Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q2 2019 (← Previous) (Next →)
Filing Date: Aug 14, 2019
Total Value: $6.457B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A S | 3,846,673 | $443M | 6.9% | — | — | SPONSORED ADR | 04351P101 |
| — | TRICIDA INC | 11,114,280 | $439M | 6.8% | — | — | COM | 89610F101 |
| BSX | BOSTON SCIENTIFIC CORP | 6,752,500 | $290M | 4.5% | — | — | COM | 101137107 |
| — | ALEXION PHARMACEUTICALS INC | 1,926,085 | $252M | 3.9% | — | — | COM | 015351109 |
| ALEC | ALECTOR INC | 13,182,329 | $250M | 3.9% | — | — | COM | 014442107 |
| MRK | MERCK & CO INC | 2,570,100 | $216M | 3.3% | — | — | COM | 58933Y105 |
| — | PREVAIL THERAPEUTICS INC | 13,822,463 | $182M | 2.8% | — | — | COM | 74140Y101 |
| VRTX | VERTEX PHARMACEUTICALS INC | 973,300 | $178M | 2.8% | — | — | COM | 92532F100 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,833,200 | $155M | 2.4% | — | — | COM | 64125C109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 5,548,326 | $136M | 2.1% | — | — | COM | 462260100 |
| TMO | THERMO FISHER SCIENTIFIC INC | 462,800 | $136M | 2.1% | — | — | COM | 883556102 |
| EW | EDWARDS LIFESCIENCES CORP | 715,000 | $132M | 2.0% | — | — | COM | 28176E108 |
| SRPT | SAREPTA THERAPEUTICS INC | 828,400 | $126M | 1.9% | — | — | COM | 803607100 |
| — | WRIGHT MED GROUP N V | 4,187,799 | $125M | 1.9% | — | — | ORD SHS | N96617118 |
| ISRG | INTUITIVE SURGICAL INC | 210,300 | $110M | 1.7% | — | — | COM NEW | 46120E602 |
| — | TURNING POINT THERAPEUTICS I | 2,567,550 | $104M | 1.6% | — | — | COM | 90041T108 |
| ELV | ANTHEM INC | 361,600 | $102M | 1.6% | — | — | COM | 036752103 |
| BHC | BAUSCH HEALTH COS INC | 3,740,700 | $94.34M | 1.5% | — | — | COM | 071734107 |
| PTCT | PTC THERAPEUTICS INC | 2,089,700 | $94.04M | 1.5% | — | — | COM | 69366J200 |
| INSP | INSPIRE MED SYS INC | 1,471,000 | $89.22M | 1.4% | — | — | COM | 457730109 |
| NTRA | NATERA INC | 3,224,328 | $88.93M | 1.4% | — | — | COM | 632307104 |
| — | LOGICBIO THERAPEUTICS INC | 6,466,783 | $84.07M | 1.3% | — | — | COM | 54142F102 |
| EXEL | EXELIXIS INC | 3,912,900 | $83.62M | 1.3% | — | — | COM | 30161Q104 |
| — | AVEDRO INC | 4,240,128 | $83.28M | 1.3% | — | — | COM | 05355N109 |
| — | DECIPHERA PHARMACEUTICALS IN | 3,618,171 | $81.59M | 1.3% | — | — | COM | 24344T101 |
| ABT | ABBOTT LABS | 938,000 | $78.89M | 1.2% | — | — | COM | 002824100 |
| EHTH | EHEALTH INC | 909,814 | $78.33M | 1.2% | — | — | COM | 28238P109 |
| — | ATHENEX INC | 3,840,130 | $76.03M | 1.2% | — | — | COM | 04685N103 |
| — | SYNTHORX INC | 5,316,355 | $71.82M | 1.1% | — | — | COM | 87167A103 |
| QURE | UNIQURE NV | 897,800 | $70.16M | 1.1% | — | — | SHS | N90064101 |
| MGTX | MEIRAGTX HOLDINGS PLC | 2,586,951 | $69.54M | 1.1% | — | — | COM | G59665102 |
