ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value ($000): $4,861,410 (100.0% shares, 0.0% debt)

Holdings (118)

EWTX EDGEWISE THERAPEUTICS INC 8.3%
Value ($000) $401,080 Shares 15,021,721 Est. Cost $31.21 Unrealized +2.0%
SVA SINOVAC BIOTECH LTD 6.9%
Value ($000) $333,997 Shares 2,718,735 Est. Cost $6.47 Unrealized 0.0%
BSX BOSTON SCIENTIFIC CORP 5.8%
Value ($000) $282,278 Shares 3,160,300 Est. Cost $25.28 Unrealized +248.2%
LLY ELI LILLY & CO 5.4%
Value ($000) $260,627 Shares 337,600 Est. Cost $450.28 Unrealized +82.4%
ISRG INTUITIVE SURGICAL INC 4.3%
Value ($000) $209,671 Shares 401,700 Est. Cost $272.47 Unrealized +91.2%
ELVN ENLIVEN THERAPEUTICS INC 3.7%
Value ($000) $179,090 Shares 7,959,538 Est. Cost $20.34 Unrealized +27.5%
NBIX NEUROCRINE BIOSCIENCES INC 2.6%
Value ($000) $128,053 Shares 938,120 Est. Cost $115.66 Unrealized +6.9%
SYK STRYKER CORPORATION 2.6%
Value ($000) $124,001 Shares 344,400 Est. Cost $240.78 Unrealized +52.1%
SRPT SAREPTA THERAPEUTICS INC 2.4%
Value ($000) $117,140 Shares 963,400 Est. Cost $112.58 Unrealized +8.9%
ARGX ARGENX SE 2.4%
Value ($000) $116,666 Shares 189,700 Est. Cost $394.78 Unrealized
IRON DISC MEDICINE INC 2.3%
Value ($000) $113,205 Shares 1,785,571 Est. Cost $47.79 Unrealized +21.0%
THC TENET HEALTHCARE CORP 2.1%
Value ($000) $99,974 Shares 792,000 Est. Cost $65.95 Unrealized +125.5%
IONS IONIS PHARMACEUTICALS INC 2.0%
Value ($000) $98,494 Shares 2,817,347 Est. Cost $40.24 Unrealized -7.1%
ALNY ALNYLAM PHARMACEUTICALS INC 2.0%
Value ($000) $97,795 Shares 415,600 Est. Cost $199.68 Unrealized +31.7%
UPB UPSTREAM BIO INC 1.9%
Value ($000) $93,603 Shares 5,693,589 Est. Cost $22.33 Unrealized 0.0%
SPRY ARS PHARMACEUTICALS INC 1.8%
Value ($000) $87,444 Shares 8,288,510 Est. Cost $31.95 Unrealized -56.2%
EW EDWARDS LIFESCIENCES CORP 1.7%
Value ($000) $84,787 Shares 1,145,302 Est. Cost $69.99 Unrealized 0.0%
MRK MERCK & CO INC 1.7%
Value ($000) $82,558 Shares 829,900 Est. Cost $103.00 Unrealized -4.2%
AVBP ARRIVENT BIOPHARMA INC 1.7%
Value ($000) $80,648 Shares 3,027,328 Est. Cost $20.17 Unrealized +42.3%
BIIB BIOGEN INC 1.6%
Value ($000) $77,852 Shares 509,100 Est. Cost $262.58 Unrealized -35.8%
ITGR INTEGER HLDGS CORP 1.6%
Value ($000) $76,199 Shares 575,000 Est. Cost $118.97 Unrealized +12.1%
CYTK CYTOKINETICS INC 1.5%
Value ($000) $74,512 Shares 1,584,005 Est. Cost $62.92 Unrealized -17.5%
MBX MBX BIOSCIENCES INC 1.4%
Value ($000) $70,259 Shares 3,812,215 Est. Cost $22.87 Unrealized -6.8%
UNH UNITEDHEALTH GROUP INC 1.4%
Value ($000) $66,217 Shares 130,900 Est. Cost $462.33 Unrealized +19.6%
NTRA NATERA INC 1.3%
Value ($000) $65,378 Shares 413,000 Est. Cost $33.87 Unrealized +330.1%
VRTX VERTEX PHARMACEUTICALS INC 1.3%
Value ($000) $60,808 Shares 151,000 Est. Cost $214.12 Unrealized +116.5%
THIRD HARMONIC BIO INC 1.2%
Value ($000) $59,467 Shares 5,779,071 Est. Cost $18.97 Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 1.1%
Value ($000) $51,079 Shares 999,000 Est. Cost $24.11 Unrealized +132.0%
