SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2018 (← Previous) (Next →)

Filing Date: Feb 14, 2019

Total Value: $887M (100.0% shares, 0.0% debt)

Holdings (100)

XBI SPDR SERIES TRUST 21.8%
Value $194M Shares 2,700,000 Est. Cost $71.73 Unrealized
MYLAN N V 5.2%
Value $45.96M Shares 1,677,241 Est. Cost $36.55 Unrealized
MRK MERCK & CO INC 4.1%
Value $36.07M Shares 472,000 Est. Cost $44.60 Unrealized +26.7%
BMY BRISTOL MYERS SQUIBB CO 3.7%
Value $32.75M Shares 630,000 Est. Cost $44.41 Unrealized -7.7%
CELGENE CORP 3.4%
Value $29.8M Shares 465,000 Est. Cost $64.09 Unrealized
CSTE CAESARSTONE LTD 2.7%
Value $23.81M Shares 469,160 Est. Cost $16.35 Unrealized -10.9%
VERINT SYS INC 2.7%
Value $23.57M Shares 149,100 Est. Cost $50.10 Unrealized
FOLD AMICUS THERAPEUTICS INC 2.6%
Value $23.45M Shares 2,447,994 Est. Cost $12.64 Unrealized -13.0%
GILD GILEAD SCIENCES INC 2.5%
Value $21.89M Shares 350,000 Est. Cost $53.36 Unrealized -0.7%
AZN ASTRAZENECA PLC 2.2%
Value $19.56M Shares 515,000 Est. Cost $37.98 Unrealized
MSFT MICROSOFT CORP 2.0%
Value $17.84M Shares 46,998 Est. Cost $84.87 Unrealized +17.8%
PANW PALO ALTO NETWORKS INC 2.0%
Value $17.51M Shares 24,885 Est. Cost $31.18 Unrealized 0.0%
ALEXION PHARMACEUTICALS INC 1.8%
Value $16.37M Shares 168,100 Est. Cost $117.98 Unrealized
ITRN ITURAN LOCATION AND CONTROL 1.6%
Value $14.64M Shares 122,177 Est. Cost $33.68 Unrealized 0.0%
BLUEBIRD BIO INC 1.6%
Value $13.77M Shares 138,796 Est. Cost $131.35 Unrealized
ALLT ALLOT COMMUNICATIONS LTD 1.5%
Value $13.51M Shares 595,764 Est. Cost $6.11 Unrealized +7.1%
SRPT SAREPTA THERAPEUTICS INC 1.4%
Value $12.72M Shares 116,517 Est. Cost $65.01 Unrealized +92.4%
REATA PHARMACEUTICALS INC 1.4%
Value $12.41M Shares 221,269 Est. Cost $45.52 Unrealized
PTCT PTC THERAPEUTICS INC 1.3%
Value $11.86M Shares 345,500 Est. Cost $39.25 Unrealized -8.4%
GLAXOSMITHKLINE PLC 1.3%
Value $11.85M Shares 310,000 Est. Cost $41.68 Unrealized
TEVA TEVA PHARMACEUTICAL INDS LTD 1.2%
Value $10.86M Shares 704,500 Est. Cost $17.16 Unrealized
ALDX ALDEYRA THERAPEUTICS INC 1.2%
Value $10.23M Shares 1,232,089 Est. Cost $6.86 Unrealized +49.5%
IMMUNOMEDICS INC 1.1%
Value $10.08M Shares 706,539 Est. Cost $15.68 Unrealized
SAGE THERAPEUTICS INC 1.1%
Value $9.914M Shares 103,500 Est. Cost $122.14 Unrealized
MELLANOX TECHNOLOGIES LTD 1.1%
Value $9.787M Shares 28,351 Est. Cost $66.88 Unrealized
ARGX ARGENX SE 0.9%
Value $8.366M Shares 87,081 Est. Cost $75.84 Unrealized
AXOVANT SCIENCES LTD 0.9%
Value $8.167M Shares 8,200,000 Est. Cost $1.00 Unrealized
GW PHARMACEUTICALS PLC 0.8%
Value $7.499M Shares 77,000 Est. Cost $97.39 Unrealized
CLLS CELLECTIS S A 0.8%
Value $7.459M Shares 447,970 Est. Cost $26.60 Unrealized
RETROPHIN INC 0.8%
Value $7.37M Shares 325,678 Est. Cost $24.21 Unrealized
RVLPQ OSMOTICA PHARMACEUTICALS PLC 0.8%
Value $7.147M Shares 922,200 Est. Cost $8.00 Unrealized 0.0%
QURE UNIQURE NV 0.8%
Value $6.711M Shares 232,849 Est. Cost $26.00 Unrealized +7.0%
