| INFINITUM ASSET MANAGEMENT, LLC | 4,123,923 | $82,973 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,106,035 | $82,613 |
| HHLR ADVISORS, LTD. | 3,929,117 | $79,054 |
| FMR LLC | 3,703,572 | $74,516 |
| ORBIMED ADVISORS LLC | 3,027,328 | $60,910 |
| BlackRock, Inc. | 2,372,838 | $47,742 |
| Octagon Capital Advisors LP | 1,971,054 | $39,658 |
| Novo Holdings A/S | 1,942,142 | $39,076 |
| VANGUARD GROUP INC | 1,869,266 | $37,610 |
| Sofinnova Investments, Inc. | 1,696,752 | $34,139 |
| General Catalyst Group Management, LLC | 1,494,786 | $30,075 |
| STATE STREET CORP | 1,091,980 | $21,971 |
| GEODE CAPITAL MANAGEMENT, LLC | 753,519 | $15,164 |
| GOLDMAN SACHS GROUP INC | 742,526 | $14,940 |
| HSG Holding Ltd | 663,308 | $16,715 |
| AIHC Capital Management Ltd | 644,788 | $12,973 |
| Fund 1 Investments, LLC | 565,851 | $11,385 |
| CITADEL ADVISORS LLC | 458,502 | $9,225 |
| UBS Group AG | 450,920 | $9,073 |
| MILLENNIUM MANAGEMENT LLC | 281,952 | $5,673 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,588 | $5,042 |
| NORTHERN TRUST CORP | 245,599 | $4,941 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,828 | $4,886 |
| D. E. Shaw & Co., Inc. | 233,324 | $4,694 |
| Point72 Asset Management, L.P. | 216,660 | $4,359 |
| Rosalind Advisors, Inc. | 215,871 | $4,343 |
| Squarepoint Ops LLC | 186,492 | $3,752 |
| Hidden Lake Asset Management LP | 152,448 | $3,067 |
| Affinity Asset Advisors, LLC | 150,000 | $3,018 |
| Woodline Partners LP | 147,386 | $2,965 |
| BARCLAYS PLC | 129,173 | $2,599 |
| AMERIPRISE FINANCIAL INC | 118,485 | $2,384 |
| JANE STREET GROUP, LLC | 103,255 | $2,077 |
| Burkehill Global Management, LP | 100,000 | $2,012 |
| MARSHALL WACE, LLP | 98,984 | $1,992 |
| MORGAN STANLEY | 97,590 | $1,964 |
| WELLINGTON MANAGEMENT GROUP LLP | 82,278 | $1,655 |
| TWO SIGMA INVESTMENTS, LP | 77,479 | $1,559 |
| Bank of New York Mellon Corp | 73,111 | $1,471 |
| JPMORGAN CHASE & CO | 69,394 | $1,396 |
| ExodusPoint Capital Management, LP | 60,129 | $1,210 |
| Moody Aldrich Partners LLC | 56,659 | $1,140 |
| BANK OF AMERICA CORP /DE/ | 56,521 | $1,137 |
| Nuveen, LLC | 53,618 | $1,079 |
| HRT FINANCIAL LP | 53,424 | $1 |
| SG Americas Securities, LLC | 51,437 | $1 |
| SIMPLEX TRADING, LLC | 45,558 | $917 |
| BALYASNY ASSET MANAGEMENT L.P. | 43,030 | $866 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 40,300 | $744 |
| Swiss National Bank | 40,000 | $805 |
| SECTORAL ASSET MANAGEMENT INC | 38,255 | $770 |
| TWO SIGMA ADVISERS, LP | 37,100 | $746 |
| Anson Funds Management LP | 35,366 | $712 |
| ALPS ADVISORS INC | 33,896 | $682 |
| NEOS Investment Management LLC | 32,487 | $654 |
| WELLS FARGO & COMPANY/MN | 32,280 | $649 |
| TEMA ETFS LLC | 32,007 | $644 |
| RHUMBLINE ADVISERS | 31,456 | $633 |
| Rafferty Asset Management, LLC | 28,878 | $581 |
| ALLIANCEBERNSTEIN L.P. | 28,200 | $567 |
| XTX Topco Ltd | 26,253 | $528 |
| Jump Financial, LLC | 24,221 | $487 |
| Walleye Capital LLC | 22,115 | $445 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,681 | $436 |
| DEUTSCHE BANK AG\ | 21,531 | $433 |
| Invesco Ltd. | 16,892 | $340 |
| MetLife Investment Management, LLC | 16,657 | $335 |
| Brevan Howard Capital Management LP | 16,635 | $335 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,115 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,378 | $310 |
| Legal & General Group Plc | 15,275 | $307 |
| DIMENSIONAL FUND ADVISORS LP | 14,743 | $297 |
| Quadrature Capital Ltd | 12,763 | $257 |
| Aquatic Capital Management LLC | 12,304 | $248 |
| AQR CAPITAL MANAGEMENT LLC | 11,475 | $231 |
| Virtu Financial LLC | 11,300 | $0 |
| UBS ASSET MANAGEMENT AMERICAS INC | 11,007 | $221 |
| INTECH INVESTMENT MANAGEMENT LLC | 11,007 | $221 |
| PROFUND ADVISORS LLC | 10,984 | $221 |
| Virtus Investment Advisers, LLC | 10,894 | $219 |
| CITIGROUP INC | 8,093 | $163 |
| Persistent Asset Partners Ltd | 7,963 | $160 |
| Police & Firemen's Retirement System of New Jersey | 7,881 | $159 |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | $157 |
| China Universal Asset Management Co., Ltd. | 6,727 | $135 |
| BNP PARIBAS ARBITRAGE, SA | 5,473 | $110 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,743 | $95 |
| KLP KAPITALFORVALTNING AS | 4,300 | $87 |
| GROUP ONE TRADING, L.P. | 2,854 | $57 |
| AlphaQuest LLC | 2,800 | $56 |
| Tower Research Capital LLC (TRC) | 2,370 | $48 |
| Ameritas Investment Partners, Inc. | 2,352 | $47 |
| Russell Investments Group, Ltd. | 2,068 | $42 |
| Mirae Asset Global Investments Co., Ltd. | 2,006 | $40 |
| US BANCORP \DE\ | 1,111 | $22 |
| ROYAL BANK OF CANADA | 981 | $21 |
| AMALGAMATED BANK | 927 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 811 | $16 |
| Caitong International Asset Management Co., Ltd | 807 | $16 |
| DV Trading LLC | 683 | $14 |
| 21 other institutions | 3,795 | $70 |