| BlackRock, Inc. | 5,756,811 | $82,898 |
| Redmile Group, LLC | 4,368,804 | $62,911 |
| JPMORGAN CHASE & CO | 3,553,502 | $51,170 |
| VANGUARD GROUP INC | 3,374,140 | $48,588 |
| STATE STREET CORP | 2,286,736 | $32,929 |
| MORGAN STANLEY | 2,014,788 | $29,013 |
| GOLDMAN SACHS GROUP INC | 1,785,437 | $25,710 |
| AQR CAPITAL MANAGEMENT LLC | 1,361,962 | $19,612 |
| Integral Health Asset Management, LLC | 1,200,000 | $17,280 |
| Assenagon Asset Management S.A. | 1,160,380 | $16,709 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,145,206 | $16,495 |
| 22NW, LP | 923,679 | $13,301 |
| DIMENSIONAL FUND ADVISORS LP | 903,851 | $13,014 |
| Nuveen, LLC | 658,510 | $9,483 |
| Pale Fire Capital SE | 499,526 | $7,193 |
| Qube Research & Technologies Ltd | 442,690 | $6,375 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 391,461 | $5,637 |
| ACADIAN ASSET MANAGEMENT LLC | 375,399 | $5 |
| NORTHERN TRUST CORP | 373,689 | $5,381 |
| STIFEL FINANCIAL CORP | 335,046 | $4,825 |
| RENAISSANCE TECHNOLOGIES LLC | 333,086 | $4,796 |
| BANK OF AMERICA CORP /DE/ | 300,609 | $4,329 |
| HRT FINANCIAL LP | 299,915 | $4 |
| Voss Capital, LLC | 295,000 | $4,248 |
| GSK plc | 271,456 | $3,909 |
| FMR LLC | 266,095 | $3,832 |
| Trexquant Investment LP | 250,698 | $3,610 |
| AMERIPRISE FINANCIAL INC | 247,367 | $3,562 |
| PANAGORA ASSET MANAGEMENT INC | 222,715 | $3,207 |
| ArchPoint Investors | 222,278 | $3,201 |
| MILLENNIUM MANAGEMENT LLC | 214,666 | $3,091 |
| UBS Group AG | 206,689 | $2,976 |
| MOORE CAPITAL MANAGEMENT, LP | 200,000 | $2,880 |
| JANE STREET GROUP, LLC | 196,521 | $2,830 |
| DEUTSCHE BANK AG\ | 192,582 | $2,773 |
| IEQ CAPITAL, LLC | 186,667 | $2,688 |
| Jump Financial, LLC | 178,025 | $2,564 |
| BARCLAYS PLC | 164,421 | $2,368 |
| Invesco Ltd. | 157,903 | $2,274 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 149,000 | $2,146 |
| Bank of New York Mellon Corp | 145,594 | $2,097 |
| ADAR1 Capital Management, LLC | 144,848 | $2,086 |
| Hudson Bay Capital Management LP | 140,000 | $2,016 |
| Susquehanna Portfolio Strategies, LLC | 133,556 | $1,923 |
| TWO SIGMA INVESTMENTS, LP | 129,941 | $1,871 |
| ROYCE & ASSOCIATES LP | 119,038 | $1,714 |
| Propel Bio Management, LLC | 116,896 | $1,683 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 114,988 | $1,656 |
| AMERICAN CENTURY COMPANIES INC | 113,134 | $1,629 |
| Hennion & Walsh Asset Management, Inc. | 93,917 | $1,352 |
| RAYMOND JAMES FINANCIAL INC | 86,001 | $1,238 |
| WELLS FARGO & COMPANY/MN | 85,103 | $1,225 |
| ACT CAPITAL MANAGEMENT, LLC | 82,500 | $1,188 |
| DekaBank Deutsche Girozentrale | 74,600 | $2 |
| CWM, LLC | 73,858 | $1 |
| Cerity Partners LLC | 71,488 | $1,029 |
| D. E. Shaw & Co., Inc. | 68,388 | $985 |
| RHUMBLINE ADVISERS | 65,825 | $948 |
| ALLIANCEBERNSTEIN L.P. | 64,730 | $932 |
| Man Group plc | 63,571 | $915 |
| Rafferty Asset Management, LLC | 59,199 | $852 |
| ExodusPoint Capital Management, LP | 55,610 | $801 |
| Mariner, LLC | 55,423 | $797 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,745 | $787 |
| Quantinno Capital Management LP | 49,993 | $720 |
| TWO SIGMA ADVISERS, LP | 48,400 | $697 |
| CITADEL ADVISORS LLC | 46,641 | $672 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 44,429 | $630 |
| HSBC HOLDINGS PLC | 43,439 | $618 |
| Squarepoint Ops LLC | 42,918 | $618 |
| ALPS ADVISORS INC | 41,568 | $599 |
| SG Americas Securities, LLC | 40,531 | $1 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,995 | $1 |
| Simplify Asset Management Inc. | 38,000 | $547 |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,591 | $541 |
| VICTORY CAPITAL MANAGEMENT INC | 37,286 | $537 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 34,054 | $437 |
| Vestal Point Capital, LP | 34,000 | $490 |
| Point72 Asset Management, L.P. | 33,384 | $481 |
| Creative Planning | 33,021 | $476 |
| LPL Financial LLC | 32,705 | $471 |
| Rockefeller Capital Management L.P. | 27,720 | $399 |
| Lion Point Capital, LP | 26,600 | $383 |
| MetLife Investment Management, LLC | 26,240 | $378 |
| DnB Asset Management AS | 25,612 | $369 |
| TUDOR INVESTMENT CORP ET AL | 24,310 | $350 |
| MERCER GLOBAL ADVISORS INC /ADV | 24,140 | $348 |
| Militia Capital Partners, LP | 23,600 | $340 |
| Graham Capital Management, L.P. | 22,632 | $326 |
| PROFUND ADVISORS LLC | 22,251 | $320 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 21,386 | $290 |
| INTECH INVESTMENT MANAGEMENT LLC | 21,367 | $308 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 19,851 | $0 |
| Virtus Investment Advisers, LLC | 19,181 | $276 |
| FRANKLIN RESOURCES INC | 18,970 | $273 |
| FOX RUN MANAGEMENT, L.L.C. | 17,501 | $252 |
| BANK OF NOVA SCOTIA | 17,473 | $252 |
| INCEPTIONR LLC | 17,440 | $251 |
| Redwood Wealth Management Group, LLC | 17,385 | $250 |
| Brevan Howard Capital Management LP | 16,840 | $242 |
| 71 other institutions | 323,986 | $4,319 |