| RA CAPITAL MANAGEMENT, L.P. | 6,955,993 | $117,069 |
| Siren, L.L.C. | 5,216,969 | $87,802 |
| Vestal Point Capital, LP | 3,575,000 | $60,167 |
| FMR LLC | 3,347,223 | $56,334 |
| RED TREE MANAGEMENT, LLC | 3,170,509 | $53,360 |
| TPG GP A, LLC | 3,010,425 | $50,665 |
| JANUS HENDERSON GROUP PLC | 2,646,285 | $44,484 |
| Deep Track Capital, LP | 2,614,004 | $43,994 |
| BlackRock, Inc. | 2,528,451 | $42,554 |
| Omega Fund Management, LLC | 2,204,650 | $37,104 |
| VANGUARD GROUP INC | 2,186,150 | $36,793 |
| STATE STREET CORP | 1,649,537 | $27,762 |
| FRANKLIN RESOURCES INC | 1,620,025 | $27,265 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,559,535 | $26 |
| GEODE CAPITAL MANAGEMENT, LLC | 811,400 | $13,659 |
| CITADEL ADVISORS LLC | 772,258 | $12,997 |
| FIL Ltd | 758,493 | $12,765 |
| ACORN CAPITAL ADVISORS, LLC | 643,382 | $10,828 |
| Aisling Capital Management LP | 568,919 | $9,575 |
| GOLDMAN SACHS GROUP INC | 552,331 | $9,296 |
| MILLENNIUM MANAGEMENT LLC | 434,699 | $7,316 |
| Rock Springs Capital Management LP | 429,095 | $7,222 |
| Ensign Peak Advisors, Inc | 401,444 | $6,756 |
| NAN FUNG TRINITY (HK) LTD | 372,385 | $6,267 |
| BANK OF AMERICA CORP /DE/ | 335,682 | $5,650 |
| ALGERT GLOBAL LLC | 318,269 | $5 |
| Clearbridge Investments, LLC | 298,762 | $5,028 |
| Palo Alto Investors LP | 298,575 | $5,025 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 272,145 | $4,580 |
| DAFNA Capital Management LLC | 261,583 | $4,402 |
| TD Asset Management Inc | 244,626 | $4,117 |
| NORTHERN TRUST CORP | 237,107 | $3,991 |
| Woodline Partners LP | 232,690 | $3,916 |
| ORBIMED ADVISORS LLC | 209,100 | $3,519 |
| UBS Group AG | 192,191 | $3,235 |
| T. Rowe Price Investment Management, Inc. | 165,243 | $3 |
| Hudson Bay Capital Management LP | 150,000 | $2,525 |
| D. E. Shaw & Co., Inc. | 136,522 | $2,298 |
| DEUTSCHE BANK AG\ | 128,626 | $2,165 |
| Napean Trading & Investment Co (Singapore) PTE Ltd | 113,780 | $1,915 |
| HealthInvest Partners AB | 111,363 | $1,874 |
| MORGAN STANLEY | 109,456 | $1,842 |
| BARCLAYS PLC | 103,241 | $1,738 |
| Soleus Capital Management, L.P. | 100,000 | $1,683 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,918 | $1,602 |
| TWO SIGMA INVESTMENTS, LP | 98,481 | $1,657 |
| BNP PARIBAS ARBITRAGE, SA | 95,901 | $1,614 |
| Bank of New York Mellon Corp | 88,677 | $1,492 |
| JANE STREET GROUP, LLC | 85,583 | $1,440 |
| CITIGROUP INC | 66,697 | $1,123 |
| Mariner, LLC | 64,562 | $1,087 |
| Shay Capital LLC | 64,300 | $1,082 |
| Y-Intercept (Hong Kong) Ltd | 59,937 | $1,009 |
| Rafferty Asset Management, LLC | 59,819 | $1,007 |
| Russell Investments Group, Ltd. | 56,598 | $953 |
| SCS Capital Management LLC | 53,430 | $899 |
| HRT FINANCIAL LP | 50,147 | $1 |
| ALPS ADVISORS INC | 44,978 | $757 |
| NORGES BANK | 42,889 | $722 |
| DIMENSIONAL FUND ADVISORS LP | 40,934 | $689 |
| RHUMBLINE ADVISERS | 40,583 | $683 |
| Nuveen, LLC | 38,841 | $654 |
| DARK FOREST CAPITAL MANAGEMENT LP | 37,636 | $633 |
| Trexquant Investment LP | 37,094 | $624 |
| WELLS FARGO & COMPANY/MN | 35,243 | $593 |
| XTX Topco Ltd | 34,067 | $573 |
| Swiss National Bank | 32,300 | $544 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,693 | $517 |
| Bleakley Financial Group, LLC | 29,182 | $491 |
| ALLIANCEBERNSTEIN L.P. | 29,110 | $490 |
| TUDOR INVESTMENT CORP ET AL | 27,391 | $461 |
| AMERICAN CENTURY COMPANIES INC | 24,493 | $412 |
| Caption Management, LLC | 23,000 | $387 |
| PROFUND ADVISORS LLC | 22,177 | $373 |
| Creative Planning | 21,834 | $367 |
| MetLife Investment Management, LLC | 21,519 | $362 |
| Invesco Ltd. | 21,006 | $354 |
| Jump Financial, LLC | 20,988 | $353 |
| Voya Investment Management LLC | 18,195 | $306 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,140 | $303 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,158 | $289 |
| GROUP ONE TRADING, L.P. | 16,914 | $285 |
| JPMORGAN CHASE & CO | 16,847 | $284 |
| AMERIPRISE FINANCIAL INC | 16,032 | $270 |
| Legal & General Group Plc | 15,958 | $269 |
| VARCOV Co. | 15,653 | $263 |
| Quantinno Capital Management LP | 15,165 | $255 |
| Virtus Investment Advisers, LLC | 14,395 | $242 |
| LPL Financial LLC | 14,283 | $240 |
| Ascent Group, LLC | 14,151 | $238 |
| Brevan Howard Capital Management LP | 14,117 | $238 |
| INTECH INVESTMENT MANAGEMENT LLC | 14,103 | $237 |
| ADAR1 Capital Management, LLC | 13,705 | $231 |
| Graham Capital Management, L.P. | 13,116 | $221 |
| Brinker Capital Investments, LLC | 11,278 | $190 |
| LETKO, BROSSEAU & ASSOCIATES INC | 11,175 | $188 |
| Aquatic Capital Management LLC | 11,127 | $187 |
| SG Americas Securities, LLC | 11,122 | $0 |
| VICTORY CAPITAL MANAGEMENT INC | 10,070 | $169 |
| Police & Firemen's Retirement System of New Jersey | 9,836 | $166 |
| 39 other institutions | 59,219 | $957 |