Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2016 (← Previous) (Next →)

Filing Date: Feb 21, 2017

Total Value ($000): $169,717 (100.0% shares, 0.0% debt)

Holdings (40)

— BLUEPRINT MEDICINES 14.5%

Value ($000) $24,684 Shares 880,000 Est. Cost $27.77 Unrealized —

AXGN AXOGEN INC 10.4%

Value ($000) $17,730 Shares 1,970,000 Est. Cost $3.33 Unrealized +159.0%

— ARIAD PHARMACEUTICALS INC 7.3%

Value ($000) $12,440 Shares 1,000,000 Est. Cost $6983.72 Unrealized —

— AEVI GENOMIC MEDICINE INC 4.6%

Value ($000) $7,770 Shares 1,500,000 Est. Cost $5.18 Unrealized —

— FIBROGEN INC 4.2%

Value ($000) $7,062 Shares 330,000 Est. Cost $25.62 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 3.2%

Value ($000) $5,495 Shares 495,000 Est. Cost $7.68 Unrealized —

AGIO AGIOS PHARMACEUTICALS 3.2%

Value ($000) $5,425 Shares 130,000 Est. Cost $43.03 Unrealized +21.9%

CDXS CODEXIS INC 3.2%

Value ($000) $5,382 Shares 1,170,000 Est. Cost $1.98 Unrealized +136.5%

— CHIMERIX INC 3.2%

Value ($000) $5,382 Shares 1,170,000 Est. Cost $4.98 Unrealized —

— AQUINOX PHARMACEUTICALS INC 3.0%

Value ($000) $5,118 Shares 310,000 Est. Cost $6.95 Unrealized —

TBPH THERAVANCE BIOPHARMA INC 3.0%

Value ($000) $5,043 Shares 158,200 Est. Cost $31.02 Unrealized 0.0%

— MOMENTA PHARMACEUTICALS INC 2.9%

Value ($000) $4,967 Shares 330,000 Est. Cost $15.05 Unrealized —

— ADAMAS PHARMACEUTICALS INC 2.8%

Value ($000) $4,817 Shares 285,000 Est. Cost $18.63 Unrealized —

— CARA THERAPEUTICS 2.6%

Value ($000) $4,413 Shares 475,000 Est. Cost $8.65 Unrealized —

PRTA PROTHENA CORP PLC 2.4%

Value ($000) $4,058 Shares 82,500 Est. Cost $54.25 Unrealized +1.7%

— LOXO ONCOLOGY 2.4%

Value ($000) $4,014 Shares 125,000 Est. Cost $26.89 Unrealized —

EGRX EAGLE PHARMACEUTICALS INC 2.3%

Value ($000) $3,967 Shares 50,000 Est. Cost $67.25 Unrealized +8.0%

— EDGE THERAPEUTICS INC 2.1%

Value ($000) $3,500 Shares 280,000 Est. Cost $9.54 Unrealized —

MGNX MACROGENICS INC 2.0%

Value ($000) $3,475 Shares 170,000 Est. Cost $24.33 Unrealized +3.4%

XENE XENON PHARMACEUTICALS INC 1.8%

Value ($000) $3,119 Shares 405,000 Est. Cost $8.69 Unrealized -7.6%

ENTA ENANTA PHARMACEUTICALS INC 1.8%

Value ($000) $3,015 Shares 90,000 Est. Cost $28.66 Unrealized 0.0%

— STRONGBRIDGE BIOPHARMA PLC 1.6%

Value ($000) $2,784 Shares 1,160,000 Est. Cost $2.40 Unrealized —

OMER OMEROS CORP 1.6%

Value ($000) $2,632 Shares 265,300 Est. Cost $10.20 Unrealized 0.0%

— CLEARSIDE BIOMEDICAL INC 1.4%

Value ($000) $2,414 Shares 270,000 Est. Cost $8.94 Unrealized —

— LION BIOTECHNOLOGIES INC 1.2%

Value ($000) $2,085 Shares 300,000 Est. Cost $8.03 Unrealized —

— ABEONA THERAPEUTICS INC 1.1%

Value ($000) $1,940 Shares 400,000 Est. Cost $5.14 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 1.1%

Value ($000) $1,868 Shares 170,000 Est. Cost $11.45 Unrealized +5.8%

— PROTEOSTASIS THERAPEUTICS INC 1.1%

Value ($000) $1,839 Shares 150,000 Est. Cost $13.20 Unrealized —

— IMPRIMIS PHARMACEUTICALS INC 1.1%

Value ($000) $1,800 Shares 720,000 Est. Cost $2946.31 Unrealized —

— SAGE THERAPEUTICS INC 1.1%

Value ($000) $1,787 Shares 35,000 Est. Cost $51.06 Unrealized —

— NEURODERM LTD 1.0%

Value ($000) $1,731 Shares 115,000 Est. Cost $16.26 Unrealized —

— WAFERGEN BIO-SYSTEMS INC 0.9%

Value ($000) $1,578 Shares 320,000 Est. Cost $4.93 Unrealized —

— CORIUM INTERNATIONAL INC 0.9%

Value ($000) $1,543 Shares 380,000 Est. Cost $7.82 Unrealized —

SGMO SANGAMO BIOSCIENCES INC 0.7%

Value ($000) $1,220 Shares 400,000 Est. Cost $3.64 Unrealized 0.0%

— ACHAOGEN INC 0.6%

Value ($000) $1,041 Shares 80,000 Est. Cost $13.01 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 0.5%

