CIK: 0001055951 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 16, 2021
Total Value ($000): $11,428,040 (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value ($000) | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| PRLD | PRELUDE THERAPEUTICS INC | 15,594,877 | $1,115,813 | 9.8% | $28.24 | +76.1% | COM | 74065P101 |
| — | SPRINGWORKS THERAPEUTICS INC | 7,406,307 | $537,105 | 4.7% | $21.68 | — | COM | 85205L107 |
| PMVP | PMV PHARMACEUTICALS INC | 7,330,423 | $450,894 | 3.9% | $36.80 | +6.6% | COM | 69353Y103 |
| SPRY | SILVERBACK THERAPEUTICS INC | 8,740,887 | $405,053 | 3.5% | $33.40 | 0.0% | COM | 82835W108 |
| ABCL | ABCELLERA BIOLOGICS INC | 8,400,768 | $338,047 | 3.0% | $45.73 | 0.0% | COM | 00288U106 |
| — | TURNING POINT THERAPEUTICS I | 2,745,327 | $334,518 | 2.9% | $40.50 | — | COM | 90041T108 |
| — | PREVAIL THERAPEUTICS INC | 13,822,463 | $318,884 | 2.8% | $13.20 | — | COM | 74140Y101 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 6,645,100 | $308,333 | 2.7% | $10.72 | +270.3% | COM | 462260100 |
| — | MIRATI THERAPEUTICS INC | 1,145,300 | $251,554 | 2.2% | $106.68 | — | COM | 60468T105 |
| BSX | BOSTON SCIENTIFIC CORP | 6,523,000 | $234,502 | 2.1% | $24.52 | +47.0% | COM | 101137107 |
| BMY | BRISTOL-MYERS SQUIBB CO | 3,549,100 | $220,151 | 1.9% | $46.88 | +6.7% | COM | 110122108 |
| — | HORIZON THERAPEUTICS PUB L | 3,008,755 | $220,090 | 1.9% | $39.87 | — | SHS | G46188101 |
| MRK | MERCK & CO. INC | 2,659,300 | $217,531 | 1.9% | $48.91 | +32.6% | COM | 58933Y105 |
| NTRA | NATERA INC | 2,110,700 | $210,057 | 1.8% | $23.60 | +254.0% | COM | 632307104 |
| VRTX | VERTEX PHARMACEUTICALS INC | 834,100 | $197,131 | 1.7% | $126.41 | +81.5% | COM | 92532F100 |
| — | PASSAGE BIO INC | 6,962,899 | $178,041 | 1.6% | $15.75 | — | COM | 702712100 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $170,857 | 1.5% | $26.32 | -6.9% | COM | 03969K108 |
| AFIB | ACUTUS MED INC | 5,477,958 | $157,820 | 1.4% | $30.36 | -10.8% | COM | 005111109 |
| — | KINNATE BIOPHARMA INC | 3,847,929 | $153,071 | 1.3% | $39.78 | — | COM | 49705R105 |
| UNH | UNITEDHEALTH GROUP INC | 390,300 | $136,870 | 1.2% | $308.19 | 0.0% | COM | 91324P102 |
| PFE | PFIZER INC | 3,616,600 | $133,127 | 1.2% | $28.63 | 0.0% | COM | 717081103 |
| — | GRAYBUG VISION INC | 4,475,847 | $129,889 | 1.1% | $12.71 | — | COM SHS | 38942Q103 |
| BIIB | BIOGEN INC | 529,400 | $129,629 | 1.1% | $299.57 | -13.5% | COM | 09062X103 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,301,715 | $124,769 | 1.1% | $91.36 | +5.7% | COM | 64125C109 |
| CNC | CENTENE CORP DEL | 1,993,700 | $119,682 | 1.0% | $61.62 | +3.1% | COM | 15135B101 |
| KROS | KEROS THERAPEUTICS INC | 1,679,417 | $118,466 | 1.0% | $30.81 | +104.5% | COM | 492327101 |
| — | REPARE THERAPEUTICS INC | 3,426,325 | $117,523 | 1.0% | $31.02 | — | COM | 760273102 |
