Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ELVN	ENLIVEN THERAPEUTICS INC	2,320,867	$90.98M	2.2%	$25.60	0.0%	COM	29337E102
PCVX	VAXCYTE INC	1,190,697	$69.19M	1.6%	$52.77	0.0%	COM	92243G108
GLTO	DAMORA THERAPEUTICS INC	2,298,000	$59.52M	1.4%	$25.80	0.0%	COM NEW	36322Q206
IRON	DISC MEDICINE INC	459,314	$29.37M	0.7%	$74.04	0.0%	COM	254604101
ORKA	ORUKA THERAPEUTICS INC	507,008	$24.87M	0.6%	$32.45	0.0%	COM	687604108
GLUE	MONTE ROSA THERAPEUTICS INC	1,250,000	$20.56M	0.5%	$20.66	0.0%	COM	61225M102
LIVN	LIVANOVA PLC	186,185	$11.83M	0.3%	$65.15	0.0%	SHS	G5509L101
RNA	ATRIUM THERAPEUTICS INC	263,096	$3.518M	0.1%	$13.37	—	COM	04965N104
EQNR	EQUINOR ASA	17,573	$742K	0.0%	$42.20	—	SPONSORED ADR	29446M102
XOM	EXXON MOBIL CORP	4,370	$741K	0.0%	$138.74	0.0%	COM	30231G102
BP	BP PLC	15,644	$735K	0.0%	$47.00	—	SPONSORED ADR	055622104
SHEL	SHELL PLC	7,844	$729K	0.0%	$93.00	—	SPON ADS	780259305
PRAX	PRAXIS PRECISION MEDICINES I	1,757	$566K	0.0%	$311.81	0.0%	COM NEW	74006W207
AGMB	AGOMAB THERAPEUTICS NV	50,000	$525K	0.0%	$10.49	—	SPONSORED ADS	00860C102
CNTA	CENTESSA PHARMACEUTICALS PLC	9,030	$359K	0.0%	$39.72	—	SPONSORED ADS	152309100
HALO	HALOZYME THERAPEUTICS INC	3,857	$249K	0.0%	$73.62	0.0%	COM	40637H109
ABVX	ABIVAX SA	1,048	$117K	0.0%	$111.35	—	SPONSORED ADS	00370M103
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	6,982	$62,489	0.0%	$8.95	—	COM NEW	107924102
QGEN	QIAGEN NV	243	$9,730	0.0%	$50.32	0.0%	ORD SHARES	N72482156

Increased Positions (32)

REGN REGENERON PHARMACEUTICALS 5.1%

Value $215M (+1902.8%) Shares 278,674 (+1900.8%) Est. Cost $773.59 Unrealized -0.6%

GILD GILEAD SCIENCES INC 3.9%

Value $163M (+2418.2%) Shares 1,169,879 (+2117.7%) Est. Cost $135.36 Unrealized +2.2%

CRNX CRINETICS PHARMACEUTICALS IN 2.8%

Value $119M (+63245.9%) Shares 3,280,000 (+81088.1%) Est. Cost $49.21 Unrealized +0.0%

AMGN AMGEN INC 2.5%

Value $104M (+1617.3%) Shares 295,358 (+1497.5%) Est. Cost $345.13 Unrealized +1.3%

RARE ULTRAGENYX PHARMACEUTICAL IN 1.2%

Value $49.86M (+83925.9%) Shares 2,380,000 (+92148.1%) Est. Cost $23.37 Unrealized -0.0%

KRYS KRYSTAL BIOTECH INC 3.0%

Value $124M (+23.0%) Shares 481,785 (+17.4%) Est. Cost $219.32 Unrealized +24.2%

MRK MERCK & CO INC 0.6%

Value $24.85M (+156.3%) Shares 206,591 (+124.3%) Est. Cost $105.39 Unrealized +8.4%

MDT MEDTRONIC PLC 2.0%

Value $82.95M (+12.6%) Shares 957,329 (+24.9%) Est. Cost $82.67 Unrealized +20.4%

DHR DANAHER CORP DEL 0.9%

Value $38.33M (-14.0%) Shares 202,164 (+3.9%) Est. Cost $193.53 Unrealized +16.1%

VRDN VIRIDIAN THERAPEUTICS INC 3.1%

Value $132M (-3.0%) Shares 6,726,144 (+54.3%) Est. Cost $28.63 Unrealized +7.7%

NUVL NUVALENT INC 2.6%

Value $108M (+3.4%) Shares 1,053,268 (+1.5%) Est. Cost $98.68 Unrealized +5.0%

JBIO JADE BIOSCIENCES INC 1.2%

Value $49.2M (-4.6%) Shares 3,501,502 (+4.8%) Est. Cost $11.87 Unrealized +24.6%

TMDX TRANSMEDICS GROUP INC 0.2%

Value $10.05M (-15.6%) Shares 101,139 (+3.3%) Est. Cost $33.94 Unrealized +298.8%

TXG 10X GENOMICS INC 0.2%

Value $6.995M (+33.2%) Shares 329,492 (+2.3%) Est. Cost $60.05 Unrealized -66.9%

WAY WAYSTAR HLDG CORP 0.1%

Value $6.176M (-22.0%) Shares 256,139 (+6.0%) Est. Cost $28.66 Unrealized -4.1%

PFE PFIZER INC 0.1%

Value $3.022M (+113.5%) Shares 107,635 (+89.3%) Est. Cost $25.68 Unrealized +1.9%

RPRX ROYALTY PHARMA PLC 0.0%

Value $1.837M (+260.1%) Shares 38,296 (+190.1%) Est. Cost $40.20 Unrealized +5.2%

