ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 14, 2018

Total Value ($000): $7,905,721 (99.1% shares, 0.9% debt)

Holdings (133)

BIIB BIOGEN INC 5.0%
Value ($000) $392,064 Shares 1,230,700 Est. Cost $263.39 Unrealized +21.8%
ALEXION PHARMACEUTICALS INC 4.4%
Value ($000) $344,368 Shares 2,879,575 Est. Cost $140.70 Unrealized
REGN REGENERON PHARMACEUTICALS 4.1%
Value ($000) $321,295 Shares 854,600 Est. Cost $380.05 Unrealized +6.0%
CELGENE CORP 4.0%
Value ($000) $319,639 Shares 3,062,850 Est. Cost $110.05 Unrealized
VRTX VERTEX PHARMACEUTICALS INC 3.3%
Value ($000) $260,951 Shares 1,741,300 Est. Cost $94.84 Unrealized +56.1%
BSX BOSTON SCIENTIFIC CORP 3.3%
Value ($000) $257,484 Shares 10,386,600 Est. Cost $16.76 Unrealized +64.6%
AMGN AMGEN INC 2.9%
Value ($000) $225,566 Shares 1,297,100 Est. Cost $86.91 Unrealized +59.0%
PBYI PUMA BIOTECHNOLOGY INC 2.7%
Value ($000) $215,941 Shares 2,184,535 Est. Cost $94.18 Unrealized +18.8%
MRK MERCK & CO INC 2.6%
Value ($000) $204,001 Shares 3,625,400 Est. Cost $42.70 Unrealized +0.7%
CLEMENTIA PHARMACEUTICALS IN 2.5%
Value ($000) $197,871 Shares 10,425,225 Est. Cost $16.89 Unrealized
CIGNA CORPORATION 2.5%
Value ($000) $196,855 Shares 969,300 Est. Cost $168.07 Unrealized
LLY LILLY ELI & CO 2.4%
Value ($000) $193,244 Shares 2,288,000 Est. Cost $67.58 Unrealized +11.4%
A AGILENT TECHNOLOGIES INC 2.2%
Value ($000) $173,499 Shares 2,590,700 Est. Cost $33.79 Unrealized +88.0%
WRIGHT MED GROUP N V 1.9%
Value ($000) $152,116 Shares 6,852,068 Est. Cost $25.17 Unrealized
ELV ANTHEM INC 1.9%
Value ($000) $148,218 Shares 658,718 Est. Cost $121.21 Unrealized +57.9%
IMMUNOMEDICS INC 1.7%
Value ($000) $136,742 Shares 8,461,727 Est. Cost $10.59 Unrealized
ASND ASCENDIS PHARMA A S 1.7%
Value ($000) $134,895 Shares 3,367,315 Est. Cost $17.43 Unrealized
CLOVIS ONCOLOGY INC 1.7%
Value ($000) $134,074 Shares 1,971,670 Est. Cost $92.29 Unrealized
AUDENTES THERAPEUTICS INC 1.6%
Value ($000) $129,051 Shares 4,129,638 Est. Cost $17.81 Unrealized
EW EDWARDS LIFESCIENCES CORP 1.6%
Value ($000) $126,697 Shares 1,124,100 Est. Cost $34.62 Unrealized +6.0%
ALNY ALNYLAM PHARMACEUTICALS INC 1.5%
Value ($000) $119,630 Shares 941,600 Est. Cost $71.38 Unrealized +76.0%
ONC BEIGENE LTD 1.3%
Value ($000) $101,774 Shares 1,041,488 Est. Cost $36.10 Unrealized
ABBV ABBVIE INC 1.3%
Value ($000) $101,604 Shares 1,050,600 Est. Cost $34.64 Unrealized +93.1%
ARRAY BIOPHARMA INC 1.2%
Value ($000) $97,554 Shares 7,621,400 Est. Cost $5.98 Unrealized
SEM SELECT MED HLDGS CORP 1.1%
Value ($000) $89,560 Shares 5,074,200 Est. Cost $7.32 Unrealized +20.2%
