| BlackRock, Inc. | 2,850,978 | $82,279 |
| VANGUARD GROUP INC | 2,561,880 | $73,936 |
| Point72 Asset Management, L.P. | 1,839,876 | $53,099 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,785,610 | $51,533 |
| TANG CAPITAL MANAGEMENT LLC | 1,700,000 | $49,062 |
| RA CAPITAL MANAGEMENT, L.P. | 1,507,844 | $43,516 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,017,332 | $29,367 |
| FMR LLC | 922,634 | $26,627 |
| CITADEL ADVISORS LLC | 901,996 | $26,032 |
| STATE STREET CORP | 829,521 | $23,940 |
| Darwin Global Management, Ltd. | 800,000 | $23,168 |
| MILLENNIUM MANAGEMENT LLC | 682,344 | $19,692 |
| Soleus Capital Management, L.P. | 646,390 | $18,655 |
| J. Goldman & Co LP | 595,376 | $17,183 |
| MORGAN STANLEY | 585,840 | $16,907 |
| Ikarian Capital, LLC | 578,015 | $16,682 |
| GOLDMAN SACHS GROUP INC | 447,983 | $12,929 |
| DG Capital Management, LLC | 413,963 | $11,947 |
| SB Capital Management Inc | 400,001 | $11,544 |
| JPMORGAN CHASE & CO | 369,134 | $10,653 |
| BALYASNY ASSET MANAGEMENT L.P. | 352,998 | $10,188 |
| NORTHERN TRUST CORP | 350,641 | $10,120 |
| Boxer Capital Management, LLC | 325,000 | $9,380 |
| RTW INVESTMENTS, LP | 250,000 | $7,215 |
| Quinn Opportunity Partners LLC | 242,883 | $7,010 |
| UBS Group AG | 238,216 | $6,875 |
| Palo Alto Investors LP | 226,304 | $6,531 |
| Woodline Partners LP | 219,086 | $6,323 |
| Moody Aldrich Partners LLC | 208,755 | $6,025 |
| HBK Sorce Advisory LLC | 203,705 | $5,036 |
| RAYMOND JAMES FINANCIAL INC | 195,390 | $5,639 |
| BOOTHBAY FUND MANAGEMENT, LLC | 190,730 | $5,504 |
| DIADEMA PARTNERS LP | 158,075 | $4,562 |
| NATIONAL BANK OF CANADA /FI/ | 143,500 | $4,141 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 130,000 | $3,752 |
| WELLINGTON MANAGEMENT GROUP LLP | 128,270 | $3,702 |
| AMERIPRISE FINANCIAL INC | 125,169 | $3,612 |
| MARSHALL WACE, LLP | 121,912 | $3,518 |
| BARCLAYS PLC | 119,372 | $3,445 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 119,352 | $3,444 |
| Bank of New York Mellon Corp | 118,364 | $3,416 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $2,886 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 96,334 | $2,780 |
| Nuveen, LLC | 90,951 | $2,625 |
| OPPENHEIMER & CO INC | 80,813 | $2,332 |
| FRED ALGER MANAGEMENT, LLC | 80,793 | $2,332 |
| Black Diamond Financial, LLC | 79,077 | $2,282 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,607 | $2,240 |
| Anson Funds Management LP | 68,018 | $1,963 |
| SIMPLEX TRADING, LLC | 55,707 | $1,608 |
| TWO SIGMA INVESTMENTS, LP | 54,773 | $1,581 |
| BANK OF AMERICA CORP /DE/ | 53,819 | $1,553 |
| Persistent Asset Partners Ltd | 51,481 | $1,486 |
| Jump Financial, LLC | 49,500 | $1,429 |
| RHUMBLINE ADVISERS | 46,977 | $1,356 |
| LPL Financial LLC | 46,601 | $1,345 |
| WELLS FARGO & COMPANY/MN | 45,604 | $1,316 |
| FARALLON CAPITAL MANAGEMENT LLC | 41,000 | $1,183 |
| OSAIC HOLDINGS, INC. | 39,881 | $1,151 |
| ALLIANCEBERNSTEIN L.P. | 38,830 | $1,121 |
| Creek Drive Management Group LLC | 36,000 | $1,039 |
| GLENMEDE TRUST CO NA | 32,090 | $926 |
| AlphaQuest LLC | 30,056 | $867 |
| DEUTSCHE BANK AG\ | 28,732 | $829 |
| ENVESTNET ASSET MANAGEMENT INC | 27,404 | $791 |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,288 | $759 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,152 | $1 |
| MetLife Investment Management, LLC | 21,976 | $634 |
| Jain Global LLC | 21,700 | $626 |
| Mariner, LLC | 21,450 | $619 |
| ACADIAN ASSET MANAGEMENT LLC | 20,100 | $1 |
| FORA Capital, LLC | 19,969 | $576 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,863 | $516 |
| STEMPOINT CAPITAL LP | 17,853 | $515 |
| Creative Planning | 15,232 | $440 |
| Entropy Technologies, LP | 14,170 | $409 |
| Invesco Ltd. | 13,621 | $393 |
| Susquehanna Portfolio Strategies, LLC | 13,295 | $384 |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,000 | $375 |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,755 | $368 |
| US BANCORP \DE\ | 12,630 | $365 |
| SEI INVESTMENTS CO | 12,610 | $364 |
| Quantinno Capital Management LP | 12,389 | $358 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,606 | $335 |
| Police & Firemen's Retirement System of New Jersey | 11,349 | $328 |
| Virtus Investment Advisers, LLC | 10,224 | $295 |
| NOMURA HOLDINGS INC | 9,876 | $285 |
| ELLERSON GROUP INC /ADV | 9,690 | $280 |
| AQR CAPITAL MANAGEMENT LLC | 8,596 | $248 |
| STONERIDGE INVESTMENT PARTNERS LLC | 8,457 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 8,294 | $239 |
| Brinker Capital Investments, LLC | 8,266 | $239 |
| MONETA GROUP INVESTMENT ADVISORS LLC | 7,391 | $213 |
| Cetera Investment Advisers | 7,193 | $208 |
| ProShare Advisors LLC | 7,033 | $203 |
| ROYAL BANK OF CANADA | 5,040 | $146 |
| Parkside Financial Bank & Trust | 5,020 | $145 |
| Russell Investments Group, Ltd. | 4,640 | $134 |
| State of Wyoming | 4,429 | $128 |
| Legal & General Group Plc | 3,969 | $115 |
| 32 other institutions | 24,675 | $649 |