UHS UNIVERSAL HLTH SVCS INC 1.0%
Value ($000) $48,318 Shares 269,300 Est. Cost $209.40 Unrealized -3.2%
SIBN SI-BONE INC 1.0%
Value ($000) $48,269 Shares 3,442,853 Est. Cost $19.80 Unrealized -32.0%
SPRINGWORKS THERAPEUTICS INC 0.9%
Value ($000) $45,344 Shares 1,255,031 Est. Cost $21.68 Unrealized
TMO THERMO FISHER SCIENTIFIC INC 0.9%
Value ($000) $43,907 Shares 84,400 Est. Cost $392.11 Unrealized +39.6%
TERN TERNS PHARMACEUTICALS INC 0.9%
Value ($000) $41,899 Shares 7,562,971 Est. Cost $12.83 Unrealized -47.2%
CGON CG ONCOLOGY INC 0.8%
Value ($000) $41,044 Shares 1,431,114 Est. Cost $34.62 Unrealized -1.2%
JANX JANUX THERAPEUTICS INC 0.8%
Value ($000) $40,614 Shares 758,566 Est. Cost $20.95 Unrealized +152.5%
EXAS EXACT SCIENCES CORP 0.8%
Value ($000) $38,199 Shares 679,816 Est. Cost $56.74 Unrealized +9.7%
NPCE NEUROPACE INC 0.8%
Value ($000) $38,117 Shares 3,406,335 Est. Cost $23.21 Unrealized -62.5%
XENE XENON PHARMACEUTICALS INC 0.8%
Value ($000) $37,157 Shares 947,877 Est. Cost $30.66 Unrealized +34.9%
CRVS CORVUS PHARMACEUTICALS INC 0.8%
Value ($000) $37,149 Shares 6,943,654 Est. Cost $11.24 Unrealized -33.6%
XBI SPDR SER TR 0.7%
Value ($000) $33,502 Shares 372,000 Est. Cost $90.06 Unrealized
CMPX COMPASS THERAPEUTICS INC 0.7%
Value ($000) $32,426 Shares 22,362,850 Est. Cost $3.29 Unrealized -49.5%
XTNT XTANT MED HLDGS INC 0.7%
Value ($000) $32,390 Shares 73,114,592 Est. Cost $1.96 Unrealized -75.3%
RNAM AVIDITY BIOSCIENCES INC 0.7%
Value ($000) $32,363 Shares 1,112,886 Est. Cost $25.70 Unrealized +62.6%
VERA VERA THERAPEUTICS INC 0.6%
Value ($000) $31,403 Shares 742,572 Est. Cost $11.27 Unrealized +292.8%
DYN DYNE THERAPEUTICS INC 0.6%
Value ($000) $28,910 Shares 1,227,080 Est. Cost $25.56 Unrealized +15.7%
CGEM CULLINAN THERAPEUTICS INC 0.5%
Value ($000) $23,660 Shares 1,942,555 Est. Cost $22.98 Unrealized -37.5%
VIR VIR BIOTECHNOLOGY INC 0.5%
Value ($000) $23,625 Shares 3,218,617 Est. Cost $9.35 Unrealized -15.6%
GILD GILEAD SCIENCES INC 0.5%
Value ($000) $22,686 Shares 245,600 Est. Cost $78.40 Unrealized +11.0%
RYTM RHYTHM PHARMACEUTICALS INC 0.5%
Value ($000) $22,392 Shares 400,000 Est. Cost $27.49 Unrealized +100.9%
IMTX IMMATICS N.V 0.5%
Value ($000) $21,952 Shares 3,087,462 Est. Cost $9.09 Unrealized -5.5%
FOLD AMICUS THERAPEUTICS INC 0.4%
Value ($000) $21,528 Shares 2,285,400 Est. Cost $10.63 Unrealized -2.3%
SCPHARMACEUTICALS INC 0.4%
Value ($000) $21,451 Shares 6,059,528 Est. Cost $9.77 Unrealized
RAPT THERAPEUTICS INC 0.4%
Value ($000) $20,754 Shares 13,135,260 Est. Cost $1.58 Unrealized
TYRA TYRA BIOSCIENCES INC 0.4%
Value ($000) $20,434 Shares 1,470,086 Est. Cost $17.23 Unrealized +5.3%
MLYS MINERALYS THERAPEUTICS INC 0.4%
Value ($000) $19,839 Shares 1,611,637 Est. Cost $12.35 Unrealized +5.9%
GILD GILEAD SCIENCES INC 0.4%
Value ($000) $18,474 Shares 200,000 Est. Cost $78.40 Unrealized +11.0%
IKENA ONCOLOGY INC 0.4%
