ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value ($000): $4,004,111 (100.0% shares, 0.0% debt)

Holdings (102)

SVA SINOVAC BIOTECH LTD 8.3%
Value ($000) $333,997 Shares 2,718,735 Est. Cost $6.47 Unrealized 0.0%
BSX BOSTON SCIENTIFIC CORP 7.5%
Value ($000) $302,166 Shares 2,813,200 Est. Cost $25.28 Unrealized +300.2%
LLY ELI LILLY & CO 6.6%
Value ($000) $263,169 Shares 337,600 Est. Cost $450.28 Unrealized +71.8%
EWTX EDGEWISE THERAPEUTICS INC 5.1%
Value ($000) $203,447 Shares 15,518,492 Est. Cost $30.67 Unrealized -53.0%
ELVN ENLIVEN THERAPEUTICS INC 4.0%
Value ($000) $159,668 Shares 7,959,538 Est. Cost $20.34 Unrealized -6.9%
ISRG INTUITIVE SURGICAL INC 3.9%
Value ($000) $158,132 Shares 291,000 Est. Cost $272.47 Unrealized +91.9%
SPRY ARS PHARMACEUTICALS INC 3.6%
Value ($000) $144,635 Shares 8,288,510 Est. Cost $31.95 Unrealized -54.8%
SYK STRYKER CORPORATION 3.5%
Value ($000) $142,110 Shares 359,200 Est. Cost $246.40 Unrealized +50.8%
EW EDWARDS LIFESCIENCES CORP 3.3%
Value ($000) $133,583 Shares 1,708,000 Est. Cost $70.82 Unrealized +5.3%
ARGX ARGENX SE 2.9%
Value ($000) $114,654 Shares 208,000 Est. Cost $410.99 Unrealized
ALNY ALNYLAM PHARMACEUTICALS INC 2.8%
Value ($000) $111,490 Shares 341,900 Est. Cost $199.68 Unrealized +38.6%
UNH UNITEDHEALTH GROUP INC 2.6%
Value ($000) $104,916 Shares 336,300 Est. Cost $434.99 Unrealized -13.8%
NTRA NATERA INC 2.5%
Value ($000) $100,255 Shares 593,434 Est. Cost $72.06 Unrealized +116.3%
VRTX VERTEX PHARMACEUTICALS INC 2.3%
Value ($000) $93,620 Shares 210,287 Est. Cost $283.89 Unrealized +62.3%
THC TENET HEALTHCARE CORP 2.0%
Value ($000) $81,840 Shares 465,000 Est. Cost $65.95 Unrealized +128.2%
CAI CARIS LIFE SCIENCES INC 2.0%
Value ($000) $81,091 Shares 3,034,858 Est. Cost $26.95 Unrealized 0.0%
IRON DISC MEDICINE INC 1.9%
Value ($000) $74,939 Shares 1,415,020 Est. Cost $47.79 Unrealized -1.7%
AVBP ARRIVENT BIOPHARMA INC 1.6%
Value ($000) $65,905 Shares 3,027,328 Est. Cost $20.17 Unrealized +2.9%
SION SIONNA THERAPEUTICS INC 1.6%
Value ($000) $64,281 Shares 3,704,959 Est. Cost $16.34 Unrealized -19.8%
UPB UPSTREAM BIO INC 1.6%
Value ($000) $62,516 Shares 5,693,589 Est. Cost $22.33 Unrealized -58.6%
NBIX NEUROCRINE BIOSCIENCES INC 1.4%
Value ($000) $55,120 Shares 438,540 Est. Cost $115.66 Unrealized -0.9%
ITGR INTEGER HLDGS CORP 1.3%
Value ($000) $53,295 Shares 433,400 Est. Cost $120.54 Unrealized -0.9%
RNAM AVIDITY BIOSCIENCES INC 1.3%
Value ($000) $51,486 Shares 1,812,886 Est. Cost $27.80 Unrealized +7.2%
CGON CG ONCOLOGY INC 1.2%
Value ($000) $48,824 Shares 1,877,850 Est. Cost $31.89 Unrealized -24.4%