| HUM | HUMANA INC | 286,100 | $117,378 | 1.0% | $286.32 | +38.5% | COM | 444859102 |
| TBPH | THERAVANCE BIOPHARMA INC | 6,219,110 | $110,514 | 1.0% | $21.57 | -16.8% | COM | G8807B106 |
| — | NANOSTRING TECHNOLOGIES INC | 1,626,900 | $108,807 | 1.0% | $35.73 | — | COM | 63009R109 |
| DXCM | DEXCOM INC | 279,100 | $103,189 | 0.9% | $51.35 | +73.9% | COM | 252131107 |
| ELV | ANTHEM INC | 310,500 | $99,698 | 0.9% | $286.17 | 0.0% | COM | 036752103 |
| ORIC | ORIC PHARMACEUTICALS INC | 2,921,967 | $98,909 | 0.9% | $31.92 | -10.1% | COM | 68622P109 |
| — | BURNING ROCK BIOTECH LTD | 4,161,675 | $96,135 | 0.8% | $27.01 | — | SPONSORED ADS | 12233L107 |
| AGIO | AGIOS PHARMACEUTICALS INC | 2,207,321 | $95,643 | 0.8% | $45.70 | -13.5% | COM | 00847X104 |
| — | ADICET BIO INC | 6,708,507 | $94,255 | 0.8% | $11.89 | — | COM | 007002108 |
| EW | EDWARDS LIFESCIENCES CORP | 1,025,800 | $93,584 | 0.8% | $71.22 | +16.5% | COM | 28176E108 |
| ABBV | ABBVIE INC | 862,300 | $92,395 | 0.8% | $73.52 | +7.4% | COM | 00287Y109 |
| ISRG | INTUITIVE SURGICAL INC | 112,800 | $92,282 | 0.8% | $142.69 | +74.0% | COM NEW | 46120E602 |
| SRPT | SAREPTA THERAPEUTICS INC | 539,049 | $91,902 | 0.8% | $105.48 | +40.5% | COM | 803607100 |
| — | 89BIO INC | 3,729,442 | $90,887 | 0.8% | $26.29 | — | COM | 282559103 |
| XTNT | XTANT MED HLDGS INC | 72,803,072 | $87,080 | 0.8% | $1.96 | -34.3% | COM NEW | 98420P308 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $72,000 | 0.6% | $4.60 | +40.7% | SHS | P8696W104 |
| PGNY | PROGYNY INC | 1,675,500 | $71,024 | 0.6% | $26.63 | +22.1% | COM | 74340E103 |
| GH | GUARDANT HEALTH INC | 538,200 | $69,363 | 0.6% | $108.30 | +6.2% | COM | 40131M109 |
| CRSP | CRISPR THERAPEUTICS AG | 451,800 | $69,175 | 0.6% | $51.78 | +128.3% | NAMEN AKT | H17182108 |
| ATRC | ATRICURE INC | 1,228,189 | $68,373 | 0.6% | $36.78 | +17.6% | COM | 04963C209 |
| — | TRICIDA INC | 9,614,280 | $67,781 | 0.6% | $30.09 | — | COM | 89610F101 |
| AUPH | AURINIA PHARMACEUTICALS INC | 4,754,000 | $65,748 | 0.6% | $12.50 | +16.4% | COM | 05156V102 |
| — | LOGICBIO THERAPEUTICS INC | 8,466,783 | $64,602 | 0.6% | $9.75 | — | COM | 54142F102 |
| — | DECIPHERA PHARMACEUTICALS IN | 1,125,700 | $64,244 | 0.6% | $24.10 | — | COM | 24344T101 |
| MGTX | MEIRAGTX HLDGS PLC | 4,102,925 | $62,118 | 0.5% | $15.88 | -11.0% | COM | G59665102 |
| — | IMARA INC | 2,719,902 | $59,974 | 0.5% | $16.03 | — | COM | 45249V107 |
| — | ADVERUM BIOTECHNOLOGIES INC | 5,501,144 | $59,632 | 0.5% | $8.36 | — | COM | 00773U108 |
| EHTH | EHEALTH INC | 844,046 | $59,598 | 0.5% | $40.38 | +88.2% | COM | 28238P109 |
| — | CHANGE HEALTHCARE INC | 3,093,700 | $57,698 | 0.5% | $14.51 | — | COM | 15912K100 |
| SYK | STRYKER CORPORATION | 235,000 | $57,584 | 0.5% | $183.63 | +16.8% | COM | 863667101 |
