Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q4 2025 (← Previous) (Next →)
Filing Date: Feb 17, 2026
Total Value: $9.761B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.192B | 22.5% | $213.24 | $82.85 | — | SH | 04351P101 |
| — | CIDARA THERAPEUTICS INC | 3,365,523 | $743M | 7.6% | $220.89 | $38.25 | — | SH | 171757206 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,666,837 | $714M | 7.3% | $107.04 | $38.97 | +172.2% | SH | 76243J105 |
| RNAM | AVIDITY BIOSCIENCES INC | 8,641,031 | $623M | 6.4% | $72.13 * | $27.64 | +133.7% | SH | 05370A108 |
| PCVX | VAXCYTE INC | 10,724,599 | $495M | 5.1% | $46.14 * | $51.21 | -12.7% | SH | 92243G108 |
| SION | SIONNA THERAPEUTICS INC | 9,905,045 | $407M | 4.2% | $41.14 * | $16.34 | +132.1% | SH | 829401108 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 9,550,191 | $335M | 3.4% | $35.08 * | $14.02 | +159.7% | SH | N62509109 |
| TYRA | TYRA BIOSCIENCES INC | 12,198,625 | $321M | 3.3% | $26.29 * | $17.16 | +7.0% | SH | 90240B106 |
| WVE | WAVE LIFE SCIENCES LTD | 18,203,009 | $309M | 3.2% | $17.00 * | $8.66 | +17.3% | SH | Y95308105 |
| MLYS | MINERALYS THERAPEUTICS INC | 7,323,750 | $266M | 2.7% | $36.29 * | $15.64 | +156.5% | SH | 603170101 |
| EWTX | EDGEWISE THERAPEUTICS INC | 10,428,437 | $259M | 2.7% | $24.81 * | $15.67 | +28.1% | SH | 28036F105 |
| SEPN | SEPTERNA INC | 6,995,858 | $195M | 2.0% | $27.88 * | $23.65 | +1.0% | SH | 81734D104 |
| NUVL | NUVALENT INC-A | 1,880,057 | $189M | 1.9% | $100.59 | $85.65 | +15.1% | SH | 670703107 |
| IRON | DISC MEDICINE INC | 1,976,132 | $157M | 1.6% | $79.41 * | $61.44 | +37.5% | SH | 254604101 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $154M | 1.6% | $13.80 * | $26.21 | -10.3% | SH | 47103J105 |
| PEPG | PEPGEN INC | 20,064,545 | $131M | 1.3% | $6.51 * | $6.78 | -23.4% | SH | 713317105 |
| TSHA | TAYSHA GENE THERAPIES INC | 23,555,648 | $130M | 1.3% | $5.50 * | $2.03 | +139.0% | SH | 877619106 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $127M | 1.3% | $11.65 * | $6.66 | +46.1% | SH | 82835W108 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 15,827,186 | $123M | 1.3% | $7.80 * | $7.23 | 0.0% | SH | 09058V103 |
| BCAX | BICARA THERAPEUTICS INC | 6,955,993 | $117M | 1.2% | $16.83 | $25.50 | -33.0% | SH | 055477103 |
| PRAX | PRAXIS PRECISION MEDICINES I | 373,787 | $110M | 1.1% | $294.74 * | $186.22 | 0.0% | SH | 74006W207 |
| GHRS | GH RESEARCH PLC | 7,676,697 | $97.49M | 1.0% | $12.70 * | $15.85 | -14.1% | SH | G3855L106 |
| GERN | GERON CORP | 63,771,366 | $84.18M | 0.9% | $1.32 * | $2.37 | -47.0% | SH | 374163103 |
| ACLX | ARCELLX INC | 1,267,156 | $82.62M | 0.8% | $65.20 * | $66.33 | +20.3% | SH | 03940C100 |
| CLYM | CLIMB BIO INC | 11,293,828 | $77.71M | 0.8% | $6.88 * | $12.52 | -80.8% | SH | 28658R106 |
| VOR | VOR BIOPHARMA INC | 5,404,998 | $70.7M | 0.7% | $13.08 * | $26.54 | -29.8% | SH | 929033207 |
| BLTE | BELITE BIO INC - ADR | 432,484 | $69.18M | 0.7% | $159.96 | $74.00 | — | SH | 07782B104 |
| FULC | FULCRUM THERAPEUTICS INC | 6,053,960 | $68.47M | 0.7% | $11.31 * | $7.35 | +38.5% | SH | 359616109 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $66.86M | 0.7% | $16.00 * | $20.79 | +40.2% | SH | 52635N103 |
| DNTH | DIANTHUS THERAPEUTICS INC | 1,611,733 | $66.42M | 0.7% | $41.21 * | $21.84 | +77.5% | SH | 252828108 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,600,000 | $65M | 0.7% | $25.00 * | $17.79 | 0.0% | SH | 68062P106 |
| EVMN | EVOMMUNE INC | 3,458,770 | $59.21M | 0.6% | $17.12 * | $18.78 | 0.0% | SH | 30054Y107 |
| JBIO | JADE BIOSCIENCES INC | 3,671,083 | $56.64M | 0.6% | $15.43 * | $17.98 | -34.7% | SH | 008064206 |
| SYRE | SPYRE THERAPEUTICS INC | 1,621,620 | $53.12M | 0.5% | $32.76 * | $26.13 | 0.0% | SH | 00773J202 |
| LXEO | LEXEO THERAPEUTICS INC | 5,000,000 | $49.65M | 0.5% | $9.93 * | $9.13 | 0.0% | SH | 52886X107 |
