Location: New York, NY
CIK: 0001055951 · Show all filings
Period: Q4 2019 (← Previous) (Next →)
Filing Date: Feb 14, 2020
Total Value: $7.004B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A S | 3,343,100 | $465M | 6.6% | — | — | SPONSORED ADR | 04351P101 |
| — | SYNTHORX INC | 5,316,355 | $372M | 5.3% | — | — | COM | 87167A103 |
| — | TRICIDA INC | 9,614,280 | $363M | 5.2% | — | — | COM | 89610F101 |
| — | SPRINGWORKS THERAPEUTICS INC | 7,406,307 | $285M | 4.1% | — | — | COM | 85205L107 |
| — | PREVAIL THERAPEUTICS INC | 13,822,463 | $219M | 3.1% | — | — | COM | 74140Y101 |
| BSX | BOSTON SCIENTIFIC CORP | 4,674,800 | $211M | 3.0% | — | — | COM | 101137107 |
| ALEC | ALECTOR INC | 10,987,944 | $189M | 2.7% | — | — | COM | 014442107 |
| — | ALEXION PHARMACEUTICALS INC | 1,662,585 | $180M | 2.6% | — | — | COM | 015351109 |
| MRK | MERCK & CO INC | 1,954,100 | $178M | 2.5% | — | — | COM | 58933Y105 |
| — | MIRATI THERAPEUTICS INC | 1,340,600 | $173M | 2.5% | — | — | COM | 60468T105 |
| VRTX | VERTEX PHARMACEUTICALS INC | 783,100 | $171M | 2.4% | — | — | COM | 92532F100 |
| — | TURNING POINT THERAPEUTICS I | 2,745,327 | $171M | 2.4% | — | — | COM | 90041T108 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 5,548,326 | $154M | 2.2% | — | — | COM | 462260100 |
| — | NEXTCURE INC | 2,711,013 | $153M | 2.2% | — | — | COM | 65343E108 |
| HUM | HUMANA INC | 391,900 | $144M | 2.1% | — | — | COM | 444859102 |
| BMY | BRISTOL MYERS SQUIBB CO | 1,700,000 | $109M | 1.6% | — | — | COM | 110122108 |
| EHTH | EHEALTH INC | 1,111,914 | $107M | 1.5% | — | — | COM | 28238P109 |
| — | 89BIO INC | 4,004,442 | $105M | 1.5% | — | — | COM | 282559103 |
| EW | EDWARDS LIFESCIENCES CORP | 434,900 | $101M | 1.4% | — | — | COM | 28176E108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 935,970 | $101M | 1.4% | — | — | COM | 64125C109 |
| CI | CIGNA CORP NEW | 489,700 | $100M | 1.4% | — | — | COM | 125523100 |
| INSP | INSPIRE MED SYS INC | 1,347,000 | $99.96M | 1.4% | — | — | COM | 457730109 |
| — | ARQULE INC | 5,000,000 | $99.8M | 1.4% | — | — | COM | 04269E107 |
| ISRG | INTUITIVE SURGICAL INC | 167,800 | $99.19M | 1.4% | — | — | COM NEW | 46120E602 |
| SRPT | SAREPTA THERAPEUTICS INC | 766,049 | $98.85M | 1.4% | — | — | COM | 803607100 |
| DHR | DANAHER CORPORATION | 638,900 | $98.06M | 1.4% | — | — | COM | 235851102 |
| BHC | BAUSCH HEALTH COS INC | 3,183,100 | $95.24M | 1.4% | — | — | COM | 071734107 |
| — | DECIPHERA PHARMACEUTICALS IN | 1,514,171 | $94.24M | 1.3% | — | — | COM | 24344T101 |
| GKOS | GLAUKOS CORP | 1,547,646 | $84.3M | 1.2% | — | — | COM | 377322102 |
| PTCT | PTC THERAPEUTICS INC | 1,729,200 | $83.05M | 1.2% | — | — | COM | 69366J200 |
| NTRA | NATERA INC | 2,440,613 | $82.22M | 1.2% | — | — | COM | 632307104 |
| REGN | REGENERON PHARMACEUTICALS | 209,300 | $78.59M | 1.1% | — | — | COM | 75886F107 |
| ARVN | ARVINAS INC | 1,898,800 | $78.02M | 1.1% | — | — | COM | 04335A105 |
