Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $4.255B (99.9% shares, 0.1% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| EWTX | EDGEWISE THERAPEUTICS INC | 15,518,492 | $252M | 5.9% | — | — | COM | 28036F105 |
| BSX | BOSTON SCIENTIFIC CORP | 2,429,300 | $237M | 5.6% | — | — | COM | 101137107 |
| LLY | ELI LILLY & CO | 301,200 | $230M | 5.4% | — | — | COM | 532457108 |
| SVA | SINOVAC BIOTECH LTD | 2,718,735 | $184M | 4.3% | — | — | SHS | P8696W104 |
| ELVN | ENLIVEN THERAPEUTICS INC | 7,959,538 | $163M | 3.8% | — | — | COM | 29337E102 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 301,600 | $138M | 3.2% | — | — | COM | 02043Q107 |
| SYK | STRYKER CORPORATION | 359,200 | $133M | 3.1% | — | — | COM | 863667101 |
| EW | EDWARDS LIFESCIENCES CORP | 1,684,000 | $131M | 3.1% | — | — | COM | 28176E108 |
| ISRG | INTUITIVE SURGICAL INC | 287,200 | $128M | 3.0% | — | — | COM NEW | 46120E602 |
| ARGX | ARGENX SE | 172,300 | $127M | 3.0% | — | — | SPONSORED ADR | 04016X101 |
| SION | SIONNA THERAPEUTICS INC | 3,704,959 | $109M | 2.6% | — | — | COM | 829401108 |
| UPB | UPSTREAM BIO INC | 5,693,589 | $107M | 2.5% | — | — | COM | 91678A107 |
| IRON | DISC MEDICINE INC | 1,415,020 | $93.5M | 2.2% | — | — | COM | 254604101 |
| CAI | CARIS LIFE SCIENCES INC | 3,034,858 | $91.8M | 2.2% | — | — | COM | 142152107 |
| SPRY | ARS PHARMACEUTICALS INC | 8,288,510 | $83.3M | 2.0% | — | — | COM | 82835W108 |
| RNAM | AVIDITY BIOSCIENCES INC | 1,638,886 | $71.41M | 1.7% | — | — | COM | 05370A108 |
| MBX | MBX BIOSCIENCES INC | 4,002,887 | $70.05M | 1.6% | — | — | COM | 55287L101 |
| CGON | CG ONCOLOGY INC | 1,726,850 | $69.56M | 1.6% | — | — | COM | 156944100 |
| NTRA | NATERA INC | 429,300 | $69.1M | 1.6% | — | — | COM | 632307104 |
| AXSM | AXSOME THERAPEUTICS INC | 531,800 | $64.59M | 1.5% | — | — | COM | 05464T104 |
| TERN | TERNS PHARMACEUTICALS INC | 7,562,971 | $56.8M | 1.3% | — | — | COM | 880881107 |
| AVBP | ARRIVENT BIOPHARMA INC | 3,027,328 | $55.85M | 1.3% | — | — | COM | 04272N102 |
| MLYS | MINERALYS THERAPEUTICS INC | 1,469,494 | $55.72M | 1.3% | — | — | COM | 603170101 |
| EXAS | EXACT SCIENCES CORP | 994,616 | $54.42M | 1.3% | — | — | COM | 30063P105 |
| CMPX | COMPASS THERAPEUTICS INC | 15,219,994 | $53.27M | 1.3% | — | — | COM | 20454B104 |
| CRVS | CORVUS PHARMACEUTICALS INC | 7,165,006 | $52.81M | 1.2% | — | — | COM | 221015100 |
| APLS | APELLIS PHARMACEUTICALS INC | 2,323,368 | $52.58M | 1.2% | — | — | COM | 03753U106 |
| DHR | DANAHER CORPORATION | 263,100 | $52.16M | 1.2% | — | — | COM | 235851102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 353,640 | $49.64M | 1.2% | — | — | COM | 64125C109 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 114,900 | $48.17M | 1.1% | — | — | COM | 91307C102 |
| CI | THE CIGNA GROUP | 162,800 | $46.93M | 1.1% | — | — | COM | 125523100 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,099,000 | $45.77M | 1.1% | — | — | COM | 22663K107 |
| ORIC | ORIC PHARMACEUTICALS INC | 3,641,756 | $43.7M | 1.0% | — | — | COM | 68622P109 |
| JANX | JANUX THERAPEUTICS INC | 1,766,100 | $43.16M | 1.0% | — | — | COM | 47103J105 |
| ROIV | ROIVANT SCIENCES LTD | 2,714,798 | $41.07M | 1.0% | — | — | SHS | G76279101 |