MDLN MEDLINE INC 0.1%

Value $6.08M (+23.0%) Shares 136,635 (+16.1%) Est. Cost $42.59 Unrealized +5.3%

ONC BEONE MEDICINES LTD 0.0%

Value $1.132M (+97.2%) Shares 3,812 (+101.7%) Est. Cost $254.61 Unrealized —

COR CENCORA INC 0.0%

Value $539K (+206.3%) Shares 1,716 (+229.4%) Est. Cost $303.71 Unrealized +16.3%

DNLI DENALI THERAPEUTICS INC 0.0%

Value $341K (+189.4%) Shares 17,766 (+148.9%) Est. Cost $18.52 Unrealized +6.0%

OLMA OLEMA PHARMACEUTICALS INC 0.0%

Value $245K (+151.3%) Shares 16,443 (+321.4%) Est. Cost $23.64 Unrealized +7.7%

CRSP CRISPR THERAPEUTICS AG 0.0%

Value $239K (+142.0%) Shares 5,016 (+166.8%) Est. Cost $55.89 Unrealized -4.3%

ALKS ALKERMES PLC 0.0%

Value $314K (+70.0%) Shares 8,870 (+34.5%) Est. Cost $29.26 Unrealized +10.5%

TVTX TRAVERE THERAPEUTICS INC 0.0%

Value $264K (+80.8%) Shares 8,899 (+132.5%) Est. Cost $31.67 Unrealized -2.0%

MDGL MADRIGAL PHARMACEUTICALS INC 0.0%

Value $1.591M (-5.2%) Shares 3,040 (+5.4%) Est. Cost $351.74 Unrealized +40.0%

MLYS MINERALYS THERAPEUTICS INC 0.0%

Value $796K (+10.6%) Shares 29,374 (+48.2%) Est. Cost $21.18 Unrealized +48.1%

TEM TEMPUS AI INC 0.0%

Value $224K (-20.6%) Shares 4,950 (+3.6%) Est. Cost $67.93 Unrealized -9.8%

SMMT SUMMIT THERAPEUTICS INC 0.0%

Value $301K (+20.5%) Shares 15,858 (+11.2%) Est. Cost $17.24 Unrealized -6.0%

BIIB BIOGEN INC 0.0%

Value $670K (+6.7%) Shares 3,653 (+2.5%) Est. Cost $147.01 Unrealized +24.7%

BBIO BRIDGEBIO PHARMA INC 0.0%

Value $1.884M (+2.2%) Shares 25,377 (+5.3%) Est. Cost $37.55 Unrealized +98.4%

A AGILENT TECHNOLOGIES INC 0.0%

Value $75,683 (+58.9%) Shares 664 (+89.7%) Est. Cost $131.08 Unrealized +2.8%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
REGN	REGENERON PHARMACEUTICALS	278,674 (+1900.8%)	$215M (+1902.8%)	5.1%	$773.59	-0.6%	COM	75886F107
GILD	GILEAD SCIENCES INC	1,169,879 (+2117.7%)	$163M (+2418.2%)	3.9%	$135.36	+2.2%	COM	375558103
CRNX	CRINETICS PHARMACEUTICALS IN	3,280,000 (+81088.1%)	$119M (+63245.9%)	2.8%	$49.21	+0.0%	COM	22663K107
AMGN	AMGEN INC	295,358 (+1497.5%)	$104M (+1617.3%)	2.5%	$345.13	+1.3%	COM	031162100
RARE	ULTRAGENYX PHARMACEUTICAL IN	2,380,000 (+92148.1%)	$49.86M (+83925.9%)	1.2%	$23.37	-0.0%	COM	90400D108
KRYS	KRYSTAL BIOTECH INC	481,785 (+17.4%)	$124M (+23.0%)	3.0%	$219.32	+24.2%	COM	501147102
MRK	MERCK & CO INC	206,591 (+124.3%)	$24.85M (+156.3%)	0.6%	$105.39	+8.4%	COM	58933Y105
MDT	MEDTRONIC PLC	957,329 (+24.9%)	$82.95M (+12.6%)	2.0%	$82.67	+20.4%	SHS	G5960L103
DHR	DANAHER CORP DEL	202,164 (+3.9%)	$38.33M (-14.0%)	0.9%	$193.53	+16.1%	COM	235851102
VRDN	VIRIDIAN THERAPEUTICS INC	6,726,144 (+54.3%)	$132M (-3.0%)	3.1%	$28.63	+7.7%	COM	92790C104
NUVL	NUVALENT INC	1,053,268 (+1.5%)	$108M (+3.4%)	2.6%	$98.68	+5.0%	COM	670703107
JBIO	JADE BIOSCIENCES INC	3,501,502 (+4.8%)	$49.2M (-4.6%)	1.2%	$11.87	+24.6%	COM NEW	008064206
TMDX	TRANSMEDICS GROUP INC	101,139 (+3.3%)	$10.05M (-15.6%)	0.2%	$33.94	+298.8%	COM	89377M109
TXG	10X GENOMICS INC	329,492 (+2.3%)	$6.995M (+33.2%)	0.2%	$60.05	-66.9%	CL A COM	88025U109
WAY	WAYSTAR HLDG CORP	256,139 (+6.0%)	$6.176M (-22.0%)	0.1%	$28.66	-4.1%	COM	946784105
PFE	PFIZER INC	107,635 (+89.3%)	$3.022M (+113.5%)	0.1%	$25.68	+1.9%	COM	717081103
RPRX	ROYALTY PHARMA PLC	38,296 (+190.1%)	$1.837M (+260.1%)	0.0%	$40.20	+5.2%	SHS CLASS A	G7709Q104
MDLN	MEDLINE INC	136,635 (+16.1%)	$6.08M (+23.0%)	0.1%	$42.59	+5.3%	COM CL A	58507V107
ONC	BEONE MEDICINES LTD	3,812 (+101.7%)	$1.132M (+97.2%)	0.0%	$254.61	—	SPONSORED ADS	07725L102
COR	CENCORA INC	1,716 (+229.4%)	$539K (+206.3%)	0.0%	$303.71	+16.3%	COM	03073E105
DNLI	DENALI THERAPEUTICS INC	17,766 (+148.9%)	$341K (+189.4%)	0.0%	$18.52	+6.0%	COM	24823R105
OLMA	OLEMA PHARMACEUTICALS INC	16,443 (+321.4%)	$245K (+151.3%)	0.0%	$23.64	+7.7%	COM	68062P106
CRSP	CRISPR THERAPEUTICS AG	5,016 (+166.8%)	$239K (+142.0%)	0.0%	$55.89	-4.3%	NAMEN AKT	H17182108
ALKS	ALKERMES PLC	8,870 (+34.5%)	$314K (+70.0%)	0.0%	$29.26	+10.5%	SHS	G01767105
TVTX	TRAVERE THERAPEUTICS INC	8,899 (+132.5%)	$264K (+80.8%)	0.0%	$31.67	-2.0%	COM	89422G107
MDGL	MADRIGAL PHARMACEUTICALS INC	3,040 (+5.4%)	$1.591M (-5.2%)	0.0%	$351.74	+40.0%	COM	558868105
MLYS	MINERALYS THERAPEUTICS INC	29,374 (+48.2%)	$796K (+10.6%)	0.0%	$21.18	+48.1%	COM	603170101
TEM	TEMPUS AI INC	4,950 (+3.6%)	$224K (-20.6%)	0.0%	$67.93	-9.8%	CL A	88023B103
SMMT	SUMMIT THERAPEUTICS INC	15,858 (+11.2%)	$301K (+20.5%)	0.0%	$17.24	-6.0%	COM	86627T108
BIIB	BIOGEN INC	3,653 (+2.5%)	$670K (+6.7%)	0.0%	$147.01	+24.7%	COM	09062X103
BBIO	BRIDGEBIO PHARMA INC	25,377 (+5.3%)	$1.884M (+2.2%)	0.0%	$37.55	+98.4%	COM	10806X102
A	AGILENT TECHNOLOGIES INC	664 (+89.7%)	$75,683 (+58.9%)	0.0%	$131.08	+2.8%	COM	00846U101

Exited Positions (40)

