Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q1 2019 (← Previous) (Next →)
Filing Date: May 15, 2019
Total Value: $6.46B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A S | 3,970,673 | $467M | 7.2% | — | — | SPONSORED ADR | 04351P101 |
| — | TRICIDA INC | 10,889,280 | $421M | 6.5% | — | — | COM | 89610F101 |
| — | CLEMENTIA PHARMACEUTICALS IN | 10,425,225 | $272M | 4.2% | — | — | COM | 185575107 |
| — | ALEXION PHARMACEUTICALS INC | 1,957,200 | $265M | 4.1% | — | — | COM | 015351109 |
| ALEC | ALECTOR INC | 13,182,329 | $247M | 3.8% | — | — | COM | 014442107 |
| BSX | BOSTON SCIENTIFIC CORP | 5,790,400 | $222M | 3.4% | — | — | COM | 101137107 |
| MRK | MERCK & CO INC | 2,570,100 | $214M | 3.3% | — | — | COM | 58933Y105 |
| VRTX | VERTEX PHARMACEUTICALS INC | 955,300 | $176M | 2.7% | — | — | COM | 92532F100 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,833,200 | $162M | 2.5% | — | — | COM | 64125C109 |
| — | MYLAN N V | 4,861,800 | $138M | 2.1% | — | — | SHS EURO | N59465109 |
| EW | EDWARDS LIFESCIENCES CORP | 715,000 | $137M | 2.1% | — | — | COM | 28176E108 |
| — | WRIGHT MED GROUP N V | 4,187,799 | $132M | 2.0% | — | — | ORD SHS | N96617118 |
| TMO | THERMO FISHER SCIENTIFIC INC | 447,300 | $122M | 1.9% | — | — | COM | 883556102 |
| ISRG | INTUITIVE SURGICAL INC | 210,300 | $120M | 1.9% | — | — | COM NEW | 46120E602 |
| GH | GUARDANT HEALTH INC | 1,534,464 | $118M | 1.8% | — | — | COM | 40131M109 |
| — | SYNTHORX INC | 5,316,355 | $108M | 1.7% | — | — | COM | 87167A103 |
| SRPT | SAREPTA THERAPEUTICS INC | 828,400 | $98.74M | 1.5% | — | — | COM | 803607100 |
| ELV | ANTHEM INC | 325,200 | $93.33M | 1.4% | — | — | COM | 036752103 |
| BHC | BAUSCH HEALTH COS INC | 3,740,700 | $92.39M | 1.4% | — | — | COM | 071734107 |
| — | PRINCIPIA BIOPHARMA INC | 2,605,713 | $88.59M | 1.4% | — | — | COM | 74257L108 |
| REGN | REGENERON PHARMACEUTICALS | 214,800 | $88.2M | 1.4% | — | — | COM | 75886F107 |
| — | DECIPHERA PHARMACEUTICALS IN | 3,618,171 | $83.98M | 1.3% | — | — | COM | 24344T101 |
| INSP | INSPIRE MED SYS INC | 1,471,000 | $83.52M | 1.3% | — | — | COM | 457730109 |
| — | IMMUNOMEDICS INC | 4,270,403 | $82.03M | 1.3% | — | — | COM | 452907108 |
| EHTH | EHEALTH INC | 1,181,214 | $73.64M | 1.1% | — | — | COM | 28238P109 |
| PBYI | PUMA BIOTECHNOLOGY INC | 1,880,000 | $72.92M | 1.1% | — | — | COM | 74587V107 |
| — | AUDENTES THERAPEUTICS INC | 1,815,000 | $70.82M | 1.1% | — | — | COM | 05070R104 |
| ILMN | ILLUMINA INC | 227,300 | $70.62M | 1.1% | — | — | COM | 452327109 |
| — | CLOVIS ONCOLOGY INC | 2,832,300 | $70.3M | 1.1% | — | — | COM | 189464100 |
| EXEL | EXELIXIS INC | 2,801,900 | $66.69M | 1.0% | — | — | COM | 30161Q104 |
