ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $4,255,380 (99.9% shares, 0.1% debt)

Holdings (109)

EWTX EDGEWISE THERAPEUTICS INC 5.9%
Value ($000) $251,710 Shares 15,518,492 Est. Cost $30.67 Unrealized -53.8%
BSX BOSTON SCIENTIFIC CORP 5.6%
Value ($000) $237,173 Shares 2,429,300 Est. Cost $25.28 Unrealized +309.6%
LLY ELI LILLY & CO 5.4%
Value ($000) $229,816 Shares 301,200 Est. Cost $450.28 Unrealized +64.8%
SVA SINOVAC BIOTECH LTD 4.3%
Value ($000) $184,466 Shares 2,718,735 Est. Cost $6.47 Unrealized 0.0%
ELVN ENLIVEN THERAPEUTICS INC 3.8%
Value ($000) $162,932 Shares 7,959,538 Est. Cost $20.34 Unrealized -0.9%
ALNY ALNYLAM PHARMACEUTICALS INC 3.2%
Value ($000) $137,530 Shares 301,600 Est. Cost $199.68 Unrealized +103.9%
SYK STRYKER CORPORATION 3.1%
Value ($000) $132,785 Shares 359,200 Est. Cost $246.40 Unrealized +56.1%
EW EDWARDS LIFESCIENCES CORP 3.1%
Value ($000) $130,965 Shares 1,684,000 Est. Cost $70.82 Unrealized +10.3%
ISRG INTUITIVE SURGICAL INC 3.0%
Value ($000) $128,444 Shares 287,200 Est. Cost $272.47 Unrealized +76.1%
ARGX ARGENX SE 3.0%
Value ($000) $127,082 Shares 172,300 Est. Cost $410.99 Unrealized
SION SIONNA THERAPEUTICS INC 2.6%
Value ($000) $108,963 Shares 3,704,959 Est. Cost $16.34 Unrealized +33.1%
UPB UPSTREAM BIO INC 2.5%
Value ($000) $107,096 Shares 5,693,589 Est. Cost $22.33 Unrealized -30.4%
IRON DISC MEDICINE INC 2.2%
Value ($000) $93,505 Shares 1,415,020 Est. Cost $47.79 Unrealized +24.5%
CAI CARIS LIFE SCIENCES INC 2.2%
Value ($000) $91,804 Shares 3,034,858 Est. Cost $26.95 Unrealized +18.3%
SPRY ARS PHARMACEUTICALS INC 2.0%
Value ($000) $83,300 Shares 8,288,510 Est. Cost $31.95 Unrealized -55.1%
RNAM AVIDITY BIOSCIENCES INC 1.7%
Value ($000) $71,406 Shares 1,638,886 Est. Cost $27.80 Unrealized +45.4%
MBX MBX BIOSCIENCES INC 1.6%
Value ($000) $70,051 Shares 4,002,887 Est. Cost $22.28 Unrealized -40.0%
CGON CG ONCOLOGY INC 1.6%
Value ($000) $69,558 Shares 1,726,850 Est. Cost $31.89 Unrealized -8.8%
NTRA NATERA INC 1.6%
Value ($000) $69,104 Shares 429,300 Est. Cost $72.06 Unrealized +119.5%
AXSM AXSOME THERAPEUTICS INC 1.5%
Value ($000) $64,587 Shares 531,800 Est. Cost $113.05 Unrealized -0.4%
TERN TERNS PHARMACEUTICALS INC 1.3%
Value ($000) $56,798 Shares 7,562,971 Est. Cost $12.83 Unrealized -50.2%
AVBP ARRIVENT BIOPHARMA INC 1.3%
Value ($000) $55,854 Shares 3,027,328 Est. Cost $20.17 Unrealized -2.6%
MLYS MINERALYS THERAPEUTICS INC 1.3%
Value ($000) $55,723 Shares 1,469,494 Est. Cost $17.94 Unrealized +20.6%
EXAS EXACT SCIENCES CORP 1.3%
Value ($000) $54,415 Shares 994,616 Est. Cost $54.10 Unrealized -7.6%
CMPX COMPASS THERAPEUTICS INC 1.3%
Value ($000) $53,270 Shares 15,219,994 Est. Cost $3.29 Unrealized -3.9%
CRVS CORVUS PHARMACEUTICALS INC 1.2%
