Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
ASND	ASCENDIS PHARMA A/S	10,281,496	$2.742B	23.8%	$266.72	—	—	Common Stock	K08588103
PBLS	PARABILIS MEDICINES INC	28,933,371	$792M	6.9%	$27.37	—	—	Common Stock	698955101
COAG	HEMAB THERAPEUTICS HOLDINGS	7,808,627	$287M	2.5%	$36.73	—	—	Common Stock	423494103
ABVX	ABIVAX SA-ADR	1,132,557	$151M	1.3%	$133.26	—	—	ADR	00370M103
ORKA	ORUKA THERAPEUTICS INC	1,554,597	$148M	1.3%	$95.17	—	—	Common Stock	687604108
NTLA	INTELLIA THERAPEUTICS INC	4,526,926	$76.6M	0.7%	$16.92	—	—	Common Stock	45826J105
DFTX	DEFINIUM THERAPEUTICS INC	1,500,000	$70.56M	0.6%	$47.04	—	—	Common Stock	24477V105
SANA	SANA BIOTECHNOLOGY INC	18,750,000	$65.44M	0.6%	$3.49	—	—	Common Stock	799566104
PRLD	PRELUDE THERAPEUTICS INC	6,475,882	$34.52M	0.3%	$5.33	—	—	Common Stock	74065P101
QTTB	Q32 BIO INC	2,332,457	$29.72M	0.3%	$12.74	—	—	Common Stock	746964105
EDIT	EDITAS MEDICINE INC	8,889,000	$28.8M	0.3%	$3.24	—	—	Common Stock	28106W103
ALT	ALTIMMUNE INC	6,500,000	$19.76M	0.2%	$3.04	—	—	Common Stock	02155H200
SNSE	FAETH THERAPEUTICS INC	722,020	$18.05M	0.2%	$25.00	—	—	Common Stock	81728A207
AURA	AURA BIOSCIENCES INC	2,500,000	$17.75M	0.2%	$7.10	—	—	Common Stock	05153U107
SPTX	SEAPORT THERAPEUTICS INC	700,000	$15.2M	0.1%	$21.72	—	—	Common Stock	81221K108
JATT	JATT II ACQUISITION CORP	500,000	$5.68M	0.0%	$11.36	—	—	Common Stock	G50765109
AMAN	AMANAT ACQUISITION CORP CL A	375,000	$3.81M	0.0%	$10.16	—	—	Common Stock	G0375M101

Increased Positions (8)

ARTV ARTIVA BIOTHERAPEUTICS INC 1.5%

Value $174M (+174.5%) Shares 17,955,642 (+82.2%) Share Price $9.70 Est. Cost/Share — Unrealized @ Report Date —

SLDB SOLID BIOSCIENCES INC 1.0%

Value $120M (+78.8%) Shares 12,036,126 (+28.9%) Share Price $9.99 Est. Cost/Share — Unrealized @ Report Date —

ACRS ACLARIS THERAPEUTICS INC 0.6%

Value $67.3M (+163.8%) Shares 12,723,026 (+87.0%) Share Price $5.29 Est. Cost/Share — Unrealized @ Report Date —

XNCR XENCOR INC 0.7%

Value $84.92M (+43.8%) Shares 5,274,274 (+7.7%) Share Price $16.10 Est. Cost/Share — Unrealized @ Report Date —

RZLT REZOLUTE INC 0.4%

Value $49.11M (+75.4%) Shares 9,445,039 (+2.9%) Share Price $5.20 Est. Cost/Share — Unrealized @ Report Date —

BIOA BIOAGE LABS INC 0.4%

Value $40.97M (+41.9%) Shares 1,671,648 (+1.3%) Share Price $24.51 Est. Cost/Share — Unrealized @ Report Date —

ACRV ACRIVON THERAPEUTICS INC 0.2%

Value $21.77M (+87.8%) Shares 12,229,396 (+46.6%) Share Price $1.78 Est. Cost/Share — Unrealized @ Report Date —