| LBRX | LB PHARMACEUTICALS INC | 2,208,604 | $49.16M | 0.5% | $22.26 * | $16.18 | +8.0% | SH | 50180M108 |
| MNPR | MONOPAR THERAPEUTICS INC | 667,207 | $43.57M | 0.4% | $65.30 * | $31.96 | +155.7% | SH | 61023L207 |
| CAPR | CAPRICOR THERAPEUTICS INC | 1,507,844 | $43.52M | 0.4% | $28.86 * | $13.06 | 0.0% | SH | 14070B309 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 5,653,211 | $42.4M | 0.4% | $7.50 * | $17.53 | -42.1% | SH | 35104E100 |
| IVVD | INVIVYD INC | 17,119,096 | $42.28M | 0.4% | $2.47 * | $0.89 | +134.5% | SH | 00534A102 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $42.27M | 0.4% | $4.29 * | $11.59 | -67.4% | SH | 04317A107 |
| GRAL | GRAIL INC | 428,266 | $36.66M | 0.4% | $85.59 | $86.40 | 0.0% | SH | 384747101 |
| ASMB | ASSEMBLY BIOSCIENCES INC | 1,020,410 | $34.7M | 0.4% | $34.01 * | $21.94 | +46.8% | SH | 045396207 |
| SLDB | SOLID BIOSCIENCES INC | 5,811,423 | $32.78M | 0.3% | $5.64 * | $6.22 | -12.9% | SH | 83422E204 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 14,932,063 | $31.51M | 0.3% | $2.11 * | $13.02 | -84.8% | SH | 00509G209 |
| BNTC | BENITEC BIOPHARMA INC | 1,850,000 | $24.92M | 0.3% | $13.47 * | $13.83 | 0.0% | SH | 08205P209 |
| CTNM | CONTINEUM THERAPEUTICS INC-A | 2,179,711 | $24.91M | 0.3% | $11.43 | $8.15 | +40.0% | SH | 21217B100 |
| RZLT | REZOLUTE INC | 9,180,000 | $21.66M | 0.2% | $2.36 * | $7.84 | 0.0% | SH | 76200L309 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $20.1M | 0.2% | $2.41 * | $10.73 | -79.7% | SH | 004890109 |
| NKTX | NKARTA INC | 10,805,129 | $19.99M | 0.2% | $1.85 * | $20.85 | -90.4% | SH | 65487U108 |
| OVID | OVID THERAPEUTICS INC | 10,714,000 | $17.46M | 0.2% | $1.63 * | $1.54 | 0.0% | SH | 690469101 |
| PALI | PALISADE BIO INC | 7,124,116 | $16.74M | 0.2% | $2.35 * | $1.92 | 0.0% | SH | 696389402 |
| SABS | SAB BIOTHERAPEUTICS INC | 4,401,500 | $16.46M | 0.2% | $3.74 * | $2.26 | +45.5% | SH | 78397T202 |
| CCCC | C4 THERAPEUTICS INC | 8,000,000 | $15.28M | 0.2% | $1.91 * | $2.37 | 0.0% | SH | 12529R107 |
| MDLN | MEDLINE INC-CL A | 335,000 | $14.07M | 0.1% | $42.00 | $42.23 | 0.0% | SH | 58507V107 |
| DSGN | DESIGN THERAPEUTICS INC | 1,461,381 | $13.71M | 0.1% | $9.38 * | $6.91 | +13.3% | SH | 25056L103 |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 141,964 | $13.09M | 0.1% | $92.23 * | $100.18 | -4.5% | SH | 457730109 |
| AVTX | AVALO THERAPEUTICS INC | 662,968 | $12.04M | 0.1% | $18.16 * | $10.31 | +63.7% | SH | 05338F306 |
| RANI | RANI THERAPEUTICS HOLDINGS-A | 8,500,000 | $11.47M | 0.1% | $1.35 * | $1.51 | 0.0% | SH | 753018100 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $9.773M | 0.1% | $13.03 * | $10.07 | +11.9% | SH | G70077105 |
| ACET | ADICET BIO INC | 948,249 | $7.984M | 0.1% | $8.42 * | $11.05 | 0.0% | SH | 007002207 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $7.667M | 0.1% | $23.00 | $0.87 | — | SH | N62509117 |
| WGS | GENEDX HOLDINGS CORP | 58,044 | $7.549M | 0.1% | $130.06 * | $78.50 | +74.8% | SH | 81663L200 |
| WAY | WAYSTAR HOLDING CORP | 144,400 | $4.729M | 0.0% | $32.75 * | $35.62 | 0.0% | SH | 946784105 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,681,307 | $4.233M | 0.0% | $0.63 * | $9.71 | -87.5% | SH | 95075A107 |
| HNGE | HINGE HEALTH INC-A | 80,113 | $3.721M | 0.0% | $46.45 * | $48.16 | 0.0% | SH | 433313103 |
| PGNY | PROGYNY INC | 96,628 | $2.481M | 0.0% | $25.68 * | $22.73 | +1.2% | SH | 74340E103 |
| — | QIAGEN N.V. | 43,976 | $2.082M | 0.0% | $47.34 | $47.34 | — | SH | N72482206 |
| KIDS | ORTHOPEDIATRICS CORP | 109,959 | $1.953M | 0.0% | $17.76 | $17.51 | 0.0% | SH | 68752L100 |
| HCAT | HEALTH CATALYST INC | 793,749 | $1.897M | 0.0% | $2.39 * | $2.73 | 0.0% | SH | 42225T107 |
| PTN | PALATIN TECHNOLOGIES INC | 70,000 | $1.077M | 0.0% | $15.38 * | $13.14 | 0.0% | SH | 696077601 |