ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q2 2021 (← Previous) (Next →)

Filing Date: Aug 16, 2021

Total Value ($000): $9,886,767 (99.3% shares, 0.7% debt)

Holdings (159)

SPRINGWORKS THERAPEUTICS INC 5.0%
Value ($000) $498,108 Shares 6,044,266 Est. Cost $21.68 Unrealized
BMY BRISTOL-MYERS SQUIBB CO 3.1%
Value ($000) $301,719 Shares 4,515,400 Est. Cost $47.77 Unrealized +12.8%
EWTX EDGEWISE THERAPEUTICS INC 3.0%
Value ($000) $297,440 Shares 13,944,680 Est. Cost $32.43 Unrealized -15.7%
BSX BOSTON SCIENTIFIC CORP 3.0%
Value ($000) $295,925 Shares 6,920,600 Est. Cost $25.28 Unrealized +66.4%
MRK MERCK & CO INC 2.9%
Value ($000) $290,269 Shares 3,732,400 Est. Cost $52.98 Unrealized +21.1%
PRLD PRELUDE THERAPEUTICS INC 2.9%
Value ($000) $287,436 Shares 10,039,691 Est. Cost $28.24 Unrealized +26.1%
HORIZON THERAPEUTICS PUB L 2.8%
Value ($000) $273,631 Shares 2,922,155 Est. Cost $42.12 Unrealized
SPRY SILVERBACK THERAPEUTICS INC 2.7%
Value ($000) $270,006 Shares 8,740,887 Est. Cost $33.40 Unrealized -4.0%
PMVP PMV PHARMACEUTICALS INC 2.5%
Value ($000) $250,407 Shares 7,330,423 Est. Cost $36.80 Unrealized -9.2%
IKENA ONCOLOGY INC 2.5%
Value ($000) $249,889 Shares 11,895,652 Est. Cost $35.45 Unrealized
NTRA NATERA INC 2.4%
Value ($000) $233,622 Shares 2,057,800 Est. Cost $26.94 Unrealized +279.8%
VRTX VERTEX PHARMACEUTICALS INC 2.2%
Value ($000) $214,817 Shares 1,065,400 Est. Cost $151.18 Unrealized +38.4%
MIRATI THERAPEUTICS INC 2.1%
Value ($000) $204,206 Shares 1,264,200 Est. Cost $112.43 Unrealized
TURNING POINT THERAPEUTICS I 1.9%
Value ($000) $184,231 Shares 2,361,327 Est. Cost $40.50 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 1.7%
Value ($000) $172,906 Shares 6,645,100 Est. Cost $10.72 Unrealized +142.4%
ARQT ARCUTIS BIOTHERAPEUTICS INC 1.7%
Value ($000) $165,755 Shares 6,073,850 Est. Cost $26.32 Unrealized +7.0%
UNH UNITEDHEALTH GROUP INC 1.6%
Value ($000) $156,051 Shares 389,700 Est. Cost $308.55 Unrealized +19.6%
GH GUARDANT HEALTH INC 1.5%
Value ($000) $152,431 Shares 1,227,400 Est. Cost $128.96 Unrealized +4.3%
HUM HUMANA INC 1.5%
Value ($000) $148,311 Shares 335,000 Est. Cost $302.53 Unrealized +38.2%
ABCL ABCELLERA BIOLOGICS INC 1.4%
Value ($000) $136,906 Shares 6,223,019 Est. Cost $45.73 Unrealized -39.7%
ABBV ABBVIE INC 1.3%
Value ($000) $131,507 Shares 1,167,500 Est. Cost $77.97 Unrealized +21.5%
ISRG INTUITIVE SURGICAL INC 1.3%
Value ($000) $128,382 Shares 139,600 Est. Cost $163.59 Unrealized +71.5%
ELV ANTHEM INC 1.3%
Value ($000) $128,170 Shares 335,700 Est. Cost $296.75 Unrealized +20.8%
DXCM DEXCOM INC 1.3%
