| FMR LLC | 8,928,574 | $694,732 |
| BAKER BROS. ADVISORS LP | 8,657,242 | $673,620 |
| Avoro Capital Advisors LLC | 7,474,747 | $581,610 |
| VANGUARD GROUP INC | 6,267,644 | $487,685 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,159,335 | $479 |
| BVF INC/IL | 5,502,710 | $428,166 |
| BlackRock, Inc. | 5,004,095 | $389,369 |
| Atlas Venture Life Science Advisors, LLC | 4,659,874 | $362,585 |
| WELLINGTON MANAGEMENT GROUP LLP | 4,412,933 | $343,370 |
| Siren, L.L.C. | 3,286,830 | $255,748 |
| STATE STREET CORP | 2,209,837 | $171,947 |
| Capital Research Global Investors | 1,560,791 | $121,445 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,417,389 | $110,307 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,069,238 | $83,197 |
| ALLIANCEBERNSTEIN L.P. | 952,065 | $74,080 |
| UBS ASSET MANAGEMENT AMERICAS INC | 912,498 | $71,001 |
| Merck & Co., Inc. | 772,165 | $60,082 |
| FEDERATED HERMES, INC. | 763,920 | $59,441 |
| Holocene Advisors, LP | 761,209 | $59,230 |
| Commodore Capital LP | 750,000 | $58,358 |
| GOLDMAN SACHS GROUP INC | 740,306 | $57,603 |
| UBS Group AG | 737,032 | $57,348 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 635,957 | $49,484 |
| EVENTIDE ASSET MANAGEMENT, LLC | 626,430 | $48,743 |
| DIMENSIONAL FUND ADVISORS LP | 624,027 | $48,557 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 561,170 | $43,665 |
| Octagon Capital Advisors LP | 535,000 | $41,628 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497,026 | $38,674 |
| Rock Springs Capital Management LP | 496,871 | $38,662 |
| JENNISON ASSOCIATES LLC | 496,665 | $38,646 |
| Pictet Asset Management Holding SA | 483,199 | $37,791 |
| NORTHERN TRUST CORP | 467,022 | $36,339 |
| BRAIDWELL LP | 454,259 | $35,346 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 430,000 | $33,458 |
| TWO SIGMA ADVISERS, LP | 373,800 | $29,085 |
| Alyeska Investment Group, L.P. | 371,889 | $28,937 |
| FRANKLIN RESOURCES INC | 354,575 | $27,589 |
| BANK OF AMERICA CORP /DE/ | 338,999 | $26,378 |
| Boxer Capital Management, LLC | 329,100 | $25,607 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 289,404 | $22,519 |
| Nextech Invest, Ltd. | 278,896 | $21,701 |
| MORGAN STANLEY | 274,018 | $21,321 |
| TWO SIGMA INVESTMENTS, LP | 265,532 | $20,661 |
| RTW INVESTMENTS, LP | 240,000 | $18,674 |
| GILDER GAGNON HOWE & CO LLC | 239,916 | $18,668 |
| Deer Management Co. LLC | 230,811 | $17,959 |
| TD Asset Management Inc | 221,178 | $17,210 |
| First Turn Management, LLC | 206,445 | $16,063 |
| Woodline Partners LP | 203,585 | $15,841 |
| Candriam S.C.A. | 201,672 | $15,693 |
| Polar Capital Holdings Plc | 200,946 | $15,636 |
| Bank of New York Mellon Corp | 192,748 | $14,998 |
| TimesSquare Capital Management, LLC | 189,900 | $14,776 |
| Point72 Asset Management, L.P. | 173,147 | $13,473 |
| CITADEL ADVISORS LLC | 159,865 | $12,439 |
| Squarepoint Ops LLC | 159,426 | $12,405 |
| Foresite Capital Management VI LLC | 146,332 | $11,386 |
| BARCLAYS PLC | 140,507 | $10,933 |
| Patient Square Capital LP | 139,000 | $10,816 |
| Eagle Health Investments LP | 136,300 | $10,606 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 135,894 | $10,607 |
| JPMORGAN CHASE & CO | 131,353 | $10,221 |
| Logos Global Management LP | 130,000 | $10,115 |
| Nuveen, LLC | 125,050 | $9,730 |
| Invesco Ltd. | 116,747 | $9,084 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 105,554 | $8,213 |
| WCM INVESTMENT MANAGEMENT, LLC | 105,194 | $8,218 |
| Monashee Investment Management LLC | 100,000 | $7,781 |
| T. Rowe Price Investment Management, Inc. | 96,833 | $8 |
| Ensign Peak Advisors, Inc | 95,047 | $7,396 |
| Swiss National Bank | 94,200 | $7,330 |
| ARMISTICE CAPITAL, LLC | 81,165 | $6,315 |
| DEUTSCHE BANK AG\ | 79,843 | $6,213 |
| Burkehill Global Management, LP | 75,000 | $5,836 |
| Yiheng Capital Management, L.P. | 73,440 | $5,714 |
| RHUMBLINE ADVISERS | 72,304 | $5,626 |
| PERCEPTIVE ADVISORS LLC | 69,935 | $5,442 |
| VICTORY CAPITAL MANAGEMENT INC | 67,086 | $5,220 |
| WELLS FARGO & COMPANY/MN | 66,489 | $5,174 |
| BNP Paribas Investment Partners S.A. | 64,775 | $5 |
| ALPS ADVISORS INC | 64,723 | $5,036 |
| FIRST TRUST ADVISORS LP | 58,862 | $4,580 |
| Rafferty Asset Management, LLC | 58,653 | $4,564 |
| NEUBERGER BERMAN GROUP LLC | 58,482 | $4,550 |
| EAM Investors, LLC | 56,455 | $4,393 |
| Nicholas Investment Partners, LP | 55,788 | $4,341 |
| Verition Fund Management LLC | 54,319 | $4,227 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52,671 | $4,115 |
| COMERICA BANK | 49,812 | $3,876 |
| Russell Investments Group, Ltd. | 45,977 | $3,578 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,742 | $3,559 |
| Legal & General Group Plc | 43,428 | $3,379 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,777 | $3,174 |
| DARK FOREST CAPITAL MANAGEMENT LP | 39,207 | $3,051 |
| Moody Aldrich Partners LLC | 38,535 | $2,998 |
| MARSHALL WACE, LLP | 38,022 | $2,958 |
| Y-Intercept (Hong Kong) Ltd | 36,429 | $2,835 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 34,589 | $2,691 |
| State of New Jersey Common Pension Fund D | 33,538 | $2,610 |
| Sio Capital Management, LLC | 32,235 | $2,508 |
| 153 other institutions | 1,142,399 | $75,120 |