| ORBIMED ADVISORS LLC | 7,959,538 | $122,577 |
| FMR LLC | 7,107,635 | $109,458 |
| Commodore Capital LP | 4,692,809 | $72,269 |
| Vestal Point Capital, LP | 3,830,000 | $58,982 |
| Fairmount Funds Management LLC | 3,711,444 | $57,156 |
| BlackRock, Inc. | 3,613,326 | $55,645 |
| Polar Capital Holdings Plc | 3,513,680 | $54,111 |
| VR Adviser, LLC | 3,226,331 | $49,685 |
| VANGUARD GROUP INC | 2,801,665 | $43,146 |
| JANUS HENDERSON GROUP PLC | 1,671,724 | $25,745 |
| Point72 Asset Management, L.P. | 1,504,601 | $23,171 |
| Novo Holdings A/S | 1,480,000 | $22,792 |
| CITADEL ADVISORS LLC | 1,424,344 | $21,935 |
| Capital Research Global Investors | 1,304,346 | $20,087 |
| Pictet Asset Management Holding SA | 1,303,235 | $20,070 |
| STATE STREET CORP | 1,052,862 | $16,214 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,048,722 | $16,154 |
| Soleus Capital Management, L.P. | 1,025,000 | $15,785 |
| Blackstone Inc. | 954,946 | $14,706 |
| Rock Springs Capital Management LP | 798,405 | $12,295 |
| 5AM Venture Management, LLC | 772,477 | $11,896 |
| Candriam S.C.A. | 453,019 | $6,977 |
| Spruce Street Capital LP | 446,084 | $6,870 |
| MORGAN STANLEY | 411,823 | $6,342 |
| DIMENSIONAL FUND ADVISORS LP | 398,893 | $6,143 |
| MARSHALL WACE, LLP | 371,906 | $5,727 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 355,192 | $5,470 |
| NORTHERN TRUST CORP | 352,239 | $5,424 |
| Logos Global Management LP | 340,000 | $5,236 |
| Patient Square Capital LP | 308,141 | $4,745 |
| Woodline Partners LP | 301,023 | $4,636 |
| MILLENNIUM MANAGEMENT LLC | 296,947 | $4,573 |
| BAKER BROS. ADVISORS LP | 271,406 | $4,180 |
| GOLDMAN SACHS GROUP INC | 237,204 | $3,653 |
| SPHERA FUNDS MANAGEMENT LTD. | 226,765 | $3,492 |
| Exome Asset Management LLC | 222,308 | $3,424 |
| Trails Edge Capital Partners, LP | 199,306 | $3,069 |
| Connor, Clark & Lunn Investment Management Ltd. | 194,735 | $2,999 |
| Avidity Partners Management LP | 140,300 | $2,161 |
| WELLINGTON MANAGEMENT GROUP LLP | 129,876 | $2,000 |
| Bank of New York Mellon Corp | 110,569 | $1,703 |
| Nuveen, LLC | 105,448 | $1,624 |
| JANE STREET GROUP, LLC | 101,971 | $1,570 |
| HighVista Strategies LLC | 82,536 | $1,271 |
| BARCLAYS PLC | 69,875 | $1,076 |
| Lighthouse Investment Partners, LLC | 65,000 | $1,001 |
| Swiss National Bank | 64,273 | $990 |
| XTX Topco Ltd | 60,702 | $935 |
| ExodusPoint Capital Management, LP | 60,415 | $930 |
| UBS Group AG | 57,868 | $891 |
| UBS ASSET MANAGEMENT AMERICAS INC | 55,210 | $850 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 52,578 | $810 |
| RHUMBLINE ADVISERS | 50,509 | $778 |
| Susquehanna Portfolio Strategies, LLC | 48,741 | $751 |
| AMERICAN CENTURY COMPANIES INC | 45,792 | $705 |
| Jump Financial, LLC | 45,354 | $698 |
| WELLS FARGO & COMPANY/MN | 43,056 | $663 |
| ALLIANCEBERNSTEIN L.P. | 36,840 | $567 |
| PRUDENTIAL FINANCIAL INC | 35,580 | $548 |
| BANK OF AMERICA CORP /DE/ | 32,711 | $504 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,206 | $496 |
| DEUTSCHE BANK AG\ | 31,420 | $484 |
| ADAR1 Capital Management, LLC | 30,000 | $462 |
| TUDOR INVESTMENT CORP ET AL | 29,673 | $457 |
| Aquatic Capital Management LLC | 27,955 | $431 |
| Legal & General Group Plc | 27,059 | $417 |
| Invesco Ltd. | 24,720 | $381 |
| MetLife Investment Management, LLC | 24,556 | $378 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,800 | $0 |
| Squarepoint Ops LLC | 20,763 | $320 |
| JPMORGAN CHASE & CO | 20,701 | $319 |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,398 | $314 |
| FRANKLIN RESOURCES INC | 20,167 | $311 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,336 | $298 |
| AMERIPRISE FINANCIAL INC | 18,949 | $292 |
| CITIGROUP INC | 18,489 | $285 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,287 | $282 |
| INTECH INVESTMENT MANAGEMENT LLC | 16,729 | $258 |
| Virtus Investment Advisers, LLC | 15,778 | $243 |
| AXQ CAPITAL, LP | 14,244 | $219 |
| SG Americas Securities, LLC | 14,035 | $0 |
| FOX RUN MANAGEMENT, L.L.C. | 12,432 | $191 |
| Seven Fleet Capital Management LP | 11,688 | $180 |
| Police & Firemen's Retirement System of New Jersey | 11,162 | $172 |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,800 | $166 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,480 | $161 |
| AlphaQuest LLC | 10,337 | $159 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,301 | $159 |
| PROFUND ADVISORS LLC | 10,179 | $157 |
| BNP PARIBAS ARBITRAGE, SA | 9,672 | $149 |
| China Universal Asset Management Co., Ltd. | 9,671 | $149 |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,097 | $140 |
| KLP KAPITALFORVALTNING AS | 6,800 | $105 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,163 | $95 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5,409 | $130 |
| Ameritas Investment Partners, Inc. | 3,449 | $53 |
| Russell Investments Group, Ltd. | 3,121 | $48 |
| Mirae Asset Global Investments Co., Ltd. | 2,884 | $44 |
| SIMPLEX TRADING, LLC | 2,649 | $41 |
| Tower Research Capital LLC (TRC) | 2,304 | $35 |
| 26 other institutions | 10,086 | $122 |