RNAM AVIDITY BIOSCIENCES INC 4.5%

Value $190M Shares 2,630,969 Est. Cost $44.82 Unrealized +62.1%

FOLD AMICUS THERAPEUTICS INC 3.6%

Value $153M Shares 10,735,195 Est. Cost $9.82 Unrealized +45.6%

MAZE MAZE THERAPEUTICS INC 0.9%

Value $36.78M Shares 887,708 Est. Cost $34.37 Unrealized +28.1%

CDNA CAREDX INC 0.2%

Value $8.121M Shares 431,070 Est. Cost $33.63 Unrealized -41.4%

MOH MOLINA HEALTHCARE INC 0.2%

Value $8.091M Shares 46,626 Est. Cost $236.59 Unrealized -28.7%

ICLR ICON PLC 0.1%

Value $4.475M Shares 24,560 Est. Cost $167.50 Unrealized -6.7%

BMRN BIOMARIN PHARMACEUTICAL INC 0.1%

Value $3.863M Shares 65,008 Est. Cost $83.12 Unrealized -29.4%

BTSG BRIGHTSPRING HEALTH SVCS INC 0.1%

Value $3.449M Shares 92,095 Est. Cost $17.95 Unrealized +119.6%

NEO NEOGENOMICS INC 0.1%

Value $3.273M Shares 278,286 Est. Cost $14.92 Unrealized -20.7%

AVTR AVANTOR INC 0.1%

Value $3.166M Shares 276,266 Est. Cost $12.52 Unrealized -12.2%

BEAM BEAM THERAPEUTICS INC 0.1%

Value $3.091M Shares 111,510 Est. Cost $33.72 Unrealized -13.5%

AZN ASTRAZENECA PLC 0.1%

Value $2.798M Shares 30,431 Est. Cost $70.83 Unrealized —

VKTX VIKING THERAPEUTICS INC 0.1%

Value $2.416M Shares 68,665 Est. Cost $29.83 Unrealized +5.1%

ROIV ROIVANT SCIENCES LTD 0.1%

Value $2.344M Shares 108,039 Est. Cost $19.73 Unrealized +22.5%

BKD BROOKDALE SR LIVING INC 0.0%

Value $1.807M Shares 167,444 Est. Cost $8.45 Unrealized +63.9%

SIBN SI-BONE INC 0.0%

Value $1.781M Shares 90,331 Est. Cost $17.88 Unrealized -5.3%

EXAS EXACT SCIENCES CORP 0.0%

Value $1.631M Shares 16,062 Est. Cost $67.99 Unrealized +50.9%

CMPS COMPASS PATHWAYS PLC 0.0%

Value $981K Shares 142,243 Est. Cost $6.90 Unrealized —

ANET ARISTA NETWORKS INC 0.0%

Value $629K Shares 4,800 Est. Cost $137.66 Unrealized -1.9%

IWM ISHARES TR 0.0%

Value $566K Shares 2,300 Est. Cost $199.49 Unrealized —

META META PLATFORMS INC 0.0%

Value $528K Shares 800 Est. Cost $705.28 Unrealized -7.0%

DOCS DOXIMITY INC 0.0%

Value $523K Shares 11,817 Est. Cost $39.64 Unrealized -11.7%

LULU LULULEMON ATHLETICA INC 0.0%

Value $465K Shares 2,240 Est. Cost $181.15 Unrealized +4.2%

PLTR PALANTIR TECHNOLOGIES INC 0.0%

Value $444K Shares 2,500 Est. Cost $181.03 Unrealized -14.8%

CORT CORCEPT THERAPEUTICS INC 0.0%

Value $365K Shares 10,495 Est. Cost $77.82 Unrealized -50.1%

PLNT PLANET FITNESS INC 0.0%

Value $344K Shares 3,173 Est. Cost $102.44 Unrealized -7.6%

EXEL EXELIXIS INC 0.0%

Value $323K Shares 7,361 Est. Cost $35.63 Unrealized +22.8%

GH GUARDANT HEALTH INC 0.0%

Value $307K Shares 3,004 Est. Cost $66.66 Unrealized +61.2%

SNY SANOFI SA 0.0%

Value $284K Shares 5,851 Est. Cost $47.20 Unrealized —

MRNA MODERNA INC 0.0%

Value $227K Shares 7,711 Est. Cost $37.72 Unrealized +13.8%

IDYA IDEAYA BIOSCIENCES INC 0.0%

Value $171K Shares 4,942 Est. Cost $31.88 Unrealized +6.2%

CGON CG ONCOLOGY INC 0.0%

Value $129K Shares 3,095 Est. Cost $41.38 Unrealized +26.7%

QURE UNIQURE NV 0.0%

Value $114K Shares 4,763 Est. Cost $8.63 Unrealized +172.9%

APLS APELLIS PHARMACEUTICALS INC 0.0%

Value $106K Shares 4,210 Est. Cost $23.46 Unrealized -3.3%

AMRX AMNEAL PHARMACEUTICALS INC 0.0%

Value $99,704 Shares 7,913 Est. Cost $8.98 Unrealized +55.1%

TRVI TREVI THERAPEUTICS INC 0.0%

Value $95,190 Shares 7,603 Est. Cost $11.56 Unrealized -5.3%

GMAB GENMAB A/S 0.0%

Value $92,677 Shares 3,009 Est. Cost $30.67 Unrealized —

TYRA TYRA BIOSCIENCES INC 0.0%

Value $82,629 Shares 3,143 Est. Cost $18.37 Unrealized +64.7%

ORIC ORIC PHARMACEUTICALS INC 0.0%

Value $79,395 Shares 9,706 Est. Cost $11.51 Unrealized -6.5%

NTLA INTELLIA THERAPEUTICS INC 0.0%

Value $26,772 Shares 2,978 Est. Cost $13.77 Unrealized -9.9%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RNAM	AVIDITY BIOSCIENCES INC	2,630,969	$190M	4.5%	$44.82	+62.1%	—	05370A108
FOLD	AMICUS THERAPEUTICS INC	10,735,195	$153M	3.6%	$9.82	+45.6%	—	03152W109
MAZE	MAZE THERAPEUTICS INC	887,708	$36.78M	0.9%	$34.37	+28.1%	—	578784100
CDNA	CAREDX INC	431,070	$8.121M	0.2%	$33.63	-41.4%	—	14167L103
MOH	MOLINA HEALTHCARE INC	46,626	$8.091M	0.2%	$236.59	-28.7%	—	60855R100
ICLR	ICON PLC	24,560	$4.475M	0.1%	$167.50	-6.7%	—	G4705A100
BMRN	BIOMARIN PHARMACEUTICAL INC	65,008	$3.863M	0.1%	$83.12	-29.4%	—	09061G101
BTSG	BRIGHTSPRING HEALTH SVCS INC	92,095	$3.449M	0.1%	$17.95	+119.6%	—	10950A106
NEO	NEOGENOMICS INC	278,286	$3.273M	0.1%	$14.92	-20.7%	—	64049M209
AVTR	AVANTOR INC	276,266	$3.166M	0.1%	$12.52	-12.2%	—	05352A100
BEAM	BEAM THERAPEUTICS INC	111,510	$3.091M	0.1%	$33.72	-13.5%	—	07373V105
AZN	ASTRAZENECA PLC	30,431	$2.798M	0.1%	$70.83	—	—	046353108
VKTX	VIKING THERAPEUTICS INC	68,665	$2.416M	0.1%	$29.83	+5.1%	—	92686J106
ROIV	ROIVANT SCIENCES LTD	108,039	$2.344M	0.1%	$19.73	+22.5%	—	G76279101
BKD	BROOKDALE SR LIVING INC	167,444	$1.807M	0.0%	$8.45	+63.9%	—	112463104
SIBN	SI-BONE INC	90,331	$1.781M	0.0%	$17.88	-5.3%	—	825704109
EXAS	EXACT SCIENCES CORP	16,062	$1.631M	0.0%	$67.99	+50.9%	—	30063P105
CMPS	COMPASS PATHWAYS PLC	142,243	$981K	0.0%	$6.90	—	—	20451W101
ANET	ARISTA NETWORKS INC	4,800	$629K	0.0%	$137.66	-1.9%	—	040413205
IWM	ISHARES TR	2,300	$566K	0.0%	$199.49	—	—	464287655
META	META PLATFORMS INC	800	$528K	0.0%	$705.28	-7.0%	—	30303M102
DOCS	DOXIMITY INC	11,817	$523K	0.0%	$39.64	-11.7%	—	26622P107
LULU	LULULEMON ATHLETICA INC	2,240	$465K	0.0%	$181.15	+4.2%	—	550021109
PLTR	PALANTIR TECHNOLOGIES INC	2,500	$444K	0.0%	$181.03	-14.8%	—	69608A108
CORT	CORCEPT THERAPEUTICS INC	10,495	$365K	0.0%	$77.82	-50.1%	—	218352102
PLNT	PLANET FITNESS INC	3,173	$344K	0.0%	$102.44	-7.6%	—	72703H101
EXEL	EXELIXIS INC	7,361	$323K	0.0%	$35.63	+22.8%	—	30161Q104
GH	GUARDANT HEALTH INC	3,004	$307K	0.0%	$66.66	+61.2%	—	40131M109
SNY	SANOFI SA	5,851	$284K	0.0%	$47.20	—	—	80105N105
MRNA	MODERNA INC	7,711	$227K	0.0%	$37.72	+13.8%	—	60770K107
IDYA	IDEAYA BIOSCIENCES INC	4,942	$171K	0.0%	$31.88	+6.2%	—	45166A102
CGON	CG ONCOLOGY INC	3,095	$129K	0.0%	$41.38	+26.7%	—	156944100
QURE	UNIQURE NV	4,763	$114K	0.0%	$8.63	+172.9%	—	N90064101
APLS	APELLIS PHARMACEUTICALS INC	4,210	$106K	0.0%	$23.46	-3.3%	—	03753U106
AMRX	AMNEAL PHARMACEUTICALS INC	7,913	$99,704	0.0%	$8.98	+55.1%	—	03168L105
TRVI	TREVI THERAPEUTICS INC	7,603	$95,190	0.0%	$11.56	-5.3%	—	89532M101
GMAB	GENMAB A/S	3,009	$92,677	0.0%	$30.67	—	—	372303206
TYRA	TYRA BIOSCIENCES INC	3,143	$82,629	0.0%	$18.37	+64.7%	—	90240B106
ORIC	ORIC PHARMACEUTICALS INC	9,706	$79,395	0.0%	$11.51	-6.5%	—	68622P109
NTLA	INTELLIA THERAPEUTICS INC	2,978	$26,772	0.0%	$13.77	-9.9%	—	45826J105