| QURE | UNIQURE NV | 1,081,765 | $77.52M | 1.1% | — | — | SHS | N90064101 |
| TMO | THERMO FISHER SCIENTIFIC INC | 220,500 | $71.63M | 1.0% | — | — | COM | 883556102 |
| MGTX | MEIRAGTX HOLDINGS PLC | 3,453,020 | $69.13M | 1.0% | — | — | COM | G59665102 |
| TNDM | TANDEM DIABETES CARE INC | 1,141,390 | $68.04M | 1.0% | — | — | COM NEW | 875372203 |
| EXEL | EXELIXIS INC | 3,753,700 | $66.14M | 0.9% | — | — | COM | 30161Q104 |
| ABT | ABBOTT LABS | 715,100 | $62.11M | 0.9% | — | — | COM | 002824100 |
| — | HORIZON THERAPEUTICS PUB LTD | 1,582,300 | $57.28M | 0.8% | — | — | SHS | G46188101 |
| KRYS | KRYSTAL BIOTECH INC | 994,808 | $55.09M | 0.8% | — | — | COM | 501147102 |
| — | BELLUS HEALTH INC NEW | 7,025,832 | $53.14M | 0.8% | — | — | COM NEW | 07987C204 |
| DXCM | DEXCOM INC | 234,900 | $51.38M | 0.7% | — | — | COM | 252131107 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 2,039,282 | $51.17M | 0.7% | — | — | COM | 22663K107 |
| — | ADVERUM BIOTECHNOLOGIES INC | 4,342,190 | $50.02M | 0.7% | — | — | COM | 00773U108 |
| AUPH | AURINIA PHARMACEUTICALS INC | 2,345,447 | $47.52M | 0.7% | — | — | COM | 05156V102 |
| CRSP | CRISPR THERAPEUTICS AG | 766,378 | $46.68M | 0.7% | — | — | NAMEN AKT | H17182108 |
| — | LOGICBIO THERAPEUTICS INC | 6,466,783 | $46.56M | 0.7% | — | — | COM | 54142F102 |
| PRTA | PROTHENA CORP PLC | 2,902,239 | $45.94M | 0.7% | — | — | SHS | G72800108 |
| — | ATHENEX INC | 2,772,221 | $42.33M | 0.6% | — | — | COM | 04685N103 |
| ARGX | ARGENX SE | 256,300 | $41.14M | 0.6% | — | — | SPONSORED ADR | 04016X101 |
| TELA | TELA BIO INC | 3,027,542 | $39.21M | 0.6% | — | — | COM | 872381108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 6,767,584 | $36.82M | 0.5% | — | — | COM | 221015100 |
| — | HARPOON THERAPEUTICS INC | 2,446,409 | $36.18M | 0.5% | — | — | COM | 41358P106 |
| ELV | ANTHEM INC | 106,600 | $32.2M | 0.5% | — | — | COM | 036752103 |
| AMGN | AMGEN INC | 122,100 | $29.43M | 0.4% | — | — | COM | 031162100 |
| HCA | HCA HEALTHCARE INC | 190,000 | $28.08M | 0.4% | — | — | COM | 40412C101 |
| IQV | IQVIA HLDGS INC | 175,000 | $27.04M | 0.4% | — | — | COM | 46266C105 |
| — | APPLIED THERAPEUTICS INC | 987,186 | $26.93M | 0.4% | — | — | COM | 03828A101 |
| ZBH | ZIMMER BIOMET HLDGS INC | 178,700 | $26.75M | 0.4% | — | — | COM | 98956P102 |
| — | VERRICA PHARMACEUTICALS INC | 1,479,733 | $23.51M | 0.3% | — | — | COM | 92511W108 |
| — | BIOMX INC | 2,313,489 | $22.41M | 0.3% | — | — | COM | 09090D103 |
| — | AEGLEA BIOTHERAPEUTICS INC | 2,865,524 | $21.89M | 0.3% | — | — | COM | 00773J103 |
| ZLAB | ZAI LAB LTD | 514,000 | $21.38M | 0.3% | — | — | ADR | 98887Q104 |
| GILD | GILEAD SCIENCES INC | 326,100 | $21.19M | 0.3% | — | — | COM | 375558103 |
| ALC | ALCON INC | 351,380 | $19.93M | 0.3% | — | — | ORD SHS | H01301128 |
| — | SCPHARMACEUTICALS INC | 3,409,865 | $19.3M | 0.3% | — | — | COM | 810648105 |
