ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: May 15, 2019

Total Value ($000): $6,459,711 (100.0% shares, 0.0% debt)

Holdings (124)

ASND ASCENDIS PHARMA A S 7.2%
Value ($000) $467,348 Shares 3,970,673 Est. Cost $29.06 Unrealized
TRICIDA INC 6.5%
Value ($000) $420,544 Shares 10,889,280 Est. Cost $29.90 Unrealized
CLEMENTIA PHARMACEUTICALS IN 4.2%
Value ($000) $272,098 Shares 10,425,225 Est. Cost $16.89 Unrealized
ALEXION PHARMACEUTICALS INC 4.1%
Value ($000) $264,574 Shares 1,957,200 Est. Cost $137.22 Unrealized
ALEC ALECTOR INC 3.8%
Value ($000) $246,773 Shares 13,182,329 Est. Cost $18.92 Unrealized 0.0%
BSX BOSTON SCIENTIFIC CORP 3.4%
Value ($000) $222,236 Shares 5,790,400 Est. Cost $16.76 Unrealized +127.9%
MRK MERCK & CO INC 3.3%
Value ($000) $213,755 Shares 2,570,100 Est. Cost $43.08 Unrealized +40.0%
VRTX VERTEX PHARMACEUTICALS INC 2.7%
Value ($000) $175,727 Shares 955,300 Est. Cost $99.02 Unrealized +86.5%
NBIX NEUROCRINE BIOSCIENCES INC 2.5%
Value ($000) $161,505 Shares 1,833,200 Est. Cost $86.20 Unrealized -3.0%
MYLAN N V 2.1%
Value ($000) $137,783 Shares 4,861,800 Est. Cost $35.28 Unrealized
EW EDWARDS LIFESCIENCES CORP 2.1%
Value ($000) $136,801 Shares 715,000 Est. Cost $43.58 Unrealized +31.0%
WRIGHT MED GROUP N V 2.0%
Value ($000) $131,706 Shares 4,187,799 Est. Cost $25.24 Unrealized
TMO THERMO FISHER SCIENTIFIC INC 1.9%
Value ($000) $122,435 Shares 447,300 Est. Cost $145.20 Unrealized +68.3%
ISRG INTUITIVE SURGICAL INC 1.9%
Value ($000) $119,993 Shares 210,300 Est. Cost $142.69 Unrealized +24.6%
GH GUARDANT HEALTH INC 1.8%
Value ($000) $117,693 Shares 1,534,464 Est. Cost $36.84 Unrealized +50.5%
SYNTHORX INC 1.7%
Value ($000) $108,294 Shares 5,316,355 Est. Cost $17.38 Unrealized
SRPT SAREPTA THERAPEUTICS INC 1.5%
Value ($000) $98,737 Shares 828,400 Est. Cost $103.76 Unrealized +23.9%
ELV ANTHEM INC 1.4%
Value ($000) $93,326 Shares 325,200 Est. Cost $212.75 Unrealized +24.0%
BHC BAUSCH HEALTH COS INC 1.4%
Value ($000) $92,395 Shares 3,740,700 Est. Cost $23.34 Unrealized +2.3%
PRINCIPIA BIOPHARMA INC 1.4%
Value ($000) $88,594 Shares 2,605,713 Est. Cost $29.22 Unrealized
REGN REGENERON PHARMACEUTICALS 1.4%
Value ($000) $88,201 Shares 214,800 Est. Cost $376.34 Unrealized +8.8%
DECIPHERA PHARMACEUTICALS IN 1.3%
Value ($000) $83,978 Shares 3,618,171 Est. Cost $24.10 Unrealized
INSP INSPIRE MED SYS INC 1.3%
Value ($000) $83,523 Shares 1,471,000 Est. Cost $32.28 Unrealized +67.4%
IMMUNOMEDICS INC 1.3%
Value ($000) $82,034 Shares 4,270,403 Est. Cost $11.06 Unrealized
EHTH EHEALTH INC 1.1%
Value ($000) $73,637 Shares 1,181,214 Est. Cost $14.94 Unrealized +268.9%
PBYI PUMA BIOTECHNOLOGY INC 1.1%
Value ($000) $72,925 Shares 1,880,000 Est. Cost $89.74 Unrealized -66.0%
AUDENTES THERAPEUTICS INC 1.1%
Value ($000) $70,821 Shares 1,815,000 Est. Cost $17.81 Unrealized
ILMN ILLUMINA INC 1.1%
Value ($000) $70,620 Shares 227,300 Est. Cost $123.96 Unrealized +135.3%
CLOVIS ONCOLOGY INC 1.1%
Value ($000) $70,298 Shares 2,832,300 Est. Cost $72.00 Unrealized
