Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q2 2015 (← Previous) (Next →)

Filing Date: Aug 14, 2015

Total Value: $251M (100.0% shares, 0.0% debt)

Holdings (46)

— CHIMERIX INC 8.1%

Value $20.33M Shares 440,000 Est. Cost $23.65 Unrealized —

— CEMPRA INC 6.7%

Value $16.84M Shares 490,000 Est. Cost $9402.92 Unrealized —

— RETROPHIN INC 6.1%

Value $15.25M Shares 460,000 Est. Cost $20.71 Unrealized —

— AMAG PHARMACEUTICALS INC 5.2%

Value $13.12M Shares 190,000 Est. Cost $54.66 Unrealized —

— ARIAD PHARMACEUTICALS INC 4.9%

Value $12.4M Shares 1,500,000 Est. Cost $6983.72 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 4.5%

Value $11.26M Shares 110,000 Est. Cost $45.89 Unrealized +69.2%

— IMPRIMIS PHARMACEUTICALS INC 3.9%

Value $9.797M Shares 1,205,000 Est. Cost $3098.93 Unrealized —

SUPN SUPERNUS PHARMACEUTICALS INC 3.6%

Value $9.084M Shares 535,000 Est. Cost $8.76 Unrealized +62.4%

— AFFIMED NV 3.2%

Value $7.951M Shares 590,300 Est. Cost $13.47 Unrealized —

— CLOVIS ONCOLOGY INC 3.1%

Value $7.909M Shares 90,000 Est. Cost $3206.92 Unrealized —

GERN GERON CORP 3.1%

Value $7.811M Shares 1,825,000 Est. Cost $2.63 Unrealized +50.6%

— FIBROGEN INC 3.0%

Value $7.638M Shares 325,000 Est. Cost $25.76 Unrealized —

MDXG MIMEDX GROUP INC 2.8%

Value $7.151M Shares 617,000 Est. Cost $9.40 Unrealized +9.5%

NBIX NEUROCRINE BIOSCIENCES INC 2.8%

Value $6.925M Shares 145,000 Est. Cost $30.55 Unrealized +38.8%

CDXS CODEXIS INC 2.7%

Value $6.706M Shares 1,724,000 Est. Cost $1.98 Unrealized +123.1%

AXGN AXOGEN INC 2.6%

Value $6.657M Shares 2,120,000 Est. Cost $3.33 Unrealized -2.9%

— FLAMEL TECHNOLOGIES SA 2.6%

Value $6.569M Shares 310,000 Est. Cost $17.52 Unrealized —

— MEDGENICS INC 2.6%

Value $6.437M Shares 1,050,000 Est. Cost $5.26 Unrealized —

— OPHTHOTECH CORP 2.2%

Value $5.487M Shares 105,000 Est. Cost $13006.66 Unrealized —

— TRILLIUM THERAPEUTICS INC 2.2%

Value $5.455M Shares 250,000 Est. Cost $9.00 Unrealized —

— ZS PHARMA INC 2.0%

Value $4.977M Shares 95,000 Est. Cost $44.25 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 1.9%