AVTX AVALO THERAPEUTICS INC 0.2%

Value $18.48M (+86.7%) Shares 1,000,000 (+50.8%) Share Price $18.48 Est. Cost/Share — Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
ARTV	ARTIVA BIOTHERAPEUTICS INC	17,955,642 (+82.2%)	$174M (+174.5%)	1.5%	$9.70	—	—	Common Stock	04317A107
SLDB	SOLID BIOSCIENCES INC	12,036,126 (+28.9%)	$120M (+78.8%)	1.0%	$9.99	—	—	Common Stock	83422E204
ACRS	ACLARIS THERAPEUTICS INC	12,723,026 (+87.0%)	$67.3M (+163.8%)	0.6%	$5.29	—	—	Common Stock	00461U105
XNCR	XENCOR INC	5,274,274 (+7.7%)	$84.92M (+43.8%)	0.7%	$16.10	—	—	Common Stock	98401F105
RZLT	REZOLUTE INC	9,445,039 (+2.9%)	$49.11M (+75.4%)	0.4%	$5.20	—	—	Common Stock	76200L309
BIOA	BIOAGE LABS INC	1,671,648 (+1.3%)	$40.97M (+41.9%)	0.4%	$24.51	—	—	Common Stock	09077V100
ACRV	ACRIVON THERAPEUTICS INC	12,229,396 (+46.6%)	$21.77M (+87.8%)	0.2%	$1.78	—	—	Common Stock	004890109
AVTX	AVALO THERAPEUTICS INC	1,000,000 (+50.8%)	$18.48M (+86.7%)	0.2%	$18.48	—	—	Common Stock	05338F306

Exited Positions (18)

ASND ASCENDIS PHARMA A/S - ADR 20.4%

Value $2.352B Shares 10,281,496 Share Price $228.73 Est. Cost/Share — Unrealized @ Report Date —

DNTH DIANTHUS THERAPEUTICS INC 1.9%

Value $219M Shares 2,611,733 Share Price $83.92 Est. Cost/Share — Unrealized @ Report Date —

PRAX PRAXIS PRECISION MEDICINES I 1.0%

Value $120M Shares 373,787 Share Price $322.19 Est. Cost/Share — Unrealized @ Report Date —

SRPT SAREPTA THERAPEUTICS INC 0.7%

Value $84.92M Shares 3,902,596 Share Price $21.76 Est. Cost/Share — Unrealized @ Report Date —

SYRE SPYRE THERAPEUTICS INC 0.7%

Value $81.79M Shares 1,621,620 Share Price $50.44 Est. Cost/Share — Unrealized @ Report Date —

FULC FULCRUM THERAPEUTICS INC 0.4%

Value $46.43M Shares 6,053,960 Share Price $7.67 Est. Cost/Share — Unrealized @ Report Date —

OLMA OLEMA PHARMACEUTICALS INC 0.3%

Value $38.77M Shares 2,600,000 Share Price $14.91 Est. Cost/Share — Unrealized @ Report Date —

DSGN DESIGN THERAPEUTICS INC 0.3%

Value $31.63M Shares 2,972,973 Share Price $10.64 Est. Cost/Share — Unrealized @ Report Date —

TVTX TRAVERE THERAPEUTICS INC 0.2%

Value $22.19M Shares 746,841 Share Price $29.71 Est. Cost/Share — Unrealized @ Report Date —

GRAL GRAIL INC 0.2%

Value $22.13M Shares 428,266 Share Price $51.68 Est. Cost/Share — Unrealized @ Report Date —

RLMD RELMADA THERAPEUTICS INC 0.2%

Value $20.51M Shares 2,947,369 Share Price $6.96 Est. Cost/Share — Unrealized @ Report Date —

STRO SUTRO BIOPHARMA INC 0.2%

Value $17.82M Shares 715,307 Share Price $24.91 Est. Cost/Share — Unrealized @ Report Date —