Value ($000) $52,806 Shares 7,165,006 Est. Cost $11.00 Unrealized -53.5%
APLS APELLIS PHARMACEUTICALS INC 1.2%
Value ($000) $52,578 Shares 2,323,368 Est. Cost $25.87 Unrealized -9.9%
DHR DANAHER CORPORATION 1.2%
Value ($000) $52,162 Shares 263,100 Est. Cost $198.37 Unrealized 0.0%
NBIX NEUROCRINE BIOSCIENCES INC 1.2%
Value ($000) $49,644 Shares 353,640 Est. Cost $115.66 Unrealized +17.1%
UTHR UNITED THERAPEUTICS CORP DEL 1.1%
Value ($000) $48,167 Shares 114,900 Est. Cost $336.31 Unrealized 0.0%
CI THE CIGNA GROUP 1.1%
Value ($000) $46,927 Shares 162,800 Est. Cost $293.19 Unrealized 0.0%
CRNX CRINETICS PHARMACEUTICALS IN 1.1%
Value ($000) $45,773 Shares 1,099,000 Est. Cost $25.00 Unrealized +27.9%
ORIC ORIC PHARMACEUTICALS INC 1.0%
Value ($000) $43,701 Shares 3,641,756 Est. Cost $9.97 Unrealized +5.5%
JANX JANUX THERAPEUTICS INC 1.0%
Value ($000) $43,163 Shares 1,766,100 Est. Cost $23.40 Unrealized +4.1%
ROIV ROIVANT SCIENCES LTD 1.0%
Value ($000) $41,075 Shares 2,714,798 Est. Cost $10.84 Unrealized +14.2%
ASND ASCENDIS PHARMA A/S 0.9%
Value ($000) $38,153 Shares 191,905 Est. Cost $194.11 Unrealized
SIBN SI-BONE INC 0.9%
Value ($000) $37,963 Shares 2,578,979 Est. Cost $19.80 Unrealized -17.5%
SCPHARMACEUTICALS INC 0.8%
Value ($000) $34,358 Shares 6,059,528 Est. Cost $9.77 Unrealized
ABVX ABIVAX SA 0.8%
Value ($000) $32,262 Shares 380,000 Est. Cost $84.90 Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.7%
Value ($000) $31,900 Shares 1,139,300 Est. Cost $29.09 Unrealized
TRVI TREVI THERAPEUTICS INC 0.7%
Value ($000) $30,272 Shares 3,308,400 Est. Cost $5.73 Unrealized +30.9%
ITGR INTEGER HLDGS CORP 0.7%
Value ($000) $29,966 Shares 290,000 Est. Cost $120.54 Unrealized -9.8%
DYN DYNE THERAPEUTICS INC 0.7%
Value ($000) $29,274 Shares 2,314,184 Est. Cost $17.61 Unrealized -35.2%
RAPT RAPT THERAPEUTICS INC 0.7%
Value ($000) $28,024 Shares 1,086,618 Est. Cost $7.63 Unrealized +71.5%
CTMX CYTOMX THERAPEUTICS INC 0.6%
Value ($000) $26,992 Shares 8,461,500 Est. Cost $1.61 Unrealized +39.7%
NPCE NEUROPACE INC 0.6%
Value ($000) $26,952 Shares 2,614,184 Est. Cost $23.21 Unrealized -59.4%
QURE UNIQURE NV 0.6%
Value ($000) $26,763 Shares 458,500 Est. Cost $18.16 Unrealized 0.0%
EYPT EYEPOINT PHARMACEUTICALS INC 0.6%
Value ($000) $25,575 Shares 1,796,000 Est. Cost $11.51 Unrealized 0.0%
AKERO THERAPEUTICS INC 0.6%
Value ($000) $24,984 Shares 526,200 Est. Cost $43.85 Unrealized
ADCT ADC THERAPEUTICS SA 0.6%
Value ($000) $23,629 Shares 5,907,351 Est. Cost $3.62 Unrealized -12.9%
TMO THERMO FISHER SCIENTIFIC INC 0.5%
Value ($000) $22,553 Shares 46,500 Est. Cost $443.16 Unrealized +4.9%
RYTM RHYTHM PHARMACEUTICALS INC 0.5%
Value ($000) $21,728 Shares 215,152 Est. Cost $27.49 Unrealized +237.7%
ABT ABBOTT LABS 0.5%
Value ($000) $20,091 Shares 150,000 Est. Cost Unrealized