| ASND | ASCENDIS PHARMA A/S | 191,905 | $38.15M | 0.9% | — | — | SPONSORED ADR | 04351P101 |
| SIBN | SI-BONE INC | 2,578,979 | $37.96M | 0.9% | — | — | COM | 825704109 |
| — | SCPHARMACEUTICALS INC | 6,059,528 | $34.36M | 0.8% | — | — | COM | 810648105 |
| ABVX | ABIVAX SA | 380,000 | $32.26M | 0.8% | — | — | SPONSORED ADS | 00370M103 |
| GPCR | STRUCTURE THERAPEUTICS INC | 1,139,300 | $31.9M | 0.7% | — | — | SPONSORED ADS | 86366E106 |
| TRVI | TREVI THERAPEUTICS INC | 3,308,400 | $30.27M | 0.7% | — | — | COM | 89532M101 |
| ITGR | INTEGER HLDGS CORP | 290,000 | $29.97M | 0.7% | — | — | COM | 45826H109 |
| DYN | DYNE THERAPEUTICS INC | 2,314,184 | $29.27M | 0.7% | — | — | COM | 26818M108 |
| RAPT | RAPT THERAPEUTICS INC | 1,086,618 | $28.02M | 0.7% | — | — | COM NEW | 75382E208 |
| CTMX | CYTOMX THERAPEUTICS INC | 8,461,500 | $26.99M | 0.6% | — | — | COM | 23284F105 |
| NPCE | NEUROPACE INC | 2,614,184 | $26.95M | 0.6% | — | — | COM | 641288105 |
| QURE | UNIQURE NV | 458,500 | $26.76M | 0.6% | — | — | SHS | N90064101 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 1,796,000 | $25.58M | 0.6% | — | — | COM NEW | 30233G209 |
| — | AKERO THERAPEUTICS INC | 526,200 | $24.98M | 0.6% | — | — | COM | 00973Y108 |
| ADCT | ADC THERAPEUTICS SA | 5,907,351 | $23.63M | 0.6% | — | — | SHS | H0036K147 |
| TMO | THERMO FISHER SCIENTIFIC INC | 46,500 | $22.55M | 0.5% | — | — | COM | 883556102 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 215,152 | $21.73M | 0.5% | — | — | COM | 76243J105 |
| ABT | ABBOTT LABS | 150,000 | $20.09M | 0.5% | — | — | Call | 002824100 |
| BSX | BOSTON SCIENTIFIC CORP | 200,000 | $19.53M | 0.5% | — | — | Call | 101137107 |
| KRYS | KRYSTAL BIOTECH INC | 102,745 | $18.14M | 0.4% | — | — | COM | 501147102 |
| FBRX | FORTE BIOSCIENCES INC | 1,196,955 | $17.95M | 0.4% | — | — | COM NEW | 34962G208 |
| AVTX | AVALO THERAPEUTICS INC | 1,349,300 | $17.15M | 0.4% | — | — | COM NEW | 05338F306 |
| XENE | XENON PHARMACEUTICALS INC | 419,600 | $16.85M | 0.4% | — | — | COM | 98420N105 |
| CARL | CARLSMED INC | 1,252,600 | $16.77M | 0.4% | — | — | COM | 14280C105 |
| KROS | KEROS THERAPEUTICS INC | 1,018,734 | $16.12M | 0.4% | — | — | COM | 492327101 |
| PRLD | PRELUDE THERAPEUTICS INC | 10,909,256 | $15.71M | 0.4% | — | — | COM | 74065P101 |
| STTK | SHATTUCK LABS INC | 6,306,127 | $15.07M | 0.4% | — | — | COM | 82024L103 |
| CRBP | CORBUS PHARMACEUTICALS HLDGS | 1,172,287 | $14.83M | 0.3% | — | — | COM NEW | 21833P301 |
| URGN | UROGEN PHARMA LTD | 689,000 | $13.75M | 0.3% | — | — | COM | M96088105 |
| VIR | VIR BIOTECHNOLOGY INC | 2,380,715 | $13.59M | 0.3% | — | — | COM | 92764N102 |
| FOLD | AMICUS THERAPEUTICS INC | 1,645,400 | $12.97M | 0.3% | — | — | COM | 03152W109 |
| PFE | PFIZER INC | 500,000 | $12.74M | 0.3% | — | — | Call | 717081103 |
| — | IMAGENEBIO INC | 6,210,899 | $12.5M | 0.3% | — | — | NONVOTING | 000000000 |
| TARS | TARSUS PHARMACEUTICALS INC | 197,900 | $11.76M | 0.3% | — | — | COM | 87650L103 |
| CCCC | C4 THERAPEUTICS INC | 5,235,146 | $11.62M | 0.3% | — | — | COM STK | 12529R107 |
| AZN | ASTRAZENECA PLC | 150,000 | $11.51M | 0.3% | — | — | Call | 046353108 |
| CGEM | CULLINAN THERAPEUTICS INC | 1,923,855 | $11.41M | 0.3% | — | — | COM | 230031106 |
