ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Feb 14, 2020

Total Value ($000): $7,004,336 (100.0% shares, 0.0% debt)

Holdings (136)

ASND ASCENDIS PHARMA A S 6.6%
Value ($000) $465,092 Shares 3,343,100 Est. Cost $29.06 Unrealized
SYNTHORX INC 5.3%
Value ($000) $371,560 Shares 5,316,355 Est. Cost $17.38 Unrealized
TRICIDA INC 5.2%
Value ($000) $362,843 Shares 9,614,280 Est. Cost $30.09 Unrealized
SPRINGWORKS THERAPEUTICS INC 4.1%
Value ($000) $285,069 Shares 7,406,307 Est. Cost $21.68 Unrealized
PREVAIL THERAPEUTICS INC 3.1%
Value ($000) $218,810 Shares 13,822,463 Est. Cost $13.20 Unrealized
BSX BOSTON SCIENTIFIC CORP 3.0%
Value ($000) $211,394 Shares 4,674,800 Est. Cost $19.85 Unrealized +110.8%
ALEC ALECTOR INC 2.7%
Value ($000) $189,322 Shares 10,987,944 Est. Cost $18.92 Unrealized -10.1%
ALEXION PHARMACEUTICALS INC 2.6%
Value ($000) $179,809 Shares 1,662,585 Est. Cost $137.22 Unrealized
MRK MERCK & CO INC 2.5%
Value ($000) $177,725 Shares 1,954,100 Est. Cost $43.08 Unrealized +56.8%
MIRATI THERAPEUTICS INC 2.5%
Value ($000) $172,750 Shares 1,340,600 Est. Cost $108.52 Unrealized
VRTX VERTEX PHARMACEUTICALS INC 2.4%
Value ($000) $171,460 Shares 783,100 Est. Cost $100.42 Unrealized +101.5%
TURNING POINT THERAPEUTICS I 2.4%
Value ($000) $171,006 Shares 2,745,327 Est. Cost $40.50 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 2.2%
Value ($000) $153,578 Shares 5,548,326 Est. Cost $6.34 Unrealized +258.6%
NEXTCURE INC 2.2%
Value ($000) $152,711 Shares 2,711,013 Est. Cost $14.98 Unrealized
HUM HUMANA INC 2.1%
Value ($000) $143,639 Shares 391,900 Est. Cost $284.03 Unrealized +5.8%
BMY BRISTOL MYERS SQUIBB CO 1.6%
Value ($000) $109,123 Shares 1,700,000 Est. Cost $45.19 Unrealized 0.0%
EHTH EHEALTH INC 1.5%
Value ($000) $106,833 Shares 1,111,914 Est. Cost $28.92 Unrealized +168.3%
89BIO INC 1.5%
Value ($000) $105,277 Shares 4,004,442 Est. Cost $26.29 Unrealized
EW EDWARDS LIFESCIENCES CORP 1.4%
Value ($000) $101,458 Shares 434,900 Est. Cost $43.58 Unrealized +79.2%
NBIX NEUROCRINE BIOSCIENCES INC 1.4%
Value ($000) $100,607 Shares 935,970 Est. Cost $86.20 Unrealized +21.5%
CI CIGNA CORP NEW 1.4%
Value ($000) $100,139 Shares 489,700 Est. Cost $178.10 Unrealized -5.8%
INSP INSPIRE MED SYS INC 1.4%
Value ($000) $99,961 Shares 1,347,000 Est. Cost $32.28 Unrealized +99.1%
ARQULE INC 1.4%
Value ($000) $99,800 Shares 5,000,000 Est. Cost $11.26 Unrealized
ISRG INTUITIVE SURGICAL INC 1.4%
Value ($000) $99,195 Shares 167,800 Est. Cost $142.69 Unrealized +31.2%
SRPT SAREPTA THERAPEUTICS INC 1.4%
Value ($000) $98,851 Shares 766,049 Est. Cost $103.91 Unrealized -2.9%
