ORBIMED ADVISORS LLC Diversified Active

Location: New York, NY

CIK: 0001055951 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $4.899B (100.0% shares, 0.0% debt)

Holdings (107)

EWTX EDGEWISE THERAPEUTICS INC 7.9%
Value $385M Shares 15,518,492 Est. Cost Unrealized
LLY ELI LILLY & CO 6.6%
Value $324M Shares 301,200 Est. Cost Unrealized
BSX BOSTON SCIENTIFIC CORP 4.7%
Value $231M Shares 2,419,300 Est. Cost Unrealized
SVA SINOVAC BIOTECH LTD 3.8%
Value $184M Shares 2,718,735 Est. Cost Unrealized
EW EDWARDS LIFESCIENCES CORP 3.2%
Value $157M Shares 1,842,900 Est. Cost Unrealized
UPB UPSTREAM BIO INC 3.2%
Value $155M Shares 5,693,589 Est. Cost Unrealized
ISRG INTUITIVE SURGICAL INC 3.0%
Value $149M Shares 263,400 Est. Cost Unrealized
SION SIONNA THERAPEUTICS INC 3.0%
Value $147M Shares 3,561,655 Est. Cost Unrealized
MBX MBX BIOSCIENCES INC 2.5%
Value $124M Shares 3,935,203 Est. Cost Unrealized
ARGX ARGENX SE 2.5%
Value $123M Shares 146,000 Est. Cost Unrealized
ELVN ENLIVEN THERAPEUTICS INC 2.5%
Value $123M Shares 7,959,538 Est. Cost Unrealized
ALNY ALNYLAM PHARMACEUTICALS INC 2.3%
Value $115M Shares 288,800 Est. Cost Unrealized
SYK STRYKER CORPORATION 2.3%
Value $114M Shares 325,000 Est. Cost Unrealized
SPRY ARS PHARMACEUTICALS INC 2.0%
Value $96.56M Shares 8,288,510 Est. Cost Unrealized
TERN TERNS PHARMACEUTICALS INC 1.8%
Value $86.99M Shares 2,153,300 Est. Cost Unrealized
IRON DISC MEDICINE INC 1.7%
Value $84.77M Shares 1,067,550 Est. Cost Unrealized
CAI CARIS LIFE SCIENCES INC 1.7%
Value $84.07M Shares 3,116,011 Est. Cost Unrealized
NTRA NATERA INC 1.7%
Value $83.8M Shares 365,800 Est. Cost Unrealized
CMPX COMPASS THERAPEUTICS INC 1.7%
Value $81.73M Shares 15,219,994 Est. Cost Unrealized
GPCR STRUCTURE THERAPEUTICS INC 1.6%
Value $80.8M Shares 1,161,803 Est. Cost Unrealized
DHR DANAHER CORPORATION 1.4%
Value $68.63M Shares 299,800 Est. Cost Unrealized
CGON CG ONCOLOGY INC 1.3%
Value $62.97M Shares 1,516,550 Est. Cost Unrealized
APLS APELLIS PHARMACEUTICALS INC 1.2%
Value $61.04M Shares 2,429,868 Est. Cost Unrealized
AVBP ARRIVENT BIOPHARMA INC 1.2%
Value $60.91M Shares 3,027,328 Est. Cost Unrealized
CI THE CIGNA GROUP 1.2%
Value $56.42M Shares 205,000 Est. Cost Unrealized
RAPT RAPT THERAPEUTICS INC 1.1%
Value $55.64M Shares 1,642,891 Est. Cost Unrealized
CRVS CORVUS PHARMACEUTICALS INC 1.1%
Value $55.17M Shares 7,165,006 Est. Cost Unrealized
UTHR UNITED THERAPEUTICS CORP DEL 1.0%
Value $51.26M Shares 105,200 Est. Cost Unrealized
ABVX ABIVAX SA 1.0%
Value $49.61M Shares 367,900 Est. Cost Unrealized
ROIV ROIVANT SCIENCES LTD 1.0%
Value $47.54M Shares 2,190,907 Est. Cost Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.9%
Value $46.5M Shares 999,000 Est. Cost Unrealized
AXSM AXSOME THERAPEUTICS INC 0.9%
Value $46.23M Shares 253,121 Est. Cost Unrealized
EYPT EYEPOINT INC 0.9%
Value $45.1M Shares 2,468,314 Est. Cost Unrealized
RNAM AVIDITY BIOSCIENCES INC 0.9%
Value $44.69M Shares 619,530 Est. Cost Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 0.9%