CTNM CONTINEUM THERAPEUTICS INC-A 0.1%

Value $16.93M Shares 1,296,012 Share Price $13.06 Est. Cost/Share — Unrealized @ Report Date —

INSP INSPIRE MEDICAL SYSTEMS INC 0.1%

Value $16.8M Shares 325,663 Share Price $51.58 Est. Cost/Share — Unrealized @ Report Date —

HNGE HINGE HEALTH INC-A 0.1%

Value $14.06M Shares 364,613 Share Price $38.56 Est. Cost/Share — Unrealized @ Report Date —

WGS GENEDX HOLDINGS CORP 0.1%

Value $13.48M Shares 209,887 Share Price $64.22 Est. Cost/Share — Unrealized @ Report Date —

RNA ATRIUM THERAPEUTICS INC 0.1%

Value $11.55M Shares 864,102 Share Price $13.37 Est. Cost/Share — Unrealized @ Report Date —

MPLT MAPLIGHT THERAPEUTICS INC 0.0%

Value $5.048M Shares 248,294 Share Price $20.33 Est. Cost/Share — Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
ASND	ASCENDIS PHARMA A/S - ADR	10,281,496	$2.352B	20.4%	$228.73	—	—	—	04351P101
DNTH	DIANTHUS THERAPEUTICS INC	2,611,733	$219M	1.9%	$83.92	—	—	—	252828108
PRAX	PRAXIS PRECISION MEDICINES I	373,787	$120M	1.0%	$322.19	—	—	—	74006W207
SRPT	SAREPTA THERAPEUTICS INC	3,902,596	$84.92M	0.7%	$21.76	—	—	—	803607100
SYRE	SPYRE THERAPEUTICS INC	1,621,620	$81.79M	0.7%	$50.44	—	—	—	00773J202
FULC	FULCRUM THERAPEUTICS INC	6,053,960	$46.43M	0.4%	$7.67	—	—	—	359616109
OLMA	OLEMA PHARMACEUTICALS INC	2,600,000	$38.77M	0.3%	$14.91	—	—	—	68062P106
DSGN	DESIGN THERAPEUTICS INC	2,972,973	$31.63M	0.3%	$10.64	—	—	—	25056L103
TVTX	TRAVERE THERAPEUTICS INC	746,841	$22.19M	0.2%	$29.71	—	—	—	89422G107
GRAL	GRAIL INC	428,266	$22.13M	0.2%	$51.68	—	—	—	384747101
RLMD	RELMADA THERAPEUTICS INC	2,947,369	$20.51M	0.2%	$6.96	—	—	—	75955J402
STRO	SUTRO BIOPHARMA INC	715,307	$17.82M	0.2%	$24.91	—	—	—	869367201
CTNM	CONTINEUM THERAPEUTICS INC-A	1,296,012	$16.93M	0.1%	$13.06	—	—	—	21217B100
INSP	INSPIRE MEDICAL SYSTEMS INC	325,663	$16.8M	0.1%	$51.58	—	—	—	457730109
HNGE	HINGE HEALTH INC-A	364,613	$14.06M	0.1%	$38.56	—	—	—	433313103
WGS	GENEDX HOLDINGS CORP	209,887	$13.48M	0.1%	$64.22	—	—	—	81663L200
RNA	ATRIUM THERAPEUTICS INC	864,102	$11.55M	0.1%	$13.37	—	—	—	04965N104
MPLT	MAPLIGHT THERAPEUTICS INC	248,294	$5.048M	0.0%	$20.33	—	—	—	56565P103

Decreased Positions (9)

NUVL NUVALENT INC-A 1.3%

Value $154M (-40.7%) Shares 1,246,456 (-50.8%) Share Price $123.50 Est. Cost/Share — Unrealized @ Report Date —

VOR VOR BIOPHARMA INC 0.4%

Value $44.22M (-54.1%) Shares 2,402,095 (-55.6%) Share Price $18.41 Est. Cost/Share — Unrealized @ Report Date —

