Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q1 2026 (← Previous) (Next →)
Filing Date: May 15, 2026
Total Value: $9.438B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.352B | 24.9% | $228.73 | $82.85 | — | SPONSORED ADR | 04351P101 |
| PCVX | VAXCYTE INC | 11,474,599 | $667M | 7.1% | $58.11 * | $51.31 | +2.8% | COMMON STOCK | 92243G108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 6,666,837 | $580M | 6.1% | $86.97 * | $38.97 | +163.9% | COMMON STOCK | 76243J105 |
| TYRA | TYRA BIOSCIENCES INC | 12,198,625 | $467M | 5.0% | $38.30 * | $17.16 | +76.3% | COMMON STOCK | 90240B106 |
| SION | SIONNA THERAPEUTICS INC | 9,905,045 | $397M | 4.2% | $40.09 * | $16.34 | +140.2% | COMMON STOCK | 829401108 |
| EWTX | EDGEWISE THERAPEUTICS INC | 10,428,437 | $328M | 3.5% | $31.50 * | $15.67 | +79.8% | COMMON STOCK | 28036F105 |
| NAMS | NEWAMSTERDAM PHARMA CO NV | 9,550,191 | $306M | 3.2% | $32.01 * | $14.02 | +140.8% | COMMON STOCK | N62509109 |
| NUVL | NUVALENT INC-A | 2,534,145 | $260M | 2.8% | $102.45 | $90.29 | +14.8% | COMMON STOCK | 670703107 |
| DNTH | DIANTHUS THERAPEUTICS INC | 2,611,733 | $219M | 2.3% | $83.92 * | $31.70 | +50.1% | COMMON STOCK | 252828108 |
| MLYS | MINERALYS THERAPEUTICS INC | 7,692,750 | $208M | 2.2% | $27.09 * | $16.39 | +91.3% | COMMON STOCK | 603170101 |
| SGP | SPYGLASS PHARMA INC | 8,021,117 | $208M | 2.2% | $25.91 | $25.91 | — | COMMON STOCK | 85220G109 |
| WVE | WAVE LIFE SCIENCES LTD | 26,975,505 | $196M | 2.1% | $7.25 * | $10.32 | +33.3% | COMMON STOCK | Y95308105 |
| SEPN | SEPTERNA INC | 6,995,858 | $168M | 1.8% | $24.03 * | $23.65 | +12.1% | COMMON STOCK | 81734D104 |
| IRON | DISC MEDICINE INC | 2,450,221 | $157M | 1.7% | $63.94 * | $63.88 | +15.9% | COMMON STOCK | 254604101 |
| JANX | JANUX THERAPEUTICS INC | 11,189,693 | $156M | 1.6% | $13.90 | $26.21 | -47.9% | COMMON STOCK | 47103J105 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 15,827,186 | $151M | 1.6% | $9.52 * | $7.23 | -3.2% | COMMON STOCK | 09058V103 |
| BCAX | BICARA THERAPEUTICS INC | 7,255,993 | $144M | 1.5% | $19.89 * | $25.12 | -35.2% | COMMON STOCK | 055477103 |
| PRAX | PRAXIS PRECISION MEDICINES I | 373,787 | $120M | 1.3% | $322.19 * | $186.22 | +67.4% | COMMON STOCK | 74006W207 |
| GHRS | GH RESEARCH PLC | 7,676,697 | $108M | 1.1% | $14.06 * | $15.85 | -0.9% | COMMON STOCK | G3855L106 |
| ZLAB | ZAI LAB LTD-ADR | 5,707,262 | $107M | 1.1% | $18.81 | $18.81 | — | COMMON STOCK | 98887Q104 |
| TSHA | TAYSHA GENE THERAPIES INC | 23,555,648 | $105M | 1.1% | $4.47 * | $2.03 | +134.3% | COMMON STOCK | 877619106 |