VRAYQ VIEWRAY INC 1.1%
Value ($000) $87,586 Shares 9,458,567 Est. Cost $4.68 Unrealized +71.1%
GLOBAL BLOOD THERAPEUTICS IN 1.1%
Value ($000) $84,907 Shares 2,157,730 Est. Cost $32.00 Unrealized
JUNO THERAPEUTICS INC 1.1%
Value ($000) $83,886 Shares 1,835,188 Est. Cost $38.15 Unrealized
MAGELLAN HEALTH INC 1.0%
Value ($000) $82,632 Shares 855,843 Est. Cost $64.56 Unrealized
JAZZ JAZZ PHARMACEUTICALS PLC 1.0%
Value ($000) $81,854 Shares 607,900 Est. Cost $132.64 Unrealized +4.6%
AETNA INC NEW 1.0%
Value ($000) $80,734 Shares 447,552 Est. Cost $135.84 Unrealized
FOLD AMICUS THERAPEUTICS INC 1.0%
Value ($000) $80,188 Shares 5,572,500 Est. Cost $13.74 Unrealized 0.0%
AERIE PHARMACEUTICALS INC 1.0%
Value ($000) $79,444 Shares 1,329,600 Est. Cost $40.50 Unrealized
LOXO ONCOLOGY INC 1.0%
Value ($000) $79,213 Shares 94,100,036 Est. Cost $1.07 Unrealized
MYLAN N V 1.0%
Value ($000) $77,609 Shares 1,834,300 Est. Cost $37.59 Unrealized
TMO THERMO FISHER SCIENTIFIC INC 0.9%
Value ($000) $73,939 Shares 389,400 Est. Cost $92.62 Unrealized +102.4%
ILMN ILLUMINA INC 0.9%
Value ($000) $71,774 Shares 328,500 Est. Cost $123.96 Unrealized +66.0%
BLUEBIRD BIO INC 0.9%
Value ($000) $68,399 Shares 384,046 Est. Cost $115.02 Unrealized
IRWD IRONWOOD PHARMACEUTICALS INC 0.9%
Value ($000) $67,833 Shares 4,525,200 Est. Cost $10.99 Unrealized +18.8%
JNJ JOHNSON & JOHNSON 0.8%
Value ($000) $65,012 Shares 465,300 Est. Cost $83.42 Unrealized +33.0%
NEVRO CORP 0.8%
Value ($000) $61,983 Shares 897,791 Est. Cost $74.48 Unrealized
ISRG INTUITIVE SURGICAL INC 0.7%
Value ($000) $56,055 Shares 153,600 Est. Cost $100.86 Unrealized +24.1%
CRVS CORVUS PHARMACEUTICALS INC 0.7%
Value ($000) $55,730 Shares 5,379,349 Est. Cost $14.33 Unrealized -10.6%
PIERIS PHARMACEUTICALS INC 0.7%
Value ($000) $54,810 Shares 7,259,620 Est. Cost $2.75 Unrealized
ASSEMBLY BIOSCIENCES INC 0.7%
Value ($000) $54,211 Shares 1,198,026 Est. Cost $25.39 Unrealized
UNH UNITEDHEALTH GROUP INC 0.7%
Value ($000) $52,800 Shares 239,500 Est. Cost $115.95 Unrealized +60.5%
INSYS THERAPEUTICS INC NEW 0.7%
Value ($000) $52,014 Shares 5,406,844 Est. Cost $27.55 Unrealized
ALLERGAN PLC 0.6%
Value ($000) $46,995 Shares 287,290 Est. Cost $300.13 Unrealized
INSM INSMED INC 0.6%
Value ($000) $46,670 Shares 1,496,791 Est. Cost $19.44 Unrealized +52.0%
GLPG GALAPAGOS NV 0.6%
Value ($000) $45,660 Shares 486,990 Est. Cost $76.76 Unrealized
NTLA INTELLIA THERAPEUTICS INC 0.6%
Value ($000) $44,930 Shares 2,337,684 Est. Cost $26.61 Unrealized -13.2%
IOVA IOVANCE BIOTHERAPEUTICS INC 0.6%