| ASND | ASCENDIS PHARMA A/S | 336,500 | $56,121 | 0.5% | $29.06 | — | SPONSORED ADR | 04351P101 |
| ARCT | ARCTURUS THERAPEUTICS HLDGS | 1,280,086 | $55,530 | 0.5% | $56.15 | +20.6% | COM | 03969T109 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 1,035,160 | $52,027 | 0.5% | $28.63 | +39.2% | COM | 00404A109 |
| TMO | THERMO FISHER SCIENTIFIC INC | 110,300 | $51,376 | 0.4% | $149.40 | +209.6% | COM | 883556102 |
| — | GALECTO INC | 4,090,937 | $51,178 | 0.4% | $12.51 | — | COM | 36322Q107 |
| MREO | MEREO BIOPHARMA GROUP PLC | 13,816,488 | $49,463 | 0.4% | $3.58 | — | ADS | 589492107 |
| TELA | TELA BIO INC | 3,027,542 | $45,534 | 0.4% | $12.23 | +32.7% | COM | 872381108 |
| — | TRILLIUM THERAPEUTICS INC | 2,960,200 | $43,545 | 0.4% | $10.90 | — | COM NEW | 89620X506 |
| SIBN | SI BONE INC | 1,368,500 | $40,918 | 0.4% | $18.37 | +32.5% | COM | 825704109 |
| — | ATHENEX INC | 3,694,061 | $40,856 | 0.4% | $15.86 | — | COM | 04685N103 |
| — | VERONA PHARMA PLC | 5,694,841 | $39,864 | 0.3% | $7.45 | — | SPONSORED ADS | 925050106 |
| — | APPLIED THERAPEUTICS INC | 1,771,831 | $38,998 | 0.3% | $26.34 | — | COM | 03828A101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 2,753,567 | $38,853 | 0.3% | $26.19 | -46.8% | COM | 22663K107 |
| — | ALPINE IMMUNE SCIENCES INC | 3,070,955 | $38,694 | 0.3% | $11.12 | — | COM | 02083G100 |
| XENE | XENON PHARMACEUTICALS INC | 2,497,917 | $38,418 | 0.3% | $12.08 | -3.1% | COM | 98420N105 |
| — | FUSION PHARMACEUTICALS INC | 3,224,770 | $37,891 | 0.3% | $17.47 | — | COM | 36118A100 |
| — | KALA PHARMACEUTICALS INC | 5,465,030 | $37,053 | 0.3% | $16.26 | — | COM | 483119103 |
| — | CURIS INC | 4,366,494 | $35,762 | 0.3% | $6.49 | — | COM NEW | 231269200 |
| — | APTOSE BIOSCIENCES INC | 8,030,000 | $35,171 | 0.3% | $4.55 | — | COM NEW | 03835T200 |
| QURE | UNIQURE NV | 969,079 | $35,013 | 0.3% | $61.75 | -31.7% | SHS | N90064101 |
| MOH | MOLINA HEALTHCARE INC | 162,400 | $34,539 | 0.3% | $206.44 | 0.0% | COM | 60855R100 |
| ALEC | ALECTOR INC | 2,225,313 | $33,602 | 0.3% | $18.92 | -34.3% | COM | 014442107 |
| — | AEGLEA BIOTHERAPEUTICS INC | 4,015,524 | $31,602 | 0.3% | $7.60 | — | COM | 00773J103 |
| OLMA | OLEMA PHARMACEUTICALS INC | 650,992 | $31,300 | 0.3% | $46.89 | 0.0% | COM | 68062P106 |
| — | CTI BIOPHARMA CORP | 9,520,600 | $30,656 | 0.3% | $2.18 | — | COM | 12648L601 |
| — | HARPOON THERAPEUTICS INC | 1,835,704 | $30,491 | 0.3% | $9.47 | — | COM | 41358P106 |
| — | NEXTCURE INC | 2,711,013 | $29,550 | 0.3% | $14.98 | — | COM | 65343E108 |
| NBP | I MAB | 606,070 | $28,576 | 0.3% | $47.03 | — | SPONSORED ADS | 44975P103 |
| — | OAK STR HEALTH INC | 448,100 | $27,406 | 0.2% | $55.40 | — | COM | 67181A107 |
| — | FLEXION THERAPEUTICS INC | 2,308,083 | $26,635 | 0.2% | $13.15 | — | COM | 33938J106 |
