Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2017 (← Previous) (Next →)

Filing Date: May 15, 2017

Total Value: $201M (100.0% shares, 0.0% debt)

Holdings (44)

— BLUEPRINT MEDICINES 17.5%

Value $35.19M Shares 880,000 Est. Cost $27.77 Unrealized —

AXGN AXOGEN INC 10.2%

Value $20.59M Shares 1,970,000 Est. Cost $3.33 Unrealized +206.6%

— FIBROGEN INC 4.0%

Value $8.134M Shares 330,000 Est. Cost $25.62 Unrealized —

— NOVELION THERAPEUTICS INC 3.9%

Value $7.84M Shares 730,000 Est. Cost $10.74 Unrealized —

— CHIMERIX INC 3.9%

Value $7.751M Shares 1,215,000 Est. Cost $5.03 Unrealized —

AGIO AGIOS PHARMACEUTICALS 3.8%

Value $7.592M Shares 130,000 Est. Cost $43.03 Unrealized +11.4%

— CARA THERAPEUTICS 3.5%

Value $7.08M Shares 385,000 Est. Cost $8.65 Unrealized —

TBPH THERAVANCE BIOPHARMA INC 3.3%

Value $6.627M Shares 180,000 Est. Cost $31.13 Unrealized +2.6%

— IMMUNOMEDICS INC 3.1%

Value $6.211M Shares 960,000 Est. Cost $6.47 Unrealized —

— MOMENTA PHARMACEUTICALS INC 2.9%

Value $5.874M Shares 440,000 Est. Cost $14.63 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 2.9%

Value $5.871M Shares 340,000 Est. Cost $12.30 Unrealized +7.0%

CDXS CODEXIS INC 2.8%

Value $5.616M Shares 1,170,000 Est. Cost $1.98 Unrealized +129.9%

— STRONGBRIDGE BIOPHARMA PLC 2.8%

Value $5.605M Shares 1,180,000 Est. Cost $2.44 Unrealized —

— LOXO ONCOLOGY 2.7%

Value $5.47M Shares 130,000 Est. Cost $27.48 Unrealized —

OCUL OCULAR THERAPEUTIX INC 2.5%

Value $5.104M Shares 550,000 Est. Cost $8.23 Unrealized +1.2%

— ADAMAS PHARMACEUTICALS INC 2.5%

Value $5.075M Shares 290,000 Est. Cost $18.61 Unrealized —

PRTA PROTHENA CORP PLC 2.4%

Value $4.859M Shares 87,100 Est. Cost $54.16 Unrealized -3.0%

EGRX EAGLE PHARMACEUTICALS INC 2.1%

Value $4.147M Shares 50,000 Est. Cost $67.25 Unrealized +10.6%

— IMPRIMIS PHARMACEUTICALS INC 1.8%

Value $3.588M Shares 860,500 Est. Cost $2465.93 Unrealized —

— SAGE THERAPEUTICS INC 1.6%

Value $3.198M Shares 45,000 Est. Cost $55.50 Unrealized —

— NEURODERM LTD 1.6%

Value $3.186M Shares 120,000 Est. Cost $16.69 Unrealized —

ENTA ENANTA PHARMACEUTICALS INC 1.5%

Value $3.08M Shares 100,000 Est. Cost $28.91 Unrealized +7.7%

SGMO SANGAMO BIOSCIENCES INC 1.5%

Value $3.021M Shares 581,000 Est. Cost $3.76 Unrealized +6.8%

— PROTALIX BIOTHERAPEUTICS INC 1.3%

Value $2.624M Shares 1,930,000 Est. Cost $1.32 Unrealized —

— EDGE THERAPEUTICS INC 1.3%

Value $2.55M Shares 280,000 Est. Cost $9.54 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 1.2%