BSX BOSTON SCIENTIFIC CORP 0.5%
Value ($000) $19,526 Shares 200,000 Est. Cost $25.28 Unrealized +309.6%
KRYS KRYSTAL BIOTECH INC 0.4%
Value ($000) $18,138 Shares 102,745 Est. Cost $146.20 Unrealized +2.4%
FBRX FORTE BIOSCIENCES INC 0.4%
Value ($000) $17,954 Shares 1,196,955 Est. Cost $10.24 Unrealized +12.5%
AVTX AVALO THERAPEUTICS INC 0.4%
Value ($000) $17,150 Shares 1,349,300 Est. Cost $9.82 Unrealized -12.5%
XENE XENON PHARMACEUTICALS INC 0.4%
Value ($000) $16,847 Shares 419,600 Est. Cost $30.66 Unrealized +14.9%
CARL CARLSMED INC 0.4%
Value ($000) $16,772 Shares 1,252,600 Est. Cost $13.67 Unrealized 0.0%
KROS KEROS THERAPEUTICS INC 0.4%
Value ($000) $16,116 Shares 1,018,734 Est. Cost $30.81 Unrealized -52.0%
PRLD PRELUDE THERAPEUTICS INC 0.4%
Value ($000) $15,709 Shares 10,909,256 Est. Cost $26.47 Unrealized -96.2%
STTK SHATTUCK LABS INC 0.4%
Value ($000) $15,072 Shares 6,306,127 Est. Cost $1.22 Unrealized 0.0%
CRBP CORBUS PHARMACEUTICALS HLDGS 0.3%
Value ($000) $14,829 Shares 1,172,287 Est. Cost $43.55 Unrealized -78.2%
URGN UROGEN PHARMA LTD 0.3%
Value ($000) $13,746 Shares 689,000 Est. Cost $12.15 Unrealized +47.8%
VIR VIR BIOTECHNOLOGY INC 0.3%
Value ($000) $13,594 Shares 2,380,715 Est. Cost $9.13 Unrealized -44.0%
FOLD AMICUS THERAPEUTICS INC 0.3%
Value ($000) $12,966 Shares 1,645,400 Est. Cost $10.63 Unrealized -33.1%
PFE PFIZER INC 0.3%
Value ($000) $12,740 Shares 500,000 Est. Cost Unrealized
IMAGENEBIO INC 0.3%
Value ($000) $12,505 Shares 6,210,899 Est. Cost $34.42 Unrealized
TARS TARSUS PHARMACEUTICALS INC 0.3%
Value ($000) $11,761 Shares 197,900 Est. Cost $49.43 Unrealized -0.4%
CCCC C4 THERAPEUTICS INC 0.3%
Value ($000) $11,622 Shares 5,235,146 Est. Cost $4.92 Unrealized -51.2%
AZN ASTRAZENECA PLC 0.3%
Value ($000) $11,508 Shares 150,000 Est. Cost Unrealized
CGEM CULLINAN THERAPEUTICS INC 0.3%
Value ($000) $11,408 Shares 1,923,855 Est. Cost $22.98 Unrealized -68.1%
VTGN VISTAGEN THERAPEUTICS INC 0.3%
Value ($000) $10,863 Shares 3,060,000 Est. Cost $2.99 Unrealized 0.0%
AMLX AMYLYX PHARMACEUTICALS INC 0.2%
Value ($000) $10,201 Shares 750,600 Est. Cost $7.45 Unrealized +26.4%
ADICET BIO INC 0.2%
Value ($000) $9,274 Shares 11,447,140 Est. Cost $8.72 Unrealized
PMVP PMV PHARMACEUTICALS INC 0.2%
Value ($000) $8,365 Shares 5,975,291 Est. Cost $36.80 Unrealized -96.2%
WHWK WHITEHAWK THERAPEUTICS INC 0.2%
Value ($000) $7,915 Shares 4,166,000 Est. Cost $2.61 Unrealized -29.6%
VSTM VERASTEM INC 0.2%
Value ($000) $7,837 Shares 887,561 Est. Cost $7.44 Unrealized 0.0%
BTSG BRIGHTSPRING HEALTH SVCS INC 0.2%
Value ($000) $7,798 Shares 263,800 Est. Cost $23.24 Unrealized 0.0%
ALMS ALUMIS INC 0.2%
Value ($000) $7,686 Shares 1,926,423 Est. Cost $4.72 Unrealized -12.8%
BCRX BIOCRYST PHARMACEUTICALS INC 0.2%