Value $44.57M Shares 314,240 Est. Cost Unrealized
DYN DYNE THERAPEUTICS INC 0.9%
Value $43.07M Shares 2,202,184 Est. Cost Unrealized
BMY BRISTOL-MYERS SQUIBB CO 0.9%
Value $41.8M Shares 775,000 Est. Cost Unrealized
PFE PFIZER INC 0.8%
Value $41.16M Shares 1,652,900 Est. Cost Unrealized
TRVI TREVI THERAPEUTICS INC 0.8%
Value $39.95M Shares 3,190,700 Est. Cost Unrealized
NPCE NEUROPACE INC 0.8%
Value $37.15M Shares 2,406,335 Est. Cost Unrealized
ASND ASCENDIS PHARMA A/S 0.7%
Value $36.67M Shares 171,977 Est. Cost Unrealized
EXAS EXACT SCIENCES CORP 0.7%
Value $35.72M Shares 351,716 Est. Cost Unrealized
MLYS MINERALYS THERAPEUTICS INC 0.7%
Value $35.58M Shares 980,400 Est. Cost Unrealized
ELV ELEVANCE HEALTH INC FORMERLY 0.7%
Value $34.74M Shares 99,100 Est. Cost Unrealized
FBRX FORTE BIOSCIENCES INC 0.7%
Value $32.64M Shares 1,196,955 Est. Cost Unrealized
PRLD PRELUDE THERAPEUTICS INC 0.6%
Value $31.64M Shares 10,909,256 Est. Cost Unrealized
HELP CYBIN INC 0.6%
Value $31.42M Shares 3,840,500 Est. Cost Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.6%
Value $29.79M Shares 3,641,756 Est. Cost Unrealized
KRYS KRYSTAL BIOTECH INC 0.6%
Value $29.54M Shares 119,800 Est. Cost Unrealized
PRAX PRAXIS PRECISION MEDICINES I 0.6%
Value $27.85M Shares 94,500 Est. Cost Unrealized
JANX JANUX THERAPEUTICS INC 0.6%
Value $26.97M Shares 1,954,426 Est. Cost Unrealized
TMO THERMO FISHER SCIENTIFIC INC 0.5%
Value $26.94M Shares 46,500 Est. Cost Unrealized
BRKR BRUKER CORP 0.5%
Value $26.18M Shares 555,789 Est. Cost Unrealized
RYTM RHYTHM PHARMACEUTICALS INC 0.5%
Value $25.67M Shares 239,800 Est. Cost Unrealized
STTK SHATTUCK LABS INC 0.5%
Value $23.02M Shares 6,306,127 Est. Cost Unrealized
ESPR ESPERION THERAPEUTICS INC NE 0.5%
Value $22.07M Shares 5,965,498 Est. Cost Unrealized
AVTX AVALO THERAPEUTICS INC 0.4%
Value $21.56M Shares 1,187,300 Est. Cost Unrealized
LXEO LEXEO THERAPEUTICS INC 0.4%
Value $21.1M Shares 2,125,000 Est. Cost Unrealized
ADCT ADC THERAPEUTICS SA 0.4%
Value $20.55M Shares 5,822,854 Est. Cost Unrealized
URGN UROGEN PHARMA LTD 0.4%
Value $20.5M Shares 875,487 Est. Cost Unrealized
IMAGENEBIO INC 0.4%
Value $20.13M Shares 6,210,899 Est. Cost Unrealized
XENE XENON PHARMACEUTICALS INC 0.4%
Value $20.04M Shares 447,200 Est. Cost Unrealized
BTSG BRIGHTSPRING HEALTH SVCS INC 0.4%
Value $18.29M Shares 488,500 Est. Cost Unrealized
VERA VERA THERAPEUTICS INC 0.4%
Value $17.9M Shares 353,500 Est. Cost Unrealized
QURE UNIQURE NV 0.4%
Value $17.65M Shares 737,400 Est. Cost Unrealized
MIND MEDICINE MINDMED INC 0.3%
Value $16.43M Shares 1,226,700 Est. Cost Unrealized
KROS KEROS THERAPEUTICS INC 0.3%
Value $16.37M Shares 804,212 Est. Cost Unrealized
CARL CARLSMED INC 0.3%
Value $15.47M Shares 1,252,600 Est. Cost Unrealized
CTMX CYTOMX THERAPEUTICS INC 0.3%
Value $15.02M Shares 3,525,650 Est. Cost Unrealized
VIR VIR BIOTECHNOLOGY INC 0.3%
Value $14.36M Shares 2,380,715 Est. Cost Unrealized
BCRX BIOCRYST PHARMACEUTICALS INC 0.3%