Value $2.475M Shares 500,000 Est. Cost $7.65 Unrealized —

— ZOSANO PHARMA CORP 1.2%

Value $2.375M Shares 1,250,000 Est. Cost $1.90 Unrealized —

— SUNESIS PHARMACEUTICALS INC 1.1%

Value $2.255M Shares 550,000 Est. Cost $4.10 Unrealized —

WVE WAVE LIFE SCIENCES LTD 1.1%

Value $2.153M Shares 78,300 Est. Cost $27.93 Unrealized 0.0%

— AEVI GENOMIC MEDICINE INC 1.0%

Value $1.99M Shares 1,070,000 Est. Cost $5.18 Unrealized —

— PORTOLA PHARMACEUTICALS INC 1.0%

Value $1.959M Shares 50,000 Est. Cost $39.18 Unrealized —

— LION BIOTECHNOLOGIES INC 0.9%

Value $1.713M Shares 230,000 Est. Cost $8.03 Unrealized —

XENE XENON PHARMACEUTICALS INC 0.7%

Value $1.44M Shares 360,000 Est. Cost $8.69 Unrealized -9.6%

— AQUINOX PHARMACEUTICALS INC 0.7%

Value $1.418M Shares 85,000 Est. Cost $6.95 Unrealized —

— ABEONA THERAPEUTICS INC 0.7%

Value $1.375M Shares 275,000 Est. Cost $5.14 Unrealized —

— TONIX PHARMACEUTICALS HOLDING 0.5%

Value $1.097M Shares 235,000 Est. Cost $4.67 Unrealized —

— CIDARA THERAPEUTICS INC 0.5%

Value $955K Shares 122,500 Est. Cost $7.80 Unrealized —

— ALBIREO PHARMA INC 0.4%

Value $876K Shares 36,500 Est. Cost $24.00 Unrealized —

— KARYOPHARM THERAPEUTICS INC 0.4%

Value $770K Shares 60,000 Est. Cost $12.83 Unrealized —

— CORIUM INTERNATIONAL INC 0.3%

Value $677K Shares 162,000 Est. Cost $7.82 Unrealized —

— ARQULE INC 0.3%

Value $593K Shares 560,000 Est. Cost $1.06 Unrealized —

— SYROS PHARMACEUTICALS INC 0.2%

Value $400K Shares 25,149 Est. Cost $15.91 Unrealized —

XOMA XOMA CORP DEL 0.1%

Value $287K Shares 40,400 Est. Cost $5.14 Unrealized 0.0%

— BIOLINERX LTD 0.1%

Value $240K Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	BLUEPRINT MEDICINES	880,000	$35.19M	17.5%	$27.77	—	COM	09627Y109
AXGN	AXOGEN INC	1,970,000	$20.59M	10.2%	$3.33	+206.6%	COM	05463X106
—	FIBROGEN INC	330,000	$8.134M	4.0%	$25.62	—	COM	31572Q808
—	NOVELION THERAPEUTICS INC	730,000	$7.84M	3.9%	$10.74	—	COM NEW	67001K202
—	CHIMERIX INC	1,215,000	$7.751M	3.9%	$5.03	—	COM	16934W106
AGIO	AGIOS PHARMACEUTICALS	130,000	$7.592M	3.8%	$43.03	+11.4%	COM	00847X104
—	CARA THERAPEUTICS	385,000	$7.08M	3.5%	$8.65	—	COM	140755109
TBPH	THERAVANCE BIOPHARMA INC	180,000	$6.627M	3.3%	$31.13	+2.6%	COM	G8807B106
—	IMMUNOMEDICS INC	960,000	$6.211M	3.1%	$6.47	—	COM	452907108
—	MOMENTA PHARMACEUTICALS INC	440,000	$5.874M	2.9%	$14.63	—	COM	60877T100
