| VR Adviser, LLC | 6,728,985 | $108,673 |
| Frazier Life Sciences Management, L.P. | 5,039,867 | $81,394 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,768,712 | $77,015 |
| TANG CAPITAL MANAGEMENT LLC | 4,573,530 | $73,863 |
| BlackRock, Inc. | 3,754,148 | $60,629 |
| MILLENNIUM MANAGEMENT LLC | 2,896,666 | $46,781 |
| Capital World Investors | 2,808,583 | $45,359 |
| VANGUARD GROUP INC | 2,509,020 | $40,521 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,427,118 | $39,198 |
| Point72 Asset Management, L.P. | 2,283,766 | $36,883 |
| Woodline Partners LP | 1,921,092 | $31,026 |
| STATE STREET CORP | 1,911,691 | $30,874 |
| Vestal Point Capital, LP | 1,890,000 | $30,524 |
| Kynam Capital Management, LP | 1,810,954 | $29,247 |
| Parkman Healthcare Partners LLC | 1,768,508 | $28,561 |
| EMERALD ADVISERS, LLC | 1,340,495 | $21,649 |
| Octagon Capital Advisors LP | 1,273,333 | $20,564 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,171,755 | $18,924 |
| GEODE CAPITAL MANAGEMENT, LLC | 944,077 | $15,251 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 855,461 | $13,816 |
| GOLDMAN SACHS GROUP INC | 835,304 | $13,490 |
| Elmind Capital, LP | 801,300 | $12,941 |
| ARMISTICE CAPITAL, LLC | 800,000 | $12,920 |
| BARCLAYS PLC | 700,573 | $11,314 |
| MORGAN STANLEY | 700,228 | $11,309 |
| Squadron Capital Management LLC | 700,000 | $11,305 |
| Bank of New York Mellon Corp | 695,175 | $11,227 |
| GREAT POINT PARTNERS LLC | 685,632 | $11,073 |
| Freestone Grove Partners LP | 633,019 | $10,223 |
| BANK OF AMERICA CORP /DE/ | 389,813 | $6,295 |
| Spruce Street Capital LP | 387,968 | $6,266 |
| ORBIMED ADVISORS LLC | 382,400 | $6,176 |
| UBS Group AG | 371,993 | $6,008 |
| Blue Owl Capital Holdings LP | 360,000 | $5,814 |
| DAFNA Capital Management LLC | 356,802 | $5,762 |
| NORTHERN TRUST CORP | 351,973 | $5,684 |
| Skandinaviska Enskilda Banken AB (publ) | 351,305 | $5,682 |
| Hennion & Walsh Asset Management, Inc. | 341,819 | $5,520 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 324,369 | $5,239 |
| Schonfeld Strategic Advisors LLC | 305,880 | $4,940 |
| HRT FINANCIAL LP | 287,052 | $5 |
| Atom Investors LP | 276,113 | $4,459 |
| F/M Investments LLC | 236,690 | $3,823 |
| RENAISSANCE TECHNOLOGIES LLC | 165,151 | $2,667 |
| NAN FUNG TRINITY (HK) LTD | 154,522 | $2,496 |
| NEXTBio Capital Management LP | 131,796 | $2,129 |
| RAYMOND JAMES FINANCIAL INC | 129,517 | $2,092 |
| WELLINGTON MANAGEMENT GROUP LLP | 122,379 | $1,976 |
| Caption Management, LLC | 117,907 | $1,904 |
| FMR LLC | 111,807 | $1,806 |
| PANAGORA ASSET MANAGEMENT INC | 109,391 | $1,767 |
| Nuveen, LLC | 107,129 | $1,730 |
| Jump Financial, LLC | 90,742 | $1,465 |
| Invesco Ltd. | 77,864 | $1,258 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,895 | $1,161 |
| Rafferty Asset Management, LLC | 65,593 | $1,059 |
| Brevan Howard Capital Management LP | 59,147 | $955 |
| Birchview Capital, LP | 57,000 | $921 |
| Russell Investments Group, Ltd. | 56,249 | $908 |
| WELLS FARGO & COMPANY/MN | 56,014 | $905 |
| Swiss National Bank | 54,900 | $887 |
| AlphaQuest LLC | 52,190 | $843 |
| Seven Fleet Capital Management LP | 48,412 | $782 |
| SG Americas Securities, LLC | 48,030 | $1 |
| RHUMBLINE ADVISERS | 47,391 | $765 |
| Creative Planning | 44,082 | $712 |
| ALPS ADVISORS INC | 41,504 | $670 |
| Virtus Investment Advisers, LLC | 40,414 | $653 |
| ALLIANCEBERNSTEIN L.P. | 40,020 | $646 |
| CITADEL ADVISORS LLC | 37,761 | $610 |
| Ikarian Capital, LLC | 35,119 | $567 |
| DEUTSCHE BANK AG\ | 35,091 | $567 |
| AMERIPRISE FINANCIAL INC | 34,929 | $564 |
| EVOKE WEALTH, LLC | 31,841 | $514 |
| JANE STREET GROUP, LLC | 31,608 | $510 |
| MARTINGALE ASSET MANAGEMENT L P | 30,939 | $500 |
| Quantinno Capital Management LP | 29,156 | $471 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,410 | $459 |
| UBS ASSET MANAGEMENT AMERICAS INC | 27,722 | $448 |
| XTX Topco Ltd | 26,508 | $428 |
| AQR CAPITAL MANAGEMENT LLC | 24,666 | $398 |
| PROFUND ADVISORS LLC | 24,392 | $394 |
| Legal & General Group Plc | 23,818 | $385 |
| Aquatic Capital Management LLC | 23,370 | $377 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,118 | $0 |
| OSAIC HOLDINGS, INC. | 21,937 | $354 |
| MetLife Investment Management, LLC | 21,688 | $350 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,624 | $347 |
| Boxer Capital Management, LLC | 20,400 | $329 |
| ExodusPoint Capital Management, LP | 20,061 | $324 |
| JPMORGAN CHASE & CO | 19,454 | $314 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,868 | $289 |
| Man Group plc | 17,446 | $282 |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 16,711 | $270 |
| Bleakley Financial Group, LLC | 15,976 | $258 |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,923 | $257 |
| ALGERT GLOBAL LLC | 13,110 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 12,919 | $209 |
| Rathbones Group PLC | 12,272 | $198 |
| SEI INVESTMENTS CO | 11,897 | $192 |
| 61 other institutions | 173,414 | $2,758 |