| A | AGILENT TECHNOLOGIES INC | 798,700 | $64.2M | 1.0% | — | — | COM | 00846U101 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 4,079,000 | $63.96M | 1.0% | — | — | SPONSORED ADS | 881624209 |
| — | LOGICBIO THERAPEUTICS INC | 6,466,783 | $63.89M | 1.0% | — | — | COM | 54142F102 |
| PTCT | PTC THERAPEUTICS INC | 1,519,700 | $57.2M | 0.9% | — | — | COM | 69366J200 |
| BMY | BRISTOL MYERS SQUIBB CO | 1,195,000 | $57.01M | 0.9% | — | — | COM | 110122108 |
| HUM | HUMANA INC | 210,300 | $55.94M | 0.9% | — | — | COM | 444859102 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 5,548,326 | $52.77M | 0.8% | — | — | COM | 462260100 |
| — | AVEDRO INC | 4,240,128 | $52.03M | 0.8% | — | — | COM | 05355N109 |
| — | ENDO INTL PLC | 6,165,464 | $49.51M | 0.8% | — | — | SHS | G30401106 |
| ABT | ABBOTT LABS | 615,400 | $49.2M | 0.8% | — | — | COM | 002824100 |
| — | MYOKARDIA INC | 906,600 | $47.13M | 0.7% | — | — | COM | 62857M105 |
| ARGX | ARGENX SE | 361,300 | $45.1M | 0.7% | — | — | SPONSORED ADR | 04016X101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,914,282 | $43.57M | 0.7% | — | — | COM | 22663K107 |
| MGTX | MEIRAGTX HOLDINGS PLC | 2,460,251 | $42.39M | 0.7% | — | — | COM | G59665102 |
| ZLAB | ZAI LAB LTD | 1,401,318 | $41.35M | 0.6% | — | — | ADR | 98887Q104 |
| CI | CIGNA CORP NEW | 252,600 | $40.62M | 0.6% | — | — | COM | 125523100 |
| TNDM | TANDEM DIABETES CARE INC | 631,300 | $40.09M | 0.6% | — | — | COM NEW | 875372203 |
| ARVN | ARVINAS INC | 2,678,810 | $39.54M | 0.6% | — | — | COM | 04335A105 |
| VRAYQ | VIEWRAY INC | 5,149,019 | $38.05M | 0.6% | — | — | COM | 92672L107 |
| ONC | BEIGENE LTD | 282,500 | $37.29M | 0.6% | — | — | SPONSORED ADR | 07725L102 |
| APLS | APELLIS PHARMACEUTICALS INC | 1,762,300 | $34.37M | 0.5% | — | — | COM | 03753U106 |
| — | OBSEVA SA | 2,605,531 | $33.33M | 0.5% | — | — | COM | H5861P103 |
| — | RESTORBIO INC | 4,830,387 | $32.94M | 0.5% | — | — | COM | 76133L103 |
| PRTA | PROTHENA CORP PLC | 2,435,278 | $29.54M | 0.5% | — | — | SHS | G72800108 |
| GNFTY | GENFIT S A | 1,230,314 | $29.53M | 0.5% | — | — | ADS | 372279109 |
| GILD | GILEAD SCIENCES INC | 443,800 | $28.85M | 0.4% | — | — | COM | 375558103 |
| — | KALA PHARMACEUTICALS INC | 3,447,840 | $28.51M | 0.4% | — | — | COM | 483119103 |
| XTNT | XTANT MED HLDGS INC | 9,207,012 | $28.08M | 0.4% | — | — | COM NEW | 98420P308 |
| — | CELGENE CORP | 295,000 | $27.83M | 0.4% | — | — | COM | 151020104 |
| PRQR | PROQR THRAPEUTICS N V | 1,982,031 | $27.49M | 0.4% | — | — | SHS EURO | N71542109 |
| HRTX | HERON THERAPEUTICS INC | 1,069,000 | $26.13M | 0.4% | — | — | COM | 427746102 |
| CDNA | CAREDX INC | 827,600 | $26.09M | 0.4% | — | — | COM | 14167L103 |
