PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

New Positions (105)

Increased Positions (86)

ACUTA CAPITAL PARTNERS, LLC
Value ($000) $24,474 (+828.2%) Shares 83,036 (+66.9%)
Logos Global Management LP
Value ($000) $110,528 (+1568.3%) Shares 375,000 (+200.0%)
PERCEPTIVE ADVISORS LLC
Value ($000) $588,297 (+609.5%) Shares 1,995,986 (+27.6%)
Vivo Capital, LLC
Value ($000) $96,939 (+819.6%) Shares 328,895 (+65.4%)
SILVERARC CAPITAL MANAGEMENT, LLC
Value ($000) $24,306 (+795.5%) Shares 82,465 (+61.0%)
B Group, Inc.
Value ($000) $9,796 (+486.8%) Shares 33,237 (+5.5%)
DEERFIELD MANAGEMENT COMPANY, L.P.
Value ($000) $266,254 (+497.4%) Shares 903,351 (+7.4%)
Ikarian Capital, LLC
Value ($000) $25,519 (+1585.2%) Shares 86,581 (+203.0%)
BAKER BROS. ADVISORS LP
Value ($000) $332,021 (+808.6%) Shares 1,126,488 (+63.4%)
DRIEHAUS CAPITAL MANAGEMENT LLC
Value ($000) $275,010 (+936.6%) Shares 933,061 (+86.4%)
JANUS HENDERSON GROUP PLC
Value ($000) $954,834 (+551.9%) Shares 3,240,086 (+17.2%)
SummitTX Capital, L.P.
Value ($000) $12,270 (+562.8%) Shares 41,629 (+19.2%)
Candriam S.C.A.
Value ($000) $32,597 (+878.3%) Shares 110,590 (+75.9%)
Caption Management, LLC
Value ($000) $9,815 (+2813.1%) Shares 33,300 (+423.8%)
BARCLAYS PLC
Value ($000) $156,434 (+7222.1%) Shares 530,751 (+1329.4%)
Qube Research & Technologies Ltd
Value ($000) $49,781 (+1539.1%) Shares 168,897 (+194.7%)
FMR LLC
Value ($000) $400,456 (+17385.8%) Shares 1,358,675 (+3044.3%)
China Universal Asset Management Co., Ltd.
Value ($000) $1,437 (+634.9%) Shares 4,875 (+32.1%)
FIRST TRUST ADVISORS LP
Value ($000) $26,145 (+1603.0%) Shares 88,704 (+206.2%)
AMERICAN CENTURY COMPANIES INC
Value ($000) $22,214 (+2645.1%) Shares 75,366 (+393.6%)

Decreased Positions (44)

Velan Capital Investment Management LP
Value ($000) $29,704 (+322.0%) Shares 100,781 (-24.1%)
Exome Asset Management LLC
Value ($000) $17,131 (+216.9%) Shares 58,122 (-43.0%)
Lion Point Capital, LP
Value ($000) $1,312 (+334.2%) Shares 4,450 (-21.9%)
Cormorant Asset Management, LP
Value ($000) $280,003 (+428.3%) Shares 950,000 (-5.0%)
Soleus Capital Management, L.P.
Value ($000) $106,981 (+134.9%) Shares 362,966 (-57.8%)
HighVista Strategies LLC
Value ($000) $7,616 (+51.3%) Shares 25,841 (-72.8%)
Sofinnova Investments, Inc.
Value ($000) $37,055 (+304.5%) Shares 125,722 (-27.3%)
PFM Health Sciences, LP
Value ($000) $9,185 (+186.1%) Shares 31,163 (-48.6%)
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $284,516 (+126.1%) Shares 965,313 (-59.3%)
READYSTATE ASSET MANAGEMENT LP
Value ($000) $10,844 (+87.4%) Shares 36,792 (-66.3%)
Quarry LP
Value ($000) $1,179 (+11.2%) Shares 4,000 (-80.0%)
Point72 Asset Management, L.P.
Value ($000) $145,114 (+83.0%) Shares 492,346 (-67.1%)
Woodline Partners LP
Value ($000) $31,069 (+40.4%) Shares 105,412 (-74.8%)
CIBC Asset Management Inc
Value ($000) $265 (-98.7%) Shares 900 (-99.8%)
PRELUDE CAPITAL MANAGEMENT, LLC
Value ($000) $4,727 (+217.4%) Shares 16,038 (-42.9%)
HUSSMAN STRATEGIC ADVISORS, INC.
Value ($000) $2,476 (+344.9%) Shares 8,400 (-20.0%)
ALGERT GLOBAL LLC
Value ($000) $24 (+178.9%) Shares 80,640 (-49.9%)
Y-Intercept (Hong Kong) Ltd
Value ($000) $547 (-67.9%) Shares 1,856 (-94.2%)
Virtus Investment Advisers, LLC
Value ($000) $291 (+117.6%) Shares 989 (-60.9%)
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $6,182 (+194.1%) Shares 20,974 (-47.1%)