EXEL EXELIXIS INC 1.0%
Value ($000) $66,685 Shares 2,801,900 Est. Cost $20.21 Unrealized +12.9%
A AGILENT TECHNOLOGIES INC 1.0%
Value ($000) $64,200 Shares 798,700 Est. Cost $38.64 Unrealized +87.1%
TEVA TEVA PHARMACEUTICAL INDS LTD 1.0%
Value ($000) $63,959 Shares 4,079,000 Est. Cost $15.68 Unrealized
LOGICBIO THERAPEUTICS INC 1.0%
Value ($000) $63,892 Shares 6,466,783 Est. Cost $10.40 Unrealized
PTCT PTC THERAPEUTICS INC 0.9%
Value ($000) $57,202 Shares 1,519,700 Est. Cost $40.50 Unrealized -17.1%
BMY BRISTOL MYERS SQUIBB CO 0.9%
Value ($000) $57,013 Shares 1,195,000 Est. Cost $41.42 Unrealized -7.5%
HUM HUMANA INC 0.9%
Value ($000) $55,940 Shares 210,300 Est. Cost $298.72 Unrealized -9.2%
IOVA IOVANCE BIOTHERAPEUTICS INC 0.8%
Value ($000) $52,765 Shares 5,548,326 Est. Cost $6.34 Unrealized +53.1%
AVEDRO INC 0.8%
Value ($000) $52,026 Shares 4,240,128 Est. Cost $12.27 Unrealized
ENDO INTL PLC 0.8%
Value ($000) $49,509 Shares 6,165,464 Est. Cost $8.03 Unrealized
ABT ABBOTT LABS 0.8%
Value ($000) $49,195 Shares 615,400 Est. Cost $57.09 Unrealized +15.8%
MYOKARDIA INC 0.7%
Value ($000) $47,134 Shares 906,600 Est. Cost $50.83 Unrealized
ARGX ARGENX SE 0.7%
Value ($000) $45,105 Shares 361,300 Est. Cost $38.81 Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.7%
Value ($000) $43,569 Shares 1,914,282 Est. Cost $29.69 Unrealized -17.2%
MGTX MEIRAGTX HOLDINGS PLC 0.7%
Value ($000) $42,390 Shares 2,460,251 Est. Cost $13.62 Unrealized +3.4%
ZLAB ZAI LAB LTD 0.6%
Value ($000) $41,353 Shares 1,401,318 Est. Cost $24.35 Unrealized
CI CIGNA CORP NEW 0.6%
Value ($000) $40,623 Shares 252,600 Est. Cost $190.77 Unrealized -12.5%
TNDM TANDEM DIABETES CARE INC 0.6%
Value ($000) $40,088 Shares 631,300 Est. Cost $17.97 Unrealized +192.4%
ARVN ARVINAS INC 0.6%
Value ($000) $39,539 Shares 2,678,810 Est. Cost $16.45 Unrealized +7.8%
VRAYQ VIEWRAY INC 0.6%
Value ($000) $38,051 Shares 5,149,019 Est. Cost $4.68 Unrealized +64.8%
ONC BEIGENE LTD 0.6%
Value ($000) $37,290 Shares 282,500 Est. Cost $46.26 Unrealized
APLS APELLIS PHARMACEUTICALS INC 0.5%
Value ($000) $34,365 Shares 1,762,300 Est. Cost $15.66 Unrealized +0.5%
OBSEVA SA 0.5%
Value ($000) $33,325 Shares 2,605,531 Est. Cost $10.41 Unrealized
RESTORBIO INC 0.5%
Value ($000) $32,943 Shares 4,830,387 Est. Cost $9.58 Unrealized
PRTA PROTHENA CORP PLC 0.5%
Value ($000) $29,540 Shares 2,435,278 Est. Cost $12.49 Unrealized 0.0%
GNFTY GENFIT S A 0.5%
Value ($000) $29,528 Shares 1,230,314 Est. Cost $24.00 Unrealized
GILD GILEAD SCIENCES INC 0.4%
Value ($000) $28,851 Shares 443,800 Est. Cost $51.16 Unrealized -0.6%
KALA PHARMACEUTICALS INC 0.4%
Value ($000) $28,514 Shares 3,447,840 Est. Cost $20.66 Unrealized
XTNT XTANT MED HLDGS INC 0.4%
Value ($000) $28,081 Shares 9,207,012 Est. Cost $6.59 Unrealized -55.8%
CELGENE CORP 0.4%
Value ($000) $27,830 Shares 295,000 Est. Cost $98.86 Unrealized
PRQR PROQR THRAPEUTICS N V 0.4%
Value ($000) $27,491 Shares 1,982,031 Est. Cost $13.70 Unrealized +9.0%
HRTX HERON THERAPEUTICS INC 0.4%