Value ($000) $17,687 Shares 12,048,773 Est. Cost $34.42 Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.4%
Value ($000) $17,683 Shares 652,028 Est. Cost $36.10 Unrealized
KROS KEROS THERAPEUTICS INC 0.3%
Value ($000) $16,127 Shares 1,018,734 Est. Cost $30.81 Unrealized +68.7%
CCCC C4 THERAPEUTICS INC 0.3%
Value ($000) $15,760 Shares 4,377,900 Est. Cost $6.00 Unrealized -17.1%
MEDP MEDPACE HLDGS INC 0.3%
Value ($000) $14,917 Shares 44,900 Est. Cost $379.89 Unrealized -10.7%
VSTM VERASTEM INC 0.3%
Value ($000) $14,799 Shares 2,862,448 Est. Cost $4.97 Unrealized -20.8%
PRLD PRELUDE THERAPEUTICS INC 0.3%
Value ($000) $13,909 Shares 10,909,256 Est. Cost $26.47 Unrealized -95.0%
CRBP CORBUS PHARMACEUTICALS HLDGS 0.3%
Value ($000) $13,833 Shares 1,172,287 Est. Cost $43.55 Unrealized -61.5%
FBRX FORTE BIOSCIENCES INC 0.3%
Value ($000) $13,626 Shares 600,000 Est. Cost $11.89 Unrealized 0.0%
INTRA-CELLULAR THERAPIES INC 0.3%
Value ($000) $13,614 Shares 163,000 Est. Cost $83.52 Unrealized
ACELYRIN INC 0.3%
Value ($000) $12,565 Shares 4,001,711 Est. Cost $20.90 Unrealized
ABCL ABCELLERA BIOLOGICS INC 0.3%
Value ($000) $12,250 Shares 4,180,768 Est. Cost $45.73 Unrealized -93.9%
ADCT ADC THERAPEUTICS SA 0.2%
Value ($000) $11,877 Shares 5,968,451 Est. Cost $3.62 Unrealized -27.7%
ADICET BIO INC 0.2%
Value ($000) $11,012 Shares 11,447,140 Est. Cost $8.72 Unrealized
PMVP PMV PHARMACEUTICALS INC 0.2%
Value ($000) $9,778 Shares 6,475,291 Est. Cost $36.80 Unrealized -95.7%
UHS UNIVERSAL HLTH SVCS INC 0.2%
Value ($000) $8,971 Shares 50,000 Est. Cost $209.40 Unrealized -3.2%
NMRA NEUMORA THERAPEUTICS INC. 0.2%
Value ($000) $8,533 Shares 804,996 Est. Cost $12.87 Unrealized -6.9%
QTTB Q32 BIO INC 0.2%
Value ($000) $7,750 Shares 2,252,987 Est. Cost $13.78 Unrealized +129.2%
GERN GERON CORP 0.2%
Value ($000) $7,675 Shares 2,168,000 Est. Cost $3.99 Unrealized 0.0%
AVTX AVALO THERAPEUTICS INC 0.1%
Value ($000) $7,185 Shares 967,000 Est. Cost $10.31 Unrealized +3.7%
CRDF CARDIFF ONCOLOGY INC 0.1%
Value ($000) $6,677 Shares 1,538,462 Est. Cost $3.13 Unrealized 0.0%
PFE PFIZER INC 0.1%
Value ($000) $6,633 Shares 250,000 Est. Cost Unrealized
SRRK SCHOLAR ROCK HLDG CORP 0.1%
Value ($000) $6,561 Shares 151,800 Est. Cost $9.82 Unrealized +231.6%
INSM INSMED INC 0.1%
Value ($000) $6,528 Shares 94,559 Est. Cost $72.02 Unrealized 0.0%
ENGN ENGENE HOLDINGS INC 0.1%
Value ($000) $6,120 Shares 920,339 Est. Cost $7.77 Unrealized 0.0%
IKENA ONCOLOGY INC 0.1%
Value ($000) $5,805 Shares 3,539,358 Est. Cost $23.86 Unrealized
NSPR INSPIREMD INC 0.1%
Value ($000) $5,611 Shares 2,133,405 Est. Cost $1.76 Unrealized +53.2%
TRAW TRAWS PHARMA INC 0.1%
Value ($000) $5,377 Shares 605,531 Est. Cost $9.11 Unrealized -38.9%
BIOA BIOAGE LABS INC 0.1%
Value ($000) $5,338 Shares 921,959 Est. Cost $20.04 Unrealized -13.9%
X4 PHARMACEUTICALS INC 0.1%
Value ($000) $5,233 Shares 7,133,515 Est. Cost $3.99 Unrealized
BCAX BICARA THERAPEUTICS INC 0.1%
Value ($000) $5,196 Shares 298,301 Est. Cost $25.09 Unrealized -17.0%