| — | ALEXION PHARMACEUTICALS INC | 169,000 | $26,405 | 0.2% | $127.08 | — | COM | 015351109 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 1,170,900 | $26,041 | 0.2% | $14.72 | +40.9% | COM | 87164F105 |
| — | SCPHARMACEUTICALS INC | 4,797,148 | $25,377 | 0.2% | $10.72 | — | COM | 810648105 |
| HRTX | HERON THERAPEUTICS INC | 1,191,846 | $25,225 | 0.2% | $17.13 | +1.5% | COM | 427746102 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,767,584 | $24,093 | 0.2% | $12.68 | -68.3% | COM | 221015100 |
| — | SIERRA ONCOLOGY INC | 1,477,320 | $23,681 | 0.2% | $9.82 | — | COM NEW | 82640U404 |
| ALC | ALCON AG | 351,380 | $23,357 | 0.2% | $57.87 | +6.6% | ORD SHS | H01301128 |
| LAB | FLUIDIGM CORP DEL | 3,892,346 | $23,354 | 0.2% | $4.32 | +52.1% | COM | 34385P108 |
| — | 9 METERS BIOPHARMA INC | 25,716,755 | $22,091 | 0.2% | $0.57 | — | COM | 654405109 |
| — | PANDION THERAPEUTICS INC | 1,480,940 | $21,992 | 0.2% | $11.46 | — | COM | 698340106 |
| PRTA | PROTHENA CORP PLC | 1,797,458 | $21,587 | 0.2% | $11.86 | -0.3% | SHS | G72800108 |
| AMGN | AMGEN INC | 91,500 | $21,038 | 0.2% | $99.69 | +96.9% | COM | 031162100 |
| — | OTONOMY INC | 3,250,000 | $21,028 | 0.2% | $4.05 | — | COM | 68906L105 |
| — | MERSANA THERAPEUTICS INC | 773,348 | $20,579 | 0.2% | $10.64 | — | COM | 59045L106 |
| — | CHINOOK THERAPEUTICS INC | 1,250,001 | $19,825 | 0.2% | $15.86 | — | COM | 16961L106 |
| LRMR | LARIMAR THERAPEUTICS INC | 886,560 | $18,981 | 0.2% | $11.65 | +72.1% | COM | 517125100 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 1,935,200 | $18,675 | 0.2% | $12.33 | — | SPONSORED ADS | 881624209 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $17,032 | 0.1% | $19.73 | — | COM | 92511W108 |
| — | SYROS PHARMACEUTICALS INC | 1,562,500 | $16,953 | 0.1% | $10.85 | — | COM | 87184Q107 |
| PCVX | VAXCYTE INC | 630,260 | $16,746 | 0.1% | $32.16 | +15.6% | COM | 92243G108 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,493,109 | $16,704 | 0.1% | $6.77 | -1.1% | COM | 59935V107 |
| CMPS | COMPASS PATHWAYS PLC | 350,000 | $16,674 | 0.1% | $34.90 | — | SPONSORED ADS | 20451W101 |
| — | IMMUNOGEN INC | 2,553,900 | $16,473 | 0.1% | $6.45 | — | COM | 45253H101 |
| — | ZYMEWORKS INC | 317,002 | $14,982 | 0.1% | $35.47 | — | COM | 98985W102 |
| — | BIOMX INC | 2,313,489 | $14,760 | 0.1% | $9.68 | — | COM | 09090D103 |
| — | VISTAGEN THERAPEUTICS INC | 7,500,000 | $14,550 | 0.1% | $1.94 | — | COM NEW | 92840H202 |
| RLAY | RELAY THERAPEUTICS INC | 350,000 | $14,546 | 0.1% | $38.13 | +18.6% | COM | 75943R102 |
| ACAD | ACADIA PHARMACEUTICALS INC | 265,772 | $14,208 | 0.1% | $47.04 | +5.5% | COM | 004225108 |
| — | PRAXIS PRECISION MEDICINES I | 255,600 | $14,063 | 0.1% | $55.02 | — | COM | 74006W108 |
| ALXO | ALX ONCOLOGY HLDGS INC | 150,000 | $12,930 | 0.1% | $60.15 | 0.0% | COM | 00166B105 |