GERN GERON CORP 0.5%

Value $54.8M (-42.3%) Shares 42,809,751 (-32.9%) Share Price $1.28 Est. Cost/Share — Unrealized @ Report Date —

AKTS AKTIS ONCOLOGY INC 0.4%

Value $42.36M (+57.5%) Shares 1,314,405 (-12.6%) Share Price $32.23 Est. Cost/Share — Unrealized @ Report Date —

EWTX EDGEWISE THERAPEUTICS INC 3.0%

Value $341M (+3.8%) Shares 8,392,730 (-19.5%) Share Price $40.63 Est. Cost/Share — Unrealized @ Report Date —

HOWL WEREWOLF THERAPEUTICS INC 0.0%

Value $859K (-84.6%) Shares 2,387,744 (-64.3%) Share Price $0.36 Est. Cost/Share — Unrealized @ Report Date —

OVID OVID THERAPEUTICS INC 0.2%

Value $28.25M (+18.8%) Shares 10,500,968 (-2.0%) Share Price $2.69 Est. Cost/Share — Unrealized @ Report Date —

PTN PALATIN TECHNOLOGIES INC 0.0%

Value $670K (-45.0%) Shares 62,124 (-11.3%) Share Price $10.79 Est. Cost/Share — Unrealized @ Report Date —

ACET ADICET BIO INC 0.1%

Value $8.058M (+0.1%) Shares 932,624 (-21.1%) Share Price $8.64 Est. Cost/Share — Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
NUVL	NUVALENT INC-A	1,246,456 (-50.8%)	$154M (-40.7%)	1.3%	$123.50	—	—	Common Stock	670703107
VOR	VOR BIOPHARMA INC	2,402,095 (-55.6%)	$44.22M (-54.1%)	0.4%	$18.41	—	—	Common Stock	929033207
GERN	GERON CORP	42,809,751 (-32.9%)	$54.8M (-42.3%)	0.5%	$1.28	—	—	Common Stock	374163103
AKTS	AKTIS ONCOLOGY INC	1,314,405 (-12.6%)	$42.36M (+57.5%)	0.4%	$32.23	—	—	Common Stock	01021M104
EWTX	EDGEWISE THERAPEUTICS INC	8,392,730 (-19.5%)	$341M (+3.8%)	3.0%	$40.63	—	—	Common Stock	28036F105
HOWL	WEREWOLF THERAPEUTICS INC	2,387,744 (-64.3%)	$859K (-84.6%)	0.0%	$0.36	—	—	Common Stock	95075A107
OVID	OVID THERAPEUTICS INC	10,500,968 (-2.0%)	$28.25M (+18.8%)	0.2%	$2.69	—	—	Common Stock	690469101
PTN	PALATIN TECHNOLOGIES INC	62,124 (-11.3%)	$670K (-45.0%)	0.0%	$10.79	—	—	Common Stock	696077601
ACET	ADICET BIO INC	932,624 (-21.1%)	$8.058M (+0.1%)	0.1%	$8.64	—	—	Common Stock	007002207

Unchanged Positions (50)

RYTM RHYTHM PHARMACEUTICALS INC 6.4%

Value $740M Shares 6,666,837 Share Price $111.03 Est. Cost/Share — Unrealized @ Report Date —

GHRS GH RESEARCH PLC 1.8%

Value $205M Shares 7,636,813 Share Price $26.88 Est. Cost/Share — Unrealized @ Report Date —

TYRA TYRA BIOSCIENCES INC 3.4%

Value $390M Shares 12,198,625 Share Price $31.94 Est. Cost/Share — Unrealized @ Report Date —

BCAX BICARA THERAPEUTICS INC 1.9%

Value $215M Shares 7,255,993 Share Price $29.69 Est. Cost/Share — Unrealized @ Report Date —