Value ($000) $44,387 Shares 5,548,326 Est. Cost $6.34 Unrealized +26.6%
SYK STRYKER CORP 0.6%
Value ($000) $44,284 Shares 286,000 Est. Cost $93.40 Unrealized +49.4%
KALA PHARMACEUTICALS INC 0.6%
Value ($000) $43,919 Shares 2,375,279 Est. Cost $22.84 Unrealized
RADIUS HEALTH INC 0.6%
Value ($000) $43,579 Shares 1,371,700 Est. Cost $37.37 Unrealized
RYTM RHYTHM PHARMACEUTICALS INC 0.6%
Value ($000) $43,519 Shares 2,901,295 Est. Cost $26.40 Unrealized 0.0%
SHIRE PLC 0.5%
Value ($000) $42,271 Shares 272,508 Est. Cost $189.62 Unrealized
BMY BRISTOL MYERS SQUIBB CO 0.5%
Value ($000) $42,161 Shares 688,000 Est. Cost $35.14 Unrealized +32.2%
AGN 5.5 03/01/18 A ALLERGAN PLC 0.5%
Value ($000) $42,034 Shares 71,700 Est. Cost $1045.68 Unrealized
SCPHARMACEUTICALS INC 0.5%
Value ($000) $41,225 Shares 3,409,865 Est. Cost $12.09 Unrealized
GILD GILEAD SCIENCES INC 0.5%
Value ($000) $37,367 Shares 521,600 Est. Cost $50.75 Unrealized +10.1%
ALPINE IMMUNE SCIENCES INC 0.5%
Value ($000) $36,943 Shares 3,298,516 Est. Cost $11.60 Unrealized
PFE PFIZER INC 0.4%
Value ($000) $35,568 Shares 982,000 Est. Cost $18.91 Unrealized +25.8%
DVA DAVITA INC 0.4%
Value ($000) $34,492 Shares 477,400 Est. Cost $61.54 Unrealized 0.0%
IART INTEGRA LIFESCIENCES HLDGS C 0.4%
Value ($000) $34,062 Shares 711,710 Est. Cost $49.95 Unrealized -2.0%
DERMIRA INC 0.4%
Value ($000) $32,848 Shares 1,181,168 Est. Cost $32.64 Unrealized
EHTH EHEALTH INC 0.4%
Value ($000) $31,869 Shares 1,834,700 Est. Cost $11.97 Unrealized +86.8%
ARGX ARGENX SE 0.4%
Value ($000) $31,570 Shares 500,000 Est. Cost $21.21 Unrealized
ENVISION HEALTHCARE CORP 0.4%
Value ($000) $30,254 Shares 875,400 Est. Cost $48.71 Unrealized
DECIPHERA PHARMACEUTICALS IN 0.3%
Value ($000) $26,662 Shares 1,176,070 Est. Cost $21.44 Unrealized
ACAD ACADIA PHARMACEUTICALS INC 0.3%
Value ($000) $25,566 Shares 849,100 Est. Cost $31.98 Unrealized 0.0%
OBSEVA SA 0.3%
Value ($000) $25,430 Shares 2,605,531 Est. Cost $10.41 Unrealized
ARSANIS INC 0.3%
Value ($000) $23,848 Shares 1,868,966 Est. Cost $12.76 Unrealized
ACHILLION PHARMACEUTICALS IN 0.3%
Value ($000) $23,532 Shares 8,170,973 Est. Cost $8.48 Unrealized
NABRIVA THERAPEUTICS PLC 0.3%
Value ($000) $23,439 Shares 3,919,600 Est. Cost $10.48 Unrealized
XNCR XENCOR INC 0.3%
Value ($000) $22,404 Shares 1,022,100 Est. Cost $14.43 Unrealized +50.3%
SVA SINOVAC BIOTECH LTD 0.3%
Value ($000) $22,375 Shares 2,839,500 Est. Cost $4.60 Unrealized +62.7%
GKOS GLAUKOS CORP 0.3%
Value ($000) $21,456 Shares 836,500 Est. Cost $29.05 Unrealized +2.4%
MDT MEDTRONIC PLC 0.3%