DHR DANAHER CORPORATION 1.4%
Value ($000) $98,058 Shares 638,900 Est. Cost $122.98 Unrealized 0.0%
BHC BAUSCH HEALTH COS INC 1.4%
Value ($000) $95,238 Shares 3,183,100 Est. Cost $23.34 Unrealized +11.4%
DECIPHERA PHARMACEUTICALS IN 1.3%
Value ($000) $94,242 Shares 1,514,171 Est. Cost $24.10 Unrealized
GKOS GLAUKOS CORP 1.2%
Value ($000) $84,300 Shares 1,547,646 Est. Cost $60.84 Unrealized 0.0%
PTCT PTC THERAPEUTICS INC 1.2%
Value ($000) $83,053 Shares 1,729,200 Est. Cost $40.23 Unrealized +5.6%
NTRA NATERA INC 1.2%
Value ($000) $82,224 Shares 2,440,613 Est. Cost $19.95 Unrealized +84.7%
REGN REGENERON PHARMACEUTICALS 1.1%
Value ($000) $78,588 Shares 209,300 Est. Cost $371.91 Unrealized -10.0%
ARVN ARVINAS INC 1.1%
Value ($000) $78,022 Shares 1,898,800 Est. Cost $16.45 Unrealized +77.9%
QURE UNIQURE NV 1.1%
Value ($000) $77,519 Shares 1,081,765 Est. Cost $61.75 Unrealized -11.1%
TMO THERMO FISHER SCIENTIFIC INC 1.0%
Value ($000) $71,634 Shares 220,500 Est. Cost $149.40 Unrealized +99.7%
MGTX MEIRAGTX HOLDINGS PLC 1.0%
Value ($000) $69,129 Shares 3,453,020 Est. Cost $16.11 Unrealized +6.2%
TNDM TANDEM DIABETES CARE INC 1.0%
Value ($000) $68,038 Shares 1,141,390 Est. Cost $39.99 Unrealized +54.2%
EXEL EXELIXIS INC 0.9%
Value ($000) $66,140 Shares 3,753,700 Est. Cost $20.42 Unrealized -17.0%
ABT ABBOTT LABS 0.9%
Value ($000) $62,114 Shares 715,100 Est. Cost $61.60 Unrealized +22.2%
HORIZON THERAPEUTICS PUB LTD 0.8%
Value ($000) $57,279 Shares 1,582,300 Est. Cost $36.20 Unrealized
KRYS KRYSTAL BIOTECH INC 0.8%
Value ($000) $55,092 Shares 994,808 Est. Cost $38.64 Unrealized +26.9%
BELLUS HEALTH INC NEW 0.8%
Value ($000) $53,137 Shares 7,025,832 Est. Cost $6.42 Unrealized
DXCM DEXCOM INC 0.7%
Value ($000) $51,382 Shares 234,900 Est. Cost $33.88 Unrealized +40.0%
CRNX CRINETICS PHARMACEUTICALS IN 0.7%
Value ($000) $51,166 Shares 2,039,282 Est. Cost $29.39 Unrealized -35.2%
ADVERUM BIOTECHNOLOGIES INC 0.7%
Value ($000) $50,022 Shares 4,342,190 Est. Cost $6.91 Unrealized
AUPH AURINIA PHARMACEUTICALS INC 0.7%
Value ($000) $47,519 Shares 2,345,447 Est. Cost $6.61 Unrealized +39.4%
CRSP CRISPR THERAPEUTICS AG 0.7%
Value ($000) $46,676 Shares 766,378 Est. Cost $50.01 Unrealized +9.2%
LOGICBIO THERAPEUTICS INC 0.7%
Value ($000) $46,561 Shares 6,466,783 Est. Cost $10.40 Unrealized
PRTA PROTHENA CORP PLC 0.7%
Value ($000) $45,942 Shares 2,902,239 Est. Cost $12.03 Unrealized -10.9%
ATHENEX INC 0.6%
Value ($000) $42,332 Shares 2,772,221 Est. Cost $19.49 Unrealized
ARGX ARGENX SE 0.6%
Value ($000) $41,141 Shares 256,300 Est. Cost $38.81 Unrealized
TELA TELA BIO INC 0.6%