Value ($000) $859 Shares 1,930,000 Est. Cost $1.32 Unrealized —

OCUL OCULAR THERAPEUTIX INC 0.5%

Value ($000) $783 Shares 93,600 Est. Cost $7.76 Unrealized 0.0%

— TRILLIUM THERAPEUTICS INC 0.4%

Value ($000) $622 Shares 110,000 Est. Cost $9.00 Unrealized —

— BIOLINERX LTD 0.1%

Value ($000) $230 Shares 250,000 Est. Cost $1426.15 Unrealized —

— AGILE THERAPEUTICS INC 0.1%

Value ($000) $85 Shares 15,000 Est. Cost $5.67 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	BLUEPRINT MEDICINES	880,000	$24,684	14.5%	$27.77	—	COM	09627Y109
AXGN	AXOGEN INC	1,970,000	$17,730	10.4%	$3.33	+159.0%	COM	05463X106
—	ARIAD PHARMACEUTICALS INC	1,000,000	$12,440	7.3%	$6983.72	—	COM	04033A100
—	AEVI GENOMIC MEDICINE INC	1,500,000	$7,770	4.6%	$5.18	—	COM	00835P105
—	FIBROGEN INC	330,000	$7,062	4.2%	$25.62	—	COM	31572Q808
—	FOAMIX PHARMACEUTICALS LTD	495,000	$5,495	3.2%	$7.68	—	SHS	M46135105
AGIO	AGIOS PHARMACEUTICALS	130,000	$5,425	3.2%	$43.03	+21.9%	COM	00847X104
CDXS	CODEXIS INC	1,170,000	$5,382	3.2%	$1.98	+136.5%	COM	192005106
—	CHIMERIX INC	1,170,000	$5,382	3.2%	$4.98	—	COM	16934W106
—	AQUINOX PHARMACEUTICALS INC	310,000	$5,118	3.0%	$6.95	—	COM	03842B101
TBPH	THERAVANCE BIOPHARMA INC	158,200	$5,043	3.0%	$31.02	0.0%	ORD SHS	G8807B106
—	MOMENTA PHARMACEUTICALS INC	330,000	$4,967	2.9%	$15.05	—	COM	60877T100
—	ADAMAS PHARMACEUTICALS INC	285,000	$4,817	2.8%	$18.63	—	COM	00548A106
—	CARA THERAPEUTICS	475,000	$4,413	2.6%	$8.65	—	COM	140755109
PRTA	PROTHENA CORP PLC	82,500	$4,058	2.4%	$54.25	+1.7%	SHS	G72800108
—	LOXO ONCOLOGY	125,000	$4,014	2.4%	$26.89	—	COM	548862101
EGRX	EAGLE PHARMACEUTICALS INC	50,000	$3,967	2.3%	$67.25	+8.0%	COM	269796108
—	EDGE THERAPEUTICS INC	280,000	$3,500	2.1%	$9.54	—	COM	279870109
MGNX	MACROGENICS INC	170,000	$3,475	2.0%	$24.33	+3.4%	COM	556099109
XENE	XENON PHARMACEUTICALS INC	405,000	$3,119	1.8%	$8.69	-7.6%	COM	98420N105
ENTA	ENANTA PHARMACEUTICALS INC	90,000	$3,015	1.8%	$28.66	0.0%	COM	29251M106
—	STRONGBRIDGE BIOPHARMA PLC	1,160,000	$2,784	1.6%	$2.40	—	ORD SHS	G85347105
OMER	OMEROS CORP	265,300	$2,632	1.6%	$10.20	0.0%	COM	682143102
—	CLEARSIDE BIOMEDICAL INC	270,000	$2,414	1.4%	$8.94	—	COM	185063104
—	LION BIOTECHNOLOGIES INC	300,000	$2,085	1.2%	$8.03	—	COM	53619R102
—	ABEONA THERAPEUTICS INC	400,000	$1,940	1.1%	$5.14	—	COM	00289Y107
CTMX	CYTOMX THERAPEUTICS INC	170,000	$1,868	1.1%	$11.45	+5.8%	COM	23284F105
—	PROTEOSTASIS THERAPEUTICS INC	150,000	$1,839	1.1%	$13.20	—	COM	74373B109
—	IMPRIMIS PHARMACEUTICALS INC	720,000	$1,800	1.1%	$2946.31	—	COM NEW	45323A201
—	SAGE THERAPEUTICS INC	35,000	$1,787	1.1%	$51.06	—	COM	78667J108
—	NEURODERM LTD	115,000	$1,731	1.0%	$16.26	—	ORD SHS	M74231107
—	WAFERGEN BIO-SYSTEMS INC	320,000	$1,578	0.9%	$4.93	—	COM	93041P506
—	CORIUM INTERNATIONAL INC	380,000	$1,543	0.9%	$7.82	—	COM	21887L107
SGMO	SANGAMO BIOSCIENCES INC	400,000	$1,220	0.7%	$3.64	0.0%	COM	800677106
—	ACHAOGEN INC	80,000	$1,041	0.6%	$13.01	—	COM	004449104
—	PROTALIX BIOTHERAPEUTICS INC	1,930,000	$859	0.5%	$1.32	—	COM	74365AAB7
OCUL	OCULAR THERAPEUTIX INC	93,600	$783	0.5%	$7.76	0.0%	COM	67576A100
—	TRILLIUM THERAPEUTICS INC	110,000	$622	0.4%	$9.00	—	COM NEW	89620X506
—	BIOLINERX LTD	250,000	$230	0.1%	$1426.15	—	SPONSORED ADR	09071M106
—	AGILE THERAPEUTICS INC	15,000	$85	0.1%	$5.67	—	COM	00847L100