Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q4 2018 (← Previous) (Next →)
Filing Date: Feb 14, 2019
Total Value: $5.408B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | TRICIDA INC | 10,889,280 | $257M | 4.7% | — | — | COM | 89610F101 |
| ASND | ASCENDIS PHARMA A S | 4,087,373 | $256M | 4.7% | — | — | SPONSORED ADR | 04351P101 |
| BIIB | BIOGEN INC | 835,249 | $251M | 4.6% | — | — | COM | 09062X103 |
| — | CELGENE CORP | 3,256,700 | $209M | 3.9% | — | — | COM | 151020104 |
| BSX | BOSTON SCIENTIFIC CORP | 5,790,400 | $205M | 3.8% | — | — | COM | 101137107 |
| — | ALEXION PHARMACEUTICALS INC | 2,047,400 | $199M | 3.7% | — | — | COM | 015351109 |
| MRK | MERCK & CO INC | 2,495,000 | $191M | 3.5% | — | — | COM | 58933Y105 |
| VRTX | VERTEX PHARMACEUTICALS INC | 1,133,200 | $188M | 3.5% | — | — | COM | 92532F100 |
| — | WRIGHT MED GROUP N V | 4,905,899 | $134M | 2.5% | — | — | ORD SHS 0.03 PAR | N96617118 |
| — | ALLERGAN PLC | 957,000 | $128M | 2.4% | — | — | SHS | G0177J108 |
| — | CLEMENTIA PHARMACEUTICALS IN | 10,425,225 | $123M | 2.3% | — | — | COM | 185575107 |
| — | MYLAN N V | 3,986,200 | $109M | 2.0% | — | — | SHS EURO | N59465109 |
| TMO | THERMO FISHER SCIENTIFIC INC | 437,500 | $97.91M | 1.8% | — | — | COM | 883556102 |
| — | SYNTHORX INC | 5,316,355 | $92.4M | 1.7% | — | — | COM | 87167A103 |
| CI | CIGNA CORP NEW | 482,700 | $91.67M | 1.7% | — | — | COM | 125523100 |
| SRPT | SAREPTA THERAPEUTICS INC | 781,000 | $85.23M | 1.6% | — | — | COM | 803607100 |
| REGN | REGENERON PHARMACEUTICALS | 222,100 | $82.95M | 1.5% | — | — | COM | 75886F107 |
| ISRG | INTUITIVE SURGICAL INC | 170,500 | $81.66M | 1.5% | — | — | COM NEW | 46120E602 |
| ELV | ANTHEM INC | 305,400 | $80.21M | 1.5% | — | — | COM | 036752103 |
| INSP | INSPIRE MED SYS INC | 1,829,449 | $77.29M | 1.4% | — | — | COM | 457730109 |
| ILMN | ILLUMINA INC | 245,900 | $73.75M | 1.4% | — | — | COM | 452327109 |
| — | PRINCIPIA BIOPHARMA INC | 2,605,713 | $71.37M | 1.3% | — | — | COM | 74257L108 |
| EW | EDWARDS LIFESCIENCES CORP | 465,600 | $71.32M | 1.3% | — | — | COM | 28176E108 |
| — | IMMUNOMEDICS INC | 4,967,403 | $70.89M | 1.3% | — | — | COM | 452907108 |
| — | LOGICBIO THERAPEUTICS INC | 6,466,783 | $67.25M | 1.2% | — | — | COM | 54142F102 |
| BHC | BAUSCH HEALTH COS INC | 3,600,300 | $66.5M | 1.2% | — | — | COM | 071734107 |
| ARGX | ARGENX SE | 647,600 | $62.22M | 1.2% | — | — | SPONSORED ADR | 04016X101 |
| HUM | HUMANA INC | 206,500 | $59.16M | 1.1% | — | — | COM | 444859102 |
| GH | GUARDANT HEALTH INC | 1,534,464 | $57.68M | 1.1% | — | — | COM | 40131M109 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,914,282 | $57.41M | 1.1% | — | — | COM | 22663K107 |
| EXEL | EXELIXIS INC | 2,801,900 | $55.11M | 1.0% | — | — | COM | 30161Q104 |
