Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 16, 2021
Total Value: $11.43B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| PRLD | PRELUDE THERAPEUTICS INC | 15,594,877 | $1.116B | 9.8% | — | — | COM | 74065P101 |
| — | SPRINGWORKS THERAPEUTICS INC | 7,406,307 | $537M | 4.7% | — | — | COM | 85205L107 |
| PMVP | PMV PHARMACEUTICALS INC | 7,330,423 | $451M | 3.9% | — | — | COM | 69353Y103 |
| SPRY | SILVERBACK THERAPEUTICS INC | 8,740,887 | $405M | 3.5% | — | — | COM | 82835W108 |
| ABCL | ABCELLERA BIOLOGICS INC | 8,400,768 | $338M | 3.0% | — | — | COM | 00288U106 |
| — | TURNING POINT THERAPEUTICS I | 2,745,327 | $335M | 2.9% | — | — | COM | 90041T108 |
| — | PREVAIL THERAPEUTICS INC | 13,822,463 | $319M | 2.8% | — | — | COM | 74140Y101 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 6,645,100 | $308M | 2.7% | — | — | COM | 462260100 |
| — | MIRATI THERAPEUTICS INC | 1,145,300 | $252M | 2.2% | — | — | COM | 60468T105 |
| BSX | BOSTON SCIENTIFIC CORP | 6,523,000 | $235M | 2.1% | — | — | COM | 101137107 |
| BMY | BRISTOL-MYERS SQUIBB CO | 3,549,100 | $220M | 1.9% | — | — | COM | 110122108 |
| — | HORIZON THERAPEUTICS PUB L | 3,008,755 | $220M | 1.9% | — | — | SHS | G46188101 |
| MRK | MERCK & CO. INC | 2,659,300 | $218M | 1.9% | — | — | COM | 58933Y105 |
| NTRA | NATERA INC | 2,110,700 | $210M | 1.8% | — | — | COM | 632307104 |
| VRTX | VERTEX PHARMACEUTICALS INC | 834,100 | $197M | 1.7% | — | — | COM | 92532F100 |
| — | PASSAGE BIO INC | 6,962,899 | $178M | 1.6% | — | — | COM | 702712100 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $171M | 1.5% | — | — | COM | 03969K108 |
| AFIB | ACUTUS MED INC | 5,477,958 | $158M | 1.4% | — | — | COM | 005111109 |
| — | KINNATE BIOPHARMA INC | 3,847,929 | $153M | 1.3% | — | — | COM | 49705R105 |
| UNH | UNITEDHEALTH GROUP INC | 390,300 | $137M | 1.2% | — | — | COM | 91324P102 |
| PFE | PFIZER INC | 3,616,600 | $133M | 1.2% | — | — | COM | 717081103 |
| — | GRAYBUG VISION INC | 4,475,847 | $130M | 1.1% | — | — | COM SHS | 38942Q103 |
| BIIB | BIOGEN INC | 529,400 | $130M | 1.1% | — | — | COM | 09062X103 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,301,715 | $125M | 1.1% | — | — | COM | 64125C109 |
| CNC | CENTENE CORP DEL | 1,993,700 | $120M | 1.0% | — | — | COM | 15135B101 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $118M | 1.0% | — | — | COM | 492327101 |
| — | REPARE THERAPEUTICS INC | 3,426,325 | $118M | 1.0% | — | — | COM | 760273102 |
| HUM | HUMANA INC | 286,100 | $117M | 1.0% | — | — | COM | 444859102 |
| TBPH | THERAVANCE BIOPHARMA INC | 6,219,110 | $111M | 1.0% | — | — | COM | G8807B106 |
| — | NANOSTRING TECHNOLOGIES INC | 1,626,900 | $109M | 1.0% | — | — | COM | 63009R109 |
| DXCM | DEXCOM INC | 279,100 | $103M | 0.9% | — | — | COM | 252131107 |
| ELV | ANTHEM INC | 310,500 | $99.7M | 0.9% | — | — | COM | 036752103 |
| ORIC | ORIC PHARMACEUTICALS INC | 2,921,967 | $98.91M | 0.9% | — | — | COM | 68622P109 |
| — | BURNING ROCK BIOTECH LTD | 4,161,675 | $96.14M | 0.8% | — | — | SPONSORED ADS | 12233L107 |
| AGIO | AGIOS PHARMACEUTICALS INC | 2,207,321 | $95.64M | 0.8% | — | — | COM | 00847X104 |
| — | ADICET BIO INC | 6,708,507 | $94.25M | 0.8% | — | — | COM | 007002108 |
