SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value: $910M (100.0% shares, 0.0% debt)

Holdings (90)

ABBV ABBVIE INC 6.9%
Value $62.85M Shares 464,194 Est. Cost $85.61 Unrealized +18.8%
AZN ASTRAZENECA PLC 6.8%
Value $61.48M Shares 1,055,467 Est. Cost $51.22 Unrealized
SNY SANOFI 6.0%
Value $54.28M Shares 1,083,400 Est. Cost $49.60 Unrealized
LLY LILLY ELI & CO 4.8%
Value $44.11M Shares 159,695 Est. Cost $188.59 Unrealized +29.3%
MRK MERCK & CO INC 2.9%
Value $26.55M Shares 346,423 Est. Cost $69.89 Unrealized 0.0%
JNJ JOHNSON & JOHNSON 2.9%
Value $26.54M Shares 155,123 Est. Cost $121.71 Unrealized +19.2%
SNDX SYNDAX PHARMACEUTICALS INC 2.8%
Value $25.75M Shares 1,176,585 Est. Cost $17.22 Unrealized +7.3%
XBI SPDR SER TR 2.7%
Value $24.63M Shares 220,000 Est. Cost Unrealized
FIVN FIVE9 INC 2.7%
Value $24.51M Shares 178,500 Est. Cost $147.91 Unrealized 0.0%
SPRINGWORKS THERAPEUTICS INC 2.3%
Value $21.23M Shares 342,566 Est. Cost $70.19 Unrealized
KYMR KYMERA THERAPEUTICS INC 2.2%
Value $20.23M Shares 318,667 Est. Cost $46.80 Unrealized +24.4%
BMRN BIOMARIN PHARMACEUTICAL INC 2.1%
Value $19.17M Shares 216,977 Est. Cost $80.03 Unrealized +3.1%
WIX COM LTD 1.9%
Value $17.34M Shares 18,959,000 Est. Cost $0.94 Unrealized
MSFT MICROSOFT CORP 1.9%
Value $17M Shares 50,536 Est. Cost $148.28 Unrealized +111.4%
GNRC GENERAC HLDGS INC 1.6%
Value $14.8M Shares 42,057 Est. Cost $183.10 Unrealized +126.5%
AMZN AMAZON COM INC 1.5%
Value $14M Shares 4,200 Est. Cost $169.42 Unrealized +1.0%
META META PLATFORMS INC 1.5%
Value $14M Shares 41,622 Est. Cost $327.46 Unrealized +0.7%
PFE PFIZER INC 1.5%
Value $13.49M Shares 228,528 Est. Cost $35.67 Unrealized +12.8%
PANW PALO ALTO NETWORKS INC 1.5%
Value $13.36M Shares 24,000 Est. Cost $70.26 Unrealized +23.1%
CCCC C4 THERAPEUTICS INC 1.4%
Value $12.83M Shares 398,469 Est. Cost $30.77 Unrealized +28.5%
FIVERR INTL LTD 1.3%
Value $12.18M Shares 13,000,000 Est. Cost $0.94 Unrealized
BURL BURLINGTON STORES INC 1.3%
Value $12.1M Shares 41,501 Est. Cost $281.17 Unrealized 0.0%
CRNX CRINETICS PHARMACEUTICALS IN 1.3%
Value $12.02M Shares 423,248 Est. Cost $16.64 Unrealized +48.1%
FIVN FIVE9 INC 1.3%
Value $11.75M Shares 85,556 Est. Cost $147.91 Unrealized 0.0%
KURA KURA ONCOLOGY INC 1.3%
Value $11.65M Shares 832,238 Est. Cost $23.39 Unrealized -30.7%
ALT ALTIMMUNE INC 1.3%
Value $11.4M Shares 1,244,241 Est. Cost $12.80 Unrealized -17.0%
FATE FATE THERAPEUTICS INC 1.2%
Value $10.85M Shares 185,476 Est. Cost $63.00 Unrealized -10.0%
MERUS N V 1.2%
Value $10.84M Shares 340,951 Est. Cost $22.08 Unrealized
RLMD RELMADA THERAPEUTICS INC 1.2%
Value $10.77M Shares 478,208 Est. Cost $22.24 Unrealized 0.0%