| VOR | VOR BIOPHARMA INC | 5,404,998 | $96.43M | 1.0% | $17.84 * | $26.54 | -47.3% | COMMON STOCK | 929033207 |
| GERN | GERON CORP | 63,771,366 | $95.02M | 1.0% | $1.49 | $2.37 | -36.3% | COMMON STOCK | 374163103 |
| SPRY | ARS PHARMACEUTICALS INC | 10,860,977 | $87.21M | 0.9% | $8.03 * | $6.66 | +53.7% | COMMON STOCK | 82835W108 |
| SRPT | SAREPTA THERAPEUTICS INC | 3,902,596 | $84.92M | 0.9% | $21.76 * | $20.24 | 0.0% | COMMON STOCK | 803607100 |
| SYRE | SPYRE THERAPEUTICS INC | 1,621,620 | $81.79M | 0.9% | $50.44 * | $26.13 | +32.2% | COMMON STOCK | 00773J202 |
| EVMN | EVOMMUNE INC | 3,494,638 | $80.34M | 0.9% | $22.99 * | $18.82 | +16.9% | COMMON STOCK | 30054Y107 |
| CLYM | CLIMB BIO INC | 11,300,939 | $77.41M | 0.8% | $6.85 * | $12.52 | -60.1% | COMMON STOCK | 28658R106 |
| SLDB | SOLID BIOSCIENCES INC | 9,339,978 | $67.25M | 0.7% | $7.20 * | $6.16 | -1.7% | COMMON STOCK | 83422E204 |
| ARTV | ARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $63.46M | 0.7% | $6.44 * | $11.59 | -61.9% | COMMON STOCK | 04317A107 |
| GLTO | DAMORA THERAPEUTICS INC | 2,399,310 | $62.14M | 0.7% | $25.90 | $25.80 | 0.0% | COMMON STOCK | 36322Q206 |
| XNCR | XENCOR INC | 4,897,237 | $59.06M | 0.6% | $12.06 * | $12.66 | 0.0% | COMMON STOCK | 98401F105 |
| LBRX | LB PHARMACEUTICALS INC | 2,208,604 | $54.46M | 0.6% | $24.66 * | $16.18 | +38.3% | COMMON STOCK | 50180M108 |
| JBIO | JADE BIOSCIENCES INC | 3,671,083 | $51.58M | 0.5% | $14.05 * | $17.98 | -17.7% | COMMON STOCK | 008064206 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 20,992,669 | $49.54M | 0.5% | $2.36 * | $9.92 | -77.0% | COMMON STOCK | 00509G209 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 5,049,779 | $47.01M | 0.5% | $9.31 * | $17.53 | -51.1% | COMMON STOCK | 35104E100 |
| FULC | FULCRUM THERAPEUTICS INC | 6,053,960 | $46.43M | 0.5% | $7.67 * | $7.35 | +41.2% | COMMON STOCK | 359616109 |
| CAPR | CAPRICOR THERAPEUTICS INC | 1,507,844 | $45.84M | 0.5% | $30.40 * | $13.06 | +90.5% | COMMON STOCK | 14070B309 |
| IPSC | CENTURY THERAPEUTICS INC | 17,754,430 | $40.13M | 0.4% | $2.26 * | $1.94 | 0.0% | COMMON STOCK | 15673T100 |
| OLMA | OLEMA PHARMACEUTICALS INC | 2,600,000 | $38.77M | 0.4% | $14.91 * | $17.79 | +43.1% | COMMON STOCK | 68062P106 |
| LENZ | LENZ THERAPEUTICS INC | 4,178,823 | $38.24M | 0.4% | $9.15 * | $20.79 | -24.3% | COMMON STOCK | 52635N103 |
| MNPR | MONOPAR THERAPEUTICS INC | 667,207 | $36.56M | 0.4% | $54.79 * | $31.96 | +96.5% | COMMON STOCK | 61023L207 |