Value $13.59M Shares 1,741,800 Est. Cost Unrealized
COGT COGENT BIOSCIENCES INC 0.3%
Value $13.18M Shares 371,000 Est. Cost Unrealized
CRBP CORBUS PHARMACEUTICALS HLDGS 0.3%
Value $13M Shares 1,597,287 Est. Cost Unrealized
EW EDWARDS LIFESCIENCES CORP 0.3%
Value $12.79M Shares 150,000 Est. Cost Unrealized
TARS TARSUS PHARMACEUTICALS INC 0.3%
Value $12.64M Shares 154,400 Est. Cost Unrealized
RLMD RELMADA THERAPEUTICS INC 0.3%
Value $12.61M Shares 2,610,600 Est. Cost Unrealized
TECX TECTONIC THERAPEUTIC INC 0.2%
Value $11.99M Shares 574,600 Est. Cost Unrealized
ALMS ALUMIS INC 0.2%
Value $10.76M Shares 1,102,730 Est. Cost Unrealized
BIOA BIOAGE LABS INC 0.2%
Value $10.46M Shares 790,901 Est. Cost Unrealized
FOLD AMICUS THERAPEUTICS INC 0.2%
Value $10.39M Shares 729,900 Est. Cost Unrealized
WHWK WHITEHAWK THERAPEUTICS INC 0.2%
Value $10.08M Shares 4,166,000 Est. Cost Unrealized
ACET ADICET BIO INC 0.2%
Value $8.655M Shares 1,027,944 Est. Cost Unrealized
REPARE THERAPEUTICS INC 0.2%
Value $8.638M Shares 3,322,488 Est. Cost Unrealized
CELC CELCUITY INC 0.2%
Value $8.544M Shares 85,664 Est. Cost Unrealized
JBIO JADE BIOSCIENCES INC 0.2%
Value $8.196M Shares 531,163 Est. Cost Unrealized
KNSA KINIKSA PHARMACEUTICALS INTL 0.2%
Value $7.722M Shares 187,199 Est. Cost Unrealized
QTTB Q32 BIO INC 0.2%
Value $7.48M Shares 2,252,987 Est. Cost Unrealized
PMVP PMV PHARMACEUTICALS INC 0.1%
Value $6.219M Shares 4,975,291 Est. Cost Unrealized
KALV KALVISTA PHARMACEUTICALS INC 0.1%
Value $6.176M Shares 382,400 Est. Cost Unrealized
PHVS PHARVARIS N V 0.1%
Value $5.7M Shares 205,400 Est. Cost Unrealized
NSPR INSPIREMD INC 0.1%
Value $5.577M Shares 3,133,405 Est. Cost Unrealized
INSM INSMED INC 0.1%
Value $4.421M Shares 25,400 Est. Cost Unrealized
PALI PALISADE BIO INC 0.1%
Value $4.398M Shares 1,871,420 Est. Cost Unrealized
BCAX BICARA THERAPEUTICS INC 0.1%
Value $3.519M Shares 209,100 Est. Cost Unrealized
CGEM CULLINAN THERAPEUTICS INC 0.1%
Value $2.795M Shares 270,006 Est. Cost Unrealized
CCCC C4 THERAPEUTICS INC 0.1%
Value $2.683M Shares 1,404,902 Est. Cost Unrealized
IMA IMAGENEBIO INC 0.1%
Value $2.612M Shares 378,556 Est. Cost Unrealized
ANRO ALTO NEUROSCIENCE INC 0.0%
Value $2.225M Shares 125,000 Est. Cost Unrealized
RVMD REVOLUTION MEDICINES INC 0.0%
Value $2.063M Shares 25,900 Est. Cost Unrealized
VTGN VISTAGEN THERAPEUTICS INC 0.0%
Value $2.025M Shares 3,060,000 Est. Cost Unrealized
OCUL OCULAR THERAPEUTIX INC 0.0%
Value $1.91M Shares 157,300 Est. Cost Unrealized
PTGX PROTAGONIST THERAPEUTICS INC 0.0%
Value $1.895M Shares 21,700 Est. Cost Unrealized
PTCT PTC THERAPEUTICS INC 0.0%
Value $1.762M Shares 23,200 Est. Cost Unrealized
COGENT BIOSCIENCES INC 0.0%
Value $1.174M Shares 1,000,000 Est. Cost Unrealized
MPLT MAPLIGHT THERAPEUTICS INC 0.0%
Value $952K Shares 56,000 Est. Cost Unrealized
TRAW TRAWS PHARMA INC 0.0%
Value $684K Shares 605,531 Est. Cost Unrealized
VTGN VISTAGEN THERAPEUTICS INC 0.0%
Value $29,918 Shares 45,200 Est. Cost Unrealized