Value $4.885M Shares 2,505,000 Est. Cost $1.95 Unrealized —

— AMARIN CORP PLC 1.7%

Value $4.315M Shares 1,754,000 Est. Cost $2.34 Unrealized —

— CARA THERAPEUTICS INC 1.6%

Value $4.131M Shares 340,000 Est. Cost $10.19 Unrealized —

EGRX EAGLE PHARMACEUTICALS INC 1.6%

Value $4.043M Shares 50,000 Est. Cost $65.14 Unrealized 0.0%

— ADAMAS PHARMACEUTICALS INC 1.6%

Value $3.933M Shares 150,000 Est. Cost $17.49 Unrealized —

MGNX MACROGENICS INC 1.4%

Value $3.417M Shares 90,000 Est. Cost $33.44 Unrealized -1.7%

— INSYS THERAPEUTICS INC NEW 1.3%

Value $3.197M Shares 89,000 Est. Cost $11640.05 Unrealized —

— TETRAPHASE PHARMACEUTICALS I 1.2%

Value $3.084M Shares 65,000 Est. Cost $10524.49 Unrealized —

— INOTEK PHARMACEUTICALS CORP 1.2%

Value $2.963M Shares 604,700 Est. Cost $4.90 Unrealized —

— AVINGER INC 1.1%

Value $2.688M Shares 208,200 Est. Cost $12.91 Unrealized —

— ACCELERATE DIAGNOSTICS INC 1.0%

Value $2.596M Shares 100,600 Est. Cost $19162.23 Unrealized —

— XOMA CORP DEL 1.0%

Value $2.522M Shares 650,000 Est. Cost $3.88 Unrealized —

— TENAX THERAPEUTICS INC 0.9%

Value $2.343M Shares 635,000 Est. Cost $3.68 Unrealized —

— AURIS MED HLDG AG 0.7%

Value $1.725M Shares 355,000 Est. Cost $4.86 Unrealized —

— TONIX PHARMACEUTICALS HLDG C 0.7%

Value $1.704M Shares 190,000 Est. Cost $8.97 Unrealized —

— ZOGENIX INC 0.6%

Value $1.533M Shares 912,500 Est. Cost $1.68 Unrealized —

— INNOCOLL AG 0.6%

Value $1.481M Shares 101,200 Est. Cost $14.63 Unrealized —

— EVOKE PHARMA INC 0.5%

Value $1.355M Shares 259,100 Est. Cost $474.90 Unrealized —

— CELGENE CORP 0.4%

Value $950K Shares 456,492 Est. Cost $2800.00 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 0.3%

