ORBIMED ADVISORS LLC Diversified Active

Location: New York, NY

CIK: 0001055951 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value: $4.195B (100.0% shares, 0.0% debt)

Holdings (110)

SVA SINOVAC BIOTECH LTD 8.0%
Value $334M Shares 2,718,735 Est. Cost Unrealized
EWTX EDGEWISE THERAPEUTICS INC 7.9%
Value $330M Shares 15,021,721 Est. Cost Unrealized
BSX BOSTON SCIENTIFIC CORP 6.8%
Value $284M Shares 2,813,200 Est. Cost Unrealized
LLY ELI LILLY & CO 6.6%
Value $279M Shares 337,600 Est. Cost Unrealized
ELVN ENLIVEN THERAPEUTICS INC 3.7%
Value $157M Shares 7,959,538 Est. Cost Unrealized
ISRG INTUITIVE SURGICAL INC 3.4%
Value $144M Shares 291,000 Est. Cost Unrealized
SYK STRYKER CORPORATION 3.2%
Value $134M Shares 359,200 Est. Cost Unrealized
ARGX ARGENX SE 2.9%
Value $122M Shares 206,700 Est. Cost Unrealized
EW EDWARDS LIFESCIENCES CORP 2.6%
Value $111M Shares 1,532,000 Est. Cost Unrealized
UNH UNITEDHEALTH GROUP INC 2.5%
Value $105M Shares 201,200 Est. Cost Unrealized
SPRY ARS PHARMACEUTICALS INC 2.5%
Value $104M Shares 8,288,510 Est. Cost Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 2.5%
Value $103M Shares 934,640 Est. Cost Unrealized
PFE PFIZER INC 2.3%
Value $97.56M Shares 3,850,200 Est. Cost Unrealized
ALNY ALNYLAM PHARMACEUTICALS INC 2.2%
Value $93.45M Shares 346,100 Est. Cost Unrealized
ITGR INTEGER HLDGS CORP 1.9%
Value $78.18M Shares 662,500 Est. Cost Unrealized
VRTX VERTEX PHARMACEUTICALS INC 1.8%
Value $77.52M Shares 159,900 Est. Cost Unrealized
NTRA NATERA INC 1.8%
Value $77.35M Shares 547,000 Est. Cost Unrealized
IONS IONIS PHARMACEUTICALS INC 1.8%
Value $76.64M Shares 2,540,136 Est. Cost Unrealized
IRON DISC MEDICINE INC 1.7%
Value $70.24M Shares 1,415,020 Est. Cost Unrealized
TMO THERMO FISHER SCIENTIFIC INC 1.5%
Value $64.19M Shares 129,000 Est. Cost Unrealized
THC TENET HEALTHCARE CORP 1.5%
Value $62.54M Shares 465,000 Est. Cost Unrealized
CYTK CYTOKINETICS INC 1.4%
Value $60.65M Shares 1,509,205 Est. Cost Unrealized
CGON CG ONCOLOGY INC 1.4%
Value $60.54M Shares 2,471,994 Est. Cost Unrealized
AVBP ARRIVENT BIOPHARMA INC 1.3%
Value $55.98M Shares 3,027,328 Est. Cost Unrealized
RNAM AVIDITY BIOSCIENCES INC 1.3%
Value $53.52M Shares 1,812,886 Est. Cost Unrealized
SIBN SI-BONE INC 1.2%
Value $48.3M Shares 3,442,853 Est. Cost Unrealized
AXSM AXSOME THERAPEUTICS INC 1.1%
Value $45.1M Shares 386,700 Est. Cost Unrealized
CMPX COMPASS THERAPEUTICS INC 1.0%
Value $42.49M Shares 22,362,850 Est. Cost Unrealized
SPRINGWORKS THERAPEUTICS INC 1.0%
Value $41.93M Shares 950,200 Est. Cost Unrealized
NPCE NEUROPACE INC 1.0%
Value $41.86M Shares 3,406,335 Est. Cost Unrealized
SION SIONNA THERAPEUTICS INC 0.9%
Value $38.75M Shares 3,704,959 Est. Cost Unrealized
UPB UPSTREAM BIO INC 0.8%
Value $34.84M Shares 5,693,589 Est. Cost Unrealized
XTNT XTANT MED HLDGS INC 0.8%
Value $34.36M Shares 73,114,592 Est. Cost Unrealized
TARS TARSUS PHARMACEUTICALS INC 0.8%
Value $33.58M Shares 653,743 Est. Cost Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.8%
Value $33.51M Shares 999,000 Est. Cost Unrealized