Value ($000) $26,126 Shares 1,069,000 Est. Cost $21.87 Unrealized +19.7%
CDNA CAREDX INC 0.4%
Value ($000) $26,086 Shares 827,600 Est. Cost $29.13 Unrealized 0.0%
ALPINE IMMUNE SCIENCES INC 0.4%
Value ($000) $25,183 Shares 3,670,955 Est. Cost $11.12 Unrealized
CYMABAY THERAPEUTICS INC 0.4%
Value ($000) $24,899 Shares 1,874,955 Est. Cost $13.28 Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.4%
Value ($000) $23,990 Shares 5,967,584 Est. Cost $13.85 Unrealized -69.5%
AMGN AMGEN INC 0.4%
Value ($000) $23,197 Shares 122,100 Est. Cost $99.69 Unrealized +55.2%
HARPOON THERAPEUTICS INC 0.4%
Value ($000) $23,167 Shares 2,446,409 Est. Cost $9.47 Unrealized
ENTA ENANTA PHARMACEUTICALS INC 0.3%
Value ($000) $22,266 Shares 233,100 Est. Cost $89.70 Unrealized 0.0%
NTRA NATERA INC 0.3%
Value ($000) $22,220 Shares 1,077,586 Est. Cost $15.75 Unrealized -0.5%
BMRN BIOMARIN PHARMACEUTICAL INC 0.3%
Value ($000) $22,208 Shares 250,000 Est. Cost $86.40 Unrealized +7.3%
RYTM RHYTHM PHARMACEUTICALS INC 0.3%
Value ($000) $21,580 Shares 787,300 Est. Cost $26.40 Unrealized +8.8%
BIIB BIOGEN INC 0.3%
Value ($000) $20,731 Shares 87,700 Est. Cost $265.33 Unrealized +18.7%
AUPH AURINIA PHARMACEUTICALS INC 0.3%
Value ($000) $20,474 Shares 3,149,810 Est. Cost $6.63 Unrealized 0.0%
TAK TAKEDA PHARMACEUTICAL CO LTD 0.3%
Value ($000) $20,370 Shares 1,000,000 Est. Cost $20.37 Unrealized
ASSEMBLY BIOSCIENCES INC 0.3%
Value ($000) $19,614 Shares 996,123 Est. Cost $30.27 Unrealized
FOAMIX PHARMACEUTICALS LTD 0.3%
Value ($000) $19,482 Shares 5,195,330 Est. Cost $5.20 Unrealized
SIBN SI BONE INC 0.3%
Value ($000) $18,564 Shares 985,368 Est. Cost $18.92 Unrealized +2.3%
SVA SINOVAC BIOTECH LTD 0.3%
Value ($000) $18,372 Shares 2,839,500 Est. Cost $4.60 Unrealized +42.0%
AEGLEA BIOTHERAPEUTICS INC 0.3%
Value ($000) $17,432 Shares 2,165,524 Est. Cost $6.69 Unrealized
NVO NOVO-NORDISK A S 0.3%
Value ($000) $17,262 Shares 330,000 Est. Cost $48.15 Unrealized
DXCM DEXCOM INC 0.3%
Value ($000) $16,519 Shares 138,700 Est. Cost $31.72 Unrealized +10.8%
VERRICA PHARMACEUTICALS INC 0.2%
Value ($000) $15,996 Shares 1,479,733 Est. Cost $19.73 Unrealized
SYNLOGIC INC 0.2%
Value ($000) $15,408 Shares 2,029,996 Est. Cost $15.62 Unrealized
TAK TAKEDA PHARMACEUTICAL CO LTD 0.2%
Value ($000) $15,278 Shares 750,000 Est. Cost $20.37 Unrealized
SPY SPDR S&P 500 ETF TR 0.2%
Value ($000) $14,124 Shares 50,000 Est. Cost Unrealized
NABRIVA THERAPEUTICS PLC 0.2%
Value ($000) $11,333 Shares 4,644,600 Est. Cost $9.27 Unrealized
CONSTELLATION PHARMCETICLS I 0.2%
Value ($000) $11,326 Shares 835,842 Est. Cost $6.73 Unrealized
SYK STRYKER CORP 0.2%
Value ($000) $10,666 Shares 54,000 Est. Cost $93.40 Unrealized +78.9%
SCPHARMACEUTICALS INC 0.2%
Value ($000) $10,230 Shares 3,409,865 Est. Cost $12.09 Unrealized
NOVUS THERAPEUTICS INC 0.2%
Value ($000) $10,199 Shares 2,537,110 Est. Cost $5.85 Unrealized
MERSANA THERAPEUTICS INC 0.2%
Value ($000) $9,947 Shares 1,891,119 Est. Cost $5.26 Unrealized
AMARIN CORP PLC 0.2%
Value ($000) $9,707 Shares 467,600 Est. Cost $19.52 Unrealized
