| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,561,111 | $74,206 |
| RA CAPITAL MANAGEMENT, L.P. | 6,053,960 | $68,470 |
| TCG Crossover Management, LLC | 5,250,000 | $59,378 |
| Nantahala Capital Management, LLC | 4,293,346 | $48,558 |
| BlackRock, Inc. | 4,263,761 | $48,223 |
| VANGUARD GROUP INC | 3,559,552 | $40,259 |
| BRAIDWELL LP | 3,061,222 | $34,622 |
| Point72 Asset Management, L.P. | 2,398,232 | $27,124 |
| Siren, L.L.C. | 1,950,000 | $22,055 |
| D. E. Shaw & Co., Inc. | 1,913,755 | $21,645 |
| First Turn Management, LLC | 1,892,683 | $21,406 |
| GSK plc | 1,785,714 | $20,196 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,700,000 | $19,227 |
| Ikarian Capital, LLC | 1,375,472 | $15,557 |
| abrdn plc | 1,254,027 | $14,183 |
| ADAR1 Capital Management, LLC | 1,253,749 | $14,180 |
| CITADEL ADVISORS LLC | 1,207,004 | $13,651 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,105,813 | $12,510 |
| DIMENSIONAL FUND ADVISORS LP | 1,051,124 | $11,888 |
| STATE STREET CORP | 1,005,345 | $11,370 |
| BALYASNY ASSET MANAGEMENT L.P. | 970,439 | $10,976 |
| Vestal Point Capital, LP | 950,000 | $10,745 |
| GREAT POINT PARTNERS LLC | 800,000 | $9,048 |
| ACADIAN ASSET MANAGEMENT LLC | 736,740 | $8 |
| Connor, Clark & Lunn Investment Management Ltd. | 582,377 | $6,587 |
| NORTHERN TRUST CORP | 552,220 | $6,246 |
| BOOTHBAY FUND MANAGEMENT, LLC | 517,526 | $5,853 |
| JANE STREET GROUP, LLC | 493,750 | $5,584 |
| Invesco Ltd. | 417,189 | $4,718 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 394,650 | $4,463 |
| Qube Research & Technologies Ltd | 392,489 | $4,439 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 388,896 | $4,398 |
| Sio Capital Management, LLC | 382,000 | $4,320 |
| Trexquant Investment LP | 355,547 | $4,021 |
| GOLDMAN SACHS GROUP INC | 323,879 | $3,663 |
| DEUTSCHE BANK AG\ | 287,096 | $3,247 |
| BESSEMER GROUP INC | 286,988 | $3 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 243,388 | $2,753 |
| BANK OF AMERICA CORP /DE/ | 231,177 | $2,615 |
| Catalio Capital Management, LP | 201,301 | $2,277 |
| Nicholas Investment Partners, LP | 182,961 | $2,069 |
| WELLS FARGO & COMPANY/MN | 166,395 | $1,882 |
| MORGAN STANLEY | 165,623 | $1,873 |
| Simplify Asset Management Inc. | 159,674 | $1,806 |
| AMERICAN CENTURY COMPANIES INC | 157,672 | $1,783 |
| WELLINGTON MANAGEMENT GROUP LLP | 146,427 | $1,656 |
| SummitTX Capital, L.P. | 138,143 | $1,562 |
| Fiduciary Trust Co | 136,555 | $1,544 |
| BARCLAYS PLC | 132,541 | $1,499 |
| Bank of New York Mellon Corp | 116,906 | $1,322 |
| Nuveen, LLC | 112,203 | $1,269 |
| Walleye Capital LLC | 108,434 | $1,226 |
| UBS Group AG | 102,967 | $1,165 |
| MARSHALL WACE, LLP | 102,921 | $1,164 |
| AMERIPRISE FINANCIAL INC | 100,675 | $1,139 |
| Maven Securities LTD | 100,000 | $1,131 |
| GSA CAPITAL PARTNERS LLP | 99,709 | $1 |
| PRINCIPAL FINANCIAL GROUP INC | 97,688 | $1,105 |
| Jump Financial, LLC | 92,200 | $1,043 |
| Exome Asset Management LLC | 92,055 | $1,041 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,930 | $994 |
| STATE OF WISCONSIN INVESTMENT BOARD | 86,499 | $978 |
| RBF Capital, LLC | 80,506 | $911 |
| Verition Fund Management LLC | 74,691 | $845 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 72,060 | $815 |
| CITIGROUP INC | 67,102 | $759 |
| Y-Intercept (Hong Kong) Ltd | 66,716 | $755 |
| Legato Capital Management LLC | 66,347 | $750 |
| Squarepoint Ops LLC | 65,852 | $745 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 63,760 | $1 |
| Integrated Quantitative Investments LLC | 62,522 | $707 |
| EAM Investors, LLC | 61,620 | $697 |
| Atom Investors LP | 60,595 | $685 |
| DekaBank Deutsche Girozentrale | 60,000 | $1 |
| NEW YORK STATE COMMON RETIREMENT FUND | 57,725 | $653 |
| RHUMBLINE ADVISERS | 55,713 | $630 |
| MILLENNIUM MANAGEMENT LLC | 54,431 | $616 |
| XTX Topco Ltd | 51,802 | $586 |
| Burkehill Global Management, LP | 50,000 | $566 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $566 |
| KVP Capital Advisors, LP | 50,000 | $566 |
| STRS OHIO | 49,300 | $558 |
| Brevan Howard Capital Management LP | 48,900 | $559 |
| Graham Capital Management, L.P. | 48,464 | $548 |
| FRANKLIN RESOURCES INC | 44,249 | $500 |
| HSBC HOLDINGS PLC | 43,262 | $498 |
| Jain Global LLC | 41,260 | $467 |
| COMMONWEALTH EQUITY SERVICES, LLC | 40,000 | $452 |
| SEI INVESTMENTS CO | 37,511 | $424 |
| Campbell & CO Investment Adviser LLC | 35,601 | $403 |
| GROUP ONE TRADING, L.P. | 34,750 | $393 |
| AXQ CAPITAL, LP | 31,545 | $357 |
| Woodline Partners LP | 30,793 | $348 |
| TWO SIGMA ADVISERS, LP | 30,500 | $345 |
| COUNTRY TRUST BANK | 30,041 | $340 |
| LMR Partners LLP | 30,000 | $339 |
| Quantinno Capital Management LP | 29,264 | $331 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,832 | $326 |
| FOX RUN MANAGEMENT, L.L.C. | 25,568 | $289 |
| MetLife Investment Management, LLC | 22,714 | $257 |
| 71 other institutions | 460,686 | $5,054 |