VERINT SYS INC 1.2%
Value $10.5M Shares 200,000 Est. Cost $46.93 Unrealized
S SENTINELONE INC 1.1%
Value $10.09M Shares 199,824 Est. Cost $58.61 Unrealized 0.0%
ARYA SCIENCES ACQU CORP IV 1.1%
Value $9.93M Shares 1,000,000 Est. Cost $10.23 Unrealized
LESLIES INC 1.0%
Value $8.815M Shares 372,569 Est. Cost $22.40 Unrealized
PTGX PROTAGONIST THERAPEUTICS INC 0.9%
Value $8.55M Shares 250,000 Est. Cost $27.87 Unrealized +13.4%
IMTX IMMATICS N.V 0.9%
Value $8.359M Shares 621,925 Est. Cost $12.72 Unrealized -1.7%
GRAPHITE BIO INC 0.9%
Value $8.244M Shares 663,194 Est. Cost $16.14 Unrealized
IVERIC BIO INC 0.9%
Value $8.109M Shares 485,001 Est. Cost $6.31 Unrealized
ABNB AIRBNB INC 0.9%
Value $7.94M Shares 47,689 Est. Cost $176.10 Unrealized 0.0%
VISTAGEN THERAPEUTICS INC 0.9%
Value $7.849M Shares 4,024,938 Est. Cost $2.00 Unrealized
RUN SUNRUN INC 0.9%
Value $7.82M Shares 228,000 Est. Cost $47.94 Unrealized -2.4%
HOWL WEREWOLF THERAPEUTICS INC 0.8%
Value $7.722M Shares 648,391 Est. Cost $13.70 Unrealized +10.2%
VINCERX PHARMA INC 0.8%
Value $7.338M Shares 720,161 Est. Cost $15.55 Unrealized
CSTE CAESARSTONE LTD 0.8%
Value $7.305M Shares 644,146 Est. Cost $12.97 Unrealized -10.1%
ASAN ASANA INC 0.8%
Value $7.194M Shares 96,500 Est. Cost $105.89 Unrealized 0.0%
ZLAB ZAI LAB LTD 0.8%
Value $7.017M Shares 111,641 Est. Cost $133.80 Unrealized
KROS KEROS THERAPEUTICS INC 0.8%
Value $7.003M Shares 119,681 Est. Cost $49.87 Unrealized 0.0%
TEVA TEVA PHARMACEUTICAL INDS LTD 0.7%
Value $6.671M Shares 832,877 Est. Cost $9.38 Unrealized
CLDX CELLDEX THERAPEUTICS INC NEW 0.7%
Value $6.444M Shares 166,766 Est. Cost $46.19 Unrealized -5.7%
IMUX IMMUNIC INC 0.7%
Value $6.379M Shares 666,602 Est. Cost $9.50 Unrealized -5.2%
TEAD OUTBRAIN INC 0.7%
Value $6.037M Shares 431,194 Est. Cost $17.62 Unrealized -12.6%
ESSA PHARMA INC 0.7%
Value $5.999M Shares 422,461 Est. Cost $16.67 Unrealized
KEZAR LIFE SCIENCES INC 0.6%
Value $5.64M Shares 337,293 Est. Cost $16.72 Unrealized
IDYA IDEAYA BIOSCIENCES INC 0.6%
Value $5.572M Shares 235,695 Est. Cost $19.80 Unrealized +17.3%
PERI PERION NETWORK LTD 0.6%
Value $5.411M Shares 225,000 Est. Cost $24.40 Unrealized 0.0%
VERONA PHARMA PLC 0.6%
Value $5.384M Shares 801,256 Est. Cost $6.26 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 0.6%
Value $5.379M Shares 281,769 Est. Cost $25.42 Unrealized -13.4%
PMVP PMV PHARMACEUTICALS INC 0.5%
Value $4.401M Shares 190,525 Est. Cost $33.95 Unrealized -28.8%
SUTRO BIOPHARMA INC 0.5%
Value $4.192M Shares 281,702 Est. Cost $22.04 Unrealized
KALV KALVISTA PHARMACEUTICALS INC 0.5%
Value $4.183M Shares 316,200 Est. Cost $15.92 Unrealized 0.0%
