ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

New Positions (111)

Increased Positions (117)

DEERFIELD MANAGEMENT COMPANY, L.P.
Value ($000) $121,689 (+255.3%) Shares 1,832,946 (+84.6%)
Tetragon Partners GP Ltd
Value ($000) $6,436 (+128.0%) Shares 96,935 (+18.4%)
FRED ALGER MANAGEMENT, LLC
Value ($000) $121,693 (+1049.9%) Shares 1,832,997 (+497.4%)
BAKER BROS. ADVISORS LP
Value ($000) $144,441 (+150.7%) Shares 2,175,645 (+30.2%)
Connor, Clark & Lunn Investment Management Ltd.
Value ($000) $44,034 (+925.2%) Shares 663,262 (+432.6%)
Aquatic Capital Management LLC
Value ($000) $5,375 (+507.1%) Shares 80,958 (+215.4%)
Pictet Asset Management Holding SA
Value ($000) $68,636 (+597.3%) Shares 1,028,736 (+253.5%)
Entropy Technologies, LP
Value ($000) $1,802 (+398.8%) Shares 27,139 (+159.1%)
ADAR1 Capital Management, LLC
Value ($000) $3,864 (+125.0%) Shares 58,200 (+16.9%)
OXFORD ASSET MANAGEMENT LLP
Value ($000) $1,064 (+114.3%) Shares 16,026 (+11.3%)
Virtus Investment Advisers, LLC
Value ($000) $647 (+167.5%) Shares 9,749 (+39.0%)
Assenagon Asset Management S.A.
Value ($000) $45,470 (+246.4%) Shares 684,889 (+79.9%)
Voya Investment Management LLC
Value ($000) $28,065 (+491.7%) Shares 422,731 (+207.4%)
MOODY LYNN & LIEBERSON, LLC
Value ($000) $1,461 (+213.7%) Shares 22,000 (+63.0%)
JANUS HENDERSON GROUP PLC
Value ($000) $84,997 (+153.5%) Shares 1,280,446 (+31.5%)
Fisher Asset Management, LLC
Value ($000) $87,086 (+139.6%) Shares 1,311,727 (+24.5%)
PROFUND ADVISORS LLC
Value ($000) $2,426 (+139.0%) Shares 36,542 (+24.1%)
Russell Investments Group, Ltd.
Value ($000) $8,107 (+1724.3%) Shares 122,115 (+847.8%)
FMR LLC
Value ($000) $432,890 (+117.9%) Shares 6,520,408 (+13.2%)
BlackRock, Inc.
Value ($000) $1,415,341 (+102.9%) Shares 21,318,582 (+5.4%)

Decreased Positions (107)

Siren, L.L.C.
Value ($000) $99,617 (+8.2%) Shares 1,500,476 (-43.8%)
ACT CAPITAL MANAGEMENT, LLC
Value ($000) $4,979 (+36.3%) Shares 75,000 (-32.1%)
Privium Fund Management B.V.
Value ($000) $26,437 (+61.7%) Shares 398,204 (-16.0%)
Slate Path Capital LP
Value ($000) $167,535 (-2.5%) Shares 2,523,500 (-49.3%)
Avoro Capital Advisors LLC
Value ($000) $705,394 (+87.6%) Shares 10,625,000 (-2.5%)
WEALTH EFFECTS LLC
Value ($000) $9,514 (+63.8%) Shares 143,300 (-14.9%)
Exome Asset Management LLC
Value ($000) $3,303 (-8.4%) Shares 49,758 (-52.4%)
PLATINUM INVESTMENT MANAGEMENT LTD
Value ($000) $5,941 (+55.1%) Shares 89,484 (-19.4%)
Integral Health Asset Management, LLC
Value ($000) $6,639 (-14.4%) Shares 100,000 (-55.6%)
DRIEHAUS CAPITAL MANAGEMENT LLC
Value ($000) $117,466 (+62.2%) Shares 1,769,340 (-15.7%)
Woodline Partners LP
Value ($000) $26,568 (-23.0%) Shares 400,184 (-60.0%)
Schonfeld Strategic Advisors LLC
Value ($000) $1,335 (-92.9%) Shares 20,105 (-96.3%)
Bayforest Capital Ltd
Value ($000) $4 (-98.2%) Shares 54 (-99.0%)
Vanguard Capital Wealth Advisors
Value ($000) $627 (+61.1%) Shares 9,444 (-16.3%)
MARSHALL WACE, LLP
Value ($000) $8,223 (-83.4%) Shares 123,855 (-91.4%)
PDT Partners, LLC
Value ($000) $4,650 (+48.5%) Shares 70,048 (-22.9%)
TEMA ETFS LLC
Value ($000) $766 (-30.1%) Shares 11,542 (-63.7%)
ExodusPoint Capital Management, LP
Value ($000) $2,789 (-46.9%) Shares 42,011 (-72.4%)
PRELUDE CAPITAL MANAGEMENT, LLC
Value ($000) $897 (-9.3%) Shares 13,507 (-52.9%)
IvyRock Asset Management (HK) Ltd
Value ($000) $564 (+55.8%) Shares 8,500 (-19.0%)

Exited Positions (26)