Value ($000) $126,990 Shares 297,400 Est. Cost $53.97 Unrealized +77.9%
XBI SPDR SER TR 1.3%
Value ($000) $126,694 Shares 935,700 Est. Cost $135.40 Unrealized
DECIPHERA PHARMACEUTICALS IN 1.2%
Value ($000) $120,714 Shares 3,297,301 Est. Cost $32.98 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 1.2%
Value ($000) $119,812 Shares 1,231,115 Est. Cost $91.36 Unrealized +4.9%
XTNT XTANT MED HLDGS INC 1.2%
Value ($000) $118,784 Shares 72,873,494 Est. Cost $1.96 Unrealized -9.3%
EW EDWARDS LIFESCIENCES CORP 1.2%
Value ($000) $116,661 Shares 1,126,400 Est. Cost $72.41 Unrealized +30.2%
REPARE THERAPEUTICS INC 1.1%
Value ($000) $106,833 Shares 3,426,325 Est. Cost $31.02 Unrealized
GRACELL BIOTECHNOLOGIES INC 1.0%
Value ($000) $102,503 Shares 7,884,870 Est. Cost $15.40 Unrealized
NPCE NEUROPACE INC 1.0%
Value ($000) $95,452 Shares 4,012,281 Est. Cost $23.21 Unrealized 0.0%
AFIB ACUTUS MED INC 0.9%
Value ($000) $93,016 Shares 5,477,958 Est. Cost $30.36 Unrealized -51.8%
PASSAGE BIO INC 0.9%
Value ($000) $92,189 Shares 6,962,899 Est. Cost $15.75 Unrealized
KINNATE BIOPHARMA INC 0.9%
Value ($000) $89,580 Shares 3,847,929 Est. Cost $39.78 Unrealized
SYK STRYKER CORPORATION 0.9%
Value ($000) $87,633 Shares 337,400 Est. Cost $197.03 Unrealized +23.6%
JANX JANUX THERAPEUTICS INC 0.9%
Value ($000) $86,486 Shares 3,466,386 Est. Cost $22.27 Unrealized 0.0%
IMMUNOGEN INC 0.9%
Value ($000) $85,252 Shares 12,936,622 Est. Cost $7.33 Unrealized
CRSP CRISPR THERAPEUTICS AG 0.8%
Value ($000) $84,021 Shares 519,000 Est. Cost $69.87 Unrealized +74.1%
PGNY PROGYNY INC 0.8%
Value ($000) $80,561 Shares 1,365,445 Est. Cost $29.24 Unrealized +92.1%
AUPH AURINIA PHARMACEUTICALS INC 0.8%
Value ($000) $78,655 Shares 6,069,032 Est. Cost $12.94 Unrealized -1.5%
OAK STR HEALTH INC 0.8%
Value ($000) $77,799 Shares 1,328,300 Est. Cost $55.82 Unrealized
SVA SINOVAC BIOTECH LTD 0.8%
Value ($000) $76,800 Shares 2,839,500 Est. Cost $4.60 Unrealized +40.7%
ADICET BIO INC 0.8%
Value ($000) $74,426 Shares 7,232,856 Est. Cost $11.98 Unrealized
KROS KEROS THERAPEUTICS INC 0.7%
Value ($000) $71,325 Shares 1,679,417 Est. Cost $30.81 Unrealized +75.8%
89BIO INC 0.7%
Value ($000) $69,741 Shares 3,729,442 Est. Cost $26.29 Unrealized
TBPH THERAVANCE BIOPHARMA INC 0.7%
Value ($000) $66,270 Shares 4,564,045 Est. Cost $21.57 Unrealized -12.9%
MGTX MEIRAGTX HLDGS PLC 0.6%
Value ($000) $63,595 Shares 4,102,925 Est. Cost $15.88 Unrealized -10.0%
VECTIVBIO HLDG AG 0.6%
Value ($000) $59,738 Shares 5,123,304 Est. Cost $11.66 Unrealized
ASND ASCENDIS PHARMA A/S 0.6%