Value ($000) $39,207 Shares 3,027,542 Est. Cost $12.23 Unrealized 0.0%
CRVS CORVUS PHARMACEUTICALS INC 0.5%
Value ($000) $36,816 Shares 6,767,584 Est. Cost $12.68 Unrealized -72.4%
HARPOON THERAPEUTICS INC 0.5%
Value ($000) $36,182 Shares 2,446,409 Est. Cost $9.47 Unrealized
ELV ANTHEM INC 0.5%
Value ($000) $32,196 Shares 106,600 Est. Cost $216.48 Unrealized +17.0%
AMGN AMGEN INC 0.4%
Value ($000) $29,435 Shares 122,100 Est. Cost $99.69 Unrealized +83.3%
HCA HCA HEALTHCARE INC 0.4%
Value ($000) $28,084 Shares 190,000 Est. Cost $127.66 Unrealized 0.0%
IQV IQVIA HLDGS INC 0.4%
Value ($000) $27,039 Shares 175,000 Est. Cost $155.62 Unrealized -6.2%
APPLIED THERAPEUTICS INC 0.4%
Value ($000) $26,930 Shares 987,186 Est. Cost $27.28 Unrealized
ZBH ZIMMER BIOMET HLDGS INC 0.4%
Value ($000) $26,748 Shares 178,700 Est. Cost $131.26 Unrealized 0.0%
VERRICA PHARMACEUTICALS INC 0.3%
Value ($000) $23,513 Shares 1,479,733 Est. Cost $19.73 Unrealized
BIOMX INC 0.3%
Value ($000) $22,406 Shares 2,313,489 Est. Cost $9.68 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.3%
Value ($000) $21,893 Shares 2,865,524 Est. Cost $6.93 Unrealized
ZLAB ZAI LAB LTD 0.3%
Value ($000) $21,377 Shares 514,000 Est. Cost $24.35 Unrealized
GILD GILEAD SCIENCES INC 0.3%
Value ($000) $21,190 Shares 326,100 Est. Cost $51.16 Unrealized +0.2%
ALC ALCON INC 0.3%
Value ($000) $19,925 Shares 351,380 Est. Cost $57.87 Unrealized -2.4%
SCPHARMACEUTICALS INC 0.3%
Value ($000) $19,300 Shares 3,409,865 Est. Cost $12.09 Unrealized
BIIB BIOGEN INC 0.3%
Value ($000) $19,139 Shares 64,500 Est. Cost $270.65 Unrealized +2.5%
NVO NOVO-NORDISK A S 0.3%
Value ($000) $19,100 Shares 330,000 Est. Cost $48.15 Unrealized
AVTR AVANTOR INC 0.3%
Value ($000) $18,382 Shares 1,012,800 Est. Cost $15.92 Unrealized 0.0%
SVA SINOVAC BIOTECH LTD 0.2%
Value ($000) $17,151 Shares 2,839,500 Est. Cost $4.60 Unrealized +40.7%
XTNT XTANT MED HLDGS INC 0.2%
Value ($000) $14,731 Shares 9,207,012 Est. Cost $6.59 Unrealized -69.0%
ALPINE IMMUNE SCIENCES INC 0.2%
Value ($000) $14,096 Shares 3,670,955 Est. Cost $11.12 Unrealized
AVROBIO INC 0.2%
Value ($000) $12,777 Shares 634,700 Est. Cost $17.14 Unrealized
KALA PHARMACEUTICALS INC 0.2%
Value ($000) $12,723 Shares 3,447,840 Est. Cost $20.66 Unrealized
XBI SPDR SERIES TRUST 0.2%
Value ($000) $12,098 Shares 127,200 Est. Cost $95.11 Unrealized
KARYOPHARM THERAPEUTICS INC 0.2%
Value ($000) $11,922 Shares 621,900 Est. Cost $5.99 Unrealized
MERSANA THERAPEUTICS INC 0.2%
Value ($000) $11,880 Shares 2,073,319 Est. Cost $5.30 Unrealized
X4 PHARMACEUTICALS INC 0.2%
Value ($000) $11,625 Shares 1,086,493 Est. Cost $15.10 Unrealized