CLYM CLIMB BIO INC 1.3%

Value $147M Shares 11,300,939 Share Price $13.04 Est. Cost/Share — Unrealized @ Report Date —

SEPN SEPTERNA INC 2.0%

Value $234M Shares 6,995,858 Share Price $33.49 Est. Cost/Share — Unrealized @ Report Date —

TSHA TAYSHA GENE THERAPIES INC 1.4%

Value $160M Shares 23,555,648 Share Price $6.81 Est. Cost/Share — Unrealized @ Report Date —

WVE WAVE LIFE SCIENCES LTD 1.4%

Value $157M Shares 26,975,505 Share Price $5.81 Est. Cost/Share — Unrealized @ Report Date —

SION SIONNA THERAPEUTICS INC 3.8%

Value $436M Shares 9,905,045 Share Price $43.99 Est. Cost/Share — Unrealized @ Report Date —

EVMN EVOMMUNE INC 0.4%

Value $46.44M Shares 3,494,638 Share Price $13.29 Est. Cost/Share — Unrealized @ Report Date —

JBIO JADE BIOSCIENCES INC 0.7%

Value $81.57M Shares 3,671,083 Share Price $22.22 Est. Cost/Share — Unrealized @ Report Date —

SGP SPYGLASS PHARMA INC 1.6%

Value $179M Shares 8,021,117 Share Price $22.26 Est. Cost/Share — Unrealized @ Report Date —

MNPR MONOPAR THERAPEUTICS INC 0.5%

Value $61.78M Shares 667,207 Share Price $92.59 Est. Cost/Share — Unrealized @ Report Date —

IRON DISC MEDICINE INC 1.6%

Value $179M Shares 2,450,221 Share Price $73.14 Est. Cost/Share — Unrealized @ Report Date —

FDMT 4D MOLECULAR THERAPEUTICS IN 0.6%

Value $67.16M Shares 5,049,779 Share Price $13.30 Est. Cost/Share — Unrealized @ Report Date —

NAMS NEWAMSTERDAM PHARMA CO NV 2.8%

Value $324M Shares 9,550,191 Share Price $33.89 Est. Cost/Share — Unrealized @ Report Date —

LBRX LB PHARMACEUTICALS INC 0.6%

Value $71.68M Shares 2,208,604 Share Price $32.46 Est. Cost/Share — Unrealized @ Report Date —

JANX JANUX THERAPEUTICS INC 1.5%

Value $172M Shares 11,189,693 Share Price $15.36 Est. Cost/Share — Unrealized @ Report Date —

CCCC C4 THERAPEUTICS INC 0.3%

Value $37.36M Shares 8,000,000 Share Price $4.67 Est. Cost/Share — Unrealized @ Report Date —

LENZ LENZ THERAPEUTICS INC 0.2%

Value $23.74M Shares 4,178,823 Share Price $5.68 Est. Cost/Share — Unrealized @ Report Date —

AVR ANTERIS TECHNOLOGIES GLOBAL 0.3%

Value $29.55M Shares 3,000,000 Share Price $9.85 Est. Cost/Share — Unrealized @ Report Date —

CAPR CAPRICOR THERAPEUTICS INC 0.3%

Value $36.31M Shares 1,507,844 Share Price $24.08 Est. Cost/Share — Unrealized @ Report Date —

KPTI KARYOPHARM THERAPEUTICS INC 0.2%

Value $18.73M Shares 1,917,354 Share Price $9.77 Est. Cost/Share — Unrealized @ Report Date —

MIRM MIRUM PHARMACEUTICALS INC 0.3%

Value $37.29M Shares 318,554 Share Price $117.07 Est. Cost/Share — Unrealized @ Report Date —

NKTX NKARTA INC 0.3%

Value $30.58M Shares 10,805,129 Share Price $2.83 Est. Cost/Share — Unrealized @ Report Date —

BCRX BIOCRYST PHARMACEUTICALS INC 1.4%

Value $158M Shares 15,827,186 Share Price $10.00 Est. Cost/Share — Unrealized @ Report Date —