| BIIB | BIOGEN INC | 64,500 | $19.14M | 0.3% | — | — | COM | 09062X103 |
| NVO | NOVO-NORDISK A S | 330,000 | $19.1M | 0.3% | — | — | ADR | 670100205 |
| AVTR | AVANTOR INC | 1,012,800 | $18.38M | 0.3% | — | — | COM | 05352A100 |
| SVA | SINOVAC BIOTECH LTD | 2,839,500 | $17.15M | 0.2% | — | — | SHS | P8696W104 |
| XTNT | XTANT MED HLDGS INC | 9,207,012 | $14.73M | 0.2% | — | — | COM NEW | 98420P308 |
| — | ALPINE IMMUNE SCIENCES INC | 3,670,955 | $14.1M | 0.2% | — | — | COM | 02083G100 |
| — | AVROBIO INC | 634,700 | $12.78M | 0.2% | — | — | COM | 05455M100 |
| — | KALA PHARMACEUTICALS INC | 3,447,840 | $12.72M | 0.2% | — | — | COM | 483119103 |
| XBI | SPDR SERIES TRUST | 127,200 | $12.1M | 0.2% | — | — | S&P BIOTECH | 78464A870 |
| — | KARYOPHARM THERAPEUTICS INC | 621,900 | $11.92M | 0.2% | — | — | COM | 48576U106 |
| — | MERSANA THERAPEUTICS INC | 2,073,319 | $11.88M | 0.2% | — | — | COM | 59045L106 |
| — | X4 PHARMACEUTICALS INC | 1,086,493 | $11.63M | 0.2% | — | — | COM | 98420X103 |
| XLV | SELECT SECTOR SPDR TR | 113,200 | $11.53M | 0.2% | — | — | SBI HEALTHCARE | 81369Y209 |
| — | NEOLEUKIN THERAPEUTICS INC | 900,000 | $11.09M | 0.2% | — | — | COM | 64049K104 |
| XBI | SPDR SERIES TRUST | 110,000 | $10.46M | 0.1% | — | — | Call | 78464A870 |
| — | OBSEVA SA | 2,605,531 | $9.953M | 0.1% | — | — | COM | H5861P103 |
| — | FOAMIX PHARMACEUTICALS LTD | 2,577,982 | $8.585M | 0.1% | — | — | SHS | M46135105 |
| — | IVERIC BIO INC | 1,000,000 | $8.58M | 0.1% | — | — | COM | 46583P102 |
| XENE | XENON PHARMACEUTICALS INC | 634,812 | $8.322M | 0.1% | — | — | COM | 98420N105 |
| — | ESSA PHARMA INC | 1,471,853 | $8.095M | 0.1% | — | — | COM NEW | 29668H708 |
| — | CTI BIOPHARMA CORP | 5,000,000 | $7.9M | 0.1% | — | — | COM | 12648L601 |
| — | RESTORBIO INC | 4,830,387 | $7.197M | 0.1% | — | — | COM | 76133L103 |
| — | VERONA PHARMA PLC | 1,250,396 | $7.19M | 0.1% | — | — | SPONSORED ADS | 925050106 |
| — | SELECTA BIOSCIENCES INC | 2,879,064 | $6.852M | 0.1% | — | — | COM | 816212104 |
| — | PFENEX INC | 614,868 | $6.751M | 0.1% | — | — | COM | 717071104 |
| — | APTOSE BIOSCIENCES INC | 1,150,000 | $6.521M | 0.1% | — | — | COM NEW | 03835T200 |
| — | ZOGENIX INC | 125,000 | $6.516M | 0.1% | — | — | Call | 98978L204 |
| IONS | IONIS PHARMACEUTICALS INC | 106,900 | $6.458M | 0.1% | — | — | COM | 462222100 |
| HCAT | HEALTH CATALYST INC | 179,598 | $6.232M | 0.1% | — | — | COM | 42225T107 |
| — | NABRIVA THERAPEUTICS PLC | 4,644,600 | $6.131M | 0.1% | — | — | SHS | G63637105 |
| ANAB | ANAPTYSBIO INC | 375,800 | $6.107M | 0.1% | — | — | COM | 032724106 |
| MIST | MILESTONE PHARMACEUTICALS IN | 364,206 | $5.831M | 0.1% | — | — | COM | 59935V107 |
| — | ACCELERON PHARMA INC | 107,500 | $5.7M | 0.1% | — | — | COM | 00434H108 |
| ATRC | ATRICURE INC | 168,621 | $5.482M | 0.1% | — | — | COM | 04963C209 |
| — | AMARIN CORP PLC | 249,600 | $5.351M | 0.1% | — | — | SPONS ADR NEW | 023111206 |