| EW | EDWARDS LIFESCIENCES CORP | 1,025,800 | $93.58M | 0.8% | — | — | COM | 28176E108 |
| ABBV | ABBVIE INC | 862,300 | $92.39M | 0.8% | — | — | COM | 00287Y109 |
| ISRG | INTUITIVE SURGICAL INC | 112,800 | $92.28M | 0.8% | — | — | COM NEW | 46120E602 |
| SRPT | SAREPTA THERAPEUTICS INC | 539,049 | $91.9M | 0.8% | — | — | COM | 803607100 |
| — | 89BIO INC | 3,729,442 | $90.89M | 0.8% | — | — | COM | 282559103 |
| XTNT | XTANT MED HLDGS INC | 72,803,072 | $87.08M | 0.8% | — | — | COM NEW | 98420P308 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $72M | 0.6% | — | — | SHS | P8696W104 |
| PGNY | PROGYNY INC | 1,675,500 | $71.02M | 0.6% | — | — | COM | 74340E103 |
| GH | GUARDANT HEALTH INC | 538,200 | $69.36M | 0.6% | — | — | COM | 40131M109 |
| CRSP | CRISPR THERAPEUTICS AG | 451,800 | $69.17M | 0.6% | — | — | NAMEN AKT | H17182108 |
| ATRC | ATRICURE INC | 1,228,189 | $68.37M | 0.6% | — | — | COM | 04963C209 |
| — | TRICIDA INC | 9,614,280 | $67.78M | 0.6% | — | — | COM | 89610F101 |
| AUPH | AURINIA PHARMACEUTICALS INC | 4,754,000 | $65.75M | 0.6% | — | — | COM | 05156V102 |
| — | LOGICBIO THERAPEUTICS INC | 8,466,783 | $64.6M | 0.6% | — | — | COM | 54142F102 |
| — | DECIPHERA PHARMACEUTICALS IN | 1,125,700 | $64.24M | 0.6% | — | — | COM | 24344T101 |
| MGTX | MEIRAGTX HLDGS PLC | 4,102,925 | $62.12M | 0.5% | — | — | COM | G59665102 |
| — | IMARA INC | 2,719,902 | $59.97M | 0.5% | — | — | COM | 45249V107 |
| — | ADVERUM BIOTECHNOLOGIES INC | 5,501,144 | $59.63M | 0.5% | — | — | COM | 00773U108 |
| EHTH | EHEALTH INC | 844,046 | $59.6M | 0.5% | — | — | COM | 28238P109 |
| — | CHANGE HEALTHCARE INC | 3,093,700 | $57.7M | 0.5% | — | — | COM | 15912K100 |
| SYK | STRYKER CORPORATION | 235,000 | $57.58M | 0.5% | — | — | COM | 863667101 |
| ASND | ASCENDIS PHARMA A/S | 336,500 | $56.12M | 0.5% | — | — | SPONSORED ADR | 04351P101 |
| ARCT | ARCTURUS THERAPEUTICS HLDGS | 1,280,086 | $55.53M | 0.5% | — | — | COM | 03969T109 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 1,035,160 | $52.03M | 0.5% | — | — | COM | 00404A109 |
| TMO | THERMO FISHER SCIENTIFIC INC | 110,300 | $51.38M | 0.4% | — | — | COM | 883556102 |
| — | GALECTO INC | 4,090,937 | $51.18M | 0.4% | — | — | COM | 36322Q107 |
| MREO | MEREO BIOPHARMA GROUP PLC | 13,816,488 | $49.46M | 0.4% | — | — | ADS | 589492107 |
| TELA | TELA BIO INC | 3,027,542 | $45.53M | 0.4% | — | — | COM | 872381108 |
| — | TRILLIUM THERAPEUTICS INC | 2,960,200 | $43.55M | 0.4% | — | — | COM NEW | 89620X506 |
| SIBN | SI BONE INC | 1,368,500 | $40.92M | 0.4% | — | — | COM | 825704109 |
| — | ATHENEX INC | 3,694,061 | $40.86M | 0.4% | — | — | COM | 04685N103 |
| — | VERONA PHARMA PLC | 5,694,841 | $39.86M | 0.3% | — | — | SPONSORED ADS | 925050106 |
| — | APPLIED THERAPEUTICS INC | 1,771,831 | $39M | 0.3% | — | — | COM | 03828A101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 2,753,567 | $38.85M | 0.3% | — | — | COM | 22663K107 |
| — | ALPINE IMMUNE SCIENCES INC | 3,070,955 | $38.69M | 0.3% | — | — | COM | 02083G100 |
| XENE | XENON PHARMACEUTICALS INC | 2,497,917 | $38.42M | 0.3% | — | — | COM | 98420N105 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $37.89M | 0.3% | — | — | COM | 36118A100 |