| PBYI | PUMA BIOTECHNOLOGY INC | 2,598,883 | $52.89M | 1.0% | — | — | COM | 74587V107 |
| PTCT | PTC THERAPEUTICS INC | 1,519,700 | $52.16M | 1.0% | — | — | COM | 69366J200 |
| CVS | CVS HEALTH CORP | 793,800 | $52.01M | 1.0% | — | — | COM | 126650100 |
| — | DECIPHERA PHARMACEUTICALS IN | 2,442,200 | $51.26M | 0.9% | — | — | COM | 24344T101 |
| A | AGILENT TECHNOLOGIES INC | 753,000 | $50.8M | 0.9% | — | — | COM | 00846U101 |
| — | CLOVIS ONCOLOGY INC | 2,752,200 | $49.43M | 0.9% | — | — | COM | 189464100 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 5,548,326 | $49.1M | 0.9% | — | — | COM | 462260100 |
| CNC | CENTENE CORP DEL | 417,400 | $48.13M | 0.9% | — | — | COM | 15135B101 |
| UNH | UNITEDHEALTH GROUP INC | 186,500 | $46.46M | 0.9% | — | — | COM | 91324P102 |
| EHTH | EHEALTH INC | 1,100,000 | $42.26M | 0.8% | — | — | COM | 28238P109 |
| — | RESTORBIO INC | 4,830,387 | $41.64M | 0.8% | — | — | COM | 76133L103 |
| ZLAB | ZAI LAB LTD | 1,753,538 | $40.72M | 0.8% | — | — | ADR | 98887Q104 |
| — | AUDENTES THERAPEUTICS INC | 1,893,500 | $40.37M | 0.7% | — | — | COM | 05070R104 |
| ONC | BEIGENE LTD | 282,500 | $39.62M | 0.7% | — | — | SPONSORED ADR | 07725L102 |
| — | BLUEBIRD BIO INC | 387,200 | $38.41M | 0.7% | — | — | COM | 09609G100 |
| HRTX | HERON THERAPEUTICS INC | 1,400,300 | $36.32M | 0.7% | — | — | COM | 427746102 |
| TNDM | TANDEM DIABETES CARE INC | 948,000 | $36M | 0.7% | — | — | COM NEW | 875372203 |
| MOH | MOLINA HEALTHCARE INC | 305,000 | $35.45M | 0.7% | — | — | COM | 60855R100 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 494,200 | $35.29M | 0.7% | — | — | COM | 64125C109 |
| ARVN | ARVINAS INC | 2,678,810 | $34.42M | 0.6% | — | — | COM | 04335A105 |
| — | OBSEVA SA | 2,605,531 | $32.99M | 0.6% | — | — | COM | H5861P103 |
| ABT | ABBOTT LABS | 448,400 | $32.43M | 0.6% | — | — | COM | 002824100 |
| — | AERIE PHARMACEUTICALS INC | 872,100 | $31.48M | 0.6% | — | — | COM | 00771V108 |
| VRAYQ | VIEWRAY INC | 5,149,019 | $31.25M | 0.6% | — | — | COM | 92672L107 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 2,878,000 | $29.82M | 0.6% | — | — | COM CL A | 46333X108 |
| GILD | GILEAD SCIENCES INC | 443,800 | $27.76M | 0.5% | — | — | COM | 375558103 |
| DVA | DAVITA INC | 534,000 | $27.48M | 0.5% | — | — | COM | 23918K108 |
| BMY | BRISTOL MYERS SQUIBB CO | 505,900 | $26.3M | 0.5% | — | — | COM | 110122108 |
| PFE | PFIZER INC | 602,200 | $26.29M | 0.5% | — | — | COM | 717081103 |
| — | SHIRE PLC | 150,000 | $26.11M | 0.5% | — | — | Call | 82481R106 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 928,500 | $24.96M | 0.5% | — | — | COM | 76243J105 |
| AMGN | AMGEN INC | 122,100 | $23.77M | 0.4% | — | — | COM | 031162100 |
| PRQR | PROQR THRAPEUTICS N V | 1,437,731 | $22.69M | 0.4% | — | — | SHS EURO | N71542109 |