| REGN | REGENERON PHARMACEUTICALS | 215,800 | $67.55M | 1.0% | — | — | COM | 75886F107 |
| A | AGILENT TECHNOLOGIES INC | 893,200 | $66.69M | 1.0% | — | — | COM | 00846U101 |
| — | AUDENTES THERAPEUTICS INC | 1,713,069 | $64.86M | 1.0% | — | — | COM | 05070R104 |
| BMY | BRISTOL MYERS SQUIBB CO | 1,345,200 | $61.01M | 0.9% | — | — | COM | 110122108 |
| ARVN | ARVINAS INC | 2,678,810 | $58.91M | 0.9% | — | — | COM | 04335A105 |
| — | PRINCIPIA BIOPHARMA INC | 1,605,713 | $53.29M | 0.8% | — | — | COM | 74257L108 |
| ILMN | ILLUMINA INC | 140,200 | $51.62M | 0.8% | — | — | COM | 452327109 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 2,039,282 | $50.98M | 0.8% | — | — | COM | 22663K107 |
| — | RESTORBIO INC | 4,830,387 | $49.27M | 0.8% | — | — | COM | 76133L103 |
| — | MYOKARDIA INC | 955,300 | $47.9M | 0.7% | — | — | COM | 62857M105 |
| APLS | APELLIS PHARMACEUTICALS INC | 1,823,700 | $46.21M | 0.7% | — | — | COM | 03753U106 |
| VRAYQ | VIEWRAY INC | 5,149,019 | $45.36M | 0.7% | — | — | COM | 92672L107 |
| ARGX | ARGENX SE | 310,400 | $43.95M | 0.7% | — | — | SPONSORED ADR | 04016X101 |
| ZLAB | ZAI LAB LTD | 1,169,000 | $40.76M | 0.6% | — | — | ADR | 98887Q104 |
| — | NEXTCURE INC | 2,711,013 | $40.61M | 0.6% | — | — | COM | 65343E108 |
| CI | CIGNA CORP NEW | 252,600 | $39.8M | 0.6% | — | — | COM | 125523100 |
| DXCM | DEXCOM INC | 262,900 | $39.39M | 0.6% | — | — | COM | 252131107 |
| TNDM | TANDEM DIABETES CARE INC | 570,790 | $36.83M | 0.6% | — | — | COM NEW | 875372203 |
| PRTA | PROTHENA CORP PLC | 3,065,278 | $32.4M | 0.5% | — | — | SHS | G72800108 |
| — | HARPOON THERAPEUTICS INC | 2,446,409 | $31.8M | 0.5% | — | — | COM | 41358P106 |
| CDNA | CAREDX INC | 827,600 | $29.79M | 0.5% | — | — | COM | 14167L103 |
| — | OBSEVA SA | 2,605,531 | $29.47M | 0.5% | — | — | COM | H5861P103 |
| SPY | SPDR S&P 500 ETF TR | 100,000 | $29.3M | 0.5% | — | — | Put | 78462F103 |
| — | CLOVIS ONCOLOGY INC | 1,913,234 | $28.45M | 0.4% | — | — | COM | 189464100 |
| XTNT | XTANT MED HLDGS INC | 9,207,012 | $27.62M | 0.4% | — | — | COM NEW | 98420P308 |
| GILD | GILEAD SCIENCES INC | 401,600 | $27.13M | 0.4% | — | — | COM | 375558103 |
| — | MYLAN N V | 1,373,305 | $26.15M | 0.4% | — | — | SHS EURO | N59465109 |
| KRYS | KRYSTAL BIOTECH INC | 642,006 | $25.85M | 0.4% | — | — | COM | 501147102 |
| — | ENDO INTL PLC | 6,165,464 | $25.4M | 0.4% | — | — | SHS | G30401106 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,565,685 | $24.56M | 0.4% | — | — | COM | 221015100 |
| — | ADVERUM BIOTECHNOLOGIES INC | 1,960,200 | $23.31M | 0.4% | — | — | COM | 00773U108 |
| AUPH | AURINIA PHARMACEUTICALS INC | 3,531,002 | $23.23M | 0.4% | — | — | COM | 05156V102 |
| BMY | BRISTOL MYERS SQUIBB CO | 500,000 | $22.68M | 0.4% | — | — | Call | 110122108 |