VERONA PHARMA PLC 0.1%
Value ($000) $8,128 Shares 1,250,396 Est. Cost $11.76 Unrealized
WRIGHT MED GROUP N V 0.1%
Value ($000) $7,863 Shares 250,000 Est. Cost $25.24 Unrealized
AMARIN CORP PLC 0.1%
Value ($000) $7,266 Shares 350,000 Est. Cost $19.52 Unrealized
FOLD AMICUS THERAPEUTICS INC 0.1%
Value ($000) $7,049 Shares 518,309 Est. Cost $13.36 Unrealized -8.6%
WVE WAVE LIFE SCIENCES LTD 0.1%
Value ($000) $6,993 Shares 180,000 Est. Cost Unrealized
SELECTA BIOSCIENCES INC 0.1%
Value ($000) $6,823 Shares 2,879,064 Est. Cost $8.74 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.1%
Value ($000) $6,795 Shares 76,500 Est. Cost $86.40 Unrealized +7.3%
ADVERUM BIOTECHNOLOGIES INC 0.1%
Value ($000) $6,514 Shares 1,243,200 Est. Cost $5.24 Unrealized
SPRO SPERO THERAPEUTICS INC 0.1%
Value ($000) $6,501 Shares 507,471 Est. Cost $10.61 Unrealized 0.0%
XENE XENON PHARMACEUTICALS INC 0.1%
Value ($000) $6,450 Shares 634,812 Est. Cost $7.72 Unrealized +9.8%
NTLA INTELLIA THERAPEUTICS INC 0.1%
Value ($000) $6,449 Shares 377,600 Est. Cost $26.61 Unrealized -44.0%
ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.1%
Value ($000) $5,808 Shares 1,350,655 Est. Cost $6.85 Unrealized
X4 PHARMACEUTICALS INC 0.1%
Value ($000) $5,423 Shares 311,493 Est. Cost $17.41 Unrealized
ATHENEX INC 0.1%
Value ($000) $5,268 Shares 430,000 Est. Cost $17.01 Unrealized
INVITAE CORP 0.1%
Value ($000) $5,200 Shares 222,017 Est. Cost $11.59 Unrealized
MENLO THERAPEUTICS INC 0.1%
Value ($000) $4,976 Shares 633,920 Est. Cost $7.85 Unrealized
CTI BIOPHARMA CORP 0.1%
Value ($000) $4,851 Shares 5,000,000 Est. Cost $3.31 Unrealized
AERPIO PHARMACEUTICALS INC 0.1%
Value ($000) $4,680 Shares 5,193,946 Est. Cost $4.15 Unrealized
AVROBIO INC 0.1%
Value ($000) $4,379 Shares 198,583 Est. Cost $28.56 Unrealized
REALM THERAPEUTICS PLC 0.1%
Value ($000) $3,933 Shares 1,021,484 Est. Cost $2.99 Unrealized
NUVECTRA CORP 0.1%
Value ($000) $3,854 Shares 350,000 Est. Cost $21.98 Unrealized
AERIE PHARMACEUTICALS INC 0.0%
Value ($000) $2,755 Shares 58,000 Est. Cost $44.54 Unrealized
KALV KALVISTA PHARMACEUTICALS INC 0.0%
Value ($000) $2,590 Shares 90,500 Est. Cost $21.68 Unrealized 0.0%
KRYS KRYSTAL BIOTECH INC 0.0%
Value ($000) $1,948 Shares 59,210 Est. Cost $23.57 Unrealized 0.0%
MARINUS PHARMACEUTICALS INC 0.0%
Value ($000) $1,664 Shares 398,101 Est. Cost $7.64 Unrealized
APLS APELLIS PHARMACEUTICALS INC 0.0%
Value ($000) $1,463 Shares 75,000 Est. Cost $15.66 Unrealized +0.5%
AEGERION PHARMACEUTICALS INC 0.0%
Value ($000) $1,381 Shares 2,000,000 Est. Cost $0.78 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.0%
Value ($000) $1,113 Shares 212,000 Est. Cost $12.54 Unrealized -54.5%
SIERRA ONCOLOGY INC 0.0%
Value ($000) $542 Shares 317,104 Est. Cost $1.53 Unrealized
BIOLINERX LTD 0.0%
Value ($000) $447 Shares 1,038,600 Est. Cost $1.62 Unrealized
RECRO PHARMA INC 0.0%
Value ($000) $255 Shares 43,499 Est. Cost $5.02 Unrealized
MEDIGUS LTD 0.0%
Value ($000) $44 Shares 15,000 Est. Cost $3.40 Unrealized