| — | ASSEMBLY BIOSCIENCES INC | 996,123 | $22.53M | 0.4% | — | — | COM | 045396108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 5,967,584 | $21.9M | 0.4% | — | — | COM | 221015100 |
| SIBN | SI BONE INC | 985,368 | $20.58M | 0.4% | — | — | COM | 825704109 |
| SYK | STRYKER CORP | 130,200 | $20.41M | 0.4% | — | — | COM | 863667101 |
| — | SPECTRUM PHARMACEUTICALS INC | 2,265,500 | $19.82M | 0.4% | — | — | COM | 84763A108 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $19.71M | 0.4% | — | — | SHS | P8696W104 |
| — | FOAMIX PHARMACEUTICALS LTD | 5,195,330 | $18.65M | 0.3% | — | — | SHS | M46135105 |
| — | KALA PHARMACEUTICALS INC | 3,447,840 | $16.86M | 0.3% | — | — | COM | 483119103 |
| DXCM | DEXCOM INC | 138,700 | $16.62M | 0.3% | — | — | COM | 252131107 |
| — | MYOKARDIA INC | 335,100 | $16.37M | 0.3% | — | — | COM | 62857M105 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,165,524 | $16.22M | 0.3% | — | — | COM | 00773J103 |
| NVO | NOVO-NORDISK A S | 330,000 | $15.2M | 0.3% | — | — | ADR | 670100205 |
| XTNT | XTANT MED HLDGS INC | 9,207,012 | $14.82M | 0.3% | — | — | COM NEW | 98420P308 |
| — | SYNLOGIC INC | 2,029,996 | $14.23M | 0.3% | — | — | COM | 87166L100 |
| ACIU | AC IMMUNE SA | 1,440,000 | $13.61M | 0.3% | — | — | SHS | H00263105 |
| — | SCPHARMACEUTICALS INC | 3,409,865 | $12.82M | 0.2% | — | — | COM | 810648105 |
| — | ALPINE IMMUNE SCIENCES INC | 3,298,516 | $12.14M | 0.2% | — | — | COM | 02083G100 |
| — | VERONA PHARMA PLC | 1,250,396 | $12.07M | 0.2% | — | — | SPONSORED ADS | 925050106 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $12.06M | 0.2% | — | — | COM | 92511W108 |
| — | INSMED INC | 16,952,000 | $12.01M | 0.2% | — | — | NOTE 1.750% 1/1 | 457669AA7 |
| THC | TENET HEALTHCARE CORP | 562,785 | $9.646M | 0.2% | — | — | COM NEW | 88033G407 |
| NTRA | NATERA INC | 684,086 | $9.55M | 0.2% | — | — | COM | 632307104 |
| HCA | HCA HEALTHCARE INC | 75,900 | $9.446M | 0.2% | — | — | COM | 40412C101 |
| — | ALLAKOS INC | 175,000 | $9.147M | 0.2% | — | — | COM | 01671P100 |
| — | INVITAE CORP | 824,549 | $9.12M | 0.2% | — | — | COM | 46185L103 |
| BSX | BOSTON SCIENTIFIC CORP | 250,000 | $8.835M | 0.2% | — | — | Call | 101137107 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $8.83M | 0.2% | — | — | COM | 00810B105 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 1,350,655 | $7.766M | 0.1% | — | — | SPONDS ADR | 00653A107 |
| — | DERMIRA INC | 1,031,596 | $7.417M | 0.1% | — | — | COM | 24983L104 |
| — | NABRIVA THERAPEUTICS PLC | 4,644,600 | $6.781M | 0.1% | — | — | SHS | G63637105 |
| — | INTERCEPT PHARMACEUTICALS IN | 66,000 | $6.652M | 0.1% | — | — | Call | 45845P108 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 76,500 | $6.514M | 0.1% | — | — | COM | 09061G101 |
| — | CELGENE CORP | 100,000 | $6.409M | 0.1% | — | — | Call | 151020104 |