ABOS ACUMEN PHARMACEUTICALS INC 0.5%

Value $56.05M Shares 20,992,669 Share Price $2.67 Est. Cost/Share — Unrealized @ Report Date —

LXEO LEXEO THERAPEUTICS INC 0.2%

Value $23.27M Shares 5,000,000 Share Price $4.66 Est. Cost/Share — Unrealized @ Report Date —

BNTC BENITEC BIOPHARMA INC 0.2%

Value $24.75M Shares 1,850,000 Share Price $13.38 Est. Cost/Share — Unrealized @ Report Date —

EQ EQUILLIUM INC 0.1%

Value $9.908M Shares 3,096,336 Share Price $3.20 Est. Cost/Share — Unrealized @ Report Date —

IPSC CENTURY THERAPEUTICS INC 0.4%

Value $43.5M Shares 17,754,430 Share Price $2.45 Est. Cost/Share — Unrealized @ Report Date —

MGNX MACROGENICS INC 0.1%

Value $8.612M Shares 1,864,176 Share Price $4.62 Est. Cost/Share — Unrealized @ Report Date —

PALI PALISADE BIO INC 0.1%

Value $14.89M Shares 7,124,116 Share Price $2.09 Est. Cost/Share — Unrealized @ Report Date —

WAY WAYSTAR HOLDING CORP 0.1%

Value $10.87M Shares 529,400 Share Price $20.53 Est. Cost/Share — Unrealized @ Report Date —

ZLAB ZAI LAB LTD-ADR 0.9%

Value $109M Shares 5,743,533 Share Price $19.00 Est. Cost/Share — Unrealized @ Report Date —

OKUR ONKURE THERAPEUTICS INC-A 0.2%

Value $18.23M Shares 3,998,333 Share Price $4.56 Est. Cost/Share — Unrealized @ Report Date —

MLYS MINERALYS THERAPEUTICS INC 1.8%

Value $208M Shares 7,692,750 Share Price $26.98 Est. Cost/Share — Unrealized @ Report Date —

ALXO ALX ONCOLOGY HOLDINGS INC 0.2%

Value $26.93M Shares 13,011,849 Share Price $2.07 Est. Cost/Share — Unrealized @ Report Date —

DRUG BRIGHT MINDS BIOSCIENCES INC 0.2%

Value $18.6M Shares 265,000 Share Price $70.20 Est. Cost/Share — Unrealized @ Report Date —

PEPG PEPGEN INC 0.3%

Value $36.12M Shares 20,064,545 Share Price $1.80 Est. Cost/Share — Unrealized @ Report Date —

HLXC HELIX ACQUISITION CORP-CL A 0.1%

Value $13.3M Shares 1,250,000 Share Price $10.64 Est. Cost/Share — Unrealized @ Report Date —

NAMSW NEWAMSTERDAM PHARMA CO NV-27 0.1%

Value $7.123M Shares 333,333 Share Price $21.37 Est. Cost/Share — Unrealized @ Report Date —

SABS SAB BIOTHERAPEUTICS INC 0.1%

Value $17.17M Shares 4,401,500 Share Price $3.90 Est. Cost/Share — Unrealized @ Report Date —

ASMB ASSEMBLY BIOSCIENCES INC 0.2%

Value $28.04M Shares 1,020,410 Share Price $27.48 Est. Cost/Share — Unrealized @ Report Date —

GLTO DAMORA THERAPEUTICS INC 0.5%

Value $62.42M Shares 2,399,702 Share Price $26.01 Est. Cost/Share — Unrealized @ Report Date —

PCVX VAXCYTE INC 5.8%

Value $667M Shares 11,474,599 Share Price $58.13 Est. Cost/Share — Unrealized @ Report Date —

RANI RANI THERAPEUTICS HOLDINGS-A 0.1%

Value $6.463M Shares 8,500,000 Share Price $0.76 Est. Cost/Share — Unrealized @ Report Date —

SPRY ARS PHARMACEUTICALS INC 0.8%

Value $87M Shares 10,860,977 Share Price $8.01 Est. Cost/Share — Unrealized @ Report Date —

CRVS CORVUS PHARMACEUTICALS INC 0.1%

Value $6.723M Shares 450,000 Share Price $14.94 Est. Cost/Share — Unrealized @ Report Date —

PCSC PERCEPTIVE CAPITAL SOLUTIONS 0.1%

Value $8.16M Shares 750,000 Share Price $10.88 Est. Cost/Share — Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
RYTM	RHYTHM PHARMACEUTICALS INC	6,666,837	$740M	6.4%	$111.03	—	—	Common Stock	76243J105
GHRS	GH RESEARCH PLC	7,636,813	$205M	1.8%	$26.88	—	—	Common Stock	G3855L106
TYRA	TYRA BIOSCIENCES INC	12,198,625	$390M	3.4%	$31.94	—	—	Common Stock	90240B106
BCAX	BICARA THERAPEUTICS INC	7,255,993	$215M	1.9%	$29.69	—	—	Common Stock	055477103
CLYM	CLIMB BIO INC	11,300,939	$147M	1.3%	$13.04	—	—	Common Stock	28658R106
SEPN	SEPTERNA INC	6,995,858	$234M	2.0%	$33.49	—	—	Common Stock	81734D104
TSHA	TAYSHA GENE THERAPIES INC	23,555,648	$160M	1.4%	$6.81	—	—	Common Stock	877619106
WVE	WAVE LIFE SCIENCES LTD	26,975,505	$157M	1.4%	$5.81	—	—	Common Stock	Y95308105
SION	SIONNA THERAPEUTICS INC	9,905,045	$436M	3.8%	$43.99	—	—	Common Stock	829401108
EVMN	EVOMMUNE INC	3,494,638	$46.44M	0.4%	$13.29	—	—	Common Stock	30054Y107
JBIO	JADE BIOSCIENCES INC	3,671,083	$81.57M	0.7%	$22.22	—	—	Common Stock	008064206
SGP	SPYGLASS PHARMA INC	8,021,117	$179M	1.6%	$22.26	—	—	Common Stock	85220G109
MNPR	MONOPAR THERAPEUTICS INC	667,207	$61.78M	0.5%	$92.59	—	—	Common Stock	61023L207
IRON	DISC MEDICINE INC	2,450,221	$179M	1.6%	$73.14	—	—	Common Stock	254604101
FDMT	4D MOLECULAR THERAPEUTICS IN	5,049,779	$67.16M	0.6%	$13.30	—	—	Common Stock	35104E100
NAMS	NEWAMSTERDAM PHARMA CO NV	9,550,191	$324M	2.8%	$33.89	—	—	Common Stock	N62509109
LBRX	LB PHARMACEUTICALS INC	2,208,604	$71.68M	0.6%	$32.46	—	—	Common Stock	50180M108
JANX	JANUX THERAPEUTICS INC	11,189,693	$172M	1.5%	$15.36	—	—	Common Stock	47103J105
CCCC	C4 THERAPEUTICS INC	8,000,000	$37.36M	0.3%	$4.67	—	—	Common Stock	12529R107
LENZ	LENZ THERAPEUTICS INC	4,178,823	$23.74M	0.2%	$5.68	—	—	Common Stock	52635N103
AVR	ANTERIS TECHNOLOGIES GLOBAL	3,000,000	$29.55M	0.3%	$9.85	—	—	Common Stock	03675P102
CAPR	CAPRICOR THERAPEUTICS INC	1,507,844	$36.31M	0.3%	$24.08	—	—	Common Stock	14070B309
KPTI	KARYOPHARM THERAPEUTICS INC	1,917,354	$18.73M	0.2%	$9.77	—	—	Common Stock	48576U205
MIRM	MIRUM PHARMACEUTICALS INC	318,554	$37.29M	0.3%	$117.07	—	—	Common Stock	604749101
NKTX	NKARTA INC	10,805,129	$30.58M	0.3%	$2.83	—	—	Common Stock	65487U108
BCRX	BIOCRYST PHARMACEUTICALS INC	15,827,186	$158M	1.4%	$10.00	—	—	Common Stock	09058V103
ABOS	ACUMEN PHARMACEUTICALS INC	20,992,669	$56.05M	0.5%	$2.67	—	—	Common Stock	00509G209
LXEO	LEXEO THERAPEUTICS INC	5,000,000	$23.27M	0.2%	$4.66	—	—	Common Stock	52886X107
BNTC	BENITEC BIOPHARMA INC	1,850,000	$24.75M	0.2%	$13.38	—	—	Common Stock	08205P209
EQ	EQUILLIUM INC	3,096,336	$9.908M	0.1%	$3.20	—	—	Common Stock	29446K106
IPSC	CENTURY THERAPEUTICS INC	17,754,430	$43.5M	0.4%	$2.45	—	—	Common Stock	15673T100
MGNX	MACROGENICS INC	1,864,176	$8.612M	0.1%	$4.62	—	—	Common Stock	556099109
PALI	PALISADE BIO INC	7,124,116	$14.89M	0.1%	$2.09	—	—	Common Stock	696389402
WAY	WAYSTAR HOLDING CORP	529,400	$10.87M	0.1%	$20.53	—	—	Common Stock	946784105
ZLAB	ZAI LAB LTD-ADR	5,743,533	$109M	0.9%	$19.00	—	—	ADR	98887Q104
OKUR	ONKURE THERAPEUTICS INC-A	3,998,333	$18.23M	0.2%	$4.56	—	—	Common Stock	68277Q105
MLYS	MINERALYS THERAPEUTICS INC	7,692,750	$208M	1.8%	$26.98	—	—	Common Stock	603170101
ALXO	ALX ONCOLOGY HOLDINGS INC	13,011,849	$26.93M	0.2%	$2.07	—	—	Common Stock	00166B105
DRUG	BRIGHT MINDS BIOSCIENCES INC	265,000	$18.6M	0.2%	$70.20	—	—	Common Stock	10919W405
PEPG	PEPGEN INC	20,064,545	$36.12M	0.3%	$1.80	—	—	Common Stock	713317105
HLXC	HELIX ACQUISITION CORP-CL A	1,250,000	$13.3M	0.1%	$10.64	—	—	Common Stock	G4444S107
NAMSW	NEWAMSTERDAM PHARMA CO NV-27	333,333	$7.123M	0.1%	$21.37	—	—	WTS	N62509117
SABS	SAB BIOTHERAPEUTICS INC	4,401,500	$17.17M	0.1%	$3.90	—	—	Common Stock	78397T202
ASMB	ASSEMBLY BIOSCIENCES INC	1,020,410	$28.04M	0.2%	$27.48	—	—	Common Stock	045396207
GLTO	DAMORA THERAPEUTICS INC	2,399,702	$62.42M	0.5%	$26.01	—	—	Common Stock	36322Q206
PCVX	VAXCYTE INC	11,474,599	$667M	5.8%	$58.13	—	—	Common Stock	92243G108
RANI	RANI THERAPEUTICS HOLDINGS-A	8,500,000	$6.463M	0.1%	$0.76	—	—	Common Stock	753018100
SPRY	ARS PHARMACEUTICALS INC	10,860,977	$87M	0.8%	$8.01	—	—	Common Stock	82835W108
CRVS	CORVUS PHARMACEUTICALS INC	450,000	$6.723M	0.1%	$14.94	—	—	Common Stock	221015100
PCSC	PERCEPTIVE CAPITAL SOLUTIONS	750,000	$8.16M	0.1%	$10.88	—	—	Common Stock	G70077105