| — | KALA PHARMACEUTICALS INC | 5,465,030 | $37.05M | 0.3% | — | — | COM | 483119103 |
| — | CURIS INC | 4,366,494 | $35.76M | 0.3% | — | — | COM NEW | 231269200 |
| — | APTOSE BIOSCIENCES INC | 8,030,000 | $35.17M | 0.3% | — | — | COM NEW | 03835T200 |
| QURE | UNIQURE NV | 969,079 | $35.01M | 0.3% | — | — | SHS | N90064101 |
| MOH | MOLINA HEALTHCARE INC | 162,400 | $34.54M | 0.3% | — | — | COM | 60855R100 |
| ALEC | ALECTOR INC | 2,225,313 | $33.6M | 0.3% | — | — | COM | 014442107 |
| — | AEGLEA BIOTHERAPEUTICS INC | 4,015,524 | $31.6M | 0.3% | — | — | COM | 00773J103 |
| OLMA | OLEMA PHARMACEUTICALS INC | 650,992 | $31.3M | 0.3% | — | — | COM | 68062P106 |
| — | CTI BIOPHARMA CORP | 9,520,600 | $30.66M | 0.3% | — | — | COM | 12648L601 |
| — | HARPOON THERAPEUTICS INC | 1,835,704 | $30.49M | 0.3% | — | — | COM | 41358P106 |
| — | NEXTCURE INC | 2,711,013 | $29.55M | 0.3% | — | — | COM | 65343E108 |
| NBP | I MAB | 606,070 | $28.58M | 0.3% | — | — | SPONSORED ADS | 44975P103 |
| — | OAK STR HEALTH INC | 448,100 | $27.41M | 0.2% | — | — | COM | 67181A107 |
| — | FLEXION THERAPEUTICS INC | 2,308,083 | $26.64M | 0.2% | — | — | COM | 33938J106 |
| — | ALEXION PHARMACEUTICALS INC | 169,000 | $26.41M | 0.2% | — | — | COM | 015351109 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 1,170,900 | $26.04M | 0.2% | — | — | COM | 87164F105 |
| — | SCPHARMACEUTICALS INC | 4,797,148 | $25.38M | 0.2% | — | — | COM | 810648105 |
| HRTX | HERON THERAPEUTICS INC | 1,191,846 | $25.23M | 0.2% | — | — | COM | 427746102 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,767,584 | $24.09M | 0.2% | — | — | COM | 221015100 |
| — | SIERRA ONCOLOGY INC | 1,477,320 | $23.68M | 0.2% | — | — | COM NEW | 82640U404 |
| ALC | ALCON AG | 351,380 | $23.36M | 0.2% | — | — | ORD SHS | H01301128 |
| LAB | FLUIDIGM CORP DEL | 3,892,346 | $23.35M | 0.2% | — | — | COM | 34385P108 |
| — | 9 METERS BIOPHARMA INC | 25,716,755 | $22.09M | 0.2% | — | — | COM | 654405109 |
| — | PANDION THERAPEUTICS INC | 1,480,940 | $21.99M | 0.2% | — | — | COM | 698340106 |
| PRTA | PROTHENA CORP PLC | 1,797,458 | $21.59M | 0.2% | — | — | SHS | G72800108 |
| AMGN | AMGEN INC | 91,500 | $21.04M | 0.2% | — | — | COM | 031162100 |
| — | OTONOMY INC | 3,250,000 | $21.03M | 0.2% | — | — | COM | 68906L105 |
| — | MERSANA THERAPEUTICS INC | 773,348 | $20.58M | 0.2% | — | — | COM | 59045L106 |
| — | CHINOOK THERAPEUTICS INC | 1,250,001 | $19.82M | 0.2% | — | — | COM | 16961L106 |
| LRMR | LARIMAR THERAPEUTICS INC | 886,560 | $18.98M | 0.2% | — | — | COM | 517125100 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 1,935,200 | $18.68M | 0.2% | — | — | SPONSORED ADS | 881624209 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $17.03M | 0.1% | — | — | COM | 92511W108 |
| — | SYROS PHARMACEUTICALS INC | 1,562,500 | $16.95M | 0.1% | — | — | COM | 87184Q107 |
| PCVX | VAXCYTE INC | 630,260 | $16.75M | 0.1% | — | — | COM | 92243G108 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,493,109 | $16.7M | 0.1% | — | — | COM | 59935V107 |
| CMPS | COMPASS PATHWAYS PLC | 350,000 | $16.67M | 0.1% | — | — | SPONSORED ADS | 20451W101 |
| — | IMMUNOGEN INC | 2,553,900 | $16.47M | 0.1% | — | — | COM | 45253H101 |
| — | ZYMEWORKS INC | 317,002 | $14.98M | 0.1% | — | — | COM | 98985W102 |