AUTL AUTOLUS THERAPEUTICS PLC 0.8%
Value $6.666M Shares 202,994 Est. Cost $28.16 Unrealized
GLOBAL BLOOD THERAPEUTICS IN 0.7%
Value $6.034M Shares 147,000 Est. Cost $41.05 Unrealized
ORCHARD THERAPEUTICS PLC 0.7%
Value $5.82M Shares 370,000 Est. Cost $15.73 Unrealized
FORESCOUT TECHNOLOGIES INC 0.6%
Value $5.746M Shares 59,169 Est. Cost $35.61 Unrealized
GILT GILAT SATELLITE NETWORKS LTD 0.6%
Value $5.705M Shares 166,663 Est. Cost $6.90 Unrealized +9.6%
VKTX VIKING THERAPEUTICS INC 0.6%
Value $5.705M Shares 745,727 Est. Cost $3.50 Unrealized +242.0%
ARQULE INC 0.6%
Value $5.63M Shares 2,032,643 Est. Cost $3.57 Unrealized
PRQR PROQR THRAPEUTICS N V 0.6%
Value $5.365M Shares 340,000 Est. Cost $4.64 Unrealized +295.9%
MINERVA NEUROSCIENCES INC 0.6%
Value $5.271M Shares 782,018 Est. Cost $8.19 Unrealized
BIOHAVEN PHARMACTL HLDG CO L 0.6%
Value $4.919M Shares 133,015 Est. Cost $27.69 Unrealized
MHK MOHAWK INDS INC 0.5%
Value $4.659M Shares 10,661 Est. Cost $133.40 Unrealized 0.0%
EPIZYME INC 0.5%
Value $4.617M Shares 749,502 Est. Cost $9.74 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.5%
Value $4.494M Shares 600,000 Est. Cost $10.36 Unrealized
LOGICBIO THERAPEUTICS INC 0.5%
Value $4.343M Shares 417,625 Est. Cost $10.40 Unrealized
RCKT ROCKET PHARMACEUTICALS INC 0.5%
Value $4.298M Shares 290,001 Est. Cost $16.60 Unrealized 0.0%
STRONGBRIDGE BIOPHARMA PLC 0.5%
Value $4.174M Shares 931,600 Est. Cost $5.51 Unrealized
CTMX CYTOMX THERAPEUTICS INC 0.5%
Value $4.125M Shares 273,151 Est. Cost $19.37 Unrealized -23.4%
SRRK SCHOLAR ROCK HLDG CORP 0.5%
Value $4.031M Shares 175,511 Est. Cost $18.86 Unrealized +19.9%
CARA THERAPEUTICS INC 0.4%
Value $3.951M Shares 303,930 Est. Cost $22.22 Unrealized
SGMO SANGAMO THERAPEUTICS INC 0.4%
Value $3.903M Shares 340,000 Est. Cost $12.42 Unrealized 0.0%
SUTRO BIOPHARMA INC 0.4%
Value $3.679M Shares 407,889 Est. Cost $13.05 Unrealized
ASND ASCENDIS PHARMA A S 0.4%
Value $3.651M Shares 58,273 Est. Cost $23.49 Unrealized
NEOS THERAPEUTICS INC 0.4%
Value $3.633M Shares 2,201,697 Est. Cost $3.53 Unrealized
KRYS KRYSTAL BIOTECH INC 0.4%
Value $3.629M Shares 174,625 Est. Cost $20.94 Unrealized 0.0%
HOMOLOGY MEDICINES INC 0.4%
Value $3.6M Shares 161,000 Est. Cost $20.51 Unrealized
EVOKE PHARMA INC 0.4%
Value $3.499M Shares 1,410,946 Est. Cost $2.61 Unrealized
ARVN ARVINAS INC 0.4%
Value $3.483M Shares 271,053 Est. Cost $16.39 Unrealized -3.2%
XBI SPDR SERIES TRUST 0.4%
Value $3.228M Shares 45,000 Est. Cost $71.73 Unrealized
AGIO AGIOS PHARMACEUTICALS INC 0.4%
Value $3.112M Shares 67,500 Est. Cost $61.72 Unrealized 0.0%
KADMON HLDGS INC 0.3%
Value $3.099M Shares 1,490,000 Est. Cost $3.60 Unrealized
ALLO ALLOGENE THERAPEUTICS INC 0.3%
Value $3.055M Shares 113,437 Est. Cost $26.57 Unrealized 0.0%
ACIU AC IMMUNE SA 0.3%
Value $2.935M Shares 310,613 Est. Cost $10.05 Unrealized -6.1%
PORTOLA PHARMACEUTICALS INC 0.3%
Value $2.869M Shares 147,000 Est. Cost $14.31 Unrealized
XENE XENON PHARMACEUTICALS INC 0.3%