| — | ALPINE IMMUNE SCIENCES INC | 3,670,955 | $25.18M | 0.4% | — | — | COM | 02083G100 |
| — | CYMABAY THERAPEUTICS INC | 1,874,955 | $24.9M | 0.4% | — | — | COM | 23257D103 |
| CRVS | CORVUS PHARMACEUTICALS INC | 5,967,584 | $23.99M | 0.4% | — | — | COM | 221015100 |
| AMGN | AMGEN INC | 122,100 | $23.2M | 0.4% | — | — | COM | 031162100 |
| — | HARPOON THERAPEUTICS INC | 2,446,409 | $23.17M | 0.4% | — | — | COM | 41358P106 |
| ENTA | ENANTA PHARMACEUTICALS INC | 233,100 | $22.27M | 0.3% | — | — | COM | 29251M106 |
| NTRA | NATERA INC | 1,077,586 | $22.22M | 0.3% | — | — | COM | 632307104 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 250,000 | $22.21M | 0.3% | — | — | Put | 09061G101 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 787,300 | $21.58M | 0.3% | — | — | COM | 76243J105 |
| BIIB | BIOGEN INC | 87,700 | $20.73M | 0.3% | — | — | COM | 09062X103 |
| AUPH | AURINIA PHARMACEUTICALS INC | 3,149,810 | $20.47M | 0.3% | — | — | COM | 05156V102 |
| TAK | TAKEDA PHARMACEUTICAL CO LTD | 1,000,000 | $20.37M | 0.3% | — | — | Call | 874060205 |
| — | ASSEMBLY BIOSCIENCES INC | 996,123 | $19.61M | 0.3% | — | — | COM | 045396108 |
| — | FOAMIX PHARMACEUTICALS LTD | 5,195,330 | $19.48M | 0.3% | — | — | SHS | M46135105 |
| SIBN | SI BONE INC | 985,368 | $18.56M | 0.3% | — | — | COM | 825704109 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $18.37M | 0.3% | — | — | SHS | P8696W104 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,165,524 | $17.43M | 0.3% | — | — | COM | 00773J103 |
| NVO | NOVO-NORDISK A S | 330,000 | $17.26M | 0.3% | — | — | ADR | 670100205 |
| DXCM | DEXCOM INC | 138,700 | $16.52M | 0.3% | — | — | COM | 252131107 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $16M | 0.2% | — | — | COM | 92511W108 |
| — | SYNLOGIC INC | 2,029,996 | $15.41M | 0.2% | — | — | COM | 87166L100 |
| TAK | TAKEDA PHARMACEUTICAL CO LTD | 750,000 | $15.28M | 0.2% | — | — | SPONSORED ADS | 874060205 |
| SPY | SPDR S&P 500 ETF TR | 50,000 | $14.12M | 0.2% | — | — | Put | 78462F103 |
| — | NABRIVA THERAPEUTICS PLC | 4,644,600 | $11.33M | 0.2% | — | — | SHS | G63637105 |
| — | CONSTELLATION PHARMCETICLS I | 835,842 | $11.33M | 0.2% | — | — | COM | 210373106 |
| SYK | STRYKER CORP | 54,000 | $10.67M | 0.2% | — | — | COM | 863667101 |
| — | SCPHARMACEUTICALS INC | 3,409,865 | $10.23M | 0.2% | — | — | COM | 810648105 |
| — | NOVUS THERAPEUTICS INC | 2,537,110 | $10.2M | 0.2% | — | — | COM | 67011N105 |
| — | MERSANA THERAPEUTICS INC | 1,891,119 | $9.947M | 0.2% | — | — | COM | 59045L106 |
| — | AMARIN CORP PLC | 467,600 | $9.707M | 0.2% | — | — | SPONS ADR NEW | 023111206 |
| — | VERONA PHARMA PLC | 1,250,396 | $8.128M | 0.1% | — | — | SPONSORED ADS | 925050106 |