SIBN SI-BONE INC 1.2%
Value ($000) $48,536 Shares 2,578,979 Est. Cost $19.80 Unrealized -16.2%
MBX MBX BIOSCIENCES INC 1.1%
Value ($000) $45,673 Shares 4,002,887 Est. Cost $22.28 Unrealized -54.3%
AXSM AXSOME THERAPEUTICS INC 1.1%
Value ($000) $44,668 Shares 427,900 Est. Cost $113.15 Unrealized -6.4%
CMPX COMPASS THERAPEUTICS INC 1.0%
Value ($000) $39,572 Shares 15,219,994 Est. Cost $3.29 Unrealized -37.2%
CYTK CYTOKINETICS INC 0.9%
Value ($000) $35,584 Shares 1,077,000 Est. Cost $62.92 Unrealized -44.7%
CRNX CRINETICS PHARMACEUTICALS IN 0.8%
Value ($000) $33,045 Shares 1,149,000 Est. Cost $25.00 Unrealized +23.5%
EXAS EXACT SCIENCES CORP 0.8%
Value ($000) $32,273 Shares 607,316 Est. Cost $56.74 Unrealized -10.5%
THIRD HARMONIC BIO INC 0.8%
Value ($000) $31,380 Shares 5,779,071 Est. Cost $18.97 Unrealized
ROIV ROIVANT SCIENCES LTD 0.8%
Value ($000) $31,324 Shares 2,779,427 Est. Cost $10.84 Unrealized 0.0%
XENE XENON PHARMACEUTICALS INC 0.7%
Value ($000) $29,669 Shares 947,877 Est. Cost $30.66 Unrealized +6.4%
NPCE NEUROPACE INC 0.7%
Value ($000) $29,122 Shares 2,614,184 Est. Cost $23.21 Unrealized -46.1%
CRVS CORVUS PHARMACEUTICALS INC 0.7%
Value ($000) $28,660 Shares 7,165,006 Est. Cost $11.00 Unrealized -66.9%
TERN TERNS PHARMACEUTICALS INC 0.7%
Value ($000) $28,210 Shares 7,562,971 Est. Cost $12.83 Unrealized -75.7%
JANX JANUX THERAPEUTICS INC 0.7%
Value ($000) $27,958 Shares 1,210,300 Est. Cost $22.97 Unrealized +14.7%
APLS APELLIS PHARMACEUTICALS INC 0.6%
Value ($000) $25,659 Shares 1,482,300 Est. Cost $27.32 Unrealized -32.2%
GPCR STRUCTURE THERAPEUTICS INC 0.6%
Value ($000) $24,873 Shares 1,199,300 Est. Cost $29.09 Unrealized
SCPHARMACEUTICALS INC 0.6%
Value ($000) $23,087 Shares 6,059,528 Est. Cost $9.77 Unrealized
CTMX CYTOMX THERAPEUTICS INC 0.5%
Value ($000) $19,208 Shares 8,461,500 Est. Cost $1.61 Unrealized 0.0%
TMO THERMO FISHER SCIENTIFIC INC 0.5%
Value ($000) $18,854 Shares 46,500 Est. Cost $443.16 Unrealized -5.9%
AGIO AGIOS PHARMACEUTICALS INC 0.5%
Value ($000) $18,556 Shares 557,900 Est. Cost $32.64 Unrealized -7.1%
TRVI TREVI THERAPEUTICS INC 0.5%
Value ($000) $18,097 Shares 3,308,400 Est. Cost $5.73 Unrealized +8.6%
ADCT ADC THERAPEUTICS SA 0.4%
Value ($000) $15,832 Shares 5,907,351 Est. Cost $3.62 Unrealized -41.9%
RYTM RHYTHM PHARMACEUTICALS INC 0.4%
Value ($000) $15,703 Shares 248,512 Est. Cost $27.49 Unrealized +122.7%
UNH UNITEDHEALTH GROUP INC 0.4%
Value ($000) $15,599 Shares 50,000 Est. Cost $434.99 Unrealized -13.8%
FBRX FORTE BIOSCIENCES INC 0.4%
Value ($000) $15,477 Shares 1,196,955 Est. Cost $10.24 Unrealized -15.9%