Decreased Positions (83)

RVMD REVOLUTION MEDICINES INC 3.6%

Value $150M (-62.3%) Shares 1,544,456 (-69.1%) Est. Cost $32.29 Unrealized +219.1%

IONS IONIS PHARMACEUTICALS INC 3.2%

Value $137M (-64.1%) Shares 1,818,665 (-62.1%) Est. Cost $61.40 Unrealized +33.2%

NBIX NEUROCRINE BIOSCIENCES INC 0.0%

Value $612K (-99.7%) Shares 4,646 (-99.7%) Est. Cost $83.66 Unrealized +60.6%

ARGX ARGENX SE 5.4%

Value $229M (-41.2%) Shares 313,000 (-32.2%) Est. Cost $157.09 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 1.8%

Value $77.6M (-56.2%) Shares 234,543 (-47.4%) Est. Cost $86.59 Unrealized +308.0%

CLDX CELLDEX THERAPEUTICS INC NEW 0.9%

Value $38.06M (-61.3%) Shares 1,200,000 (-66.8%) Est. Cost $30.41 Unrealized -16.4%

BSX BOSTON SCIENTIFIC CORP 2.2%

Value $92.05M (-38.1%) Shares 1,466,894 (-5.9%) Est. Cost $39.68 Unrealized +116.3%

SYK STRYKER CORPORATION 1.7%

Value $71.38M (-43.7%) Shares 217,237 (-39.8%) Est. Cost $224.18 Unrealized +62.7%

ISRG INTUITIVE SURGICAL INC 3.1%

Value $132M (-27.5%) Shares 286,654 (-11.0%) Est. Cost $268.75 Unrealized +93.9%

ABT ABBOTT LABORATORIES 2.8%

Value $118M (-28.3%) Shares 1,151,635 (-12.6%) Est. Cost $78.52 Unrealized +47.0%

PEN PENUMBRA INC 0.1%

Value $4.028M (-90.4%) Shares 12,267 (-90.9%) Est. Cost $200.28 Unrealized +69.5%

BDX BECTON DICKINSON & CO 0.5%

Value $19.16M (-62.8%) Shares 121,887 (-54.1%) Est. Cost $218.55 Unrealized -23.2%

WVE WAVE LIFE SCIENCES LTD 0.0%

Value $38,142 (-99.8%) Shares 5,261 (-99.6%) Est. Cost $16.12 Unrealized -14.7%

EW EDWARDS LIFESCIENCES CORP 1.6%

Value $67.22M (-24.4%) Shares 839,451 (-19.5%) Est. Cost $76.43 Unrealized +7.2%

PODD INSULET CORP 0.8%

Value $34.34M (-35.3%) Shares 163,656 (-12.3%) Est. Cost $199.47 Unrealized +32.5%

UNH UNITEDHEALTH GROUP INC 1.0%

Value $40.1M (-30.6%) Shares 148,203 (-15.4%) Est. Cost $354.01 Unrealized -12.8%

TNGX TANGO THERAPEUTICS INC 1.2%

Value $50.21M (+44.3%) Shares 2,400,000 (-38.9%) Est. Cost $8.62 Unrealized +38.2%

GKOS GLAUKOS CORP 0.4%

Value $15.69M (-47.0%) Shares 145,703 (-44.4%) Est. Cost $95.06 Unrealized +22.1%

IDXX IDEXX LABS INC 1.2%

Value $50.08M (-21.7%) Shares 89,131 (-5.7%) Est. Cost $425.27 Unrealized +57.6%

MASI MASIMO CORP 0.0%

Value $1.557M (-87.7%) Shares 8,753 (-91.0%) Est. Cost $165.13 Unrealized -12.1%

ABBV ABBVIE INC 0.5%

Value $20.35M (-34.0%) Shares 93,567 (-30.6%) Est. Cost $180.55 Unrealized +23.3%

GPCR STRUCTURE THERAPEUTICS INC 0.0%

Value $328K (-96.8%) Shares 6,803 (-95.3%) Est. Cost $34.28 Unrealized —

IQV IQVIA HLDGS INC 0.0%

Value $126K (-98.6%) Shares 740 (-98.2%) Est. Cost $206.31 Unrealized +1.9%

ELV ELEVANCE HEALTH INC FORMERLY 0.4%

Value $15.37M (-37.0%) Shares 52,518 (-24.6%) Est. Cost $357.03 Unrealized -1.5%

VEEV VEEVA SYS INC 0.2%

Value $9.928M (-44.8%) Shares 56,517 (-29.8%) Est. Cost $197.26 Unrealized +3.4%

HUM HUMANA INC 0.3%

Value $11.18M (-40.3%) Shares 64,498 (-11.7%) Est. Cost $307.13 Unrealized -27.2%

ZBH ZIMMER BIOMET HOLDINGS INC 0.3%

Value $14.07M (-34.5%) Shares 155,571 (-34.8%) Est. Cost $118.00 Unrealized -22.3%