Value ($000) $20,527 Shares 254,200 Est. Cost $61.08 Unrealized +6.4%
UHS UNIVERSAL HLTH SVCS INC 0.3%
Value ($000) $19,814 Shares 174,800 Est. Cost $108.48 Unrealized -5.0%
IMMUNOGEN INC 0.2%
Value ($000) $18,167 Shares 2,834,126 Est. Cost $10.82 Unrealized
SELECTA BIOSCIENCES INC 0.2%
Value ($000) $18,078 Shares 1,842,797 Est. Cost $13.99 Unrealized
NVO NOVO-NORDISK A S 0.2%
Value ($000) $17,711 Shares 330,000 Est. Cost $48.15 Unrealized
STEADYMED LTD 0.2%
Value ($000) $15,711 Shares 4,246,196 Est. Cost $4.34 Unrealized
MOMENTA PHARMACEUTICALS INC 0.2%
Value ($000) $15,706 Shares 1,125,900 Est. Cost $15.05 Unrealized
CELGENE CORP 0.2%
Value ($000) $15,654 Shares 150,000 Est. Cost $110.05 Unrealized
VERONA PHARMA PLC 0.2%
Value ($000) $14,843 Shares 1,250,396 Est. Cost $11.76 Unrealized
VNDA VANDA PHARMACEUTICALS INC 0.2%
Value ($000) $14,711 Shares 967,859 Est. Cost $14.40 Unrealized +3.0%
DBV TECHNOLOGIES S A 0.2%
Value ($000) $14,231 Shares 578,500 Est. Cost $34.68 Unrealized
NTRA NATERA INC 0.2%
Value ($000) $14,170 Shares 1,576,190 Est. Cost $15.79 Unrealized -31.6%
ZLAB ZAI LAB LTD 0.2%
Value ($000) $13,973 Shares 658,160 Est. Cost $27.00 Unrealized
INVITAE CORP 0.2%
Value ($000) $13,785 Shares 1,518,197 Est. Cost $11.59 Unrealized
CTI BIOPHARMA CORP 0.2%
Value ($000) $13,400 Shares 5,000,000 Est. Cost $3.31 Unrealized
WRIGHT MED GROUP N V 0.2%
Value ($000) $13,207 Shares 8,746,583 Est. Cost $1.52 Unrealized
CHRS COHERUS BIOSCIENCES INC 0.2%
Value ($000) $12,949 Shares 1,471,500 Est. Cost $22.53 Unrealized -52.5%
NUVASIVE INC 0.2%
Value ($000) $12,909 Shares 220,700 Est. Cost $51.61 Unrealized
ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.2%
Value ($000) $12,790 Shares 1,914,660 Est. Cost $7.98 Unrealized
SYNLOGIC INC 0.2%
Value ($000) $12,755 Shares 1,314,996 Est. Cost $19.02 Unrealized
AEGERION PHARMACEUTICALS INC 0.2%
Value ($000) $12,006 Shares 15,000,000 Est. Cost $0.78 Unrealized
SIERRA ONCOLOGY INC 0.2%
Value ($000) $11,950 Shares 3,203,704 Est. Cost $1.53 Unrealized
HRTX HERON THERAPEUTICS INC 0.1%
Value ($000) $11,765 Shares 650,000 Est. Cost $13.84 Unrealized +17.8%
AMEDISYS INC 0.1%
Value ($000) $10,937 Shares 207,500 Est. Cost $52.71 Unrealized
NOVUS THERAPEUTICS INC 0.1%
Value ($000) $10,301 Shares 2,537,110 Est. Cost $5.85 Unrealized
LAB FLUIDIGM CORP DEL 0.1%
Value ($000) $9,328 Shares 1,583,700 Est. Cost $23.26 Unrealized -76.5%
BMRN BIOMARIN PHARMACEUTICAL INC 0.1%
Value ($000) $8,971 Shares 100,600 Est. Cost $86.66 Unrealized +0.3%
FLUIDIGM CORP DEL 0.1%