Value $871K Shares 85,000 Est. Cost $10.25 Unrealized —

— BIOLINERX LTD 0.2%

Value $495K Shares 250,000 Est. Cost $1426.15 Unrealized —

— AGILE THERAPEUTICS INC 0.2%

Value $472K Shares 55,000 Est. Cost $8.58 Unrealized —

— NEURODERM LTD 0.2%

Value $399K Shares 26,000 Est. Cost $15.35 Unrealized —

— DERMIRA INC 0.1%

Value $330K Shares 18,800 Est. Cost $17.55 Unrealized —

— TRACON PHARMACEUTICALS INC 0.1%

Value $138K Shares 12,172 Est. Cost $11.34 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	CHIMERIX INC	440,000	$20.33M	8.1%	$23.65	—	COM	16934W106
—	CEMPRA INC	490,000	$16.84M	6.7%	$9402.92	—	COM	15130J109
—	RETROPHIN INC	460,000	$15.25M	6.1%	$20.71	—	COM	761299106
—	AMAG PHARMACEUTICALS INC	190,000	$13.12M	5.2%	$54.66	—	COM	00163U106
—	ARIAD PHARMACEUTICALS INC	1,500,000	$12.4M	4.9%	$6983.72	—	COM	04033A100
RARE	ULTRAGENYX PHARMACEUTICAL IN	110,000	$11.26M	4.5%	$45.89	+69.2%	COM	90400D108
—	IMPRIMIS PHARMACEUTICALS INC	1,205,000	$9.797M	3.9%	$3098.93	—	COM	45323A201
SUPN	SUPERNUS PHARMACEUTICALS INC	535,000	$9.084M	3.6%	$8.76	+62.4%	COM	868459108
—	AFFIMED NV	590,300	$7.951M	3.2%	$13.47	—	COM	N01045108
—	CLOVIS ONCOLOGY INC	90,000	$7.909M	3.1%	$3206.92	—	COM	189464100
GERN	GERON CORP	1,825,000	$7.811M	3.1%	$2.63	+50.6%	COM	374163103
—	FIBROGEN INC	325,000	$7.638M	3.0%	$25.76	—	COM	31572Q808
MDXG	MIMEDX GROUP INC	617,000	$7.151M	2.8%	$9.40	+9.5%	COM	602496101
NBIX	NEUROCRINE BIOSCIENCES INC	145,000	$6.925M	2.8%	$30.55	+38.8%	COM	64125C109
CDXS	CODEXIS INC	1,724,000	$6.706M	2.7%	$1.98	+123.1%	COM	192005106
AXGN	AXOGEN INC	2,120,000	$6.657M	2.6%	$3.33	-2.9%	COM	05463X106
—	FLAMEL TECHNOLOGIES SA	310,000	$6.569M	2.6%	$17.52	—	COM	338488109
—	MEDGENICS INC	1,050,000	$6.437M	2.6%	$5.26	—	COM NEW	58436Q203
—	OPHTHOTECH CORP	105,000	$5.487M	2.2%	$13006.66	—	COM	683745103
—	TRILLIUM THERAPEUTICS INC	250,000	$5.455M	2.2%	$9.00	—	COM	89620X506
—	ZS PHARMA INC	95,000	$4.977M	2.0%	$44.25	—	COM	98979G105
—	PROTALIX BIOTHERAPEUTICS INC	2,505,000	$4.885M	1.9%	$1.95	—	COM	74365AAB7
—	AMARIN CORP PLC	1,754,000	$4.315M	1.7%	$2.34	—	COM	023111206
—	CARA THERAPEUTICS INC	340,000	$4.131M	1.6%	$10.19	—	COM	140755109
EGRX	EAGLE PHARMACEUTICALS INC	50,000	$4.043M	1.6%	$65.14	0.0%	COM	269796108
—	ADAMAS PHARMACEUTICALS INC	150,000	$3.933M	1.6%	$17.49	—	COM	00548A106
MGNX	MACROGENICS INC	90,000	$3.417M	1.4%	$33.44	-1.7%	COM	556099109
—	INSYS THERAPEUTICS INC NEW	89,000	$3.197M	1.3%	$11640.05	—	COM NEW	45824V209
—	TETRAPHASE PHARMACEUTICALS I	65,000	$3.084M	1.2%	$10524.49	—	COM	88165N105
—	INOTEK PHARMACEUTICALS CORP	604,700	$2.963M	1.2%	$4.90	—	COM	45780VAA0
—	AVINGER INC	208,200	$2.688M	1.1%	$12.91	—	COM	053734109
—	ACCELERATE DIAGNOSTICS INC	100,600	$2.596M	1.0%	$19162.23	—	COM	00430H102
—	XOMA CORP DEL	650,000	$2.522M	1.0%	$3.88	—	COM	98419J107
—	TENAX THERAPEUTICS INC	635,000	$2.343M	0.9%	$3.68	—	COM	88032L100
—	AURIS MED HLDG AG	355,000	$1.725M	0.7%	$4.86	—	COM	H03579101
—	TONIX PHARMACEUTICALS HLDG C	190,000	$1.704M	0.7%	$8.97	—	COM	890260201
—	ZOGENIX INC	912,500	$1.533M	0.6%	$1.68	—	COM	98978L105
—	INNOCOLL AG	101,200	$1.481M	0.6%	$14.63	—	COM	45780Q103
—	EVOKE PHARMA INC	259,100	$1.355M	0.5%	$474.90	—	COM	30049G104
—	CELGENE CORP	456,492	$950K	0.4%	$2800.00	—	RIGHTS	151020112
—	FOAMIX PHARMACEUTICALS LTD	85,000	$871K	0.3%	$10.25	—	COM	M46135105
—	BIOLINERX LTD	250,000	$495K	0.2%	$1426.15	—	COM	09071M106
—	AGILE THERAPEUTICS INC	55,000	$472K	0.2%	$8.58	—	COM	00847L100
—	NEURODERM LTD	26,000	$399K	0.2%	$15.35	—	COM	M74231107
—	DERMIRA INC	18,800	$330K	0.1%	$17.55	—	COM	24983L104
—	TRACON PHARMACEUTICALS INC	12,172	$138K	0.1%	$11.34	—	COM	89237H10A