| — | NUVECTRA CORP | 350,000 | $5.719M | 0.1% | — | — | COM | 67075N108 |
| — | ATHENEX INC | 430,000 | $5.457M | 0.1% | — | — | COM | 04685N103 |
| NTLA | INTELLIA THERAPEUTICS INC | 377,600 | $5.154M | 0.1% | — | — | COM | 45826J105 |
| — | INTERCEPT PHARMACEUTICALS IN | 47,800 | $4.818M | 0.1% | — | — | COM | 45845P108 |
| MGTX | MEIRAGTX HOLDINGS PLC | 469,953 | $4.53M | 0.1% | — | — | COM | G59665102 |
| — | ARSANIS INC | 1,868,966 | $4.336M | 0.1% | — | — | COM | 042873109 |
| APLS | APELLIS PHARMACEUTICALS INC | 327,000 | $4.313M | 0.1% | — | — | COM | 03753U106 |
| — | SELECTA BIOSCIENCES INC | 1,579,064 | $4.2M | 0.1% | — | — | COM | 816212104 |
| — | AVROBIO INC | 249,900 | $4.161M | 0.1% | — | — | COM | 05455M100 |
| — | NOVUS THERAPEUTICS INC | 2,537,110 | $4.059M | 0.1% | — | — | COM | 67011N105 |
| XENE | XENON PHARMACEUTICALS INC | 634,812 | $4.006M | 0.1% | — | — | COM | 98420N105 |
| — | CTI BIOPHARMA CORP | 5,000,000 | $3.668M | 0.1% | — | — | COM NEW | 12648L601 |
| — | SAGE THERAPEUTICS INC | 36,300 | $3.477M | 0.1% | — | — | COM | 78667J108 |
| — | CONSTELLATION PHARMCETICLS I | 835,842 | $3.352M | 0.1% | — | — | COM | 210373106 |
| FOLD | AMICUS THERAPEUTICS INC | 323,009 | $3.094M | 0.1% | — | — | COM | 03152W109 |
| — | 111 INC | 500,000 | $3.07M | 0.1% | — | — | ADS | 68247Q102 |
| — | RA MED SYS INC | 350,000 | $2.783M | 0.1% | — | — | COM | 74933X104 |
| — | ELECTROCORE INC | 397,826 | $2.49M | 0.0% | — | — | COM | 28531P103 |
| — | REALM THERAPEUTICS PLC | 1,021,484 | $1.89M | 0.0% | — | — | SPONSORED ADS | 75606L103 |
| — | AEGERION PHARMACEUTICALS INC | 2,000,000 | $1.676M | 0.0% | — | — | NOTE 2.000% 8/1 | 00767EAB8 |
| — | MARINUS PHARMACEUTICALS INC | 498,101 | $1.43M | 0.0% | — | — | COM | 56854Q101 |
| — | IMMUNOMEDICS INC | 100,000 | $1.427M | 0.0% | — | — | Call | 452907108 |
| — | AMARIN CORP PLC | 81,000 | $1.102M | 0.0% | — | — | SPONS ADR NEW | 023111206 |
| — | MEDICINES CO | 54,600 | $1.045M | 0.0% | — | — | COM | 584688105 |
| — | AFFIMED N V | 326,650 | $1.016M | 0.0% | — | — | COM | N01045108 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 212,000 | $943K | 0.0% | — | — | COM | 87164F105 |
| — | ADAMAS PHARMACEUTICALS INC | 100,000 | $854K | 0.0% | — | — | Call | 00548A106 |
| — | RECRO PHARMA INC | 107,357 | $762K | 0.0% | — | — | COM | 75629F109 |
| — | SIERRA ONCOLOGY INC | 417,104 | $551K | 0.0% | — | — | COM | 82640U107 |
| — | BIOLINERX LTD | 1,038,600 | $454K | 0.0% | — | — | SPONSORED ADS | 09071M106 |
| — | REDHILL BIOPHARMA LTD | 54,600 | $303K | 0.0% | — | — | SPONSORED ADS | 757468103 |
| — | ALIMERA SCIENCES INC | 250,000 | $180K | 0.0% | — | — | COM | 016259103 |
| — | WRIGHT MED GROUP N V | 8,746,583 | $109K | 0.0% | — | — | RIGHT 03/01/2019 | N96617126 |
| — | MEDIGUS LTD | 15,000 | $39,000 | 0.0% | — | — | SPONSORED ADS | 58471G300 |