Value ($000) $8,302 Shares 10,000,000 Est. Cost $1.10 Unrealized
KIDS ORTHOPEDIATRICS CORP 0.1%
Value ($000) $8,160 Shares 425,200 Est. Cost $19.13 Unrealized 0.0%
AUPH AURINIA PHARMACEUTICALS INC 0.1%
Value ($000) $8,142 Shares 1,797,400 Est. Cost $4.62 Unrealized +20.2%
AEGLEA BIOTHERAPEUTICS INC 0.1%
Value ($000) $7,950 Shares 1,469,524 Est. Cost $5.05 Unrealized
ENDO INTL PLC 0.1%
Value ($000) $7,939 Shares 1,024,386 Est. Cost $7.75 Unrealized
ALKS ALKERMES PLC 0.1%
Value ($000) $7,936 Shares 145,000 Est. Cost $56.71 Unrealized -10.0%
IRWD IRONWOOD PHARMACEUTICALS INC 0.1%
Value ($000) $5,996 Shares 400,000 Est. Cost $10.99 Unrealized +18.8%
INOTEK PHARMACEUTICALS CORP 0.1%
Value ($000) $5,918 Shares 7,000,000 Est. Cost $1.36 Unrealized
GW PHARMACEUTICALS PLC 0.1%
Value ($000) $5,861 Shares 44,400 Est. Cost $112.66 Unrealized
TESARO INC 0.1%
Value ($000) $5,576 Shares 67,281 Est. Cost $82.88 Unrealized
SRPT SAREPTA THERAPEUTICS INC 0.1%
Value ($000) $5,531 Shares 99,400 Est. Cost $52.98 Unrealized 0.0%
MARINUS PHARMACEUTICALS INC 0.1%
Value ($000) $4,632 Shares 567,600 Est. Cost $7.64 Unrealized
PRQR PROQR THRAPEUTICS N V 0.1%
Value ($000) $4,202 Shares 1,302,955 Est. Cost $14.69 Unrealized -75.6%
SNDX SYNDAX PHARMACEUTICALS INC 0.0%
Value ($000) $3,828 Shares 437,000 Est. Cost $12.54 Unrealized -21.1%
REDHILL BIOPHARMA LTD 0.0%
Value ($000) $2,904 Shares 564,900 Est. Cost $14.14 Unrealized
SRPT SAREPTA THERAPEUTICS INC 0.0%
Value ($000) $2,782 Shares 50,000 Est. Cost $52.98 Unrealized 0.0%
SERES THERAPEUTICS INC 0.0%
Value ($000) $2,225 Shares 219,458 Est. Cost $16.04 Unrealized
XENE XENON PHARMACEUTICALS INC 0.0%
Value ($000) $1,793 Shares 634,812 Est. Cost $7.72 Unrealized -64.8%
OREXIGEN THERAPEUTICS INC 0.0%
Value ($000) $1,787 Shares 5,210,000 Est. Cost $0.50 Unrealized
VALEANT PHARMACEUTICALS INTL 0.0%
Value ($000) $1,596 Shares 76,800 Est. Cost $101.43 Unrealized
BIOLINERX LTD 0.0%
Value ($000) $1,132 Shares 1,038,600 Est. Cost $1.62 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $594 Shares 500,000 Est. Cost $1.08 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $540 Shares 500,000 Est. Cost $1.07 Unrealized
AFFIMED N V 0.0%
Value ($000) $425 Shares 326,650 Est. Cost $6.30 Unrealized
ALIMERA SCIENCES INC 0.0%
Value ($000) $333 Shares 250,000 Est. Cost $7.89 Unrealized
NOVELION THERAPEUTICS INC 0.0%
Value ($000) $312 Shares 100,000 Est. Cost $8.42 Unrealized
XTANT MED HLDGS INC 0.0%
Value ($000) $272 Shares 4,754,386 Est. Cost $0.38 Unrealized
MEDIGUS LTD 0.0%
Value ($000) $79 Shares 60,000 Est. Cost $3.08 Unrealized