| BVF INC/IL | 2,590,303 | $68,876 |
| MORGAN STANLEY | 1,714,668 | $45,593 |
| FMR LLC | 1,161,889 | $30,895 |
| VANGUARD GROUP INC | 701,657 | $18,657 |
| BlackRock, Inc. | 611,515 | $16,260 |
| Opaleye Management Inc. | 292,590 | $7,780 |
| Woodline Partners LP | 262,933 | $6,991 |
| GEODE CAPITAL MANAGEMENT, LLC | 221,566 | $5,893 |
| STATE STREET CORP | 174,908 | $4,651 |
| Stonepine Capital Management, LLC | 115,000 | $3,058 |
| HighVista Strategies LLC | 112,917 | $3,002 |
| NORTHERN TRUST CORP | 90,403 | $2,404 |
| Bank of New York Mellon Corp | 68,384 | $1,818 |
| TLS Advisors LLC | 47,923 | $2 |
| DIMENSIONAL FUND ADVISORS LP | 43,335 | $1,152 |
| CM Management, LLC | 40,000 | $1,064 |
| RENAISSANCE TECHNOLOGIES LLC | 39,017 | $1,037 |
| RBF Capital, LLC | 30,000 | $798 |
| WELLINGTON MANAGEMENT GROUP LLP | 29,591 | $787 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,375 | $781 |
| UBS Group AG | 26,047 | $693 |
| PANAGORA ASSET MANAGEMENT INC | 21,229 | $564 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,332 | $642 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,580 | $467 |
| GOLDMAN SACHS GROUP INC | 16,097 | $428 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 15,000 | $399 |
| BARCLAYS PLC | 14,822 | $394 |
| Nuveen, LLC | 12,706 | $338 |
| BANK OF AMERICA CORP /DE/ | 11,942 | $318 |
| RHUMBLINE ADVISERS | 11,584 | $308 |
| WELLS FARGO & COMPANY/MN | 10,755 | $286 |
| DIVERSIFIED MANAGEMENT INC | 10,000 | $266 |
| TWO SIGMA INVESTMENTS, LP | 9,715 | $258 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,593 | $255 |
| Squarepoint Ops LLC | 8,901 | $237 |
| SG Americas Securities, LLC | 6,356 | $0 |
| MetLife Investment Management, LLC | 5,677 | $151 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,498 | $120 |
| JPMORGAN CHASE & CO | 3,835 | $102 |
| OSAIC HOLDINGS, INC. | 3,544 | $94 |
| Police & Firemen's Retirement System of New Jersey | 2,856 | $76 |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | $63 |
| BNP PARIBAS ARBITRAGE, SA | 2,152 | $57 |
| ROYAL BANK OF CANADA | 1,243 | $33 |
| State of Alaska, Department of Revenue | 1,050 | $0 |
| Legal & General Group Plc | 976 | $26 |
| Ameritas Investment Partners, Inc. | 959 | $26 |
| Russell Investments Group, Ltd. | 778 | $21 |
| Costello Asset Management, INC | 600 | $16 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 585 | $16 |
| CITIGROUP INC | 555 | $15 |
| Tower Research Capital LLC (TRC) | 469 | $12 |
| NATIXIS | 372 | $10 |
| FEDERATED HERMES, INC. | 335 | $9 |
| AMALGAMATED BANK | 298 | $0 |
| Truvestments Capital LLC | 290 | $8 |
| Sterling Capital Management LLC | 233 | $6 |
| SIMPLEX TRADING, LLC | 173 | $5 |
| CWM, LLC | 134 | $0 |
| DEUTSCHE BANK AG\ | 124 | $3 |
| GAMMA Investing LLC | 113 | $3 |
| EverSource Wealth Advisors, LLC | 69 | $2 |
| Optiver Holding B.V. | 66 | $2 |
| PNC Financial Services Group, Inc. | 25 | $1 |
| MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | 20 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 19 | $1 |
| SBI Securities Co., Ltd. | 12 | $0 |
| Allworth Financial LP | 10 | $0 |
| ROTHSCHILD INVESTMENT LLC | 3 | $0 |
| SRS Capital Advisors, Inc. | 3 | $0 |
| True Wealth Design, LLC | 3 | $0 |
| IFP Advisors, Inc | 1 | $0 |
| TD Waterhouse Canada Inc. | 1 | $0 |