MIST MILESTONE PHARMACEUTICALS IN 0.1%
Value ($000) $4,720 Shares 2,000,000 Est. Cost $1.62 Unrealized +5.7%
REPARE THERAPEUTICS INC 0.1%
Value ($000) $4,352 Shares 3,322,488 Est. Cost $31.02 Unrealized
PASSAGE BIO INC 0.1%
Value ($000) $4,199 Shares 7,404,869 Est. Cost $11.43 Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.1%
Value ($000) $4,068 Shares 150,000 Est. Cost $36.10 Unrealized
KRYS KRYSTAL BIOTECH INC 0.1%
Value ($000) $3,682 Shares 23,500 Est. Cost $110.89 Unrealized +60.0%
ARDT ARDENT HEALTH PARTNERS INC 0.1%
Value ($000) $3,518 Shares 206,000 Est. Cost $17.67 Unrealized -1.9%
SIBN SI-BONE INC 0.1%
Value ($000) $3,505 Shares 250,000 Est. Cost $19.80 Unrealized -32.0%
THC TENET HEALTHCARE CORP 0.1%
Value ($000) $3,156 Shares 25,000 Est. Cost $65.95 Unrealized +125.5%
CHEMOMAB THERAPEUTICS LTD 0.1%
Value ($000) $3,152 Shares 1,741,273 Est. Cost $28.71 Unrealized
CBLL CERIBELL INC 0.1%
Value ($000) $2,912 Shares 112,500 Est. Cost $27.25 Unrealized 0.0%
FATE FATE THERAPEUTICS INC 0.1%
Value ($000) $2,773 Shares 1,680,580 Est. Cost $4.54 Unrealized -44.5%
PEPG PEPGEN INC 0.1%
Value ($000) $2,475 Shares 653,016 Est. Cost $11.83 Unrealized -47.3%
TIL INSTIL BIO INC 0.0%
Value ($000) $2,229 Shares 116,785 Est. Cost $28.49 Unrealized +7.0%
NKTX NKARTA INC 0.0%
Value ($000) $2,045 Shares 821,400 Est. Cost $8.23 Unrealized -62.5%
LYELL IMMUNOPHARMA INC 0.0%
Value ($000) $1,986 Shares 3,103,623 Est. Cost $1.47 Unrealized
IMVT IMMUNOVANT INC 0.0%
Value ($000) $1,944 Shares 78,500 Est. Cost $28.37 Unrealized 0.0%
AKERO THERAPEUTICS INC 0.0%
Value ($000) $1,836 Shares 66,000 Est. Cost $27.82 Unrealized
TNGX TANGO THERAPEUTICS INC 0.0%
Value ($000) $1,700 Shares 550,000 Est. Cost $4.64 Unrealized 0.0%
TURNSTONE BIOLOGICS CORP 0.0%
Value ($000) $1,540 Shares 3,099,265 Est. Cost $3.94 Unrealized
AMLX AMYLYX PHARMACEUTICALS INC 0.0%
Value ($000) $1,315 Shares 348,000 Est. Cost $4.71 Unrealized 0.0%
BIOMX INC 0.0%
Value ($000) $1,305 Shares 1,787,767 Est. Cost $1.02 Unrealized
KZR KEZAR LIFE SCIENCES INC 0.0%
Value ($000) $1,295 Shares 192,700 Est. Cost $7.45 Unrealized 0.0%
KRRO KORRO BIO INC 0.0%
Value ($000) $1,233 Shares 32,400 Est. Cost $51.39 Unrealized 0.0%
ANRO ALTO NEUROSCIENCE INC 0.0%
Value ($000) $1,058 Shares 250,000 Est. Cost $6.24 Unrealized 0.0%
NEXTCURE INC 0.0%
Value ($000) $880 Shares 1,141,200 Est. Cost $14.98 Unrealized
AGIO AGIOS PHARMACEUTICALS INC 0.0%
Value ($000) $877 Shares 26,700 Est. Cost $46.98 Unrealized 0.0%
CCCC C4 THERAPEUTICS INC 0.0%
Value ($000) $540 Shares 150,000 Est. Cost $6.00 Unrealized -17.1%
ELEVATION ONCOLOGY INC 0.0%
Value ($000) $530 Shares 941,275 Est. Cost $1.52 Unrealized
IVVD INVIVYD INC 0.0%
Value ($000) $509 Shares 1,149,300 Est. Cost $35.34 Unrealized -97.8%
LSBCF LAKESHORE BIOPHARMA CO LTD 0.0%
Value ($000) $486 Shares 140,428 Est. Cost $3.11 Unrealized 0.0%
XERS XERIS BIOPHARMA HOLDINGS INC 0.0%
Value ($000) $273 Shares 80,420 Est. Cost $2.59 Unrealized +24.3%