XLV SELECT SECTOR SPDR TR 0.2%
Value ($000) $11,531 Shares 113,200 Est. Cost $101.86 Unrealized
NEOLEUKIN THERAPEUTICS INC 0.2%
Value ($000) $11,088 Shares 900,000 Est. Cost $12.32 Unrealized
XBI SPDR SERIES TRUST 0.1%
Value ($000) $10,462 Shares 110,000 Est. Cost $95.11 Unrealized
OBSEVA SA 0.1%
Value ($000) $9,953 Shares 2,605,531 Est. Cost $10.41 Unrealized
FOAMIX PHARMACEUTICALS LTD 0.1%
Value ($000) $8,585 Shares 2,577,982 Est. Cost $5.20 Unrealized
IVERIC BIO INC 0.1%
Value ($000) $8,580 Shares 1,000,000 Est. Cost $8.58 Unrealized
XENE XENON PHARMACEUTICALS INC 0.1%
Value ($000) $8,322 Shares 634,812 Est. Cost $7.72 Unrealized +36.2%
ESSA PHARMA INC 0.1%
Value ($000) $8,095 Shares 1,471,853 Est. Cost $3.37 Unrealized
CTI BIOPHARMA CORP 0.1%
Value ($000) $7,900 Shares 5,000,000 Est. Cost $3.31 Unrealized
RESTORBIO INC 0.1%
Value ($000) $7,197 Shares 4,830,387 Est. Cost $9.58 Unrealized
VERONA PHARMA PLC 0.1%
Value ($000) $7,190 Shares 1,250,396 Est. Cost $11.76 Unrealized
SELECTA BIOSCIENCES INC 0.1%
Value ($000) $6,852 Shares 2,879,064 Est. Cost $8.74 Unrealized
PFENEX INC 0.1%
Value ($000) $6,751 Shares 614,868 Est. Cost $10.98 Unrealized
APTOSE BIOSCIENCES INC 0.1%
Value ($000) $6,521 Shares 1,150,000 Est. Cost $5.67 Unrealized
ZOGENIX INC 0.1%
Value ($000) $6,516 Shares 125,000 Est. Cost Unrealized
IONS IONIS PHARMACEUTICALS INC 0.1%
Value ($000) $6,458 Shares 106,900 Est. Cost $59.58 Unrealized 0.0%
HCAT HEALTH CATALYST INC 0.1%
Value ($000) $6,232 Shares 179,598 Est. Cost $39.36 Unrealized -15.9%
NABRIVA THERAPEUTICS PLC 0.1%
Value ($000) $6,131 Shares 4,644,600 Est. Cost $9.27 Unrealized
ANAB ANAPTYSBIO INC 0.1%
Value ($000) $6,107 Shares 375,800 Est. Cost $23.65 Unrealized 0.0%
MIST MILESTONE PHARMACEUTICALS IN 0.1%
Value ($000) $5,831 Shares 364,206 Est. Cost $17.77 Unrealized 0.0%
ACCELERON PHARMA INC 0.1%
Value ($000) $5,700 Shares 107,500 Est. Cost $53.02 Unrealized
ATRC ATRICURE INC 0.1%
Value ($000) $5,482 Shares 168,621 Est. Cost $28.46 Unrealized 0.0%
AMARIN CORP PLC 0.1%
Value ($000) $5,351 Shares 249,600 Est. Cost $19.70 Unrealized
PSNL PERSONALIS INC 0.1%
Value ($000) $5,274 Shares 483,842 Est. Cost $24.72 Unrealized -57.9%
SYNLOGIC INC 0.1%
Value ($000) $5,237 Shares 2,029,996 Est. Cost $15.62 Unrealized
INCY INCYTE CORP 0.1%
Value ($000) $5,196 Shares 59,500 Est. Cost $85.43 Unrealized 0.0%
ARENA PHARMACEUTICALS INC 0.1%
Value ($000) $4,996 Shares 110,000 Est. Cost $58.63 Unrealized
ACAD ACADIA PHARMACEUTICALS INC 0.1%
Value ($000) $4,113 Shares 96,143 Est. Cost $25.54 Unrealized +70.3%
NTLA INTELLIA THERAPEUTICS INC 0.1%