| — | BELLUS HEALTH INC NEW | 4,189,593 | $12,573 | 0.1% | $6.42 | — | COM NEW | 07987C204 |
| GILD | GILEAD SCIENCES INC | 192,200 | $11,198 | 0.1% | $54.09 | -8.8% | COM | 375558103 |
| — | AVROBIO INC | 793,712 | $11,064 | 0.1% | $17.13 | — | COM | 05455M100 |
| TARA | PROTARA THERAPEUTICS INC | 450,000 | $10,895 | 0.1% | $23.19 | -7.0% | COM STK | 74365U107 |
| VTRS | VIATRIS INC | 535,149 | $10,029 | 0.1% | $13.33 | 0.0% | COM | 92556V106 |
| NRIX | NURIX THERAPEUTICS INC | 300,000 | $9,864 | 0.1% | $25.20 | +31.5% | COM | 67080M103 |
| LUNG | PULMONX CORP | 125,000 | $8,628 | 0.1% | $48.97 | 0.0% | COM | 745848101 |
| SRPT | SAREPTA THERAPEUTICS INC | 50,000 | $8,525 | 0.1% | $105.48 | +40.5% | Call | 803607100 |
| — | STRONGBRIDGE BIOPHARMA PLC | 3,489,369 | $8,479 | 0.1% | $2.10 | — | SHS USD | G85347105 |
| — | INOZYME PHARMA INC | 400,400 | $8,264 | 0.1% | $26.29 | — | COM | 45790W108 |
| NBTX | NANOBIOTIX SA | 500,000 | $8,250 | 0.1% | $16.50 | — | SPONSORED ADS | 63009J107 |
| HCAT | HEALTH CATALYST INC | 179,598 | $7,818 | 0.1% | $39.36 | -6.3% | COM | 42225T107 |
| — | TCR2 THERAPEUTICS INC | 249,279 | $7,710 | 0.1% | $30.93 | — | COM | 87808K106 |
| — | SUTRO BIOPHARMA INC | 350,000 | $7,599 | 0.1% | $21.71 | — | COM | 869367102 |
| COGT | COGENT BIOSCIENCES INC | 655,000 | $7,356 | 0.1% | $10.99 | 0.0% | COM | 19240Q201 |
| DYN | DYNE THERAPEUTICS INC | 350,000 | $7,350 | 0.1% | $21.96 | -9.9% | COM | 26818M108 |
| — | OUTSET MED INC | 125,000 | $7,105 | 0.1% | $50.00 | — | COM | 690145107 |
| — | X4 PHARMACEUTICALS INC | 1,086,493 | $6,986 | 0.1% | $15.10 | — | COM | 98420X103 |
| — | HEALTH SCIENCES ACQ CORP 2 | 500,000 | $6,405 | 0.1% | $11.00 | — | ORD SHS | G4411D109 |
| — | AKOUOS INC | 315,000 | $6,246 | 0.1% | $22.50 | — | COM | 00973J101 |
| — | ESSA PHARMA INC | 460,500 | $5,494 | 0.0% | $3.37 | — | COM NEW | 29668H708 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 125,000 | $5,181 | 0.0% | $41.28 | 0.0% | COM | 35104E100 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $5,090 | 0.0% | $4.15 | — | COM | 00810B105 |
| — | SYNLOGIC INC | 2,029,996 | $4,385 | 0.0% | $15.62 | — | COM | 87166L100 |
| — | FORTE BIOSCIENCES INC | 92,200 | $3,357 | 0.0% | $14.58 | — | COM | 34962G109 |
| IFRX | INFLARX NV | 556,025 | $2,797 | 0.0% | $3.70 | +21.5% | COM | N44821101 |
| MASS | 908 DEVICES INC | 40,000 | $2,278 | 0.0% | $58.41 | 0.0% | COM | 65443P102 |
| — | SELECTA BIOSCIENCES INC | 539,169 | $1,634 | 0.0% | $8.74 | — | COM | 816212104 |
| — | PURPLE BIOTECH LTD | 346,197 | $1,319 | 0.0% | $3.81 | — | SPONSORED ADS | 74638P109 |
| — | CALITHERA BIOSCIENCES INC | 250,300 | $1,229 | 0.0% | — | — | Put | 13089P101 |
| — | NOVUS THERAPEUTICS INC | 73,650 | $1,105 | 0.0% | $15.00 | — | COM | 67011N204 |
| — | BRISTOL-MYERS SQUIBB CO | 400,000 | $276 | 0.0% | $2.92 | — | RIGHT 99/99/9999 | 110122157 |