RLAY RELAY THERAPEUTICS INC 1.8%

Value $77.56M (+9.9%) Shares 7,795,242 (-6.6%) Est. Cost $21.23 Unrealized -60.9%

DXCM DEXCOM INC 1.2%

Value $49.53M (-11.9%) Shares 788,766 (-6.9%) Est. Cost $98.21 Unrealized -27.8%

NTRA NATERA INC 0.2%

Value $6.338M (-50.6%) Shares 31,694 (-43.4%) Est. Cost $74.76 Unrealized +202.1%

TMO THERMO FISHER SCIENTIFIC INC 0.8%

Value $31.66M (-16.0%) Shares 64,412 (-1.0%) Est. Cost $470.67 Unrealized +22.1%

PRVA PRIVIA HEALTH GROUP INC 0.1%

Value $4.663M (-56.1%) Shares 226,703 (-49.4%) Est. Cost $31.03 Unrealized -26.5%

GEHC GE HEALTHCARE TECHNOLOGIES I 0.7%

Value $29.67M (-14.8%) Shares 416,887 (-1.8%) Est. Cost $70.33 Unrealized +16.9%

ASND ASCENDIS PHARMA A/S 0.0%

Value $123K (-97.6%) Shares 536 (-97.8%) Est. Cost $170.28 Unrealized —

AXSM AXSOME THERAPEUTICS INC. 0.0%

Value $538K (-89.3%) Shares 3,181 (-88.5%) Est. Cost $56.28 Unrealized +220.3%

COO COOPER COS INC 0.5%

Value $19.46M (-18.7%) Shares 272,184 (-6.8%) Est. Cost $96.75 Unrealized -15.1%

INSP INSPIRE MED SYS INC 0.1%

Value $5.144M (-44.6%) Shares 99,735 (-1.0%) Est. Cost $131.09 Unrealized -40.9%

CI THE CIGNA GROUP 0.6%

Value $26.21M (-13.4%) Shares 98,263 (-10.7%) Est. Cost $273.46 Unrealized +2.6%

ADPT ADAPTIVE BIOTECHNOLOGIES COR 0.0%

Value $1.057M (-78.2%) Shares 76,181 (-74.4%) Est. Cost $13.98 Unrealized +21.5%

STE STERIS PLC 0.5%

Value $22.09M (-14.3%) Shares 99,878 (-1.8%) Est. Cost $221.24 Unrealized +15.5%

PRCT PROCEPT BIOROBOTICS CORP 0.3%

Value $12.56M (-22.5%) Shares 502,286 (-2.6%) Est. Cost $38.47 Unrealized -23.1%

RMD RESMED INC 0.9%

Value $35.77M (-7.9%) Shares 159,346 (-1.2%) Est. Cost $188.96 Unrealized +35.4%

JNJ JOHNSON & JOHNSON 0.7%

Value $29.11M (+10.9%) Shares 119,102 (-6.1%) Est. Cost $170.87 Unrealized +33.4%

CNC CENTENE CORP DEL 0.2%

Value $8.547M (-24.1%) Shares 261,066 (-4.6%) Est. Cost $46.52 Unrealized -6.8%

TEVA TEVA PHARMACEUTICAL INDS LTD 0.2%

Value $7.532M (-26.4%) Shares 250,082 (-23.7%) Est. Cost $16.59 Unrealized —

HCA HCA HEALTHCARE INC 0.4%

Value $17.87M (-12.8%) Shares 37,765 (-14.0%) Est. Cost $223.94 Unrealized +122.4%

BMY BRISTOL-MYERS SQUIBB CO 0.0%

Value $1.033M (-71.4%) Shares 17,038 (-74.6%) Est. Cost $45.80 Unrealized +25.4%

SRRK SCHOLAR ROCK HLDG CORP 4.2%

Value $176M (-1.4%) Shares 3,584,573 (-11.6%) Est. Cost $25.47 Unrealized +78.6%

BNTX BIONTECH SE 0.0%

Value $1.853M (-55.5%) Shares 20,851 (-52.3%) Est. Cost $106.12 Unrealized —

CVS CVS HEALTH CORP 0.2%

Value $6.418M (-25.8%) Shares 89,363 (-18.1%) Est. Cost $72.21 Unrealized +8.0%

PHR PHREESIA INC 0.0%

Value $1.098M (-64.6%) Shares 130,992 (-28.5%) Est. Cost $34.11 Unrealized -58.2%

ALGN ALIGN TECHNOLOGY INC 0.6%

Value $23.95M (+8.4%) Shares 139,680 (-1.3%) Est. Cost $307.47 Unrealized -43.2%

GMED GLOBUS MED INC 0.5%

Value $21.3M (-7.1%) Shares 247,261 (-5.9%) Est. Cost $54.84 Unrealized +66.1%

CAH CARDINAL HEALTH INC 0.0%

Value $182K (-88.4%) Shares 863 (-88.7%) Est. Cost $98.91 Unrealized +117.7%

LH LABCORP HOLDINGS INC 0.0%

Value $74,707 (-94.7%) Shares 280 (-95.1%) Est. Cost $240.40 Unrealized +12.8%

MCK MCKESSON CORP 0.5%

Value $19.34M (-6.0%) Shares 22,352 (-10.9%) Est. Cost $592.29 Unrealized +47.8%

DGX QUEST DIAGNOSTICS INC 0.0%

Value $25,673 (-98.0%) Shares 131 (-98.2%) Est. Cost $172.09 Unrealized +10.7%

EHC ENCOMPASS HEALTH CORP 0.0%

Value $951K (-53.1%) Shares 9,829 (-48.5%) Est. Cost $94.80 Unrealized +8.6%

OMDA OMADA HEALTH INC 0.0%

Value $1.985M (-29.3%) Shares 157,938 (-11.2%) Est. Cost $17.31 Unrealized -19.3%

GDX VANECK ETF TRUST 0.0%

Value $528K (-60.3%) Shares 5,750 (-62.9%) Est. Cost $33.91 Unrealized —

INSM INSMED INC 0.0%

Value $1.641M (-32.2%) Shares 10,034 (-27.9%) Est. Cost $28.84 Unrealized +451.5%

THC TENET HEALTHCARE CORP 0.2%

Value $7.222M (-9.7%) Shares 38,269 (-4.9%) Est. Cost $177.42 Unrealized +16.2%

LEGN LEGEND BIOTECH CORP 0.0%

Value $649K (-53.3%) Shares 35,886 (-43.9%) Est. Cost $45.72 Unrealized —

RYTM RHYTHM PHARMACEUTICALS INC 0.0%

Value $88,362 (-89.0%) Shares 1,016 (-86.5%) Est. Cost $42.97 Unrealized +139.3%

ARWR ARROWHEAD PHARMACEUTICALS IN 0.0%

Value $96,872 (-87.4%) Shares 1,545 (-86.6%) Est. Cost $49.01 Unrealized +34.1%

UTHR UNITED THERAPEUTICS CORP DEL 0.0%

Value $1.232M (-35.1%) Shares 2,077 (-46.7%) Est. Cost $378.00 Unrealized +27.1%

NVDA NVIDIA CORPORATION 0.0%

Value $71,155 (-90.3%) Shares 408 (-89.6%) Est. Cost $170.24 Unrealized +9.6%

GOOGL ALPHABET INC 0.0%

Value $90,294 (-86.0%) Shares 314 (-84.8%) Est. Cost $228.46 Unrealized +41.5%

MSFT MICROSOFT CORP 0.0%

Value $63,669 (-89.7%) Shares 172 (-86.6%) Est. Cost $480.35 Unrealized -9.5%

AMZN AMAZON COM INC 0.0%

Value $282K (-65.5%) Shares 1,353 (-61.8%) Est. Cost $223.16 Unrealized +1.6%

ILMN ILLUMINA INC 0.1%

Value $2.493M (-17.2%) Shares 20,223 (-11.8%) Est. Cost $276.89 Unrealized -51.1%