| — | SPARK THERAPEUTICS INC | 219,900 | $22.51M | 0.3% | — | — | COM | 84652J103 |
| AMGN | AMGEN INC | 122,100 | $22.5M | 0.3% | — | — | COM | 031162100 |
| GNFTY | GENFIT S A | 1,125,607 | $22.23M | 0.3% | — | — | ADS | 372279109 |
| — | KALA PHARMACEUTICALS INC | 3,447,840 | $22M | 0.3% | — | — | COM | 483119103 |
| ALC | ALCON INC | 351,380 | $21.68M | 0.3% | — | — | ORD SHS | H01301128 |
| BIIB | BIOGEN INC | 87,700 | $20.51M | 0.3% | — | — | COM | 09062X103 |
| SIBN | SI BONE INC | 985,368 | $20.04M | 0.3% | — | — | COM | 825704109 |
| — | KARYOPHARM THERAPEUTICS INC | 3,148,475 | $18.86M | 0.3% | — | — | COM | 48576U106 |
| — | SYNLOGIC INC | 2,029,996 | $18.47M | 0.3% | — | — | COM | 87166L100 |
| TAK | TAKEDA PHARMACEUTICAL CO LTD | 1,000,000 | $17.7M | 0.3% | — | — | Call | 874060205 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 787,300 | $17.32M | 0.3% | — | — | COM | 76243J105 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $17.19M | 0.3% | — | — | COM | 92511W108 |
| NVO | NOVO-NORDISK A S | 330,000 | $16.84M | 0.3% | — | — | ADR | 670100205 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $16.61M | 0.3% | — | — | SHS | P8696W104 |
| — | ALPINE IMMUNE SCIENCES INC | 3,670,955 | $15.46M | 0.2% | — | — | COM | 02083G100 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,165,524 | $14.83M | 0.2% | — | — | COM | 00773J103 |
| ABBV | ABBVIE INC | 200,000 | $14.54M | 0.2% | — | — | Call | 00287Y109 |
| — | X4 PHARMACEUTICALS INC | 936,493 | $14.05M | 0.2% | — | — | COM | 98420X103 |
| — | AMARIN CORP PLC | 717,600 | $13.91M | 0.2% | — | — | SPONS ADR NEW | 023111206 |
| TAK | TAKEDA PHARMACEUTICAL CO LTD | 750,000 | $13.28M | 0.2% | — | — | SPONSORED ADS | 874060205 |
| PRQR | PROQR THRAPEUTICS N V | 1,382,502 | $12.58M | 0.2% | — | — | SHS EURO | N71542109 |
| — | FOAMIX PHARMACEUTICALS LTD | 5,195,330 | $12.37M | 0.2% | — | — | SHS | M46135105 |
| — | IMMUNOMEDICS INC | 818,200 | $11.35M | 0.2% | — | — | COM | 452907108 |
| — | NABRIVA THERAPEUTICS PLC | 4,644,600 | $11.29M | 0.2% | — | — | SHS | G63637105 |
| SYK | STRYKER CORP | 54,000 | $11.1M | 0.2% | — | — | COM | 863667101 |
| — | ARQULE INC | 1,000,000 | $11.01M | 0.2% | — | — | COM | 04269E107 |
| — | SCPHARMACEUTICALS INC | 3,409,865 | $10.88M | 0.2% | — | — | COM | 810648105 |
| PFE | PFIZER INC | 250,000 | $10.83M | 0.2% | — | — | Put | 717081103 |
| — | CONSTELLATION PHARMCETICLS I | 835,842 | $10.26M | 0.2% | — | — | COM | 210373106 |
| — | REATA PHARMACEUTICALS INC | 100,000 | $9.435M | 0.1% | — | — | Put | 75615P103 |
| PSNL | PERSONALIS INC | 300,000 | $8.145M | 0.1% | — | — | COM | 71535D106 |
| PBYI | PUMA BIOTECHNOLOGY INC | 624,249 | $7.934M | 0.1% | — | — | COM | 74587V107 |
| — | MERSANA THERAPEUTICS INC | 1,891,119 | $7.659M | 0.1% | — | — | COM | 59045L106 |
