350,000 | $2.468M | 0.0% | $9.50 | — | SPONSORED ADR | 62957M104 |
| — | Juno Therapeutics, Inc. | 80,000 | $2.401M | 0.0% | $52.22 | — | COM | 48205A109 |
| — | Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 | 3,423,000 | $2.294M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| — | Epizyme, Inc. | 232,481 | $2.288M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $2.111M | 0.0% | $31.09 | — | COM | 48576U106 |
| IONS | Ionis Pharmaceuticals, Inc. | 57,140 | $2.094M | 0.0% | $53.96 | -42.0% | COM | 462222100 |
| ENTA | Enanta Pharmaceuticals, Inc. | 75,357 | $2.005M | 0.0% | $19.50 | +19.1% | COM | 29251M106 |
| — | SCYNEXIS, Inc. | 467,600 | $1.81M | 0.0% | $2.17 | — | COM | 811292101 |
| — | Assembly Biosciences, Inc. | 250,000 | $1.803M | 0.0% | $13.24 | — | COM | 045396108 |
| QURE | uniQure N.V. | 230,000 | $1.76M | 0.0% | $14.92 | -46.8% | SHS | N90064101 |
| — | MediWound Ltd. | 226,000 | $1.74M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | Ophthotech Corporation | 35,649 | $1.644M | 0.0% | $32.35 | — | COM | 683745103 |
| — | MyoKardia, Inc. | 100,000 | $1.634M | 0.0% | $16.34 | — | COM | 62857M105 |
| — | Seres Therapeutics, Inc. | 125,000 | $1.536M | 0.0% | $41.50 | — | COM | 81750R102 |
| — | Palatin Technologies, Inc. | 2,050,000 | $1.289M | 0.0% | $0.73 | — | COM PAR $.01 | 696077403 |
| CLLS | Cellectis S.A. | 50,000 | $1.204M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | CoLucid Pharmaceuticals, Inc. | 30,310 | $1.156M | 0.0% | $38.14 | — | COM | 19716T101 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $1.153M | 0.0% | $9.20 | 0.0% | COM | 359664109 |
| — | Immune Design Corp. | 148,937 | $1.129M | 0.0% | $20.65 | — | COM | 45252L103 |
| — | Affimed N.V. | 400,000 | $1.112M | 0.0% | $6.30 | — | COM | N01045108 |
| ALDX | Aldeyra Therapeutics, Inc. | 142,000 | $1.11M | 0.0% | $10.20 | -40.1% | COM | 01438T106 |
| — | Acceleron Pharma Inc. | 28,765 | $1.041M | 0.0% | $39.60 | — | COM | 00434H108 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $1.01M | 0.0% | $16.80 | — | COM | 33830X104 |
| — | Tenax Therapeutics, Inc. | 420,000 | $972K | 0.0% | $3.58 | — | COM | 88032L100 |
| — | Mast Therapeutics, Inc. | 8,584,051 | $944K | 0.0% | $0.31 | — | COM | 576314108 |
| — | Aptose Biosciences Inc. | 404,211 | $909K | 0.0% | $2.25 | — | COM NEW | 03835T200 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $905K | 0.0% | $1.54 | 0.0% | COM | 45665G303 |
| — | Dynavax Technologies Corporation | 75,000 | $787K | 0.0% | $24.55 | — | COM NEW | 268158201 |
| ALNY | Alnylam Pharmaceuticals, Inc. | 11,340 | $769K | 0.0% | $77.42 | -8.9% | COM | 02043Q107 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 57,762 | $732K | 0.0% | $9.69 | 0.0% | COM | 558868105 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $705K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Ritter Pharmaceuticals, Inc. | 400,000 | $672K | 0.0% | $4.45 | — | COM | 767836109 |
| — | Windtree Therapeutics, Inc. | 254,973 | $653K | 0.0% | $1.93 | — | COM | 97382D105 |
| — | Chimerix, Inc. | 115,216 | $638K | 0.0% | $40.26 | — | COM | 16934W106 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $621K | 0.0% | $8.87 | -55.9% | COM | 03879J100 |
| — | Abeona Therapeutics Inc. | 101,680 | $610K | 0.0% | $6.00 | — | COM | 00289Y107 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $567K | 0.0% | $5.21 | — | COM | 09060J106 |
| — | Foundation Medicine, Inc. | 20,892 | $488K | 0.0% | $25.16 | — | COM | 350465100 |
| — | Achaogen, Inc. | 100,000 | $479K | 0.0% | $15.46 | — | COM | 004449104 |
| — | CytRx Corporation | 659,995 | $388K | 0.0% | $3.49 | — | COM PAR $.001 | 232828509 |
| — | ProNAi Therapeutics, Inc. | 200,000 | $364K | 0.0% | $20.52 | — | COM | 74346L101 |
| — | La Jolla Pharmaceutical Company | 13,746 | $327K | 0.0% | $10.24 | — | COM PAR $.0001 2 | 503459604 |
| — | ChemoCentryx, Inc. | 49,064 | $296K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $90,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $17,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |