Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q2 2026 (← Previous)
Filing Date: Aug 14, 2026
Total Value: $11.51B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 10,281,496 | $2.742B | 23.8% | — | — | Common Stock | K08588103 |
| PBLS | PARABILIS MEDICINES INC | 28,933,371 | $792M | 6.9% | — | — | Common Stock | 698955101 |
| COAG | HEMAB THERAPEUTICS HOLDINGS | 7,808,627 | $287M | 2.5% | — | — | Common Stock | 423494103 |
| ABVX | ABIVAX SA-ADR | 1,132,557 | $151M | 1.3% | — | — | ADR | 00370M103 |
| ORKA | ORUKA THERAPEUTICS INC | 1,554,597 | $148M | 1.3% | — | — | Common Stock | 687604108 |
| NTLA | INTELLIA THERAPEUTICS INC | 4,526,926 | $76.6M | 0.7% | — | — | Common Stock | 45826J105 |
| DFTX | DEFINIUM THERAPEUTICS INC | 1,500,000 | $70.56M | 0.6% | — | — | Common Stock | 24477V105 |
| SANA | SANA BIOTECHNOLOGY INC | 18,750,000 | $65.44M | 0.6% | — | — | Common Stock | 799566104 |
| PRLD | PRELUDE THERAPEUTICS INC | 6,475,882 | $34.52M | 0.3% | — | — | Common Stock | 74065P101 |
| QTTB | Q32 BIO INC | 2,332,457 | $29.72M | 0.3% | — | — | Common Stock | 746964105 |
| EDIT | EDITAS MEDICINE INC | 8,889,000 | $28.8M | 0.3% | — | — | Common Stock | 28106W103 |
| ALT | ALTIMMUNE INC | 6,500,000 | $19.76M | 0.2% | — | — | Common Stock | 02155H200 |
| SNSE | FAETH THERAPEUTICS INC | 722,020 | $18.05M | 0.2% | — | — | Common Stock | 81728A207 |
| AURA | AURA BIOSCIENCES INC | 2,500,000 | $17.75M | 0.2% | — | — | Common Stock | 05153U107 |
| SPTX | SEAPORT THERAPEUTICS INC | 700,000 | $15.2M | 0.1% | — | — | Common Stock | 81221K108 |
| JATT | JATT II ACQUISITION CORP | 500,000 | $5.68M | 0.0% | — | — | Common Stock | G50765109 |
| AMAN | AMANAT ACQUISITION CORP CL A | 375,000 | $3.81M | 0.0% | — | — | Common Stock | G0375M101 |
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 17,955,642 (+82.2%) | $174M (+174.5%) | 1.5% | — | — | Common Stock | 04317A107 |
| SLDB | SOLID BIOSCIENCES INC | 12,036,126 (+28.9%) | $120M (+78.8%) | 1.0% | — | — | Common Stock | 83422E204 |
| ACRS | ACLARIS THERAPEUTICS INC | 12,723,026 (+87.0%) | $67.3M (+163.8%) | 0.6% | — | — | Common Stock | 00461U105 |
| XNCR | XENCOR INC | 5,274,274 (+7.7%) | $84.92M (+43.8%) | 0.7% | — | — | Common Stock | 98401F105 |
| RZLT | REZOLUTE INC | 9,445,039 (+2.9%) | $49.11M (+75.4%) | 0.4% | — | — | Common Stock | 76200L309 |
| BIOA | BIOAGE LABS INC | 1,671,648 (+1.3%) | $40.97M (+41.9%) | 0.4% | — | — | Common Stock | 09077V100 |
| ACRV | ACRIVON THERAPEUTICS INC | 12,229,396 (+46.6%) | $21.77M (+87.8%) | 0.2% | — | — | Common Stock | 004890109 |
| AVTX | AVALO THERAPEUTICS INC | 1,000,000 (+50.8%) | $18.48M (+86.7%) | 0.2% | — | — | Common Stock | 05338F306 |
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.352B | 20.4% | — | — | — | 04351P101 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,611,733 | $219M | 1.9% | — | — | — | 252828108 |
| PRAX | PRAXIS PRECISION MEDICINES I | 373,787 | $120M | 1.0% | — | — | — | 74006W207 |
| SRPT | SAREPTA THERAPEUTICS INC | 3,902,596 | $84.92M | 0.7% | — | — | — | 803607100 |
| SYRE | SPYRE THERAPEUTICS INC | 1,621,620 | $81.79M | 0.7% | — | — | — | 00773J202 |
| FULC | FULCRUM THERAPEUTICS INC | 6,053,960 | $46.43M | 0.4% | — | — | — | 359616109 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,600,000 | $38.77M | 0.3% | — | — | — | 68062P106 |
| DSGN | DESIGN THERAPEUTICS INC | 2,972,973 | $31.63M | 0.3% | — | — | — | 25056L103 |