| PSNL | PERSONALIS INC | 483,842 | $5.274M | 0.1% | — | — | COM | 71535D106 |
| — | SYNLOGIC INC | 2,029,996 | $5.237M | 0.1% | — | — | COM | 87166L100 |
| INCY | INCYTE CORP | 59,500 | $5.196M | 0.1% | — | — | COM | 45337C102 |
| — | ARENA PHARMACEUTICALS INC | 110,000 | $4.996M | 0.1% | — | — | COM NEW | 040047607 |
| ACAD | ACADIA PHARMACEUTICALS INC | 96,143 | $4.113M | 0.1% | — | — | COM | 004225108 |
| NTLA | INTELLIA THERAPEUTICS INC | 262,100 | $3.845M | 0.1% | — | — | COM | 45826J105 |
| — | DERMIRA INC | 250,000 | $3.79M | 0.1% | — | — | Call | 24983L104 |
| AZN | ASTRAZENECA PLC | 69,600 | $3.47M | 0.0% | — | — | SPONSORED ADR | 046353108 |
| SNY | SANOFI | 68,400 | $3.434M | 0.0% | — | — | SPONSORED ADR | 80105N105 |
| — | AERPIO PHARMACEUTICALS INC | 5,193,946 | $3.238M | 0.0% | — | — | COM | 00810B105 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 34,700 | $2.934M | 0.0% | — | — | COM | 09061G101 |
| KALV | KALVISTA PHARMACEUTICALS INC | 160,541 | $2.859M | 0.0% | — | — | COM | 483497103 |
| — | INTERCEPT PHARMACEUTICALS IN | 22,800 | $2.825M | 0.0% | — | — | COM | 45845P108 |
| — | FLEXION THERAPEUTICS INC | 133,000 | $2.753M | 0.0% | — | — | COM | 33938J106 |
| — | CURIS INC | 1,358,363 | $2.309M | 0.0% | — | — | COM NEW | 231269200 |
| — | MYOKARDIA INC | 27,900 | $2.033M | 0.0% | — | — | COM | 62857M105 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 212,000 | $1.861M | 0.0% | — | — | COM | 87164F105 |
| — | NOVUS THERAPEUTICS INC | 3,183,314 | $1.846M | 0.0% | — | — | COM | 67011N105 |
| MIRM | MIRUM PHARMACEUTICALS INC | 71,300 | $1.748M | 0.0% | — | — | COM | 604749101 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 1,350,655 | $1.621M | 0.0% | — | — | SPONDS ADR | 00653A107 |
| — | IMMUNOGEN INC | 286,800 | $1.464M | 0.0% | — | — | COM | 45253H101 |
| INSM | INSMED INC | 59,000 | $1.409M | 0.0% | — | — | COM PAR $.01 | 457669307 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 191,209 | $1.348M | 0.0% | — | — | COM | 74366E102 |
| — | OTONOMY INC | 350,700 | $1.343M | 0.0% | — | — | COM | 68906L105 |
| SPRO | SPERO THERAPEUTICS INC | 131,653 | $1.266M | 0.0% | — | — | COM | 84833T103 |
| — | SUTRO BIOPHARMA INC | 104,800 | $1.153M | 0.0% | — | — | COM | 869367102 |
| RGNX | REGENXBIO INC | 26,800 | $1.098M | 0.0% | — | — | COM | 75901B107 |
| — | BRISTOL MYERS SQUIBB CO | 350,000 | $1.054M | 0.0% | — | — | RIGHT 99/99/9999 | 110122157 |
| — | MUSTANG BIO INC | 251,685 | $1.027M | 0.0% | — | — | COM | 62818Q104 |
| — | RUBIUS THERAPEUTICS INC | 100,000 | $950K | 0.0% | — | — | Put | 78116T103 |
| — | ZAFGEN INC | 821,000 | $911K | 0.0% | — | — | COM | 98885E103 |
| — | APTINYX INC | 143,000 | $489K | 0.0% | — | — | COM | 03836N103 |
| — | BIOLINERX LTD | 69,240 | $156K | 0.0% | — | — | SPONSORED ADS | 09071M205 |
| — | MEDIGUS LTD | 15,000 | $26,000 | 0.0% | — | — | SPONSORED ADS | 58471G300 |