Value ($000) $58,916 Shares 447,859 Est. Cost $62.39 Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.6%
Value ($000) $56,491 Shares 2,996,876 Est. Cost $25.49 Unrealized -31.1%
TMO THERMO FISHER SCIENTIFIC INC 0.6%
Value ($000) $55,643 Shares 110,300 Est. Cost $149.40 Unrealized +211.9%
SINGULAR GENOMICS SYSTEMS IN 0.6%
Value ($000) $54,919 Shares 1,998,521 Est. Cost $27.48 Unrealized
MREO MEREO BIOPHARMA GROUP PLC 0.6%
Value ($000) $54,730 Shares 17,264,764 Est. Cost $3.54 Unrealized
BURNING ROCK BIOTECH LTD 0.6%
Value ($000) $54,684 Shares 1,856,201 Est. Cost $27.01 Unrealized
SEM SELECT MED HLDGS CORP 0.5%
Value ($000) $53,717 Shares 1,271,100 Est. Cost $19.14 Unrealized 0.0%
CHEMOMAB THERAPEUTICS LTD 0.5%
Value ($000) $49,037 Shares 2,578,174 Est. Cost $28.71 Unrealized
TELA TELA BIO INC 0.5%
Value ($000) $48,774 Shares 3,027,542 Est. Cost $12.23 Unrealized +12.1%
APPLIED THERAPEUTICS INC 0.5%
Value ($000) $46,909 Shares 2,257,387 Est. Cost $24.71 Unrealized
TERN TERNS PHARMACEUTICALS INC 0.5%
Value ($000) $46,480 Shares 3,791,204 Est. Cost $21.92 Unrealized -22.3%
VISTAGEN THERAPEUTICS INC 0.5%
Value ($000) $45,574 Shares 14,467,872 Est. Cost $2.44 Unrealized
DECIBEL THERAPEUTICS INC 0.4%
Value ($000) $42,529 Shares 4,945,192 Est. Cost $11.36 Unrealized
NVAX NOVAVAX INC 0.4%
Value ($000) $42,525 Shares 200,295 Est. Cost $195.71 Unrealized -6.4%
TRICIDA INC 0.4%
Value ($000) $41,534 Shares 9,614,280 Est. Cost $30.09 Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.4%
Value ($000) $41,352 Shares 2,337,574 Est. Cost $31.92 Unrealized -31.3%
IKENA ONCOLOGY INC 0.4%
Value ($000) $41,193 Shares 2,933,941 Est. Cost $28.25 Unrealized
SIBN SI-BONE INC 0.4%
Value ($000) $41,078 Shares 1,305,300 Est. Cost $18.37 Unrealized +76.1%
MERSANA THERAPEUTICS INC 0.4%
Value ($000) $38,027 Shares 2,800,247 Est. Cost $13.81 Unrealized
GEMINI THERAPEUTICS INC 0.4%
Value ($000) $37,696 Shares 5,826,224 Est. Cost $13.55 Unrealized
LOGICBIO THERAPEUTICS INC 0.4%
Value ($000) $37,593 Shares 8,466,783 Est. Cost $9.75 Unrealized
VERONA PHARMA PLC 0.4%
Value ($000) $37,244 Shares 5,694,841 Est. Cost $7.45 Unrealized
HARPOON THERAPEUTICS INC 0.4%
Value ($000) $36,219 Shares 2,611,308 Est. Cost $11.99 Unrealized
NANOSTRING TECHNOLOGIES INC 0.4%
Value ($000) $36,023 Shares 556,000 Est. Cost $35.73 Unrealized
GRAPHITE BIO INC 0.3%
Value ($000) $33,997 Shares 1,106,307 Est. Cost $30.73 Unrealized
TRILLIUM THERAPEUTICS INC 0.3%
Value ($000) $32,226 Shares 3,322,300 Est. Cost $10.83 Unrealized
GHRS GH RESEARCH PLC 0.3%
Value ($000) $31,045 Shares 1,428,666 Est. Cost $20.43 Unrealized 0.0%
CGEM CULLINAN ONCOLOGY INC 0.3%