| PEPG | PEPGEN INC | 20,064,545 | $35.51M | 0.4% | $1.77 * | $6.78 | -14.0% | COMMON STOCK | 713317105 |
| DSGN | DESIGN THERAPEUTICS INC | 2,972,973 | $31.63M | 0.3% | $10.64 * | $8.48 | +17.8% | COMMON STOCK | 25056L103 |
| MIRM | MIRUM PHARMACEUTICALS INC | 318,554 | $29.43M | 0.3% | $92.38 * | $96.57 | 0.0% | COMMON STOCK | 604749101 |
| BIOA | BIOAGE LABS INC | 1,650,648 | $28.87M | 0.3% | $17.49 * | $19.20 | 0.0% | COMMON STOCK | 09077V100 |
| LXEO | LEXEO THERAPEUTICS INC | 5,000,000 | $28.7M | 0.3% | $5.74 * | $9.13 | -17.4% | COMMON STOCK | 52886X107 |
| ASMB | ASSEMBLY BIOSCIENCES INC | 1,020,410 | $28.32M | 0.3% | $27.75 * | $21.94 | +29.9% | COMMON STOCK | 045396207 |
| RZLT | REZOLUTE INC | 9,180,000 | $28M | 0.3% | $3.05 | $7.84 | -61.0% | COMMON STOCK | 76200L309 |
| AKTS | AKTIS ONCOLOGY INC | 1,503,084 | $26.89M | 0.3% | $17.89 | $17.89 | — | COMMON STOCK | 01021M104 |
| ALXO | ALX ONCOLOGY HOLDINGS INC | 13,011,849 | $26.09M | 0.3% | $2.00 * | $1.77 | 0.0% | COMMON STOCK | 00166B105 |
| ACRS | ACLARIS THERAPEUTICS INC | 6,804,072 | $25.52M | 0.3% | $3.75 * | $3.33 | 0.0% | COMMON STOCK | 00461U105 |
| OVID | OVID THERAPEUTICS INC | 10,714,000 | $23.79M | 0.3% | $2.22 * | $1.54 | +3.6% | COMMON STOCK | 690469101 |
| NKTX | NKARTA INC | 10,805,129 | $22.8M | 0.2% | $2.11 * | $20.85 | -89.5% | COMMON STOCK | 65487U108 |
| TVTX | TRAVERE THERAPEUTICS INC | 746,841 | $22.19M | 0.2% | $29.71 * | $31.03 | 0.0% | COMMON STOCK | 89422G107 |
| GRAL | GRAIL INC | 428,266 | $22.13M | 0.2% | $51.68 * | $86.40 | +9.2% | COMMON STOCK | 384747101 |
| CCCC | C4 THERAPEUTICS INC | 8,000,000 | $21.04M | 0.2% | $2.63 * | $2.37 | -11.9% | COMMON STOCK | 12529R107 |
| RLMD | RELMADA THERAPEUTICS INC | 2,947,369 | $20.51M | 0.2% | $6.96 * | $4.01 | 0.0% | COMMON STOCK | 75955J402 |
| BNTC | BENITEC BIOPHARMA INC | 1,850,000 | $19.7M | 0.2% | $10.65 * | $13.83 | -14.8% | COMMON STOCK | 08205P209 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 265,000 | $19.34M | 0.2% | $72.97 * | $84.00 | 0.0% | COMMON STOCK | 10919W405 |
| STRO | SUTRO BIOPHARMA INC | 715,307 | $17.82M | 0.2% | $24.91 * | $15.08 | 0.0% | COMMON STOCK | 869367201 |
| CTNM | CONTINEUM THERAPEUTICS INC-A | 1,296,012 | $16.93M | 0.2% | $13.06 * | $8.15 | +63.8% | COMMON STOCK | 21217B100 |
| SABS | SAB BIOTHERAPEUTICS INC | 4,401,500 | $16.86M | 0.2% | $3.83 * | $2.26 | +77.0% | COMMON STOCK | 78397T202 |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 325,663 | $16.8M | 0.2% | $51.58 * | $87.35 | -11.4% | COMMON STOCK | 457730109 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 3,000,000 | $16.65M | 0.2% | $5.55 | $5.58 | 0.0% | COMMON STOCK | 03675P102 |