INCY INCYTE CORP 0.0%

Value $45,742 (-90.3%) Shares 486 (-89.8%) Est. Cost $80.18 Unrealized +28.6%

NAMS NEWAMSTERDAM PHARMA COMPANY 0.0%

Value $885K (-30.5%) Shares 27,661 (-23.9%) Est. Cost $29.81 Unrealized +13.2%

PTCT PTC THERAPEUTICS INC 0.0%

Value $132K (-74.3%) Shares 1,935 (-71.4%) Est. Cost $61.50 Unrealized +19.8%

SPY STATE STR SPDR S&P 500 ETF T 0.0%

Value $1.756M (-16.9%) Shares 2,700 (-12.9%) Est. Cost $586.08 Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 0.0%

Value $1.523M (+5.4%) Shares 14,447 (-12.7%) Est. Cost $33.92 Unrealized +145.5%

GRMN GARMIN LTD 0.0%

Value $306K (-12.5%) Shares 1,321 (-23.5%) Est. Cost $186.62 Unrealized +15.0%

ZTS ZOETIS INC 0.0%

Value $63,006 (-31.3%) Shares 533 (-26.9%) Est. Cost $169.47 Unrealized -25.7%

ORCL ORACLE CORP 0.0%

Value $28,098 (-29.0%) Shares 191 (-5.9%) Est. Cost $114.45 Unrealized +48.2%

QCOM QUALCOMM INC 0.0%

Value $25,370 (-29.0%) Shares 197 (-5.7%) Est. Cost $133.12 Unrealized +15.6%

MTD METTLER TOLEDO INTERNATIONAL 0.0%

Value $45,403 (-14.3%) Shares 36 (-5.3%) Est. Cost $1170.94 Unrealized +20.7%

RXRX RECURSION PHARMACEUTICALS IN 0.0%

Value $14,205 (-29.4%) Shares 4,627 (-6.0%) Est. Cost $10.66 Unrealized -60.8%

CYTK CYTOKINETICS INC 0.0%

Value $583K (-0.6%) Shares 8,841 (-4.2%) Est. Cost $56.66 Unrealized +13.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	REVOLUTION MEDICINES INC	1,544,456 (-69.1%)	$150M (-62.3%)	3.6%	$32.29	+219.1%	COM	76155X100
IONS	IONIS PHARMACEUTICALS INC	1,818,665 (-62.1%)	$137M (-64.1%)	3.2%	$61.40	+33.2%	COM	462222100
NBIX	NEUROCRINE BIOSCIENCES INC	4,646 (-99.7%)	$612K (-99.7%)	0.0%	$83.66	+60.6%	COM	64125C109
ARGX	ARGENX SE	313,000 (-32.2%)	$229M (-41.2%)	5.4%	$157.09	—	SPONSORED ADR	04016X101
ALNY	ALNYLAM PHARMACEUTICALS INC	234,543 (-47.4%)	$77.6M (-56.2%)	1.8%	$86.59	+308.0%	COM	02043Q107
CLDX	CELLDEX THERAPEUTICS INC NEW	1,200,000 (-66.8%)	$38.06M (-61.3%)	0.9%	$30.41	-16.4%	COM NEW	15117B202
BSX	BOSTON SCIENTIFIC CORP	1,466,894 (-5.9%)	$92.05M (-38.1%)	2.2%	$39.68	+116.3%	COM	101137107
SYK	STRYKER CORPORATION	217,237 (-39.8%)	$71.38M (-43.7%)	1.7%	$224.18	+62.7%	COM	863667101
ISRG	INTUITIVE SURGICAL INC	286,654 (-11.0%)	$132M (-27.5%)	3.1%	$268.75	+93.9%	COM NEW	46120E602
ABT	ABBOTT LABORATORIES	1,151,635 (-12.6%)	$118M (-28.3%)	2.8%	$78.52	+47.0%	COM	002824100
PEN	PENUMBRA INC	12,267 (-90.9%)	$4.028M (-90.4%)	0.1%	$200.28	+69.5%	COM	70975L107
BDX	BECTON DICKINSON & CO	121,887 (-54.1%)	$19.16M (-62.8%)	0.5%	$218.55	-23.2%	COM	075887109
WVE	WAVE LIFE SCIENCES LTD	5,261 (-99.6%)	$38,142 (-99.8%)	0.0%	$16.12	-14.7%	SHS	Y95308105
EW	EDWARDS LIFESCIENCES CORP	839,451 (-19.5%)	$67.22M (-24.4%)	1.6%	$76.43	+7.2%	COM	28176E108
PODD	INSULET CORP	163,656 (-12.3%)	$34.34M (-35.3%)	0.8%	$199.47	+32.5%	COM	45784P101
UNH	UNITEDHEALTH GROUP INC	148,203 (-15.4%)	$40.1M (-30.6%)	1.0%	$354.01	-12.8%	COM	91324P102
TNGX	TANGO THERAPEUTICS INC	2,400,000 (-38.9%)	$50.21M (+44.3%)	1.2%	$8.62	+38.2%	COM	87583X109
GKOS	GLAUKOS CORP	145,703 (-44.4%)	$15.69M (-47.0%)	0.4%	$95.06	+22.1%	COM	377322102
IDXX	IDEXX LABS INC	89,131 (-5.7%)	$50.08M (-21.7%)	1.2%	$425.27	+57.6%	COM	45168D104
MASI	MASIMO CORP	8,753 (-91.0%)	$1.557M (-87.7%)	0.0%	$165.13	-12.1%	COM	574795100
ABBV	ABBVIE INC	93,567 (-30.6%)	$20.35M (-34.0%)	0.5%	$180.55	+23.3%	COM	00287Y109
GPCR	STRUCTURE THERAPEUTICS INC	6,803 (-95.3%)	$328K (-96.8%)	0.0%	$34.28	—	SPONSORED ADS	86366E106
IQV	IQVIA HLDGS INC	740 (-98.2%)	$126K (-98.6%)	0.0%	$206.31	+1.9%	COM	46266C105
ELV	ELEVANCE HEALTH INC FORMERLY	52,518 (-24.6%)	$15.37M (-37.0%)	0.4%	$357.03	-1.5%	COM	036752103
VEEV	VEEVA SYS INC	56,517 (-29.8%)	$9.928M (-44.8%)	0.2%	$197.26	+3.4%	CL A COM	922475108
HUM	HUMANA INC	64,498 (-11.7%)	$11.18M (-40.3%)	0.3%	$307.13	-27.2%	COM	444859102
ZBH	ZIMMER BIOMET HOLDINGS INC	155,571 (-34.8%)	$14.07M (-34.5%)	0.3%	$118.00	-22.3%	COM	98956P102
RLAY	RELAY THERAPEUTICS INC	7,795,242 (-6.6%)	$77.56M (+9.9%)	1.8%	$21.23	-60.9%	COM	75943R102
DXCM	DEXCOM INC	788,766 (-6.9%)	$49.53M (-11.9%)	1.2%	$98.21	-27.8%	COM	252131107
NTRA	NATERA INC	31,694 (-43.4%)	$6.338M (-50.6%)	0.2%	$74.76	+202.1%	COM	632307104
TMO	THERMO FISHER SCIENTIFIC INC	64,412 (-1.0%)	$31.66M (-16.0%)	0.8%	$470.67	+22.1%	COM	883556102
PRVA	PRIVIA HEALTH GROUP INC	226,703 (-49.4%)	$4.663M (-56.1%)	0.1%	$31.03	-26.5%	COM	74276R102
GEHC	GE HEALTHCARE TECHNOLOGIES I	416,887 (-1.8%)	$29.67M (-14.8%)	0.7%	$70.33	+16.9%	COMMON STOCK	36266G107