CGEM CULLINAN THERAPEUTICS INC 0.4%
Value ($000) $14,487 Shares 1,923,855 Est. Cost $22.98 Unrealized -65.0%
KROS KEROS THERAPEUTICS INC 0.3%
Value ($000) $13,600 Shares 1,018,734 Est. Cost $30.81 Unrealized -56.2%
RAPT RAPT THERAPEUTICS INC 0.3%
Value ($000) $13,135 Shares 1,641,906 Est. Cost $7.63 Unrealized 0.0%
IKENA ONCOLOGY INC 0.3%
Value ($000) $13,131 Shares 12,048,773 Est. Cost $34.42 Unrealized
FOLD AMICUS THERAPEUTICS INC 0.3%
Value ($000) $13,095 Shares 2,285,400 Est. Cost $10.63 Unrealized -39.3%
VIR VIR BIOTECHNOLOGY INC 0.3%
Value ($000) $11,999 Shares 2,380,715 Est. Cost $9.13 Unrealized -41.3%
ABCL ABCELLERA BIOLOGICS INC 0.3%
Value ($000) $11,472 Shares 3,344,568 Est. Cost $45.73 Unrealized -94.6%
AKERO THERAPEUTICS INC 0.3%
Value ($000) $11,275 Shares 211,300 Est. Cost $38.44 Unrealized
MLYS MINERALYS THERAPEUTICS INC 0.3%
Value ($000) $10,288 Shares 760,351 Est. Cost $14.49 Unrealized 0.0%
DYN DYNE THERAPEUTICS INC 0.2%
Value ($000) $9,819 Shares 1,031,400 Est. Cost $25.32 Unrealized -56.5%
CCCC C4 THERAPEUTICS INC 0.2%
Value ($000) $9,767 Shares 6,830,300 Est. Cost $4.92 Unrealized -70.4%
ORIC ORIC PHARMACEUTICALS INC 0.2%
Value ($000) $9,128 Shares 899,281 Est. Cost $8.29 Unrealized -19.1%
CPRX CATALYST PHARMACEUTICALS INC 0.2%
Value ($000) $9,047 Shares 416,900 Est. Cost $23.61 Unrealized 0.0%
PRLD PRELUDE THERAPEUTICS INC 0.2%
Value ($000) $8,830 Shares 10,909,256 Est. Cost $26.47 Unrealized -96.7%
CRBP CORBUS PHARMACEUTICALS HLDGS 0.2%
Value ($000) $8,089 Shares 1,172,287 Est. Cost $43.55 Unrealized -83.3%
ZLAB ZAI LAB LTD 0.2%
Value ($000) $8,078 Shares 231,000 Est. Cost $34.97 Unrealized
TARS TARSUS PHARMACEUTICALS INC 0.2%
Value ($000) $8,017 Shares 197,900 Est. Cost $49.43 Unrealized -9.0%
WHWK WHITEHAWK THERAPEUTICS INC 0.2%
Value ($000) $7,790 Shares 4,166,000 Est. Cost $2.61 Unrealized -33.4%
TYRA TYRA BIOSCIENCES INC 0.2%
Value ($000) $7,700 Shares 804,603 Est. Cost $16.54 Unrealized -42.6%
AZN ASTRAZENECA PLC 0.2%
Value ($000) $6,988 Shares 100,000 Est. Cost Unrealized
ADICET BIO INC 0.2%
Value ($000) $6,983 Shares 11,447,140 Est. Cost $8.72 Unrealized
ITEOS THERAPEUTICS INC 0.2%
Value ($000) $6,979 Shares 700,000 Est. Cost $9.97 Unrealized
PMVP PMV PHARMACEUTICALS INC 0.2%
Value ($000) $6,864 Shares 6,475,291 Est. Cost $36.80 Unrealized -97.3%
URGN UROGEN PHARMA LTD 0.2%
Value ($000) $6,554 Shares 478,400 Est. Cost $9.60 Unrealized 0.0%
ASND ASCENDIS PHARMA A/S 0.1%
Value ($000) $5,937 Shares 34,400 Est. Cost $172.60 Unrealized
ALMS ALUMIS INC 0.1%
Value ($000) $5,779 Shares 1,926,423 Est. Cost $4.72 Unrealized 0.0%