Value $2.836M Shares 449,484 Est. Cost $6.63 Unrealized +34.0%
DECIPHERA PHARMACEUTICALS IN 0.3%
Value $2.415M Shares 115,033 Est. Cost $32.02 Unrealized
GLYCOMIMETICS INC 0.3%
Value $2.377M Shares 251,013 Est. Cost $16.45 Unrealized
SAGE THERAPEUTICS INC 0.3%
Value $2.347M Shares 24,500 Est. Cost $122.14 Unrealized
TRANSLATE BIO INC 0.3%
Value $2.321M Shares 309,400 Est. Cost $10.85 Unrealized
VISTAGEN THERAPEUTICS INC 0.2%
Value $2.211M Shares 1,473,918 Est. Cost $2.29 Unrealized
KRNT KORNIT DIGITAL LTD 0.2%
Value $2.122M Shares 30,342 Est. Cost $19.58 Unrealized 0.0%
ARYA SCIENCES ACQUISITION CO 0.2%
Value $2.048M Shares 200,000 Est. Cost $10.24 Unrealized
ABEONA THERAPEUTICS INC 0.2%
Value $1.928M Shares 270,036 Est. Cost $14.54 Unrealized
AERPIO PHARMACEUTICALS INC 0.2%
Value $1.924M Shares 1,131,819 Est. Cost $4.12 Unrealized
ALLENA PHARMACEUTICALS INC 0.2%
Value $1.881M Shares 345,199 Est. Cost $9.60 Unrealized
ZAFGEN INC 0.2%
Value $1.881M Shares 380,000 Est. Cost $10.23 Unrealized
PIERIS PHARMACEUTICALS INC 0.2%
Value $1.862M Shares 700,000 Est. Cost $3.22 Unrealized
ARRAY BIOPHARMA INC 0.2%
Value $1.781M Shares 125,000 Est. Cost $7.93 Unrealized
MOLECULAR TEMPLATES INC 0.2%
Value $1.616M Shares 400,000 Est. Cost $5.39 Unrealized
APLS APELLIS PHARMACEUTICALS INC 0.2%
Value $1.543M Shares 117,000 Est. Cost $20.83 Unrealized -26.3%
UROV UROVANT SCIENCES LTD 0.2%
Value $1.41M Shares 214,030 Est. Cost $10.73 Unrealized
DOVA PHARMACEUTICALS INC 0.2%
Value $1.402M Shares 185,000 Est. Cost $16.26 Unrealized
NICE SYS INC 0.1%
Value $1.286M Shares 250,000 Est. Cost $1.44 Unrealized
MELINTA THERAPEUTICS INC 0.1%
Value $1.282M Shares 1,616,867 Est. Cost $6.61 Unrealized
CLEARSIDE BIOMEDICAL INC 0.1%
Value $1.268M Shares 1,185,124 Est. Cost $8.85 Unrealized
IDERA PHARMACEUTICALS INC 0.1%
Value $1.234M Shares 445,558 Est. Cost $2.77 Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.1%
Value $1.18M Shares 321,430 Est. Cost $12.39 Unrealized -45.0%
SVRA SAVARA INC 0.1%
Value $833K Shares 110,000 Est. Cost $11.50 Unrealized -21.8%
ERYTECH PHARMA 0.1%
Value $796K Shares 120,000 Est. Cost $8.72 Unrealized
VERRICA PHARMACEUTICALS INC 0.1%
Value $791K Shares 97,000 Est. Cost $19.73 Unrealized
MGTX MEIRAGTX HOLDINGS PLC 0.1%
Value $686K Shares 71,159 Est. Cost $12.62 Unrealized 0.0%
SPRING BK PHARMACEUTICALS IN 0.1%
Value $530K Shares 51,015 Est. Cost $10.39 Unrealized
KEZAR LIFE SCIENCES INC 0.1%
Value $472K Shares 20,000 Est. Cost $17.30 Unrealized
SIERRA ONCOLOGY INC 0.0%
Value $341K Shares 258,510 Est. Cost $2.98 Unrealized
CONSTELLATION PHARMCETICLS I 0.0%
Value $281K Shares 70,162 Est. Cost $4.01 Unrealized
CUE CUE BIOPHARMA INC 0.0%
Value $235K Shares 50,000 Est. Cost $7.48 Unrealized -19.1%
ADVERUM BIOTECHNOLOGIES INC 0.0%
Value $200K Shares 63,355 Est. Cost $6.05 Unrealized
BENITEC BIOPHARMA LTD 0.0%
Value $180K Shares 120,000 Est. Cost $2.45 Unrealized
CELLECTAR BIOSCIENCES INC 0.0%
Value $136K Shares 87,500 Est. Cost $3.01 Unrealized