XENE XENON PHARMACEUTICALS INC 0.8%
Value $31.8M Shares 947,877 Est. Cost Unrealized
APLS APELLIS PHARMACEUTICALS INC 0.7%
Value $31.32M Shares 1,432,300 Est. Cost Unrealized
MBX MBX BIOSCIENCES INC 0.7%
Value $29.54M Shares 4,002,887 Est. Cost Unrealized
EXAS EXACT SCIENCES CORP 0.7%
Value $29.43M Shares 679,816 Est. Cost Unrealized
GILD GILEAD SCIENCES INC 0.5%
Value $22.13M Shares 197,500 Est. Cost Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.5%
Value $22.08M Shares 6,943,654 Est. Cost Unrealized
TERN TERNS PHARMACEUTICALS INC 0.5%
Value $20.87M Shares 7,562,971 Est. Cost Unrealized
JANX JANUX THERAPEUTICS INC 0.5%
Value $20.48M Shares 758,566 Est. Cost Unrealized
RYTM RHYTHM PHARMACEUTICALS INC 0.5%
Value $20.13M Shares 380,000 Est. Cost Unrealized
THIRD HARMONIC BIO INC 0.5%
Value $20.05M Shares 5,779,071 Est. Cost Unrealized
FOLD AMICUS THERAPEUTICS INC 0.4%
Value $18.65M Shares 2,285,400 Est. Cost Unrealized
VSTM VERASTEM INC 0.4%
Value $17.26M Shares 2,862,448 Est. Cost Unrealized
TYRA TYRA BIOSCIENCES INC 0.4%
Value $16.3M Shares 1,752,831 Est. Cost Unrealized
RAPT THERAPEUTICS INC 0.4%
Value $16.03M Shares 13,135,260 Est. Cost Unrealized
SCPHARMACEUTICALS INC 0.4%
Value $15.94M Shares 6,059,528 Est. Cost Unrealized
VIR VIR BIOTECHNOLOGY INC 0.3%
Value $14.57M Shares 2,248,249 Est. Cost Unrealized
CGEM CULLINAN THERAPEUTICS INC 0.3%
Value $14.56M Shares 1,923,855 Est. Cost Unrealized
IMTX IMMATICS N.V 0.3%
Value $13.92M Shares 3,087,462 Est. Cost Unrealized
AMGN AMGEN INC 0.3%
Value $13.77M Shares 44,200 Est. Cost Unrealized
PFE PFIZER INC 0.3%
Value $12.67M Shares 500,000 Est. Cost Unrealized
IKENA ONCOLOGY INC 0.3%
Value $12.51M Shares 12,048,773 Est. Cost Unrealized
VERA VERA THERAPEUTICS INC 0.3%
Value $11.56M Shares 481,065 Est. Cost Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.3%
Value $11.29M Shares 652,028 Est. Cost Unrealized
CCCC C4 THERAPEUTICS INC 0.3%
Value $10.93M Shares 6,830,300 Est. Cost Unrealized
DYN DYNE THERAPEUTICS INC 0.3%
Value $10.61M Shares 1,014,611 Est. Cost Unrealized
KROS KEROS THERAPEUTICS INC 0.2%
Value $10.38M Shares 1,018,734 Est. Cost Unrealized
ACELYRIN INC 0.2%
Value $9.884M Shares 4,001,711 Est. Cost Unrealized
AGIO AGIOS PHARMACEUTICALS INC 0.2%
Value $9.537M Shares 325,500 Est. Cost Unrealized
ABCL ABCELLERA BIOLOGICS INC 0.2%
Value $9.323M Shares 4,180,768 Est. Cost Unrealized
ADICET BIO INC 0.2%
Value $8.643M Shares 11,447,140 Est. Cost Unrealized
ADCT ADC THERAPEUTICS SA 0.2%
Value $8.416M Shares 5,968,451 Est. Cost Unrealized
PRLD PRELUDE THERAPEUTICS INC 0.2%
Value $8.378M Shares 10,909,256 Est. Cost Unrealized
XBI SPDR SER TR 0.2%
Value $8.11M Shares 100,000 Est. Cost Unrealized
AVTX AVALO THERAPEUTICS INC 0.2%
Value $7.746M Shares 967,000 Est. Cost Unrealized
SPRINGWORKS THERAPEUTICS INC 0.2%
Value $7.617M Shares 172,600 Est. Cost Unrealized
WHWK WHITEHAWK THERAPEUTICS INC 0.2%
Value $7.415M Shares 4,166,000 Est. Cost Unrealized
AKERO THERAPEUTICS INC 0.2%
Value $7.282M Shares 179,900 Est. Cost Unrealized
