SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 15, 2024

Total Value: $621M (100.0% shares, 0.0% debt)

Holdings (99)

XBI SPDR SER TR 7.2%
Value $44.65M Shares 500,000 Est. Cost $83.20 Unrealized
TEVA TEVA PHARMACEUTICAL INDS LTD 4.1%
Value $25.78M Shares 2,469,100 Est. Cost $10.05 Unrealized
SNY SANOFI 4.0%
Value $24.84M Shares 499,515 Est. Cost $46.09 Unrealized
CYTK CYTOKINETICS INC 3.0%
Value $18.69M Shares 223,820 Est. Cost $33.30 Unrealized +8.7%
NVMI NOVA LTD 2.9%
Value $18.14M Shares 132,000 Est. Cost $115.56 Unrealized 0.0%
SNDX SYNDAX PHARMACEUTICALS INC 2.7%
Value $16.7M Shares 772,964 Est. Cost $17.49 Unrealized -12.1%
TSEM TOWER SEMICONDUCTOR LTD 2.6%
Value $16.12M Shares 528,300 Est. Cost $34.34 Unrealized -24.0%
NICE NICE LTD 2.2%
Value $13.51M Shares 67,718 Est. Cost $215.77 Unrealized
MRK MERCK & CO INC 2.2%
Value $13.47M Shares 123,600 Est. Cost $73.08 Unrealized +32.5%
TEVA TEVA PHARMACEUTICAL INDS LTD 2.2%
Value $13.4M Shares 1,284,000 Est. Cost $10.05 Unrealized
CLDX CELLDEX THERAPEUTICS INC NEW 2.0%
Value $12.52M Shares 315,644 Est. Cost $31.71 Unrealized -7.2%
JNJ JOHNSON & JOHNSON 2.0%
Value $12.51M Shares 79,831 Est. Cost $136.97 Unrealized +4.8%
META META PLATFORMS INC 2.0%
Value $12.14M Shares 34,303 Est. Cost $312.66 Unrealized +3.4%
AZN ASTRAZENECA PLC 2.0%
Value $12.13M Shares 180,060 Est. Cost $51.62 Unrealized
BIIB BIOGEN INC 1.9%
Value $11.99M Shares 46,346 Est. Cost $255.13 Unrealized -3.7%
BBIO BRIDGEBIO PHARMA INC 1.8%
Value $11.39M Shares 282,146 Est. Cost $12.82 Unrealized +134.3%
GLBE GLOBAL E ONLINE LTD 1.7%
Value $10.69M Shares 269,794 Est. Cost $36.01 Unrealized 0.0%
FUSION PHARMACEUTICALS INC 1.7%
Value $10.43M Shares 1,085,639 Est. Cost $3.78 Unrealized
KURA KURA ONCOLOGY INC 1.6%
Value $10.11M Shares 703,287 Est. Cost $18.44 Unrealized -46.7%
NVO NOVO-NORDISK A S 1.5%
Value $9.629M Shares 93,080 Est. Cost $102.35 Unrealized
RARE ULTRAGENYX PHARMACEUTICAL IN 1.5%
Value $9.614M Shares 201,044 Est. Cost $47.50 Unrealized -18.4%
MSFT MICROSOFT CORP 1.4%
Value $8.968M Shares 23,848 Est. Cost $249.46 Unrealized +40.4%
ASTRIA THERAPEUTICS INC 1.4%
Value $8.841M Shares 1,151,145 Est. Cost $10.32 Unrealized
INHIBRX INC 1.4%
Value $8.609M Shares 226,551 Est. Cost $19.83 Unrealized
AMZN AMAZON COM INC 1.4%
Value $8.459M Shares 55,676 Est. Cost $102.08 Unrealized +37.3%
LLY ELI LILLY & CO 1.3%
Value $8.272M Shares 14,190 Est. Cost $258.77 Unrealized +122.2%
DAWN DAY ONE BIOPHARMACEUTICALS I 1.2%
Value $7.49M Shares 513,000 Est. Cost $13.06 Unrealized -7.2%
TBLA TABOOLA.COM LTD 1.2%
Value $7.469M Shares 1,724,948 Est. Cost $3.78 Unrealized 0.0%
AMD ADVANCED MICRO DEVICES INC 1.2%
Value $7.428M Shares 50,387 Est. Cost $108.94 Unrealized +8.2%
PRAXIS PRECISION MEDICINES I 1.2%
Value $7.33M Shares 328,986 Est. Cost $1.15 Unrealized
ABBV ABBVIE INC 1.1%
Value $7.129M Shares 46,000 Est. Cost $93.90 Unrealized +44.5%
WIX WIX COM LTD 1.1%
Value $7.071M Shares 57,477 Est. Cost $96.48 Unrealized 0.0%
