| BML Capital Management, LLC | 14,250,000 | $42,893 |
| Vivo Capital, LLC | 8,888,888 | $26,756 |
| BlackRock, Inc. | 6,804,841 | $20,483 |
| VANGUARD GROUP INC | 6,502,080 | $19,571 |
| Rock Springs Capital Management LP | 4,453,741 | $13,406 |
| Decheng Capital LLC | 4,041,736 | $12,166 |
| MORGAN STANLEY | 3,415,390 | $10,280 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,371,000 | $10,147 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,392,772 | $7,204 |
| ACADIAN ASSET MANAGEMENT LLC | 2,122,399 | $6 |
| D. E. Shaw & Co., Inc. | 2,096,651 | $6,311 |
| KOTLER KEVIN | 1,705,929 | $5,135 |
| Palo Alto Investors LP | 1,566,840 | $4,716 |
| STATE STREET CORP | 1,506,403 | $4,534 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,434,164 | $4,317 |
| CITADEL ADVISORS LLC | 1,205,281 | $3,628 |
| RENAISSANCE TECHNOLOGIES LLC | 1,125,331 | $3,387 |
| MILLENNIUM MANAGEMENT LLC | 1,053,246 | $3,170 |
| DEUTSCHE BANK AG\ | 987,351 | $2,972 |
| Aldebaran Capital, LLC | 954,262 | $2,872 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 916,846 | $2,760 |
| Bollard Group LLC | 804,445 | $2 |
| Woodline Partners LP | 742,009 | $2,233 |
| Three Bridge Wealth Advisors, LLC | 714,823 | $2,152 |
| NORTHERN TRUST CORP | 664,258 | $1,999 |
| GOLDMAN SACHS GROUP INC | 632,502 | $1,904 |
| JPMORGAN CHASE & CO | 625,963 | $1,884 |
| ADAR1 Capital Management, LLC | 613,986 | $1,848 |
| Logos Global Management LP | 600,000 | $1,806 |
| TWO SIGMA INVESTMENTS, LP | 574,213 | $1,728 |
| MARSHALL WACE, LLP | 485,501 | $1,461 |
| Qube Research & Technologies Ltd | 447,175 | $1,346 |
| Aisling Capital Management LP | 434,455 | $1,308 |
| UBS Group AG | 362,538 | $1,091 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 330,019 | $993 |
| AMERIPRISE FINANCIAL INC | 318,426 | $958 |
| HighTower Advisors, LLC | 305,948 | $921 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284,604 | $857 |
| DIMENSIONAL FUND ADVISORS LP | 270,850 | $815 |
| RAYMOND JAMES FINANCIAL INC | 269,684 | $812 |
| WELLINGTON MANAGEMENT GROUP LLP | 264,359 | $796 |
| TWO SIGMA ADVISERS, LP | 255,400 | $769 |
| Nuveen, LLC | 237,830 | $716 |
| Invesco Ltd. | 209,903 | $632 |
| Bank of New York Mellon Corp | 203,517 | $613 |
| Assenagon Asset Management S.A. | 154,554 | $465 |
| BARCLAYS PLC | 143,414 | $432 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 140,167 | $0 |
| XTX Topco Ltd | 112,912 | $340 |
| Seven Fleet Capital Management LP | 107,419 | $323 |
| WELLS FARGO & COMPANY/MN | 104,465 | $314 |
| AQR CAPITAL MANAGEMENT LLC | 103,792 | $312 |
| ALPS ADVISORS INC | 88,966 | $268 |
| Point72 Asset Management, L.P. | 87,175 | $262 |
| AMERICAN CENTURY COMPANIES INC | 77,568 | $233 |
| RHUMBLINE ADVISERS | 71,804 | $216 |
| PANAGORA ASSET MANAGEMENT INC | 68,190 | $205 |
| BANK OF AMERICA CORP /DE/ | 64,521 | $194 |
| Quadrature Capital Ltd | 57,670 | $174 |
| Creative Planning | 51,171 | $154 |
| INTECH INVESTMENT MANAGEMENT LLC | 46,646 | $140 |
| FMR LLC | 45,807 | $138 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,568 | $128 |
| Man Group plc | 42,435 | $128 |
| Cambridge Investment Research Advisors, Inc. | 41,873 | $0 |
| CITIGROUP INC | 41,630 | $125 |
| Susquehanna Portfolio Strategies, LLC | 39,701 | $120 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,998 | $87 |
| Valeo Financial Advisors, LLC | 27,540 | $83 |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,300 | $82 |
| JANE STREET GROUP, LLC | 27,216 | $82 |
| Vontobel Holding Ltd. | 26,000 | $78 |
| MetLife Investment Management, LLC | 25,597 | $77 |
| AXQ CAPITAL, LP | 24,186 | $73 |
| Persistent Asset Partners Ltd | 22,259 | $67 |
| ProShare Advisors LLC | 21,553 | $65 |
| BNP PARIBAS ARBITRAGE, SA | 21,516 | $65 |
| Police & Firemen's Retirement System of New Jersey | 19,700 | $59 |
| NEUBERGER BERMAN GROUP LLC | 18,955 | $57 |
| CRA Financial Services, LLC | 17,782 | $54 |
| China Universal Asset Management Co., Ltd. | 17,655 | $53 |
| CIBC Asset Management Inc | 17,428 | $52 |
| Voya Investment Management LLC | 17,248 | $52 |
| Mariner, LLC | 16,670 | $50 |
| SIMPLEX TRADING, LLC | 16,668 | $50 |
| SG Americas Securities, LLC | 15,423 | $0 |
| ALLIANCEBERNSTEIN L.P. | 15,200 | $46 |
| GROUP ONE TRADING, L.P. | 12,433 | $37 |
| R Squared Ltd | 12,408 | $37 |
| TWO SIGMA SECURITIES, LLC | 11,545 | $35 |
| Jefferies Financial Group Inc. | 11,002 | $33 |
| VICTORY CAPITAL MANAGEMENT INC | 10,651 | $32 |
| MERCER GLOBAL ADVISORS INC /ADV | 10,167 | $31 |
| Russell Investments Group, Ltd. | 9,785 | $29 |
| Ameritas Investment Partners, Inc. | 9,267 | $28 |
| Legal & General Group Plc | 8,242 | $25 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,649 | $17 |
| Sterling Capital Management LLC | 5,288 | $16 |
| Mirae Asset Global Investments Co., Ltd. | 5,265 | $16 |
| Tower Research Capital LLC (TRC) | 3,750 | $11 |
| 21 other institutions | 16,666 | $36 |