Value ($000) $3,845 Shares 262,100 Est. Cost $26.61 Unrealized -47.7%
DERMIRA INC 0.1%
Value ($000) $3,790 Shares 250,000 Est. Cost Unrealized
AZN ASTRAZENECA PLC 0.0%
Value ($000) $3,470 Shares 69,600 Est. Cost $49.86 Unrealized
SNY SANOFI 0.0%
Value ($000) $3,434 Shares 68,400 Est. Cost $50.20 Unrealized
AERPIO PHARMACEUTICALS INC 0.0%
Value ($000) $3,238 Shares 5,193,946 Est. Cost $4.15 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $2,934 Shares 34,700 Est. Cost $75.53 Unrealized 0.0%
KALV KALVISTA PHARMACEUTICALS INC 0.0%
Value ($000) $2,859 Shares 160,541 Est. Cost $13.80 Unrealized -5.4%
INTERCEPT PHARMACEUTICALS IN 0.0%
Value ($000) $2,825 Shares 22,800 Est. Cost $66.37 Unrealized
FLEXION THERAPEUTICS INC 0.0%
Value ($000) $2,753 Shares 133,000 Est. Cost $20.70 Unrealized
CURIS INC 0.0%
Value ($000) $2,309 Shares 1,358,363 Est. Cost $2.19 Unrealized
MYOKARDIA INC 0.0%
Value ($000) $2,033 Shares 27,900 Est. Cost $50.80 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.0%
Value ($000) $1,861 Shares 212,000 Est. Cost $12.54 Unrealized -41.4%
NOVUS THERAPEUTICS INC 0.0%
Value ($000) $1,846 Shares 3,183,314 Est. Cost $4.87 Unrealized
MIRM MIRUM PHARMACEUTICALS INC 0.0%
Value ($000) $1,748 Shares 71,300 Est. Cost $10.66 Unrealized 0.0%
ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.0%
Value ($000) $1,621 Shares 1,350,655 Est. Cost $6.85 Unrealized
IMMUNOGEN INC 0.0%
Value ($000) $1,464 Shares 286,800 Est. Cost $5.10 Unrealized
INSM INSMED INC 0.0%
Value ($000) $1,409 Shares 59,000 Est. Cost $19.31 Unrealized +5.3%
PTGX PROTAGONIST THERAPEUTICS INC 0.0%
Value ($000) $1,348 Shares 191,209 Est. Cost $9.93 Unrealized 0.0%
OTONOMY INC 0.0%
Value ($000) $1,343 Shares 350,700 Est. Cost $3.83 Unrealized
SPRO SPERO THERAPEUTICS INC 0.0%
Value ($000) $1,266 Shares 131,653 Est. Cost $10.61 Unrealized +1.6%
SUTRO BIOPHARMA INC 0.0%
Value ($000) $1,153 Shares 104,800 Est. Cost $11.00 Unrealized
RGNX REGENXBIO INC 0.0%
Value ($000) $1,098 Shares 26,800 Est. Cost $39.50 Unrealized 0.0%
BRISTOL MYERS SQUIBB CO 0.0%
Value ($000) $1,054 Shares 350,000 Est. Cost $3.01 Unrealized
MUSTANG BIO INC 0.0%
Value ($000) $1,027 Shares 251,685 Est. Cost $4.08 Unrealized
RUBIUS THERAPEUTICS INC 0.0%
Value ($000) $950 Shares 100,000 Est. Cost Unrealized
ZAFGEN INC 0.0%
Value ($000) $911 Shares 821,000 Est. Cost $1.11 Unrealized
APTINYX INC 0.0%
Value ($000) $489 Shares 143,000 Est. Cost $3.42 Unrealized
BIOLINERX LTD 0.0%
Value ($000) $156 Shares 69,240 Est. Cost $2.64 Unrealized
MEDIGUS LTD 0.0%
Value ($000) $26 Shares 15,000 Est. Cost $3.40 Unrealized