Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2015 (← Previous) (Next →)

Filing Date: May 15, 2015

Total Value: $215M (100.0% shares, 0.0% debt)

Holdings (37)

— CHIMERIX INC 9.9%

Value $21.3M Shares 565,000 Est. Cost $23.65 Unrealized —

— CEMPRA INC 8.0%

Value $17.16M Shares 500,000 Est. Cost $9402.92 Unrealized —

— ARIAD PHARMACEUTICALS INC 5.7%

Value $12.36M Shares 1,500,000 Est. Cost $6983.72 Unrealized —

— RETROPHIN INC 5.6%

Value $11.98M Shares 500,000 Est. Cost $20.71 Unrealized —

— CLOVIS ONCOLOGY INC 4.8%

Value $10.39M Shares 140,000 Est. Cost $3206.92 Unrealized —

— AMAG PHARMACEUTICALS INC 4.8%

Value $10.38M Shares 190,000 Est. Cost $54.66 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 3.9%

Value $8.487M Shares 90,000 Est. Cost $40.76 Unrealized +174.9%

CDXS CODEXIS INC 3.6%

Value $7.861M Shares 1,724,000 Est. Cost $1.98 Unrealized +77.9%

GERN GERON CORP 3.2%

Value $6.88M Shares 1,825,000 Est. Cost $2.63 Unrealized +29.0%

— MEDGENICS INC 3.2%

Value $6.851M Shares 850,000 Est. Cost $5.06 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 3.2%