JBIO JADE BIOSCIENCES INC 0.1%
Value ($000) $5,306 Shares 531,163 Est. Cost $33.31 Unrealized 0.0%
NSPR INSPIREMD INC 0.1%
Value ($000) $4,843 Shares 2,133,405 Est. Cost $1.76 Unrealized +41.9%
AVTX AVALO THERAPEUTICS INC 0.1%
Value ($000) $4,825 Shares 967,000 Est. Cost $10.31 Unrealized -54.7%
IKENA ONCOLOGY INC 0.1%
Value ($000) $4,743 Shares 3,539,358 Est. Cost $23.86 Unrealized
REPARE THERAPEUTICS INC 0.1%
Value ($000) $4,618 Shares 3,322,488 Est. Cost $31.02 Unrealized
CGON CG ONCOLOGY INC 0.1%
Value ($000) $3,900 Shares 150,000 Est. Cost $31.89 Unrealized -24.4%
IMTX IMMATICS N.V 0.1%
Value ($000) $3,873 Shares 719,901 Est. Cost $9.09 Unrealized -45.4%
BIOA BIOAGE LABS INC 0.1%
Value ($000) $3,808 Shares 921,959 Est. Cost $20.04 Unrealized -79.9%
QTTB Q32 BIO INC 0.1%
Value ($000) $3,357 Shares 2,252,987 Est. Cost $13.78 Unrealized -87.6%
ENGN ENGENE HOLDINGS INC 0.1%
Value ($000) $2,468 Shares 677,977 Est. Cost $7.77 Unrealized -51.7%
PASSAGE BIO INC 0.1%
Value ($000) $2,424 Shares 6,055,300 Est. Cost $11.43 Unrealized
AMLX AMYLYX PHARMACEUTICALS INC 0.1%
Value ($000) $2,008 Shares 313,200 Est. Cost $4.71 Unrealized +3.4%
MURAL ONCOLOGY PUB LTD CO 0.0%
Value ($000) $1,454 Shares 588,800 Est. Cost $2.47 Unrealized
INSM INSMED INC 0.0%
Value ($000) $1,355 Shares 13,459 Est. Cost $72.02 Unrealized +6.2%
KRYS KRYSTAL BIOTECH INC 0.0%
Value ($000) $1,265 Shares 9,200 Est. Cost $110.89 Unrealized +32.5%
TURNSTONE BIOLOGICS CORP 0.0%
Value ($000) $1,113 Shares 3,099,265 Est. Cost $3.94 Unrealized
CHEMOMAB THERAPEUTICS LTD 0.0%
Value ($000) $1,092 Shares 940,990 Est. Cost $28.71 Unrealized
TRAW TRAWS PHARMA INC 0.0%
Value ($000) $896 Shares 605,531 Est. Cost $9.11 Unrealized -82.5%
KZR KEZAR LIFE SCIENCES INC 0.0%
Value ($000) $883 Shares 192,700 Est. Cost $7.45 Unrealized -42.4%
APLS APELLIS PHARMACEUTICALS INC 0.0%
Value ($000) $866 Shares 50,000 Est. Cost $27.32 Unrealized -32.2%
ANRO ALTO NEUROSCIENCE INC 0.0%
Value ($000) $550 Shares 250,000 Est. Cost $6.24 Unrealized -61.9%
DIH HLDG US INC 0.0%
Value ($000) $469 Shares 1,915,000 Est. Cost $0.23 Unrealized
LYEL LYELL IMMUNOPHARMA INC 0.0%
Value ($000) $457 Shares 51,727 Est. Cost $9.11 Unrealized 0.0%
KRRO KORRO BIO INC 0.0%
Value ($000) $405 Shares 32,400 Est. Cost $51.39 Unrealized -72.0%
XERS XERIS BIOPHARMA HOLDINGS INC 0.0%
Value ($000) $376 Shares 80,420 Est. Cost $2.59 Unrealized +77.1%
INMB INMUNE BIO INC 0.0%
Value ($000) $116 Shares 50,000 Est. Cost Unrealized
LSBCF LAKESHORE BIOPHARMA CO LTD 0.0%
Value ($000) $56 Shares 54,799 Est. Cost $3.11 Unrealized -59.7%