Value ($000) $29,513 Shares 1,146,145 Est. Cost $40.60 Unrealized -24.2%
SCPHARMACEUTICALS INC 0.3%
Value ($000) $29,311 Shares 4,797,148 Est. Cost $10.72 Unrealized
KALA PHARMACEUTICALS INC 0.3%
Value ($000) $28,965 Shares 5,465,030 Est. Cost $16.26 Unrealized
SIERRA ONCOLOGY INC 0.3%
Value ($000) $28,763 Shares 1,477,320 Est. Cost $9.82 Unrealized
LAB FLUIDIGM CORP DEL 0.3%
Value ($000) $28,717 Shares 4,661,871 Est. Cost $4.51 Unrealized +18.5%
ARCT ARCTURUS THERAPEUTICS HLDGS 0.3%
Value ($000) $28,713 Shares 848,503 Est. Cost $56.15 Unrealized -39.7%
CURIS INC 0.3%
Value ($000) $28,418 Shares 3,521,400 Est. Cost $6.49 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.3%
Value ($000) $27,948 Shares 4,015,524 Est. Cost $7.60 Unrealized
ALEXION PHARMACEUTICALS INC 0.3%
Value ($000) $27,722 Shares 150,900 Est. Cost $145.39 Unrealized
ALPINE IMMUNE SCIENCES INC 0.3%
Value ($000) $27,639 Shares 3,070,955 Est. Cost $11.12 Unrealized
APTOSE BIOSCIENCES INC 0.3%
Value ($000) $26,660 Shares 8,030,000 Est. Cost $4.55 Unrealized
FUSION PHARMACEUTICALS INC 0.3%
Value ($000) $26,056 Shares 3,224,770 Est. Cost $17.47 Unrealized
XENE XENON PHARMACEUTICALS INC 0.3%
Value ($000) $24,843 Shares 1,334,217 Est. Cost $12.08 Unrealized +52.6%
BIIB BIOGEN INC 0.2%
Value ($000) $23,339 Shares 67,400 Est. Cost $299.57 Unrealized +1.1%
FLEXION THERAPEUTICS INC 0.2%
Value ($000) $22,792 Shares 2,769,383 Est. Cost $12.33 Unrealized
GRAYBUG VISION INC 0.2%
Value ($000) $22,607 Shares 4,163,347 Est. Cost $12.71 Unrealized
OLMA OLEMA PHARMACEUTICALS INC 0.2%
Value ($000) $22,602 Shares 807,792 Est. Cost $43.43 Unrealized -34.5%
NEXTCURE INC 0.2%
Value ($000) $21,769 Shares 2,711,013 Est. Cost $14.98 Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.2%
Value ($000) $21,502 Shares 8,053,298 Est. Cost $11.24 Unrealized -75.5%
IMARA INC 0.2%
Value ($000) $21,487 Shares 2,719,902 Est. Cost $16.03 Unrealized
PCVX VAXCYTE INC 0.2%
Value ($000) $21,281 Shares 945,400 Est. Cost $28.36 Unrealized -27.8%
GALECTO INC 0.2%
Value ($000) $20,700 Shares 4,090,937 Est. Cost $12.51 Unrealized
MAGENTA THERAPEUTICS INC 0.2%
Value ($000) $19,890 Shares 2,033,759 Est. Cost $10.74 Unrealized
GILD GILEAD SCIENCES INC 0.2%
Value ($000) $19,804 Shares 287,600 Est. Cost $53.85 Unrealized +3.7%
CHINOOK THERAPEUTICS INC 0.2%
Value ($000) $18,833 Shares 1,333,801 Est. Cost $15.75 Unrealized
CTI BIOPHARMA CORP 0.2%
Value ($000) $18,802 Shares 7,520,600 Est. Cost $2.18 Unrealized
VERRICA PHARMACEUTICALS INC 0.2%
Value ($000) $16,721 Shares 1,479,733 Est. Cost $19.73 Unrealized
GLPG GALAPAGOS NV 0.2%