ALNY ALNYLAM PHARMACEUTICALS INC 1.1%
Value $6.935M Shares 36,230 Est. Cost $198.26 Unrealized -14.1%
PHVS PHARVARIS N V 1.1%
Value $6.872M Shares 245,000 Est. Cost $20.23 Unrealized 0.0%
INOZYME PHARMA INC 1.1%
Value $6.658M Shares 1,562,907 Est. Cost $4.01 Unrealized
IMTX IMMATICS N.V 1.1%
Value $6.54M Shares 621,111 Est. Cost $11.90 Unrealized -22.7%
MDGL MADRIGAL PHARMACEUTICALS INC 1.0%
Value $6.425M Shares 27,767 Est. Cost $229.44 Unrealized -23.7%
MLYS MINERALYS THERAPEUTICS INC 1.0%
Value $6.395M Shares 743,591 Est. Cost $12.93 Unrealized -39.3%
MERUS N V 1.0%
Value $6.334M Shares 230,333 Est. Cost $22.47 Unrealized
SPRINGWORKS THERAPEUTICS INC 1.0%
Value $6.215M Shares 170,270 Est. Cost $58.22 Unrealized
NVS NOVARTIS AG 1.0%
Value $6.058M Shares 60,000 Est. Cost $92.00 Unrealized
S SENTINELONE INC 0.9%
Value $5.856M Shares 213,418 Est. Cost $19.37 Unrealized 0.0%
RCKT ROCKET PHARMACEUTICALS INC 0.9%
Value $5.718M Shares 190,783 Est. Cost $19.58 Unrealized +12.7%
JASPER THERAPEUTICS INC 0.9%
Value $5.626M Shares 713,063 Est. Cost $1.52 Unrealized
INCY INCYTE CORP 0.9%
Value $5.623M Shares 89,556 Est. Cost $56.56 Unrealized 0.0%
GRACELL BIOTECHNOLOGIES INC 0.8%
Value $5.049M Shares 502,936 Est. Cost $2.06 Unrealized
SHL TELEMEDICINE LTD 0.8%
Value $5.044M Shares 632,456 Est. Cost $11.14 Unrealized
PANW PALO ALTO NETWORKS INC 0.8%
Value $4.891M Shares 16,585 Est. Cost $91.50 Unrealized +46.1%
ENPH ENPHASE ENERGY INC 0.7%
Value $4.598M Shares 34,800 Est. Cost $106.06 Unrealized 0.0%
CLDX CELLDEX THERAPEUTICS INC NEW 0.7%
Value $4.589M Shares 115,700 Est. Cost $31.71 Unrealized -7.2%
89BIO INC 0.7%
Value $4.565M Shares 408,674 Est. Cost $15.67 Unrealized
SEDG SOLAREDGE TECHNOLOGIES INC 0.7%
Value $4.493M Shares 48,000 Est. Cost $91.03 Unrealized 0.0%
ALPINE IMMUNE SCIENCES INC 0.7%
Value $4.476M Shares 234,841 Est. Cost $9.97 Unrealized
ARWR ARROWHEAD PHARMACEUTICALS IN 0.7%
Value $4.434M Shares 144,899 Est. Cost $26.56 Unrealized 0.0%
ENPH ENPHASE ENERGY INC 0.7%
Value $4.242M Shares 32,100 Est. Cost $106.06 Unrealized 0.0%
VTGN VISTAGEN THERAPEUTICS INC 0.7%
Value $4.156M Shares 808,550 Est. Cost $3.87 Unrealized -2.1%
ALNY ALNYLAM PHARMACEUTICALS INC 0.6%
Value $3.828M Shares 20,000 Est. Cost $198.26 Unrealized -14.1%
FROG JFROG LTD 0.6%
Value $3.804M Shares 109,905 Est. Cost $27.04 Unrealized 0.0%
PTCT PTC THERAPEUTICS INC 0.6%
Value $3.763M Shares 136,525 Est. Cost $41.09 Unrealized -44.4%
UPWK UPWORK INC 0.6%
Value $3.759M Shares 252,784 Est. Cost $12.90 Unrealized 0.0%
GSK GSK PLC 0.6%
Value $3.706M Shares 100,000 Est. Cost $35.64 Unrealized
PLRX PLIANT THERAPEUTICS INC 0.6%
Value $3.505M Shares 193,554 Est. Cost $16.92 Unrealized -10.2%
ENLT ENLIGHT RENEWABLE ENERGY LTD 0.5%
Value $3.24M Shares 169,280 Est. Cost $15.65 Unrealized 0.0%
CYTK CYTOKINETICS INC 0.5%
Value $2.989M Shares 35,800 Est. Cost $33.30 Unrealized +8.7%
AMLX AMYLYX PHARMACEUTICALS INC 0.4%
Value $2.703M Shares 183,650 Est. Cost $24.17 Unrealized -36.6%
PFE PFIZER INC 0.4%