ASND	ASCENDIS PHARMA A/S	536 (-97.8%)	$123K (-97.6%)	0.0%	$170.28	—	SPONSORED ADR	04351P101
AXSM	AXSOME THERAPEUTICS INC.	3,181 (-88.5%)	$538K (-89.3%)	0.0%	$56.28	+220.3%	COM	05464T104
COO	COOPER COS INC	272,184 (-6.8%)	$19.46M (-18.7%)	0.5%	$96.75	-15.1%	COM	216648501
INSP	INSPIRE MED SYS INC	99,735 (-1.0%)	$5.144M (-44.6%)	0.1%	$131.09	-40.9%	COM	457730109
CI	THE CIGNA GROUP	98,263 (-10.7%)	$26.21M (-13.4%)	0.6%	$273.46	+2.6%	COM	125523100
ADPT	ADAPTIVE BIOTECHNOLOGIES COR	76,181 (-74.4%)	$1.057M (-78.2%)	0.0%	$13.98	+21.5%	COM	00650F109
STE	STERIS PLC	99,878 (-1.8%)	$22.09M (-14.3%)	0.5%	$221.24	+15.5%	SHS USD	G8473T100
PRCT	PROCEPT BIOROBOTICS CORP	502,286 (-2.6%)	$12.56M (-22.5%)	0.3%	$38.47	-23.1%	COM	74276L105
RMD	RESMED INC	159,346 (-1.2%)	$35.77M (-7.9%)	0.9%	$188.96	+35.4%	COM	761152107
JNJ	JOHNSON & JOHNSON	119,102 (-6.1%)	$29.11M (+10.9%)	0.7%	$170.87	+33.4%	COM	478160104
CNC	CENTENE CORP DEL	261,066 (-4.6%)	$8.547M (-24.1%)	0.2%	$46.52	-6.8%	COM	15135B101
TEVA	TEVA PHARMACEUTICAL INDS LTD	250,082 (-23.7%)	$7.532M (-26.4%)	0.2%	$16.59	—	SPONSORED ADS	881624209
HCA	HCA HEALTHCARE INC	37,765 (-14.0%)	$17.87M (-12.8%)	0.4%	$223.94	+122.4%	COM	40412C101
BMY	BRISTOL-MYERS SQUIBB CO	17,038 (-74.6%)	$1.033M (-71.4%)	0.0%	$45.80	+25.4%	COM	110122108
SRRK	SCHOLAR ROCK HLDG CORP	3,584,573 (-11.6%)	$176M (-1.4%)	4.2%	$25.47	+78.6%	COM	80706P103
BNTX	BIONTECH SE	20,851 (-52.3%)	$1.853M (-55.5%)	0.0%	$106.12	—	SPONSORED ADS	09075V102
CVS	CVS HEALTH CORP	89,363 (-18.1%)	$6.418M (-25.8%)	0.2%	$72.21	+8.0%	COM	126650100
PHR	PHREESIA INC	130,992 (-28.5%)	$1.098M (-64.6%)	0.0%	$34.11	-58.2%	COM	71944F106
ALGN	ALIGN TECHNOLOGY INC	139,680 (-1.3%)	$23.95M (+8.4%)	0.6%	$307.47	-43.2%	COM	016255101
GMED	GLOBUS MED INC	247,261 (-5.9%)	$21.3M (-7.1%)	0.5%	$54.84	+66.1%	CL A	379577208
CAH	CARDINAL HEALTH INC	863 (-88.7%)	$182K (-88.4%)	0.0%	$98.91	+117.7%	COM	14149Y108
LH	LABCORP HOLDINGS INC	280 (-95.1%)	$74,707 (-94.7%)	0.0%	$240.40	+12.8%	COM SHS	504922105
MCK	MCKESSON CORP	22,352 (-10.9%)	$19.34M (-6.0%)	0.5%	$592.29	+47.8%	COM	58155Q103
DGX	QUEST DIAGNOSTICS INC	131 (-98.2%)	$25,673 (-98.0%)	0.0%	$172.09	+10.7%	COM	74834L100
EHC	ENCOMPASS HEALTH CORP	9,829 (-48.5%)	$951K (-53.1%)	0.0%	$94.80	+8.6%	COM	29261A100
OMDA	OMADA HEALTH INC	157,938 (-11.2%)	$1.985M (-29.3%)	0.0%	$17.31	-19.3%	COM	68170A108
GDX	VANECK ETF TRUST	5,750 (-62.9%)	$528K (-60.3%)	0.0%	$33.91	—	GOLD MINERS ETF	92189F106
INSM	INSMED INC	10,034 (-27.9%)	$1.641M (-32.2%)	0.0%	$28.84	+451.5%	COM PAR $.01	457669307
THC	TENET HEALTHCARE CORP	38,269 (-4.9%)	$7.222M (-9.7%)	0.2%	$177.42	+16.2%	COM NEW	88033G407
LEGN	LEGEND BIOTECH CORP	35,886 (-43.9%)	$649K (-53.3%)	0.0%	$45.72	—	SPONSORED ADS	52490G102
RYTM	RHYTHM PHARMACEUTICALS INC	1,016 (-86.5%)	$88,362 (-89.0%)	0.0%	$42.97	+139.3%	COM	76243J105
ARWR	ARROWHEAD PHARMACEUTICALS IN	1,545 (-86.6%)	$96,872 (-87.4%)	0.0%	$49.01	+34.1%	COM	04280A100
UTHR	UNITED THERAPEUTICS CORP DEL	2,077 (-46.7%)	$1.232M (-35.1%)	0.0%	$378.00	+27.1%	COM	91307C102
NVDA	NVIDIA CORPORATION	408 (-89.6%)	$71,155 (-90.3%)	0.0%	$170.24	+9.6%	COM	67066G104
GOOGL	ALPHABET INC	314 (-84.8%)	$90,294 (-86.0%)	0.0%	$228.46	+41.5%	CAP STK CL A	02079K305
MSFT	MICROSOFT CORP	172 (-86.6%)	$63,669 (-89.7%)	0.0%	$480.35	-9.5%	COM	594918104
AMZN	AMAZON COM INC	1,353 (-61.8%)	$282K (-65.5%)	0.0%	$223.16	+1.6%	COM	023135106
ILMN	ILLUMINA INC	20,223 (-11.8%)	$2.493M (-17.2%)	0.1%	$276.89	-51.1%	COM	452327109
INCY	INCYTE CORP	486 (-89.8%)	$45,742 (-90.3%)	0.0%	$80.18	+28.6%	COM	45337C102
NAMS	NEWAMSTERDAM PHARMA COMPANY	27,661 (-23.9%)	$885K (-30.5%)	0.0%	$29.81	+13.2%	ORDINARY SHARES	N62509109
PTCT	PTC THERAPEUTICS INC	1,935 (-71.4%)	$132K (-74.3%)	0.0%	$61.50	+19.8%	COM	69366J200
SPY	STATE STR SPDR S&P 500 ETF T	2,700 (-12.9%)	$1.756M (-16.9%)	0.0%	$586.08	—	TR UNIT	78462F103
PTGX	PROTAGONIST THERAPEUTICS INC	14,447 (-12.7%)	$1.523M (+5.4%)	0.0%	$33.92	+145.5%	COM	74366E102
GRMN	GARMIN LTD	1,321 (-23.5%)	$306K (-12.5%)	0.0%	$186.62	+15.0%	SHS	H2906T109
ZTS	ZOETIS INC	533 (-26.9%)	$63,006 (-31.3%)	0.0%	$169.47	-25.7%	CL A	98978V103
ORCL	ORACLE CORP	191 (-5.9%)	$28,098 (-29.0%)	0.0%	$114.45	+48.2%	COM	68389X105
QCOM	QUALCOMM INC	197 (-5.7%)	$25,370 (-29.0%)	0.0%	$133.12	+15.6%	COM	747525103
MTD	METTLER TOLEDO INTERNATIONAL	36 (-5.3%)	$45,403 (-14.3%)	0.0%	$1170.94	+20.7%	COM	592688105
RXRX	RECURSION PHARMACEUTICALS IN	4,627 (-6.0%)	$14,205 (-29.4%)	0.0%	$10.66	-60.8%	CL A	75629V104
CYTK	CYTOKINETICS INC	8,841 (-4.2%)	$583K (-0.6%)	0.0%	$56.66	+13.7%	COM NEW	23282W605