Value ($000) $15,907 Shares 230,905 Est. Cost $77.09 Unrealized
NAUT NAUTILUS BIOTECHNOLOGY INC 0.2%
Value ($000) $15,622 Shares 1,546,700 Est. Cost $10.83 Unrealized 0.0%
VOR BIOPHARMA INC 0.2%
Value ($000) $15,542 Shares 833,333 Est. Cost $43.10 Unrealized
ACHILLES THERAPEUTICS PLC 0.2%
Value ($000) $15,516 Shares 1,584,845 Est. Cost $16.55 Unrealized
JOUNCE THERAPEUTICS INC 0.1%
Value ($000) $14,602 Shares 2,147,400 Est. Cost $9.75 Unrealized
QURE UNIQURE NV 0.1%
Value ($000) $14,512 Shares 471,174 Est. Cost $61.75 Unrealized -45.7%
SYNLOGIC INC 0.1%
Value ($000) $14,380 Shares 3,696,662 Est. Cost $10.33 Unrealized
MIST MILESTONE PHARMACEUTICALS IN 0.1%
Value ($000) $14,211 Shares 2,583,821 Est. Cost $6.79 Unrealized -16.4%
AMGN AMGEN INC 0.1%
Value ($000) $13,918 Shares 57,100 Est. Cost $99.69 Unrealized +113.2%
RLAY RELAY THERAPEUTICS INC 0.1%
Value ($000) $12,807 Shares 350,000 Est. Cost $38.13 Unrealized -13.6%
ALEC ALECTOR INC 0.1%
Value ($000) $12,737 Shares 611,478 Est. Cost $18.92 Unrealized -0.3%
BIOMX INC 0.1%
Value ($000) $12,632 Shares 2,313,489 Est. Cost $9.68 Unrealized
MAPS WM TECHNOLOGY INC 0.1%
Value ($000) $12,509 Shares 700,400 Est. Cost $17.36 Unrealized 0.0%
BELLUS HEALTH INC NEW 0.1%
Value ($000) $12,272 Shares 3,954,800 Est. Cost $6.42 Unrealized
AEROVATE THERAPEUTICS INC 0.1%
Value ($000) $12,230 Shares 535,714 Est. Cost $22.83 Unrealized
ONCOCYTE CORP 0.1%
Value ($000) $12,054 Shares 2,100,000 Est. Cost $5.19 Unrealized
IPSC CENTURY THERAPEUTICS INC 0.1%
Value ($000) $11,943 Shares 407,047 Est. Cost $25.37 Unrealized 0.0%
CONVEY HLDG PARENT INC 0.1%
Value ($000) $11,380 Shares 1,000,000 Est. Cost $11.38 Unrealized
CVRX CVRX INC 0.1%
Value ($000) $11,200 Shares 400,000 Est. Cost $28.00 Unrealized 0.0%
BSX BOSTON SCIENTIFIC CORP 0.1%
Value ($000) $10,690 Shares 250,000 Est. Cost $25.28 Unrealized +66.4%
CUREVAC N V 0.1%
Value ($000) $10,287 Shares 140,000 Est. Cost Unrealized
SYROS PHARMACEUTICALS INC 0.1%
Value ($000) $10,014 Shares 1,837,500 Est. Cost $10.35 Unrealized
NANOSTRING TECHNOLOGIES INC 0.1%
Value ($000) $9,705 Shares 6,000,000 Est. Cost $1.62 Unrealized
CTMX CYTOMX THERAPEUTICS INC 0.1%
Value ($000) $9,578 Shares 1,513,168 Est. Cost $7.79 Unrealized 0.0%
9 METERS BIOPHARMA INC 0.1%
Value ($000) $9,423 Shares 8,565,974 Est. Cost $0.57 Unrealized
NBP I MAB 0.1%
Value ($000) $9,329 Shares 111,120 Est. Cost $77.79 Unrealized
CATALYST BIOSCIENCES INC 0.1%
Value ($000) $9,174 Shares 2,118,600 Est. Cost $5.04 Unrealized
X4 PHARMACEUTICALS INC 0.1%
Value ($000) $8,930 Shares 1,373,849 Est. Cost $13.74 Unrealized