NAUT NAUTILUS BIOTECHNOLOGY INC 0.5%
Value $4.144M Shares 800,000 Est. Cost $10.83 Unrealized -50.6%
ALLT ALLOT LTD 0.4%
Value $4.05M Shares 340,912 Est. Cost $9.29 Unrealized +41.2%
OMEGA THERAPEUTICS INC 0.4%
Value $3.999M Shares 352,948 Est. Cost $18.85 Unrealized
BCAB BIOATLA INC 0.4%
Value $3.534M Shares 180,006 Est. Cost $38.96 Unrealized -34.3%
CAMT CAMTEK LTD 0.4%
Value $3.453M Shares 75,000 Est. Cost $41.91 Unrealized 0.0%
POINT BIOPHARMA GLOBAL INC 0.4%
Value $3.319M Shares 592,592 Est. Cost $7.69 Unrealized
TURNING POINT THERAPEUTICS I 0.4%
Value $3.279M Shares 68,734 Est. Cost $47.71 Unrealized
BIIB BIOGEN INC 0.3%
Value $3.119M Shares 13,000 Est. Cost $257.12 Unrealized 0.0%
ONCORUS INC 0.3%
Value $3.01M Shares 571,204 Est. Cost $31.44 Unrealized
INHIBRX INC 0.3%
Value $2.705M Shares 61,931 Est. Cost $28.82 Unrealized
ADICET BIO INC 0.3%
Value $2.624M Shares 150,000 Est. Cost $17.49 Unrealized
OTONOMO TECHNOLOGIES LTD 0.3%
Value $2.428M Shares 593,650 Est. Cost $4.78 Unrealized
CMPX COMPASS THERAPEUTICS INC 0.2%
Value $2.219M Shares 700,000 Est. Cost $3.29 Unrealized 0.0%
BCLS ACQUISITION CORP 0.2%
Value $2.132M Shares 216,250 Est. Cost $10.98 Unrealized
AYALA PHARMACEUTICALS INC 0.2%
Value $2.128M Shares 250,000 Est. Cost $8.51 Unrealized
QURE UNIQURE NV 0.2%
Value $2.074M Shares 100,000 Est. Cost $33.51 Unrealized -14.4%
CYCLACEL PHARMACEUTICALS INC 0.2%
Value $1.977M Shares 508,322 Est. Cost $7.11 Unrealized
ARYA SCIENCES ACQUISITN CORP 0.2%
Value $1.94M Shares 200,000 Est. Cost $9.88 Unrealized
CHINOOK THERAPEUTICS INC 0.2%
Value $1.821M Shares 111,653 Est. Cost $16.31 Unrealized
LIANY LIANBIO 0.2%
Value $1.662M Shares 275,007 Est. Cost $6.04 Unrealized
ARGX ARGENX SE 0.2%
Value $1.503M Shares 4,291 Est. Cost $84.36 Unrealized
ANNX ANNEXON INC 0.2%
Value $1.421M Shares 123,637 Est. Cost $22.16 Unrealized -27.1%
DYN DYNE THERAPEUTICS INC 0.1%
Value $1.251M Shares 105,204 Est. Cost $19.79 Unrealized -29.0%
MGIC MAGIC SOFTWARE ENTERPRISES L 0.1%
Value $1.208M Shares 57,704 Est. Cost $15.21 Unrealized +21.4%
CYTEIR THERAPEUTICS INC 0.1%
Value $1.124M Shares 98,860 Est. Cost $21.11 Unrealized
ARBE ARBE ROBOTICS LTD 0.1%
Value $1.12M Shares 120,400 Est. Cost $10.07 Unrealized 0.0%
VRTX VERTEX PHARMACEUTICALS INC 0.1%
Value $969K Shares 4,411 Est. Cost $194.45 Unrealized 0.0%
NICE SYS INC 0.1%
Value $921K Shares 250,000 Est. Cost $1.78 Unrealized
LAVA THERAPEUTICS NV 0.1%
Value $758K Shares 137,857 Est. Cost $15.19 Unrealized
IMMATICS N.V 0.0%
Value $439K Shares 100,000 Est. Cost $3.50 Unrealized
OUTLOOK THERAPEUTICS INC 0.0%
Value $15,000 Shares 129,500 Est. Cost $1.00 Unrealized