| OKUR | ONKURE THERAPEUTICS INC-A | 3,998,333 | $16.55M | 0.2% | $4.14 * | $2.73 | 0.0% | COMMON STOCK | 68277Q105 |
| HNGE | HINGE HEALTH INC-A | 364,613 | $14.06M | 0.1% | $38.56 * | $42.25 | -3.9% | COMMON STOCK | 433313103 |
| WGS | GENEDX HOLDINGS CORP | 209,887 | $13.48M | 0.1% | $64.22 * | $94.87 | +6.6% | COMMON STOCK | 81663L200 |
| WAY | WAYSTAR HOLDING CORP | 529,400 | $12.76M | 0.1% | $24.11 * | $29.71 | -7.5% | COMMON STOCK | 946784105 |
| HLXC | HELIX ACQUISITION CORP-CL A | 1,250,000 | $12.7M | 0.1% | $10.16 | $10.16 | — | COMMON STOCK | G4444S107 |
| PALI | PALISADE BIO INC | 7,124,116 | $12.47M | 0.1% | $1.75 | $1.92 | -7.2% | COMMON STOCK | 696389402 |
| ACRV | ACRIVON THERAPEUTICS INC | 8,340,508 | $11.59M | 0.1% | $1.39 * | $10.73 | -82.8% | COMMON STOCK | 004890109 |
| RNA | ATRIUM THERAPEUTICS INC | 864,102 | $11.55M | 0.1% | $13.37 | $13.37 | — | COMMON STOCK | 04965N104 |
| KPTI | KARYOPHARM THERAPEUTICS INC | 1,917,354 | $10.68M | 0.1% | $5.57 * | $7.62 | 0.0% | COMMON STOCK | 48576U205 |
| AVTX | AVALO THERAPEUTICS INC | 662,968 | $9.898M | 0.1% | $14.93 * | $10.31 | +50.3% | COMMON STOCK | 05338F306 |
| PCSC | PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $8.227M | 0.1% | $10.97 * | $10.07 | +35.3% | COMMON STOCK | G70077105 |
| ACET | ADICET BIO INC | 1,182,624 | $8.054M | 0.1% | $6.81 * | $10.40 | -25.4% | COMMON STOCK | 007002207 |
| NAMSW | NEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $6.68M | 0.1% | $20.04 | $0.87 | — | W EXP 99/99/999 | N62509117 |
| CRVS | CORVUS PHARMACEUTICALS INC | 450,000 | $6.583M | 0.1% | $14.63 * | $16.29 | 0.0% | COMMON STOCK | 221015100 |
| RANI | RANI THERAPEUTICS HOLDINGS-A | 8,500,000 | $6.246M | 0.1% | $0.73 * | $1.51 | -12.3% | COMMON STOCK | 753018100 |
| EQ | EQUILLIUM INC | 3,096,336 | $6.193M | 0.1% | $2.00 * | $1.44 | 0.0% | COMMON STOCK | 29446K106 |
| HOWL | WEREWOLF THERAPEUTICS INC | 6,681,307 | $5.563M | 0.1% | $0.83 * | $9.71 | -93.4% | COMMON STOCK | 95075A107 |
| MGNX | MACROGENICS INC | 1,864,176 | $5.387M | 0.1% | $2.89 * | $1.76 | 0.0% | COMMON STOCK | 556099109 |
| MPLT | MAPLIGHT THERAPEUTICS INC | 248,294 | $5.048M | 0.1% | $20.33 * | $17.62 | 0.0% | COMMON STOCK | 56565P103 |
| PTN | PALATIN TECHNOLOGIES INC | 70,000 | $1.219M | 0.0% | $17.42 | $13.14 | +32.8% | COMMON STOCK | 696077601 |