| — | ASSEMBLY BIOSCIENCES INC | 523,600 | $7.063M | 0.1% | — | — | COM | 045396108 |
| GILD | GILEAD SCIENCES INC | 100,000 | $6.756M | 0.1% | — | — | Call | 375558103 |
| FOLD | AMICUS THERAPEUTICS INC | 518,309 | $6.468M | 0.1% | — | — | COM | 03152W109 |
| — | ARENA PHARMACEUTICALS INC | 110,000 | $6.449M | 0.1% | — | — | COM NEW | 040047607 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 75,000 | $6.424M | 0.1% | — | — | Put | 09061G101 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 75,000 | $6.424M | 0.1% | — | — | COM | 09061G101 |
| — | VERONA PHARMA PLC | 1,250,396 | $6.377M | 0.1% | — | — | SPONSORED ADS | 925050106 |
| XENE | XENON PHARMACEUTICALS INC | 634,812 | $6.259M | 0.1% | — | — | COM | 98420N105 |
| SPRO | SPERO THERAPEUTICS INC | 507,471 | $5.841M | 0.1% | — | — | COM | 84833T103 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 120,000 | $5.796M | 0.1% | — | — | COM | 00650F109 |
| — | MEDICINES CO | 151,515 | $5.526M | 0.1% | — | — | COM | 584688105 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 1,350,655 | $5.43M | 0.1% | — | — | SPONDS ADR | 00653A107 |
| NTLA | INTELLIA THERAPEUTICS INC | 327,600 | $5.363M | 0.1% | — | — | COM | 45826J105 |
| — | SELECTA BIOSCIENCES INC | 2,879,064 | $5.154M | 0.1% | — | — | COM | 816212104 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 79,607 | $5.055M | 0.1% | — | — | COM | 90400D108 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $4.726M | 0.1% | — | — | COM | 00810B105 |
| — | CTI BIOPHARMA CORP | 5,000,000 | $4.297M | 0.1% | — | — | COM | 12648L601 |
| — | MENLO THERAPEUTICS INC | 673,700 | $4.035M | 0.1% | — | — | COM | 586858102 |
| STOK | STOKE THERAPEUTICS INC | 130,000 | $3.792M | 0.1% | — | — | COM | 86150R107 |
| — | NOVUS THERAPEUTICS INC | 3,183,314 | $3.215M | 0.0% | — | — | COM | 67011N105 |
| — | REALM THERAPEUTICS PLC | 1,021,484 | $2.87M | 0.0% | — | — | SPONSORED ADS | 75606L103 |
| ACAD | ACADIA PHARMACEUTICALS INC | 101,900 | $2.724M | 0.0% | — | — | COM | 004225108 |
| — | DYNAVAX TECHNOLOGIES CORP | 583,500 | $2.328M | 0.0% | — | — | COM NEW | 268158201 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 212,000 | $1.974M | 0.0% | — | — | COM | 87164F105 |
| APLS | APELLIS PHARMACEUTICALS INC | 75,000 | $1.901M | 0.0% | — | — | Call | 03753U106 |
| — | AVROBIO INC | 106,000 | $1.724M | 0.0% | — | — | COM | 05455M100 |
| — | MARINUS PHARMACEUTICALS INC | 398,101 | $1.652M | 0.0% | — | — | COM | 56854Q101 |
| — | NUVECTRA CORP | 350,000 | $1.173M | 0.0% | — | — | COM | 67075N108 |
| — | FLEXION THERAPEUTICS INC | 89,919 | $1.106M | 0.0% | — | — | COM | 33938J106 |
| — | BIOLINERX LTD | 1,038,600 | $379K | 0.0% | — | — | SPONSORED ADS | 09071M106 |
| — | MEDIGUS LTD | 15,000 | $37,000 | 0.0% | — | — | SPONSORED ADS | 58471G300 |