PMVP PMV PHARMACEUTICALS INC 0.2%
Value $7.058M Shares 6,475,291 Est. Cost Unrealized
TRVI TREVI THERAPEUTICS INC 0.2%
Value $7.045M Shares 1,120,000 Est. Cost Unrealized
KMTS KESTRA MED TECHNOLOGIES LTD 0.1%
Value $6.23M Shares 250,000 Est. Cost Unrealized
CRBP CORBUS PHARMACEUTICALS HLDGS 0.1%
Value $6.225M Shares 1,172,287 Est. Cost Unrealized
NSPR INSPIREMD INC 0.1%
Value $5.739M Shares 2,133,405 Est. Cost Unrealized
SRRK SCHOLAR ROCK HLDG CORP 0.1%
Value $4.88M Shares 151,800 Est. Cost Unrealized
FBRX FORTE BIOSCIENCES INC 0.1%
Value $4.602M Shares 593,088 Est. Cost Unrealized
IKENA ONCOLOGY INC 0.1%
Value $4.53M Shares 3,539,358 Est. Cost Unrealized
KRYS KRYSTAL BIOTECH INC 0.1%
Value $4.237M Shares 23,500 Est. Cost Unrealized
ENGN ENGENE HOLDINGS INC 0.1%
Value $3.994M Shares 891,616 Est. Cost Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.1%
Value $3.906M Shares 700,000 Est. Cost Unrealized
BCAX BICARA THERAPEUTICS INC 0.1%
Value $3.887M Shares 298,301 Est. Cost Unrealized
QTTB Q32 BIO INC 0.1%
Value $3.717M Shares 2,252,987 Est. Cost Unrealized
BIOA BIOAGE LABS INC 0.1%
Value $3.467M Shares 921,959 Est. Cost Unrealized
REPARE THERAPEUTICS INC 0.1%
Value $3.276M Shares 3,322,488 Est. Cost Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.1%
Value $2.596M Shares 150,000 Est. Cost Unrealized
PASSAGE BIO INC 0.1%
Value $2.484M Shares 7,034,626 Est. Cost Unrealized
INSM INSMED INC 0.1%
Value $2.186M Shares 28,659 Est. Cost Unrealized
CBLL CERIBELL INC 0.1%
Value $2.161M Shares 112,500 Est. Cost Unrealized
TIL INSTIL BIO INC 0.0%
Value $2.027M Shares 116,785 Est. Cost Unrealized
CHEMOMAB THERAPEUTICS LTD 0.0%
Value $1.898M Shares 1,741,273 Est. Cost Unrealized
CRDF CARDIFF ONCOLOGY INC 0.0%
Value $1.802M Shares 573,884 Est. Cost Unrealized
X4 PHARMACEUTICALS INC 0.0%
Value $1.602M Shares 6,776,515 Est. Cost Unrealized
NKTX NKARTA INC 0.0%
Value $1.511M Shares 821,400 Est. Cost Unrealized
TRAW TRAWS PHARMA INC 0.0%
Value $1.393M Shares 605,531 Est. Cost Unrealized
FATE FATE THERAPEUTICS INC 0.0%
Value $1.328M Shares 1,680,580 Est. Cost Unrealized
TURNSTONE BIOLOGICS CORP 0.0%
Value $1.271M Shares 3,099,265 Est. Cost Unrealized
AMLX AMYLYX PHARMACEUTICALS INC 0.0%
Value $1.232M Shares 348,000 Est. Cost Unrealized
BIOMX INC 0.0%
Value $993K Shares 1,787,767 Est. Cost Unrealized
KZR KEZAR LIFE SCIENCES INC 0.0%
Value $940K Shares 192,700 Est. Cost Unrealized
TNGX TANGO THERAPEUTICS INC 0.0%
Value $754K Shares 550,000 Est. Cost Unrealized
IVVD INVIVYD INC 0.0%
Value $565K Shares 933,500 Est. Cost Unrealized
KRRO KORRO BIO INC 0.0%
Value $564K Shares 32,400 Est. Cost Unrealized
NEXTCURE INC 0.0%
Value $548K Shares 1,141,200 Est. Cost Unrealized
ANRO ALTO NEUROSCIENCE INC 0.0%
Value $540K Shares 250,000 Est. Cost Unrealized
DIH HLDG US INC 0.0%
Value $443K Shares 1,915,000 Est. Cost Unrealized
XERS XERIS BIOPHARMA HOLDINGS INC 0.0%
Value $442K Shares 80,420 Est. Cost Unrealized
LSBCF LAKESHORE BIOPHARMA CO LTD 0.0%
Value $344K Shares 140,428 Est. Cost Unrealized