| VTGN | VISTAGEN THERAPEUTICS INC | 3,060,000 | $10.86M | 0.3% | — | — | COM | 92840H400 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 750,600 | $10.2M | 0.2% | — | — | COM | 03237H101 |
| — | ADICET BIO INC | 11,447,140 | $9.274M | 0.2% | — | — | COM | 007002108 |
| PMVP | PMV PHARMACEUTICALS INC | 5,975,291 | $8.365M | 0.2% | — | — | COM | 69353Y103 |
| WHWK | WHITEHAWK THERAPEUTICS INC | 4,166,000 | $7.915M | 0.2% | — | — | COM | 00032Q104 |
| VSTM | VERASTEM INC | 887,561 | $7.837M | 0.2% | — | — | COM NEW | 92337C203 |
| BTSG | BRIGHTSPRING HEALTH SVCS INC | 263,800 | $7.798M | 0.2% | — | — | COM | 10950A106 |
| ALMS | ALUMIS INC | 1,926,423 | $7.686M | 0.2% | — | — | COM | 022307102 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 901,500 | $6.842M | 0.2% | — | — | COM | 09058V103 |
| MIST | MILESTONE PHARMACEUTICALS IN | 3,221,828 | $6.444M | 0.2% | — | — | COM | 59935V107 |
| — | REPARE THERAPEUTICS INC | 3,322,488 | $5.848M | 0.1% | — | — | COM | 760273102 |
| APLS | APELLIS PHARMACEUTICALS INC | 250,000 | $5.657M | 0.1% | — | — | Call | 03753U106 |
| NSPR | INSPIREMD INC | 2,133,405 | $5.142M | 0.1% | — | — | COM | 45779A846 |
| BIOA | BIOAGE LABS INC | 790,901 | $4.65M | 0.1% | — | — | COM | 09077V100 |
| JBIO | JADE BIOSCIENCES INC | 531,163 | $4.584M | 0.1% | — | — | COM NEW | 008064206 |
| QTTB | Q32 BIO INC | 2,252,987 | $4.461M | 0.1% | — | — | COM | 746964105 |
| BTSG | BRIGHTSPRING HEALTH SVCS INC | 150,000 | $4.434M | 0.1% | — | — | Call | 10950A106 |
| — | MIND MEDICINE MINDMED INC | 367,824 | $4.337M | 0.1% | — | — | COM NEW | 60255C885 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 100,000 | $4.165M | 0.1% | — | — | Put | 22663K107 |
| CELC | CELCUITY INC | 84,020 | $4.151M | 0.1% | — | — | COM | 15102K100 |
| IMTX | IMMATICS N.V | 466,601 | $3.975M | 0.1% | — | — | SHS | N44445109 |
| SRRK | SCHOLAR ROCK HLDG CORP | 100,000 | $3.724M | 0.1% | — | — | Call | 80706P103 |
| TGTX | TG THERAPEUTICS INC | 100,000 | $3.612M | 0.1% | — | — | Call | 88322Q108 |
| IMA | IMAGENEBIO INC | 378,556 | $3.085M | 0.1% | — | — | COM | 45175G207 |
| — | CELCUITY INC | 2,000,000 | $2.684M | 0.1% | — | — | NOTE 2.750% 8/0 | 15102KAA8 |
| INSM | INSMED INC | 13,459 | $1.938M | 0.0% | — | — | COM PAR $.01 | 457669307 |
| — | ATAI LIFE SCIENCES NV | 347,000 | $1.836M | 0.0% | — | — | SHS | N0731H103 |
| KRRO | KORRO BIO INC | 32,400 | $1.552M | 0.0% | — | — | COM | 500946108 |
| — | MURAL ONCOLOGY PUB LTD CO | 588,800 | $1.219M | 0.0% | — | — | ORD SHS | G63365103 |
| TRAW | TRAWS PHARMA INC | 605,531 | $1.12M | 0.0% | — | — | COM NEW | 68232V884 |
| ANRO | ALTO NEUROSCIENCE INC | 250,000 | $1.005M | 0.0% | — | — | COM SHS | 02157Q109 |
| LYEL | LYELL IMMUNOPHARMA INC | 51,727 | $840K | 0.0% | — | — | COM NEW | 55083R203 |
| KZR | KEZAR LIFE SCIENCES INC | 192,700 | $752K | 0.0% | — | — | COM NEW | 49372L209 |
| XERS | XERIS BIOPHARMA HOLDINGS INC | 80,420 | $655K | 0.0% | — | — | COM | 98422E103 |
| PASG | PASSAGE BIO INC | 59,046 | $474K | 0.0% | — | — | COM NEW | 702712209 |
| — | DIH HLDG US INC | 1,915,000 | $358K | 0.0% | — | — | CL A | 23290B106 |
| VTGN | VISTAGEN THERAPEUTICS INC | 45,200 | $160K | 0.0% | — | — | Call | 92840H400 |