| — | WRIGHT MED GROUP N V | 250,000 | $7.863M | 0.1% | — | — | Call | N96617118 |
| — | AMARIN CORP PLC | 350,000 | $7.266M | 0.1% | — | — | Call | 023111206 |
| FOLD | AMICUS THERAPEUTICS INC | 518,309 | $7.049M | 0.1% | — | — | COM | 03152W109 |
| WVE | WAVE LIFE SCIENCES LTD | 180,000 | $6.993M | 0.1% | — | — | Put | Y95308105 |
| — | SELECTA BIOSCIENCES INC | 2,879,064 | $6.823M | 0.1% | — | — | COM | 816212104 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 76,500 | $6.795M | 0.1% | — | — | COM | 09061G101 |
| — | ADVERUM BIOTECHNOLOGIES INC | 1,243,200 | $6.514M | 0.1% | — | — | COM | 00773U108 |
| SPRO | SPERO THERAPEUTICS INC | 507,471 | $6.501M | 0.1% | — | — | COM | 84833T103 |
| XENE | XENON PHARMACEUTICALS INC | 634,812 | $6.45M | 0.1% | — | — | COM | 98420N105 |
| NTLA | INTELLIA THERAPEUTICS INC | 377,600 | $6.449M | 0.1% | — | — | COM | 45826J105 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 1,350,655 | $5.808M | 0.1% | — | — | SPONDS ADR | 00653A107 |
| — | X4 PHARMACEUTICALS INC | 311,493 | $5.423M | 0.1% | — | — | COM | 98420X103 |
| — | ATHENEX INC | 430,000 | $5.268M | 0.1% | — | — | COM | 04685N103 |
| — | INVITAE CORP | 222,017 | $5.2M | 0.1% | — | — | COM | 46185L103 |
| — | MENLO THERAPEUTICS INC | 633,920 | $4.976M | 0.1% | — | — | COM | 586858102 |
| — | CTI BIOPHARMA CORP | 5,000,000 | $4.851M | 0.1% | — | — | COM NEW | 12648L601 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $4.68M | 0.1% | — | — | COM | 00810B105 |
| — | AVROBIO INC | 198,583 | $4.379M | 0.1% | — | — | COM | 05455M100 |
| — | REALM THERAPEUTICS PLC | 1,021,484 | $3.933M | 0.1% | — | — | SPONSORED ADS | 75606L103 |
| — | NUVECTRA CORP | 350,000 | $3.854M | 0.1% | — | — | COM | 67075N108 |
| — | AERIE PHARMACEUTICALS INC | 58,000 | $2.755M | 0.0% | — | — | COM | 00771V108 |
| KALV | KALVISTA PHARMACEUTICALS INC | 90,500 | $2.59M | 0.0% | — | — | COM | 483497103 |
| KRYS | KRYSTAL BIOTECH INC | 59,210 | $1.948M | 0.0% | — | — | COM | 501147102 |
| — | MARINUS PHARMACEUTICALS INC | 398,101 | $1.664M | 0.0% | — | — | COM | 56854Q101 |
| APLS | APELLIS PHARMACEUTICALS INC | 75,000 | $1.463M | 0.0% | — | — | Call | 03753U106 |
| — | AEGERION PHARMACEUTICALS INC | 2,000,000 | $1.381M | 0.0% | — | — | NOTE 2.000% 8/1 | 00767EAB8 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 212,000 | $1.113M | 0.0% | — | — | COM | 87164F105 |
| — | SIERRA ONCOLOGY INC | 317,104 | $542K | 0.0% | — | — | COM | 82640U107 |
| — | BIOLINERX LTD | 1,038,600 | $447K | 0.0% | — | — | SPONSORED ADS | 09071M106 |
| — | RECRO PHARMA INC | 43,499 | $255K | 0.0% | — | — | COM | 75629F109 |
| — | MEDIGUS LTD | 15,000 | $44,000 | 0.0% | — | — | SPONSORED ADS | 58471G300 |