| TVTX | TRAVERE THERAPEUTICS INC | 746,841 | $22.19M | 0.2% | — | — | — | 89422G107 |
| GRAL | GRAIL INC | 428,266 | $22.13M | 0.2% | — | — | — | 384747101 |
| RLMD | RELMADA THERAPEUTICS INC | 2,947,369 | $20.51M | 0.2% | — | — | — | 75955J402 |
| STRO | SUTRO BIOPHARMA INC | 715,307 | $17.82M | 0.2% | — | — | — | 869367201 |
| CTNM | CONTINEUM THERAPEUTICS INC-A | 1,296,012 | $16.93M | 0.1% | — | — | — | 21217B100 |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 325,663 | $16.8M | 0.1% | — | — | — | 457730109 |
| HNGE | HINGE HEALTH INC-A | 364,613 | $14.06M | 0.1% | — | — | — | 433313103 |
| WGS | GENEDX HOLDINGS CORP | 209,887 | $13.48M | 0.1% | — | — | — | 81663L200 |
| RNA | ATRIUM THERAPEUTICS INC | 864,102 | $11.55M | 0.1% | — | — | — | 04965N104 |
| MPLT | MAPLIGHT THERAPEUTICS INC | 248,294 | $5.048M | 0.0% | — | — | — | 56565P103 |
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| NUVL | NUVALENT INC-A | 1,246,456 (-50.8%) | $154M (-40.7%) | 1.3% | — | — | Common Stock | 670703107 |
| VOR | VOR BIOPHARMA INC | 2,402,095 (-55.6%) | $44.22M (-54.1%) | 0.4% | — | — | Common Stock | 929033207 |
| GERN | GERON CORP | 42,809,751 (-32.9%) | $54.8M (-42.3%) | 0.5% | — | — | Common Stock | 374163103 |
| AKTS | AKTIS ONCOLOGY INC | 1,314,405 (-12.6%) | $42.36M (+57.5%) | 0.4% | — | — | Common Stock | 01021M104 |
| EWTX | EDGEWISE THERAPEUTICS INC | 8,392,730 (-19.5%) | $341M (+3.8%) | 3.0% | — | — | Common Stock | 28036F105 |
| HOWL | WEREWOLF THERAPEUTICS INC | 2,387,744 (-64.3%) | $859K (-84.6%) | 0.0% | — | — | Common Stock | 95075A107 |
| OVID | OVID THERAPEUTICS INC | 10,500,968 (-2.0%) | $28.25M (+18.8%) | 0.2% | — | — | Common Stock | 690469101 |
| PTN | PALATIN TECHNOLOGIES INC | 62,124 (-11.3%) | $670K (-45.0%) | 0.0% | — | — | Common Stock | 696077601 |
| ACET | ADICET BIO INC | 932,624 (-21.1%) | $8.058M (+0.1%) | 0.1% | — | — | Common Stock | 007002207 |
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,666,837 | $740M | 6.4% | — | — | Common Stock | 76243J105 |
| GHRS | GH RESEARCH PLC | 7,636,813 | $205M | 1.8% | — | — | Common Stock | G3855L106 |
| TYRA | TYRA BIOSCIENCES INC | 12,198,625 | $390M | 3.4% | — | — | Common Stock | 90240B106 |
| BCAX | BICARA THERAPEUTICS INC | 7,255,993 | $215M | 1.9% | — | — | Common Stock | 055477103 |
| CLYM | CLIMB BIO INC | 11,300,939 | $147M | 1.3% | — | — | Common Stock | 28658R106 |
| SEPN | SEPTERNA INC | 6,995,858 | $234M | 2.0% | — | — | Common Stock | 81734D104 |
| TSHA | TAYSHA GENE THERAPIES INC | 23,555,648 | $160M | 1.4% | — | — | Common Stock | 877619106 |
| WVE | WAVE LIFE SCIENCES LTD | 26,975,505 | $157M | 1.4% | — | — | Common Stock | Y95308105 |
| SION | SIONNA THERAPEUTICS INC | 9,905,045 | $436M | 3.8% | — | — | Common Stock | 829401108 |
| EVMN | EVOMMUNE INC | 3,494,638 | $46.44M | 0.4% | — | — | Common Stock | 30054Y107 |
| JBIO | JADE BIOSCIENCES INC | 3,671,083 | $81.57M | 0.7% | — | — | Common Stock | 008064206 |
| SGP | SPYGLASS PHARMA INC | 8,021,117 | $179M | 1.6% | — | — | Common Stock | 85220G109 |
| MNPR | MONOPAR THERAPEUTICS INC | 667,207 | $61.78M | 0.5% | — | — | Common Stock | 61023L207 |
| IRON | DISC MEDICINE INC | 2,450,221 | $179M | 1.6% | — | — | Common Stock | 254604101 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 5,049,779 | $67.16M | 0.6% | — | — | Common Stock | 35104E100 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 9,550,191 | $324M | 2.8% | — | — | Common Stock | N62509109 |