CTMX	CYTOMX THERAPEUTICS INC	340,000	$5.871M	2.9%	$12.30	+7.0%	COM	23284F105
CDXS	CODEXIS INC	1,170,000	$5.616M	2.8%	$1.98	+129.9%	COM	192005106
—	STRONGBRIDGE BIOPHARMA PLC	1,180,000	$5.605M	2.8%	$2.44	—	COM	G85347105
—	LOXO ONCOLOGY	130,000	$5.47M	2.7%	$27.48	—	COM	548862101
OCUL	OCULAR THERAPEUTIX INC	550,000	$5.104M	2.5%	$8.23	+1.2%	COM	67576A100
—	ADAMAS PHARMACEUTICALS INC	290,000	$5.075M	2.5%	$18.61	—	COM	00548A106
PRTA	PROTHENA CORP PLC	87,100	$4.859M	2.4%	$54.16	-3.0%	SHS	G72800108
EGRX	EAGLE PHARMACEUTICALS INC	50,000	$4.147M	2.1%	$67.25	+10.6%	COM	269796108
—	IMPRIMIS PHARMACEUTICALS INC	860,500	$3.588M	1.8%	$2465.93	—	COM NEW	45323A201
—	SAGE THERAPEUTICS INC	45,000	$3.198M	1.6%	$55.50	—	COM	78667J108
—	NEURODERM LTD	120,000	$3.186M	1.6%	$16.69	—	ORD SHS	M74231107
ENTA	ENANTA PHARMACEUTICALS INC	100,000	$3.08M	1.5%	$28.91	+7.7%	COM	29251M106
SGMO	SANGAMO BIOSCIENCES INC	581,000	$3.021M	1.5%	$3.76	+6.8%	COM	800677106
—	PROTALIX BIOTHERAPEUTICS INC	1,930,000	$2.624M	1.3%	$1.32	—	COM	74365AAB7
—	EDGE THERAPEUTICS INC	280,000	$2.55M	1.3%	$9.54	—	COM	279870109
—	FOAMIX PHARMACEUTICALS LTD	500,000	$2.475M	1.2%	$7.65	—	SHS	M46135105
—	ZOSANO PHARMA CORP	1,250,000	$2.375M	1.2%	$1.90	—	COM	98979H103
—	SUNESIS PHARMACEUTICALS INC	550,000	$2.255M	1.1%	$4.10	—	COM PAR	867328700
WVE	WAVE LIFE SCIENCES LTD	78,300	$2.153M	1.1%	$27.93	0.0%	SHS	Y95308105
—	AEVI GENOMIC MEDICINE INC	1,070,000	$1.99M	1.0%	$5.18	—	COM	00835P105
—	PORTOLA PHARMACEUTICALS INC	50,000	$1.959M	1.0%	$39.18	—	COM	737010108
—	LION BIOTECHNOLOGIES INC	230,000	$1.713M	0.9%	$8.03	—	COM	53619R102
XENE	XENON PHARMACEUTICALS INC	360,000	$1.44M	0.7%	$8.69	-9.6%	COM	98420N105
—	AQUINOX PHARMACEUTICALS INC	85,000	$1.418M	0.7%	$6.95	—	COM	03842B101
—	ABEONA THERAPEUTICS INC	275,000	$1.375M	0.7%	$5.14	—	COM	00289Y107
—	TONIX PHARMACEUTICALS HOLDING	235,000	$1.097M	0.5%	$4.67	—	COM NEW	890260201
—	CIDARA THERAPEUTICS INC	122,500	$955K	0.5%	$7.80	—	COM	171757107
—	ALBIREO PHARMA INC	36,500	$876K	0.4%	$24.00	—	COM	01345P106
—	KARYOPHARM THERAPEUTICS INC	60,000	$770K	0.4%	$12.83	—	COM	48576U106
—	CORIUM INTERNATIONAL INC	162,000	$677K	0.3%	$7.82	—	COM	21887L107
—	ARQULE INC	560,000	$593K	0.3%	$1.06	—	COM	04269E107
—	SYROS PHARMACEUTICALS INC	25,149	$400K	0.2%	$15.91	—	COM	87184Q107
XOMA	XOMA CORP DEL	40,400	$287K	0.1%	$5.14	0.0%	COM NEW	98419J206
—	BIOLINERX LTD	250,000	$240K	0.1%	$1426.15	—	SPONSORED ADR	09071M106