ARRIVENT BIOPHARMA INC

Institution	Shares	Value ($000)
Rosalind Advisors, Inc.	215,871	$4,343
Affinity Asset Advisors, LLC	150,000	$3,018
Persistent Asset Partners Ltd	7,963	$160
TEMA ETFS LLC	32,007	$644
XTX Topco Ltd	26,253	$528
Point72 Asset Management, L.P.	216,660	$4,359
D. E. Shaw & Co., Inc.	233,324	$4,694
CITADEL ADVISORS LLC	458,502	$9,225
PROFUND ADVISORS LLC	10,984	$221
NEOS Investment Management LLC	32,487	$654
ALPS ADVISORS INC	33,896	$682
Aquatic Capital Management LLC	12,304	$248
SUSQUEHANNA INTERNATIONAL GROUP, LLP	242,828	$4,886
LOS ANGELES CAPITAL MANAGEMENT LLC	40,300	$744
AMERIPRISE FINANCIAL INC	118,485	$2,384
JANE STREET GROUP, LLC	103,255	$2,077
BALYASNY ASSET MANAGEMENT L.P.	43,030	$866
Quadrature Capital Ltd	12,763	$257
Brevan Howard Capital Management LP	16,635	$335
INTECH INVESTMENT MANAGEMENT LLC	11,007	$221

Increased Positions (40)

INFINITUM ASSET MANAGEMENT, LLC

Value ($000) $82,973 (+16.2%) Shares 4,123,923 (+6.6%)

SUVRETTA CAPITAL MANAGEMENT, LLC

Value ($000) $82,613 (+20.9%) Shares 4,106,035 (+10.9%)

Virtus Investment Advisers, LLC

Value ($000) $219 (+146.7%) Shares 10,894 (+126.2%)

GOLDMAN SACHS GROUP INC

Value ($000) $14,940 (+87.5%) Shares 742,526 (+71.9%)

FMR LLC

Value ($000) $74,516 (+18.5%) Shares 3,703,572 (+8.7%)

ExodusPoint Capital Management, LP

Value ($000) $1,210 (+81.5%) Shares 60,129 (+66.4%)

BlackRock, Inc.

Value ($000) $47,742 (+26.5%) Shares 2,372,838 (+16.0%)

BARCLAYS PLC

Value ($000) $2,599 (+166.4%) Shares 129,173 (+211.1%)

Squarepoint Ops LLC

Value ($000) $3,752 (+58.5%) Shares 186,492 (+45.3%)

STATE STREET CORP

Value ($000) $21,971 (+15.9%) Shares 1,091,980 (+6.3%)

JPMORGAN CHASE & CO

Value ($000) $1,396 (+440.9%) Shares 69,394 (+396.0%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $15,164 (+14.7%) Shares 753,519 (+5.2%)

SIMPLEX TRADING, LLC

Value ($000) $917 (+668970.1%) Shares 45,558 (+511.2%)

WELLS FARGO & COMPANY/MN

Value ($000) $649 (+131.9%) Shares 32,280 (+112.7%)

NORTHERN TRUST CORP

Value ($000) $4,941 (+15.9%) Shares 245,599 (+6.2%)

BANK OF AMERICA CORP /DE/

Value ($000) $1,137 (+34.1%) Shares 56,521 (+22.9%)

Bank of New York Mellon Corp

Value ($000) $1,471 (+26.0%) Shares 73,111 (+15.5%)

Jump Financial, LLC

Value ($000) $487 (+29.5%) Shares 24,221 (+18.7%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $5,042 (+12.2%) Shares 250,588 (+2.9%)

Nuveen, LLC

Value ($000) $1,079 (+22.7%) Shares 53,618 (+12.5%)

Institution	Prev Shares	Curr Shares	Change
INFINITUM ASSET MANAGEMENT, LLC	3,868,923	4,123,923	+255,000 (+6.6%)
SUVRETTA CAPITAL MANAGEMENT, LLC	3,703,452	4,106,035	+402,583 (+10.9%)
Virtus Investment Advisers, LLC	4,816	10,894	+6,078 (+126.2%)
GOLDMAN SACHS GROUP INC	431,939	742,526	+310,587 (+71.9%)
FMR LLC	3,407,549	3,703,572	+296,023 (+8.7%)
ExodusPoint Capital Management, LP	36,136	60,129	+23,993 (+66.4%)
BlackRock, Inc.	2,046,138	2,372,838	+326,700 (+16.0%)
BARCLAYS PLC	41,522	129,173	+87,651 (+211.1%)
Squarepoint Ops LLC	128,307	186,492	+58,185 (+45.3%)
STATE STREET CORP	1,027,628	1,091,980	+64,352 (+6.3%)
JPMORGAN CHASE & CO	13,991	69,394	+55,403 (+396.0%)
GEODE CAPITAL MANAGEMENT, LLC	716,288	753,519	+37,231 (+5.2%)
SIMPLEX TRADING, LLC	7,454	45,558	+38,104 (+511.2%)
WELLS FARGO & COMPANY/MN	15,179	32,280	+17,101 (+112.7%)
NORTHERN TRUST CORP	231,167	245,599	+14,432 (+6.2%)
BANK OF AMERICA CORP /DE/	45,977	56,521	+10,544 (+22.9%)
Bank of New York Mellon Corp	63,283	73,111	+9,828 (+15.5%)
Jump Financial, LLC	20,400	24,221	+3,821 (+18.7%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	243,486	250,588	+7,102 (+2.9%)
Nuveen, LLC	47,663	53,618	+5,955 (+12.5%)

Decreased Positions (34)

HHLR ADVISORS, LTD.