| LBRX | LB PHARMACEUTICALS INC | 2,208,604 | $71.68M | 0.6% | — | — | Common Stock | 50180M108 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $172M | 1.5% | — | — | Common Stock | 47103J105 |
| CCCC | C4 THERAPEUTICS INC | 8,000,000 | $37.36M | 0.3% | — | — | Common Stock | 12529R107 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $23.74M | 0.2% | — | — | Common Stock | 52635N103 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 3,000,000 | $29.55M | 0.3% | — | — | Common Stock | 03675P102 |
| CAPR | CAPRICOR THERAPEUTICS INC | 1,507,844 | $36.31M | 0.3% | — | — | Common Stock | 14070B309 |
| KPTI | KARYOPHARM THERAPEUTICS INC | 1,917,354 | $18.73M | 0.2% | — | — | Common Stock | 48576U205 |
| MIRM | MIRUM PHARMACEUTICALS INC | 318,554 | $37.29M | 0.3% | — | — | Common Stock | 604749101 |
| NKTX | NKARTA INC | 10,805,129 | $30.58M | 0.3% | — | — | Common Stock | 65487U108 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 15,827,186 | $158M | 1.4% | — | — | Common Stock | 09058V103 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 20,992,669 | $56.05M | 0.5% | — | — | Common Stock | 00509G209 |
| LXEO | LEXEO THERAPEUTICS INC | 5,000,000 | $23.27M | 0.2% | — | — | Common Stock | 52886X107 |
| BNTC | BENITEC BIOPHARMA INC | 1,850,000 | $24.75M | 0.2% | — | — | Common Stock | 08205P209 |
| EQ | EQUILLIUM INC | 3,096,336 | $9.908M | 0.1% | — | — | Common Stock | 29446K106 |
| IPSC | CENTURY THERAPEUTICS INC | 17,754,430 | $43.5M | 0.4% | — | — | Common Stock | 15673T100 |
| MGNX | MACROGENICS INC | 1,864,176 | $8.612M | 0.1% | — | — | Common Stock | 556099109 |
| PALI | PALISADE BIO INC | 7,124,116 | $14.89M | 0.1% | — | — | Common Stock | 696389402 |
| WAY | WAYSTAR HOLDING CORP | 529,400 | $10.87M | 0.1% | — | — | Common Stock | 946784105 |
| ZLAB | ZAI LAB LTD-ADR | 5,743,533 | $109M | 0.9% | — | — | ADR | 98887Q104 |
| OKUR | ONKURE THERAPEUTICS INC-A | 3,998,333 | $18.23M | 0.2% | — | — | Common Stock | 68277Q105 |
| MLYS | MINERALYS THERAPEUTICS INC | 7,692,750 | $208M | 1.8% | — | — | Common Stock | 603170101 |
| ALXO | ALX ONCOLOGY HOLDINGS INC | 13,011,849 | $26.93M | 0.2% | — | — | Common Stock | 00166B105 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 265,000 | $18.6M | 0.2% | — | — | Common Stock | 10919W405 |
| PEPG | PEPGEN INC | 20,064,545 | $36.12M | 0.3% | — | — | Common Stock | 713317105 |
| HLXC | HELIX ACQUISITION CORP-CL A | 1,250,000 | $13.3M | 0.1% | — | — | Common Stock | G4444S107 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $7.123M | 0.1% | — | — | WTS | N62509117 |
| SABS | SAB BIOTHERAPEUTICS INC | 4,401,500 | $17.17M | 0.1% | — | — | Common Stock | 78397T202 |
| ASMB | ASSEMBLY BIOSCIENCES INC | 1,020,410 | $28.04M | 0.2% | — | — | Common Stock | 045396207 |
| GLTO | DAMORA THERAPEUTICS INC | 2,399,702 | $62.42M | 0.5% | — | — | Common Stock | 36322Q206 |
| PCVX | VAXCYTE INC | 11,474,599 | $667M | 5.8% | — | — | Common Stock | 92243G108 |
| RANI | RANI THERAPEUTICS HOLDINGS-A | 8,500,000 | $6.463M | 0.1% | — | — | Common Stock | 753018100 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $87M | 0.8% | — | — | Common Stock | 82835W108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 450,000 | $6.723M | 0.1% | — | — | Common Stock | 221015100 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $8.16M | 0.1% | — | — | Common Stock | G70077105 |