Value ($000) $6,842 Shares 901,500 Est. Cost $8.33 Unrealized 0.0%
MIST MILESTONE PHARMACEUTICALS IN 0.2%
Value ($000) $6,444 Shares 3,221,828 Est. Cost $1.76 Unrealized 0.0%
REPARE THERAPEUTICS INC 0.1%
Value ($000) $5,848 Shares 3,322,488 Est. Cost $31.02 Unrealized
APLS APELLIS PHARMACEUTICALS INC 0.1%
Value ($000) $5,658 Shares 250,000 Est. Cost $25.87 Unrealized -9.9%
NSPR INSPIREMD INC 0.1%
Value ($000) $5,142 Shares 2,133,405 Est. Cost $1.76 Unrealized +38.2%
BIOA BIOAGE LABS INC 0.1%
Value ($000) $4,650 Shares 790,901 Est. Cost $20.04 Unrealized -76.6%
JBIO JADE BIOSCIENCES INC 0.1%
Value ($000) $4,584 Shares 531,163 Est. Cost $33.31 Unrealized -75.5%
QTTB Q32 BIO INC 0.1%
Value ($000) $4,461 Shares 2,252,987 Est. Cost $13.78 Unrealized -86.1%
BTSG BRIGHTSPRING HEALTH SVCS INC 0.1%
Value ($000) $4,434 Shares 150,000 Est. Cost $23.24 Unrealized 0.0%
MIND MEDICINE MINDMED INC 0.1%
Value ($000) $4,337 Shares 367,824 Est. Cost $11.79 Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.1%
Value ($000) $4,165 Shares 100,000 Est. Cost $25.00 Unrealized +27.9%
CELC CELCUITY INC 0.1%
Value ($000) $4,151 Shares 84,020 Est. Cost $40.03 Unrealized 0.0%
IMTX IMMATICS N.V 0.1%
Value ($000) $3,975 Shares 466,601 Est. Cost $9.09 Unrealized -32.3%
SRRK SCHOLAR ROCK HLDG CORP 0.1%
Value ($000) $3,724 Shares 100,000 Est. Cost Unrealized
TGTX TG THERAPEUTICS INC 0.1%
Value ($000) $3,613 Shares 100,000 Est. Cost Unrealized
IMA IMAGENEBIO INC 0.1%
Value ($000) $3,085 Shares 378,556 Est. Cost $13.25 Unrealized 0.0%
CELCUITY INC 0.1%
Value ($000) $2,684 Shares 2,000,000 Est. Cost $1.34 Unrealized
INSM INSMED INC 0.0%
Value ($000) $1,938 Shares 13,459 Est. Cost $72.02 Unrealized +70.1%
ATAI LIFE SCIENCES NV 0.0%
Value ($000) $1,836 Shares 347,000 Est. Cost $5.29 Unrealized
KRRO KORRO BIO INC 0.0%
Value ($000) $1,552 Shares 32,400 Est. Cost $51.39 Unrealized -56.8%
MURAL ONCOLOGY PUB LTD CO 0.0%
Value ($000) $1,219 Shares 588,800 Est. Cost $2.47 Unrealized
TRAW TRAWS PHARMA INC 0.0%
Value ($000) $1,120 Shares 605,531 Est. Cost $9.11 Unrealized -82.1%
ANRO ALTO NEUROSCIENCE INC 0.0%
Value ($000) $1,005 Shares 250,000 Est. Cost $6.24 Unrealized -46.9%
LYEL LYELL IMMUNOPHARMA INC 0.0%
Value ($000) $840 Shares 51,727 Est. Cost $9.11 Unrealized +25.3%
KZR KEZAR LIFE SCIENCES INC 0.0%
Value ($000) $752 Shares 192,700 Est. Cost $7.45 Unrealized -44.9%
XERS XERIS BIOPHARMA HOLDINGS INC 0.0%
Value ($000) $655 Shares 80,420 Est. Cost $2.59 Unrealized +156.8%
PASG PASSAGE BIO INC 0.0%
Value ($000) $474 Shares 59,046 Est. Cost $6.96 Unrealized 0.0%
DIH HLDG US INC 0.0%
Value ($000) $358 Shares 1,915,000 Est. Cost $0.23 Unrealized
VTGN VISTAGEN THERAPEUTICS INC 0.0%
Value ($000) $160 Shares 45,200 Est. Cost $2.99 Unrealized 0.0%