Value ($000) $79,054 (-4.5%) Shares 3,929,117 (-12.4%)

Hidden Lake Asset Management LP

Value ($000) $3,067 (-47.1%) Shares 152,448 (-51.5%)

Fund 1 Investments, LLC

Value ($000) $11,385 (-0.4%) Shares 565,851 (-8.7%)

Anson Funds Management LP

Value ($000) $712 (-61.4%) Shares 35,366 (-64.6%)

AlphaQuest LLC

Value ($000) $56 (-92.6%) Shares 2,800 (-93.2%)

SECTORAL ASSET MANAGEMENT INC

Value ($000) $770 (+6.3%) Shares 38,255 (-2.5%)

Woodline Partners LP

Value ($000) $2,965 (-45.9%) Shares 147,386 (-50.4%)

Moody Aldrich Partners LLC

Value ($000) $1,140 (+3.9%) Shares 56,659 (-4.7%)

MORGAN STANLEY

Value ($000) $1,964 (-72.9%) Shares 97,590 (-75.1%)

MARSHALL WACE, LLP

Value ($000) $1,992 (-40.1%) Shares 98,984 (-45.1%)

VANGUARD GROUP INC

Value ($000) $37,610 (+0.4%) Shares 1,869,266 (-7.9%)

UBS Group AG

Value ($000) $9,073 (-1.2%) Shares 450,920 (-9.4%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $110 (-85.9%) Shares 5,473 (-87.1%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,559 (-7.9%) Shares 77,479 (-15.5%)

ROYAL BANK OF CANADA

Value ($000) $21 (-93.6%) Shares 981 (-94.5%)

TWO SIGMA ADVISERS, LP

Value ($000) $746 (-7.6%) Shares 37,100 (-15.3%)

Walleye Capital LLC

Value ($000) $445 (-13.1%) Shares 22,115 (-20.4%)

Rafferty Asset Management, LLC

Value ($000) $581 (-8.3%) Shares 28,878 (-16.0%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $5,673 (+7.5%) Shares 281,952 (-1.5%)

RHUMBLINE ADVISERS

Value ($000) $633 (+1.5%) Shares 31,456 (-6.9%)

Institution	Prev Shares	Curr Shares	Change
HHLR ADVISORS, LTD.	4,484,672	3,929,117	-555,555 (-12.4%)
Hidden Lake Asset Management LP	314,036	152,448	-161,588 (-51.5%)
Fund 1 Investments, LLC	619,851	565,851	-54,000 (-8.7%)
Anson Funds Management LP	99,887	35,366	-64,521 (-64.6%)
AlphaQuest LLC	41,449	2,800	-38,649 (-93.2%)
SECTORAL ASSET MANAGEMENT INC	39,235	38,255	-980 (-2.5%)
Woodline Partners LP	296,916	147,386	-149,530 (-50.4%)
Moody Aldrich Partners LLC	59,454	56,659	-2,795 (-4.7%)
MORGAN STANLEY	392,022	97,590	-294,432 (-75.1%)
MARSHALL WACE, LLP	180,223	98,984	-81,239 (-45.1%)
VANGUARD GROUP INC	2,029,531	1,869,266	-160,265 (-7.9%)
UBS Group AG	497,601	450,920	-46,681 (-9.4%)
BNP PARIBAS ARBITRAGE, SA	42,268	5,473	-36,795 (-87.1%)
TWO SIGMA INVESTMENTS, LP	91,718	77,479	-14,239 (-15.5%)
ROYAL BANK OF CANADA	17,794	981	-16,813 (-94.5%)
TWO SIGMA ADVISERS, LP	43,800	37,100	-6,700 (-15.3%)
Walleye Capital LLC	27,768	22,115	-5,653 (-20.4%)
Rafferty Asset Management, LLC	34,361	28,878	-5,483 (-16.0%)
MILLENNIUM MANAGEMENT LLC	286,104	281,952	-4,152 (-1.5%)
RHUMBLINE ADVISERS	33,803	31,456	-2,347 (-6.9%)

Exited Positions (13)

Siren, L.L.C.

Value ($000) $12,915 Shares 700,000

COOPERMAN LEON G

Value ($000) $7,773 Shares 421,278

FRANKLIN RESOURCES INC

Value ($000) $4,731 Shares 256,422

Corient Private Wealth LLC

Value ($000) $618 Shares 33,500

Verition Fund Management LLC

Value ($000) $278 Shares 15,045

WEXFORD CAPITAL LP

Value ($000) $29 Shares 1,567

Caption Management, LLC

Value ($000) $129 Shares 7,000

Parallel Advisors, LLC

Value ($000) $2 Shares 82

PRINCIPAL SECURITIES, INC.

Value ($000) $0 Shares 16

MONTAG A & ASSOCIATES INC

Value ($000) $0 Shares 11

BESSEMER GROUP INC

Value ($000) $0 Shares 1,395

Clearstead Advisors, LLC

Value ($000) $0 Shares 1

IFP Advisors, Inc

Value ($000) $0 Shares 1

Institution	Prev Shares	Prev Value ($000)
Siren, L.L.C.	700,000	$12,915
COOPERMAN LEON G	421,278	$7,773
FRANKLIN RESOURCES INC	256,422	$4,731
Corient Private Wealth LLC	33,500	$618
Verition Fund Management LLC	15,045	$278
WEXFORD CAPITAL LP	1,567	$29
Caption Management, LLC	7,000	$129
Parallel Advisors, LLC	82	$2
PRINCIPAL SECURITIES, INC.	16	$0
MONTAG A & ASSOCIATES INC	11	$0
BESSEMER GROUP INC	1,395	$0
Clearstead Advisors, LLC	1	$0
IFP Advisors, Inc	1	$0