Value $2.591M Shares 90,000 Est. Cost $36.55 Unrealized -27.8%
SRPT SAREPTA THERAPEUTICS INC 0.4%
Value $2.546M Shares 26,400 Est. Cost $129.61 Unrealized -26.0%
SEDG SOLAREDGE TECHNOLOGIES INC 0.4%
Value $2.508M Shares 26,800 Est. Cost $91.03 Unrealized 0.0%
PRTA PROTHENA CORP PLC 0.4%
Value $2.478M Shares 68,200 Est. Cost Unrealized
HOWL WEREWOLF THERAPEUTICS INC 0.4%
Value $2.419M Shares 626,810 Est. Cost $13.12 Unrealized -80.5%
PROMIS NEUROSCIENCES INC 0.3%
Value $2.109M Shares 1,834,042 Est. Cost $2.01 Unrealized
ICL ICL GROUP LTD 0.3%
Value $2.104M Shares 420,000 Est. Cost $6.03 Unrealized -15.6%
AVGO BROADCOM INC 0.3%
Value $2.009M Shares 1,800 Est. Cost $92.23 Unrealized 0.0%
KEZAR LIFE SCIENCES INC 0.3%
Value $1.944M Shares 2,051,676 Est. Cost $7.20 Unrealized
VIGIL NEUROSCIENCE INC 0.3%
Value $1.809M Shares 535,120 Est. Cost $3.38 Unrealized
RIGEL PHARMACEUTICALS INC 0.3%
Value $1.781M Shares 1,228,126 Est. Cost $1.15 Unrealized
CARGO THERAPEUTICS INC 0.3%
Value $1.736M Shares 75,000 Est. Cost $23.15 Unrealized
GILD GILEAD SCIENCES INC 0.3%
Value $1.62M Shares 20,000 Est. Cost $72.58 Unrealized -0.5%
COGT COGENT BIOSCIENCES INC 0.2%
Value $1.524M Shares 259,201 Est. Cost $12.41 Unrealized -38.3%
CGEN COMPUGEN LTD 0.2%
Value $1.523M Shares 769,239 Est. Cost $0.89 Unrealized -1.5%
AMLX AMYLYX PHARMACEUTICALS INC 0.2%
Value $1.472M Shares 100,000 Est. Cost $24.17 Unrealized -36.6%
GOSS GOSSAMER BIO INC 0.2%
Value $1.221M Shares 1,338,090 Est. Cost $1.15 Unrealized -35.9%
SRPT SAREPTA THERAPEUTICS INC 0.2%
Value $1.205M Shares 12,500 Est. Cost $129.61 Unrealized -26.0%
FIVN FIVE9 INC 0.2%
Value $1.18M Shares 15,000 Est. Cost $69.64 Unrealized 0.0%
ORIC ORIC PHARMACEUTICALS INC 0.2%
Value $1.167M Shares 126,800 Est. Cost $7.23 Unrealized 0.0%
RZLT REZOLUTE INC 0.2%
Value $989K Shares 996,710 Est. Cost $3.32 Unrealized -72.4%
APGE APOGEE THERAPEUTICS INC 0.1%
Value $838K Shares 30,000 Est. Cost $22.03 Unrealized -9.0%
PRME PRIME MEDICINE INC 0.1%
Value $655K Shares 73,980 Est. Cost $7.70 Unrealized 0.0%
CARTESIAN THERAPEUTICS INC 0.1%
Value $519K Shares 752,137 Est. Cost $1.39 Unrealized
MDWD MEDIWOUND LTD 0.1%
Value $498K Shares 48,980 Est. Cost $10.92 Unrealized -17.8%
ELEVATION ONCOLOGY INC 0.1%
Value $483K Shares 900,000 Est. Cost $1.52 Unrealized
VTYX VENTYX BIOSCIENCES INC 0.1%
Value $445K Shares 180,000 Est. Cost $9.50 Unrealized 0.0%
MORPHIC HLDG INC 0.1%
Value $432K Shares 14,952 Est. Cost $57.33 Unrealized
IMMATICS N.V 0.0%
Value $292K Shares 100,000 Est. Cost $3.50 Unrealized
GLUE MONTE ROSA THERAPEUTICS INC 0.0%
Value $274K Shares 48,511 Est. Cost $3.92 Unrealized 0.0%
REPL REPLIMUNE GROUP INC 0.0%
Value $136K Shares 16,096 Est. Cost $19.64 Unrealized -41.0%
FREELINE THERAPEUTICS HLDGS 0.0%
Value $105K Shares 16,445 Est. Cost $6.37 Unrealized
ARBE ARBE ROBOTICS LTD 0.0%
Value $94,100 Shares 43,165 Est. Cost $2.02 Unrealized 0.0%
PERSPECTIVE THERAPEUTICS INC 0.0%
Value $10,320 Shares 25,671 Est. Cost $0.40 Unrealized