Value $6.83M Shares 110,000 Est. Cost $45.89 Unrealized +21.0%

SUPN SUPERNUS PHARMACEUTICALS INC 3.0%

Value $6.468M Shares 535,000 Est. Cost $8.76 Unrealized +7.8%

— TETRAPHASE PHARMACEUTICALS I 3.0%

Value $6.412M Shares 175,000 Est. Cost $10524.49 Unrealized —

— INSYS THERAPEUTICS INC NEW 3.0%

Value $6.394M Shares 110,000 Est. Cost $11640.05 Unrealized —

MDXG MIMEDX GROUP INC 2.8%

Value $6.136M Shares 590,000 Est. Cost $9.36 Unrealized 0.0%

— FIBROGEN INC 2.8%

Value $6.004M Shares 191,338 Est. Cost $27.34 Unrealized —

NBIX NEUROCRINE BIOSCIENCES INC 2.7%

Value $5.758M Shares 145,000 Est. Cost $30.55 Unrealized +17.1%

— IMPRIMIS PHARMACEUTICALS INC 2.5%

Value $5.49M Shares 687,100 Est. Cost $5428.61 Unrealized —

— FLAMEL TECHNOLOGIES SA 2.5%

Value $5.394M Shares 300,000 Est. Cost $17.40 Unrealized —

— TRILLIUM THERAPEUTICS INC 2.4%

Value $5.26M Shares 260,000 Est. Cost $9.00 Unrealized —

— OPHTHOTECH CORP 2.3%

Value $4.886M Shares 105,000 Est. Cost $13006.66 Unrealized —

— ADAMAS PHARMACEUTICALS INC 2.1%

Value $4.46M Shares 255,000 Est. Cost $17.49 Unrealized —

— KITE PHARMA INC 2.0%

Value $4.384M Shares 76,000 Est. Cost $57.67 Unrealized —

— AMARIN CORP PLC 1.9%

Value $4.104M Shares 1,754,000 Est. Cost $2.34 Unrealized —

AXGN AXOGEN INC 1.6%

Value $3.451M Shares 985,900 Est. Cost $3.44 Unrealized 0.0%

— CARA THERAPEUTICS INC 1.5%

Value $3.166M Shares 315,000 Est. Cost $10.03 Unrealized —

— ZS PHARMA INC 1.5%

Value $3.156M Shares 75,000 Est. Cost $42.08 Unrealized —

— LION BIOTECHNOLOGIES INC 1.1%

Value $2.422M Shares 200,000 Est. Cost $12.11 Unrealized —

— ACCELERATE DIAGNOSTICS 1.1%

Value $2.264M Shares 100,600 Est. Cost $19162.23 Unrealized —

— TENAX THERAPEUTICS INC 0.9%

Value $1.976M Shares 606,200 Est. Cost $3.68 Unrealized —

— EVOKE PHARMA INC 0.8%

Value $1.727M Shares 245,000 Est. Cost $501.93 Unrealized —

MGNX MACROGENICS INC 0.7%

Value $1.569M Shares 50,000 Est. Cost $33.89 Unrealized 0.0%

— BIODELIVERY SCIENCES INTL IN 0.7%

Value $1.475M Shares 140,500 Est. Cost $10.50 Unrealized —

— CELGENE CORP 0.7%

Value $1.455M Shares 490,000 Est. Cost $2800.00 Unrealized —

— BIOLINERX LTD 0.2%

Value $528K Shares 250,000 Est. Cost $1426.15 Unrealized —

— INSPIREMD INC 0.2%

Value $400K Shares 1,250,000 Est. Cost $0.32 Unrealized —

— TRACON PHARMACEUTICALS INC 0.1%

Value $171K Shares 12,172 Est. Cost $14.05 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	CHIMERIX INC	565,000	$21.3M	9.9%	$23.65	—	COM	16934W106
—	CEMPRA INC	500,000	$17.16M	8.0%	$9402.92	—	COM	15130J109
—	ARIAD PHARMACEUTICALS INC	1,500,000	$12.36M	5.7%	$6983.72	—	COM	04033A100
—	RETROPHIN INC	500,000	$11.98M	5.6%	$20.71	—	COM	761299106
—	CLOVIS ONCOLOGY INC	140,000	$10.39M	4.8%	$3206.92	—	COM	189464100
—	AMAG PHARMACEUTICALS INC	190,000	$10.38M	4.8%	$54.66	—	COM	00163U106
AGIO	AGIOS PHARMACEUTICALS INC	90,000	$8.487M	3.9%	$40.76	+174.9%	COM	00847X104
CDXS	CODEXIS INC	1,724,000	$7.861M	3.6%	$1.98	+77.9%	COM	192005106
GERN	GERON CORP	1,825,000	$6.88M	3.2%	$2.63	+29.0%	COM	374163103
—	MEDGENICS INC	850,000	$6.851M	3.2%	$5.06	—	COM NEW	58436Q203
RARE	ULTRAGENYX PHARMACEUTICAL IN	110,000	$6.83M	3.2%	$45.89	+21.0%	COM	90400D108
SUPN	SUPERNUS PHARMACEUTICALS INC	535,000	$6.468M	3.0%	$8.76	+7.8%	COM	868459108
—	TETRAPHASE PHARMACEUTICALS I	175,000	$6.412M	3.0%	$10524.49	—	COM	88165N105
—	INSYS THERAPEUTICS INC NEW	110,000	$6.394M	3.0%	$11640.05	—	COM NEW	45824V209
MDXG	MIMEDX GROUP INC	590,000	$6.136M	2.8%	$9.36	0.0%	COM	602496101
—	FIBROGEN INC	191,338	$6.004M	2.8%	$27.34	—	COM	31572Q808
NBIX	NEUROCRINE BIOSCIENCES INC	145,000	$5.758M	2.7%	$30.55	+17.1%	COM	64125C109
—	IMPRIMIS PHARMACEUTICALS INC	687,100	$5.49M	2.5%	$5428.61	—	COM NEW	45323A201
—	FLAMEL TECHNOLOGIES SA	300,000	$5.394M	2.5%	$17.40	—	SPONSORED ADR	338488109
—	TRILLIUM THERAPEUTICS INC	260,000	$5.26M	2.4%	$9.00	—	COM NEW	89620X506
—	OPHTHOTECH CORP	105,000	$4.886M	2.3%	$13006.66	—	COM	683745103
—	ADAMAS PHARMACEUTICALS INC	255,000	$4.46M	2.1%	$17.49	—	COM	00548A106
—	KITE PHARMA INC	76,000	$4.384M	2.0%	$57.67	—	COM	49803L109
—	AMARIN CORP PLC	1,754,000	$4.104M	1.9%	$2.34	—	SPONSORED ADR NEW	023111206
AXGN	AXOGEN INC	985,900	$3.451M	1.6%	$3.44	0.0%	COM	05463X106
—	CARA THERAPEUTICS INC	315,000	$3.166M	1.5%	$10.03	—	COM	140755109
—	ZS PHARMA INC	75,000	$3.156M	1.5%	$42.08	—	COM	98979G105
—	LION BIOTECHNOLOGIES INC	200,000	$2.422M	1.1%	$12.11	—	COM	53619R102
—	ACCELERATE DIAGNOSTICS	100,600	$2.264M	1.1%	$19162.23	—	COM	00430H102
—	TENAX THERAPEUTICS INC	606,200	$1.976M	0.9%	$3.68	—	COM	88032L100
—	EVOKE PHARMA INC	245,000	$1.727M	0.8%	$501.93	—	COM	30049G104
MGNX	MACROGENICS INC	50,000	$1.569M	0.7%	$33.89	0.0%	COM	556099109
—	BIODELIVERY SCIENCES INTL IN	140,500	$1.475M	0.7%	$10.50	—	COM	09060J106
—	CELGENE CORP	490,000	$1.455M	0.7%	$2800.00	—	RIGHT 12/31/2030	151020112
—	BIOLINERX LTD	250,000	$528K	0.2%	$1426.15	—	SPONSORED ADR	09071M106
—	INSPIREMD INC	1,250,000	$400K	0.2%	$0.32	—	COM NEW	45779A309
—	TRACON PHARMACEUTICALS INC	12,172	$171K	0.1%	$14.05	—	COM	89237H100