| TCG Crossover Management, LLC | 2,582,408 | $87,466 |
| FCPM III SERVICES B.V. | 1,833,333 | $62,095 |
| ORBIMED ADVISORS LLC | 1,642,891 | $55,645 |
| RTW INVESTMENTS, LP | 1,637,165 | $55,451 |
| Foresite Capital Management VI LLC | 1,562,500 | $52,922 |
| Siren, L.L.C. | 1,375,000 | $46,571 |
| VANGUARD GROUP INC | 1,186,791 | $40,197 |
| Frazier Life Sciences Management, L.P. | 983,333 | $33,305 |
| BRAIDWELL LP | 929,694 | $31,489 |
| Redmile Group, LLC | 885,927 | $30,006 |
| PERCEPTIVE ADVISORS LLC | 825,890 | $27,973 |
| Soleus Capital Management, L.P. | 764,000 | $25,877 |
| Nantahala Capital Management, LLC | 754,153 | $25,543 |
| Ikarian Capital, LLC | 665,271 | $22,533 |
| Caligan Partners LP | 644,400 | $21,826 |
| STATE STREET CORP | 639,804 | $21,670 |
| CITADEL ADVISORS LLC | 591,802 | $20,044 |
| GREAT POINT PARTNERS LLC | 581,187 | $19,685 |
| Octagon Capital Advisors LP | 574,000 | $19,441 |
| ADAR1 Capital Management, LLC | 509,679 | $17,263 |
| BlackRock, Inc. | 486,153 | $16,466 |
| BOONE CAPITAL MANAGEMENT LLC | 470,456 | $15,934 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 424,862 | $14,390 |
| MPM BioImpact LLC | 397,906 | $13,477 |
| BOOTHBAY FUND MANAGEMENT, LLC | 390,747 | $13,235 |
| FMR LLC | 275,758 | $9,340 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 275,000 | $9,314 |
| GOLDMAN SACHS GROUP INC | 254,053 | $8,605 |
| Commodore Capital LP | 250,000 | $8,468 |
| GEODE CAPITAL MANAGEMENT, LLC | 239,790 | $8,125 |
| Rock Springs Capital Management LP | 213,731 | $7,239 |
| Invesco Ltd. | 167,030 | $5,657 |
| AWM Investment Company, Inc. | 162,560 | $5,506 |
| Qube Research & Technologies Ltd | 158,292 | $5,361 |
| Opaleye Management Inc. | 150,000 | $213 |
| Tetragon Partners GP Ltd | 131,770 | $4,463 |
| Deep Track Capital, LP | 110,448 | $3,741 |
| Velan Capital Investment Management LP | 108,000 | $3,658 |
| MILLENNIUM MANAGEMENT LLC | 106,671 | $3,613 |
| Atika Capital Management LLC | 94,245 | $3,192 |
| RENAISSANCE TECHNOLOGIES LLC | 91,173 | $3,088 |
| JANE STREET GROUP, LLC | 84,778 | $2,871 |
| MARSHALL WACE, LLP | 84,596 | $2,865 |
| Euclidean Capital LLC | 82,234 | $2,785 |
| BARCLAYS PLC | 76,659 | $2,596 |
| UBS Group AG | 66,225 | $2,243 |
| BANK OF AMERICA CORP /DE/ | 58,330 | $1,976 |
| Quadrature Capital Ltd | 57,590 | $1,951 |
| Trexquant Investment LP | 54,016 | $1,830 |
| MORGAN STANLEY | 51,324 | $1,738 |
| Burkehill Global Management, LP | 50,000 | $1,694 |
| Connor, Clark & Lunn Investment Management Ltd. | 49,021 | $1,660 |
| NORTHERN TRUST CORP | 40,504 | $1,372 |
| Rafferty Asset Management, LLC | 32,984 | $1,117 |
| TWO SIGMA INVESTMENTS, LP | 31,128 | $1,054 |
| Point72 Asset Management, L.P. | 25,185 | $853 |
| Squarepoint Ops LLC | 24,572 | $832 |
| GSA CAPITAL PARTNERS LLP | 22,944 | $1 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 22,859 | $774 |
| Sigma Planning Corp | 19,000 | $644 |
| Man Group plc | 18,802 | $637 |
| TWO SIGMA ADVISERS, LP | 18,448 | $625 |
| XTX Topco Ltd | 18,195 | $616 |
| ACADIAN ASSET MANAGEMENT LLC | 16,788 | $1 |
| Birchview Capital, LP | 15,000 | $508 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 14,375 | $487 |
| Exome Asset Management LLC | 14,194 | $481 |
| HighTower Advisors, LLC | 12,525 | $424 |
| PROFUND ADVISORS LLC | 11,892 | $403 |
| OMERS ADMINISTRATION Corp | 11,600 | $393 |
| Y-Intercept (Hong Kong) Ltd | 11,237 | $381 |
| AMERICAN CENTURY COMPANIES INC | 10,218 | $346 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,000 | $339 |
| Jump Financial, LLC | 9,845 | $333 |
| Engineers Gate Manager LP | 9,784 | $331 |
| DIMENSIONAL FUND ADVISORS LP | 8,934 | $302 |
| Hudson Bay Capital Management LP | 8,900 | $301 |
| CANADA PENSION PLAN INVESTMENT BOARD | 8,800 | $298 |
| CITIGROUP INC | 8,566 | $290 |
| Jain Global LLC | 7,420 | $251 |
| Virtus Investment Advisers, LLC | 7,229 | $245 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 6,893 | $233 |
| BANK OF NOVA SCOTIA | 6,700 | $227 |
| GROUP ONE TRADING, L.P. | 5,282 | $179 |
| China Universal Asset Management Co., Ltd. | 4,515 | $153 |
| Tower Research Capital LLC (TRC) | 3,085 | $104 |
| SIMPLEX TRADING, LLC | 2,846 | $96 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 1,924 | $64 |
| JPMORGAN CHASE & CO | 1,668 | $56 |
| Mirae Asset Global Investments Co., Ltd. | 1,347 | $46 |
| GF FUND MANAGEMENT CO. LTD. | 544 | $18 |
| BNP PARIBAS ARBITRAGE, SA | 498 | $17 |
| PNC Financial Services Group, Inc. | 497 | $17 |
| Daiwa Securities Group Inc. | 92 | $0 |
| NISA INVESTMENT ADVISORS, LLC | 79 | $3 |
| Fortitude Family Office, LLC | 63 | $2 |
| ROYAL BANK OF CANADA | 35 | $1 |
| CWM, LLC | 32 | $0 |
| EverSource Wealth Advisors, LLC | 20 | $1 |
| BESSEMER GROUP INC | 11 | $0 |
| 1 other institutions | 1 | $0 |