AERPIO PHARMACEUTICALS INC 0.1%
Value ($000) $8,778 Shares 5,193,946 Est. Cost $4.15 Unrealized
ASLAN PHARMACEUTICALS LTD 0.1%
Value ($000) $8,316 Shares 2,520,000 Est. Cost $3.35 Unrealized
ALXO ALX ONCOLOGY HLDGS INC 0.1%
Value ($000) $8,202 Shares 150,000 Est. Cost $60.15 Unrealized -0.5%
SUTRO BIOPHARMA INC 0.1%
Value ($000) $8,062 Shares 433,700 Est. Cost $21.11 Unrealized
NRIX NURIX THERAPEUTICS INC 0.1%
Value ($000) $7,959 Shares 300,000 Est. Cost $25.20 Unrealized +16.5%
GLUE MONTE ROSA THERAPEUTICS INC 0.1%
Value ($000) $7,945 Shares 350,000 Est. Cost $20.37 Unrealized 0.0%
LANDOS BIOPHARMA INC 0.1%
Value ($000) $7,866 Shares 681,000 Est. Cost $9.63 Unrealized
DYN DYNE THERAPEUTICS INC 0.1%
Value ($000) $7,364 Shares 350,000 Est. Cost $21.96 Unrealized -14.4%
OTONOMY INC 0.1%
Value ($000) $7,248 Shares 3,250,000 Est. Cost $4.05 Unrealized
NBTX NANOBIOTIX SA 0.1%
Value ($000) $6,890 Shares 500,000 Est. Cost $16.50 Unrealized
ACRS ACLARIS THERAPEUTICS INC 0.1%
Value ($000) $6,357 Shares 362,000 Est. Cost $22.72 Unrealized 0.0%
PROMETHEUS BIOSCIENCES INC 0.1%
Value ($000) $6,140 Shares 250,000 Est. Cost $18.26 Unrealized
VERVE THERAPEUTICS INC 0.1%
Value ($000) $6,025 Shares 100,000 Est. Cost $60.25 Unrealized
LUNG PULMONX CORP 0.1%
Value ($000) $5,515 Shares 125,000 Est. Cost $48.97 Unrealized -11.1%
STRONGBRIDGE BIOPHARMA PLC 0.1%
Value ($000) $5,182 Shares 1,744,669 Est. Cost $2.10 Unrealized
HEALTH SCIENCES ACQ CORP 2 0.1%
Value ($000) $5,100 Shares 500,000 Est. Cost $11.00 Unrealized
OGN ORGANON & CO 0.1%
Value ($000) $5,052 Shares 166,939 Est. Cost $26.93 Unrealized 0.0%
SRPT SAREPTA THERAPEUTICS INC 0.1%
Value ($000) $5,030 Shares 64,700 Est. Cost $105.48 Unrealized -28.1%
TARA PROTARA THERAPEUTICS INC 0.0%
Value ($000) $4,383 Shares 450,000 Est. Cost $23.19 Unrealized -51.2%
ADAG ADAGENE INC 0.0%
Value ($000) $3,729 Shares 275,000 Est. Cost $17.95 Unrealized
TALARIS THERAPEUTICS INC 0.0%
Value ($000) $3,632 Shares 247,240 Est. Cost $14.69 Unrealized
INOZYME PHARMA INC 0.0%
Value ($000) $3,216 Shares 188,704 Est. Cost $17.04 Unrealized
IFRX INFLARX NV 0.0%
Value ($000) $3,160 Shares 1,064,118 Est. Cost $4.38 Unrealized -24.3%
KEZAR LIFE SCIENCES INC 0.0%
Value ($000) $3,026 Shares 557,191 Est. Cost $5.43 Unrealized
CUREVAC N V 0.0%
Value ($000) $2,204 Shares 30,000 Est. Cost Unrealized
LONGBOARD PHARMACEUTICALS IN 0.0%
Value ($000) $1,035 Shares 113,500 Est. Cost $16.38 Unrealized
MAPSW WM TECHNOLOGY INC 0.0%
Value ($000) $954 Shares 150,200 Est. Cost Unrealized
PURPLE BIOTECH LTD 0.0%
Value ($000) $86 Shares 17,712 Est. Cost $3.81 Unrealized