Unchanged Positions (21)

VERA VERA THERAPEUTICS INC 1.6%

Value $68.82M Shares 1,710,771 Est. Cost $35.52 Unrealized +26.6%

IMCR IMMUNOCORE HLDGS PLC 2.0%

Value $84.32M Shares 2,796,803 Est. Cost $44.88 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 1.1%

Value $48.15M Shares 1,528,518 Est. Cost $15.98 Unrealized +76.4%

LLY ELI LILLY & CO 0.7%

Value $31.21M Shares 33,932 Est. Cost $420.39 Unrealized +149.1%

VRTX VERTEX PHARMACEUTICALS INC 7.2%

Value $304M Shares 681,908 Est. Cost $289.65 Unrealized +61.4%

ANNX ANNEXON INC 0.7%

Value $28.57M Shares 5,157,290 Est. Cost $5.18 Unrealized +10.9%

BBNX BETA BIONICS INC 0.0%

Value $723K Shares 72,152 Est. Cost $19.54 Unrealized -12.5%

KMTS KESTRA MED TECHNOLOGIES LTD 0.1%

Value $2.304M Shares 115,590 Est. Cost $22.98 Unrealized +9.6%

CERT CERTARA INC 0.0%

Value $567K Shares 99,442 Est. Cost $14.20 Unrealized -41.8%

ADBE ADOBE INC 0.0%

Value $292K Shares 1,200 Est. Cost $340.09 Unrealized -14.8%

ACN ACCENTURE PLC IRELAND 0.0%

Value $297K Shares 1,500 Est. Cost $254.06 Unrealized -0.3%

BABA ALIBABA GROUP HLDG LTD 0.0%

Value $590K Shares 4,700 Est. Cost $146.58 Unrealized —

MA MASTERCARD INCORPORATED 0.0%

Value $550K Shares 1,100 Est. Cost $558.95 Unrealized -3.6%

V VISA INC 0.0%

Value $423K Shares 1,400 Est. Cost $340.38 Unrealized -3.3%

AAPL APPLE INC 0.0%

Value $843K Shares 3,320 Est. Cost $247.62 Unrealized +6.1%

CAI CARIS LIFE SCIENCES INC 0.0%

Value $115K Shares 6,418 Est. Cost $26.95 Unrealized -11.9%

BLK BLACKROCK INC 0.0%

Value $433K Shares 450 Est. Cost $1089.41 Unrealized +0.7%

BLLN BILLIONTOONE INC 0.0%

Value $833K Shares 10,554 Est. Cost $101.40 Unrealized -14.3%

JD JD.COM INC 0.0%

Value $325K Shares 11,000 Est. Cost $28.70 Unrealized —

CSCO CISCO SYS INC 0.0%

Value $621K Shares 8,000 Est. Cost $73.79 Unrealized +5.6%

PG PROCTER & GAMBLE CO 0.0%

Value $563K Shares 3,900 Est. Cost $147.17 Unrealized +3.1%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
VERA	VERA THERAPEUTICS INC	1,710,771	$68.82M	1.6%	$35.52	+26.6%	CL A	92337R101
IMCR	IMMUNOCORE HLDGS PLC	2,796,803	$84.32M	2.0%	$44.88	—	ADS	45258D105
EWTX	EDGEWISE THERAPEUTICS INC	1,528,518	$48.15M	1.1%	$15.98	+76.4%	COM	28036F105
LLY	ELI LILLY & CO	33,932	$31.21M	0.7%	$420.39	+149.1%	COM	532457108
VRTX	VERTEX PHARMACEUTICALS INC	681,908	$304M	7.2%	$289.65	+61.4%	COM	92532F100
ANNX	ANNEXON INC	5,157,290	$28.57M	0.7%	$5.18	+10.9%	COM	03589W102
BBNX	BETA BIONICS INC	72,152	$723K	0.0%	$19.54	-12.5%	COM	08659B102
KMTS	KESTRA MED TECHNOLOGIES LTD	115,590	$2.304M	0.1%	$22.98	+9.6%	SHS	G52441105
CERT	CERTARA INC	99,442	$567K	0.0%	$14.20	-41.8%	COM	15687V109
ADBE	ADOBE INC	1,200	$292K	0.0%	$340.09	-14.8%	COM	00724F101
ACN	ACCENTURE PLC IRELAND	1,500	$297K	0.0%	$254.06	-0.3%	SHS CLASS A	G1151C101
BABA	ALIBABA GROUP HLDG LTD	4,700	$590K	0.0%	$146.58	—	SPONSORED ADS	01609W102
MA	MASTERCARD INCORPORATED	1,100	$550K	0.0%	$558.95	-3.6%	CL A	57636Q104
V	VISA INC	1,400	$423K	0.0%	$340.38	-3.3%	COM CL A	92826C839
AAPL	APPLE INC	3,320	$843K	0.0%	$247.62	+6.1%	COM	037833100
CAI	CARIS LIFE SCIENCES INC	6,418	$115K	0.0%	$26.95	-11.9%	COM	142152107
BLK	BLACKROCK INC	450	$433K	0.0%	$1089.41	+0.7%	COM	09290D101
BLLN	BILLIONTOONE INC	10,554	$833K	0.0%	$101.40	-14.3%	CL A	090168105
JD	JD.COM INC	11,000	$325K	0.0%	$28.70	—	SPON ADS CL A	47215P106
CSCO	CISCO SYS INC	8,000	$621K	0.0%	$73.79	+5.6%	COM	17275R102
PG	PROCTER & GAMBLE CO	3,900	$563K	0.0%	$147.17	+3.1%	COM	742718109