| — | BIOMX INC | 2,313,489 | $14.76M | 0.1% | — | — | COM | 09090D103 |
| — | VISTAGEN THERAPEUTICS INC | 7,500,000 | $14.55M | 0.1% | — | — | COM NEW | 92840H202 |
| RLAY | RELAY THERAPEUTICS INC | 350,000 | $14.55M | 0.1% | — | — | COM | 75943R102 |
| ACAD | ACADIA PHARMACEUTICALS INC | 265,772 | $14.21M | 0.1% | — | — | COM | 004225108 |
| — | PRAXIS PRECISION MEDICINES I | 255,600 | $14.06M | 0.1% | — | — | COM | 74006W108 |
| ALXO | ALX ONCOLOGY HLDGS INC | 150,000 | $12.93M | 0.1% | — | — | COM | 00166B105 |
| — | BELLUS HEALTH INC NEW | 4,189,593 | $12.57M | 0.1% | — | — | COM NEW | 07987C204 |
| GILD | GILEAD SCIENCES INC | 192,200 | $11.2M | 0.1% | — | — | COM | 375558103 |
| — | AVROBIO INC | 793,712 | $11.06M | 0.1% | — | — | COM | 05455M100 |
| TARA | PROTARA THERAPEUTICS INC | 450,000 | $10.89M | 0.1% | — | — | COM STK | 74365U107 |
| VTRS | VIATRIS INC | 535,149 | $10.03M | 0.1% | — | — | COM | 92556V106 |
| NRIX | NURIX THERAPEUTICS INC | 300,000 | $9.864M | 0.1% | — | — | COM | 67080M103 |
| LUNG | PULMONX CORP | 125,000 | $8.628M | 0.1% | — | — | COM | 745848101 |
| SRPT | SAREPTA THERAPEUTICS INC | 50,000 | $8.525M | 0.1% | — | — | Call | 803607100 |
| — | STRONGBRIDGE BIOPHARMA PLC | 3,489,369 | $8.479M | 0.1% | — | — | SHS USD | G85347105 |
| — | INOZYME PHARMA INC | 400,400 | $8.264M | 0.1% | — | — | COM | 45790W108 |
| NBTX | NANOBIOTIX SA | 500,000 | $8.25M | 0.1% | — | — | SPONSORED ADS | 63009J107 |
| HCAT | HEALTH CATALYST INC | 179,598 | $7.818M | 0.1% | — | — | COM | 42225T107 |
| — | TCR2 THERAPEUTICS INC | 249,279 | $7.71M | 0.1% | — | — | COM | 87808K106 |
| — | SUTRO BIOPHARMA INC | 350,000 | $7.599M | 0.1% | — | — | COM | 869367102 |
| COGT | COGENT BIOSCIENCES INC | 655,000 | $7.356M | 0.1% | — | — | COM | 19240Q201 |
| DYN | DYNE THERAPEUTICS INC | 350,000 | $7.35M | 0.1% | — | — | COM | 26818M108 |
| — | OUTSET MED INC | 125,000 | $7.105M | 0.1% | — | — | COM | 690145107 |
| — | X4 PHARMACEUTICALS INC | 1,086,493 | $6.986M | 0.1% | — | — | COM | 98420X103 |
| — | HEALTH SCIENCES ACQ CORP 2 | 500,000 | $6.405M | 0.1% | — | — | ORD SHS | G4411D109 |
| — | AKOUOS INC | 315,000 | $6.246M | 0.1% | — | — | COM | 00973J101 |
| — | ESSA PHARMA INC | 460,500 | $5.494M | 0.0% | — | — | COM NEW | 29668H708 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 125,000 | $5.181M | 0.0% | — | — | COM | 35104E100 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $5.09M | 0.0% | — | — | COM | 00810B105 |
| — | SYNLOGIC INC | 2,029,996 | $4.385M | 0.0% | — | — | COM | 87166L100 |
| — | FORTE BIOSCIENCES INC | 92,200 | $3.357M | 0.0% | — | — | COM | 34962G109 |
| IFRX | INFLARX NV | 556,025 | $2.797M | 0.0% | — | — | COM | N44821101 |
| MASS | 908 DEVICES INC | 40,000 | $2.278M | 0.0% | — | — | COM | 65443P102 |
| — | SELECTA BIOSCIENCES INC | 539,169 | $1.634M | 0.0% | — | — | COM | 816212104 |
| — | PURPLE BIOTECH LTD | 346,197 | $1.319M | 0.0% | — | — | SPONSORED ADS | 74638P109 |
| — | CALITHERA BIOSCIENCES INC | 250,300 | $1.229M | 0.0% | — | — | Put | 13089P101 |
| — | NOVUS THERAPEUTICS INC | 73,650 | $1.105M | 0.0% | — | — | COM | 67011N204 |
| — | BRISTOL-MYERS SQUIBB CO | 400,000 | $276K | 0.0% | — | — | RIGHT 99/99/9999 | 110122157 |