Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q3 2016 (← Previous) (Next →)

Filing Date: Nov 14, 2016

Total Value: $191M (100.0% shares, 0.0% debt)

Holdings (44)

— BLUEPRINT MEDICINES CORP 12.2%

Value $23.32M Shares 785,000 Est. Cost $27.74 Unrealized —

AXGN AXOGEN INC 9.5%

Value $18.06M Shares 2,000,000 Est. Cost $3.33 Unrealized +144.5%

— ARIAD PHARMACEUTICALS INC 7.5%

Value $14.31M Shares 1,045,000 Est. Cost $6983.72 Unrealized —

— MEDGENICS INC 5.2%

Value $10.03M Shares 1,800,000 Est. Cost $5.38 Unrealized —

AGIO AGIOS PHARMACEUTICALS 3.6%

Value $6.867M Shares 130,000 Est. Cost $43.03 Unrealized +1.2%

— FIBROGEN INC 3.6%

Value $6.831M Shares 330,000 Est. Cost $25.62 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 3.1%

Value $5.834M Shares 630,000 Est. Cost $7.68 Unrealized —

— CARA THERAPEUTICS INC 2.9%

Value $5.636M Shares 675,000 Est. Cost $8.65 Unrealized —

CDXS CODEXIS INC 2.7%

Value $5.195M Shares 1,170,000 Est. Cost $1.98 Unrealized +111.9%

— CYNAPSUS THERAPEUTICS INC 2.6%

Value $5.029M Shares 125,000 Est. Cost $15.24 Unrealized —

— HORIZON GLOBAL CORP 2.6%

Value $4.986M Shares 275,000 Est. Cost $16.92 Unrealized —

EGRX EAGLE PHARMACEUTICALS INC 2.6%

Value $4.9M Shares 70,000 Est. Cost $67.25 Unrealized -17.6%

— IMPRIMIS PHARMACEUTICALS INC 2.4%

Value $4.631M Shares 1,215,381 Est. Cost $2946.31 Unrealized —

— GLOBAL BLOOD THERAPEUTICS IN 2.4%

Value $4.61M Shares 200,000 Est. Cost $18.14 Unrealized —

— PROTALIX BIOTHERAPEUTICS INC 2.4%

Value $4.6M Shares 8,070,000 Est. Cost $1.32 Unrealized —

MGNX MACROGENICS INC 2.3%

Value $4.337M Shares 145,000 Est. Cost $24.19 Unrealized +23.0%

— CHIMERIX INC 2.3%

Value $4.321M Shares 780,000 Est. Cost $5.17 Unrealized —

— AQUINOX PHARMACEUTICALS INC 2.2%

Value $4.142M Shares 310,000 Est. Cost $6.95 Unrealized —

— ADAMAS PHARMACEUTICALS INC 2.1%

Value $4.103M Shares 250,000 Est. Cost $18.87 Unrealized —

— IMMUNOMEDICS INC 2.0%

Value $3.9M Shares 1,200,000 Est. Cost $2.62 Unrealized —

— INOTEK PHARMACEUTICALS CORP 2.0%

Value $3.792M Shares 400,000 Est. Cost $5.17 Unrealized —

XENE XENON PHARMACEUTICALS INC 1.7%

Value $3.321M Shares 410,000 Est. Cost $8.69 Unrealized -11.1%

PRTA PROTHENA CORP PLC 1.6%

Value $2.999M Shares 50,000 Est. Cost $53.65 Unrealized 0.0%

— EDGE THERAPEUTICS INC 1.5%

Value $2.915M Shares 280,000 Est. Cost $9.54 Unrealized —

— LOXO ONCOLOGY INC 1.5%

Value $2.88M Shares 110,000 Est. Cost $26.18 Unrealized —

— TRILLIUM THERAPEUTICS INC 1.4%

Value $2.587M Shares 175,000 Est. Cost $9.00 Unrealized —

— ZOGENIX INC 1.3%

Value $2.515M Shares 220,000 Est. Cost $8.05 Unrealized —

CTMX CYTOMX THERAPEUTICS INC 1.3%

Value $2.509M Shares 160,000 Est. Cost $11.41 Unrealized +6.1%

RARE ULTRAGENYX PHARMACEUTICAL IN 1.3%

Value $2.483M Shares 35,000 Est. Cost $45.89 Unrealized +39.1%

— PROTEOSTASIS THERAPEUTICS IN 1.2%

Value $2.37M Shares 152,000 Est. Cost $13.20 Unrealized —

— LION BIOTECHNOLOGIES INC 1.2%

Value $2.304M Shares 280,000 Est. Cost $8.11 Unrealized —

— CORIUM INTL INC 1.2%

Value $2.252M Shares 400,000 Est. Cost $7.82 Unrealized —

— AMARIN CORP PLC 1.2%

Value $2.233M Shares 700,000 Est. Cost $2.34 Unrealized —

— NEURODERM LTD 1.0%

Value $1.821M Shares 98,500 Est. Cost $16.47 Unrealized —

— NABRIVA THERAPEUTICS AG 0.9%

Value $1.688M Shares 239,500 Est. Cost $9.49 Unrealized —

— INNOCOLL HLDGS PLC 0.8%

Value $1.563M Shares 269,100 Est. Cost $5.51 Unrealized —

— AFFIMED N V 0.6%

Value $1.195M Shares 430,000 Est. Cost $13.23 Unrealized —

— INTEC PHARMA LTD JERUSALEM 0.5%

Value $1.029M Shares 175,000 Est. Cost $5.56 Unrealized —

— TENAX THERAPEUTICS INC 0.5%

Value $905K Shares 390,000 Est. Cost $3.68 Unrealized —

— PORTOLA PHARMACEUTICALS INC 0.4%

Value $795K Shares 35,000 Est. Cost $22.71 Unrealized —

— ABEONA THERAPEUTICS INC 0.3%

Value $600K Shares 100,000 Est. Cost $6.00 Unrealized —

— AMAG PHARMACEUTICALS INC 0.2%

Value $368K Shares 15,000 Est. Cost $44.20 Unrealized —

— BIOLINERX LTD 0.2%

Value $288K Shares 250,000 Est. Cost $1426.15 Unrealized —

— DEPOMED INC 0.0%

Value $41,000 Shares 1,650 Est. Cost $24.85 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	BLUEPRINT MEDICINES CORP	785,000	$23.32M	12.2%	$27.74	—	COM	09627Y109
AXGN	AXOGEN INC	2,000,000	$18.06M	9.5%	$3.33	+144.5%	COM	05463X106
—	ARIAD PHARMACEUTICALS INC	1,045,000	$14.31M	7.5%	$6983.72	—	COM	04033A100
—	MEDGENICS INC	1,800,000	$10.03M	5.2%	$5.38	—	COM NEW	58436Q203
AGIO	AGIOS PHARMACEUTICALS	130,000	$6.867M	3.6%	$43.03	+1.2%	COM	00847X104
—	FIBROGEN INC	330,000	$6.831M	3.6%	$25.62	—	COM	31572Q808
—	FOAMIX PHARMACEUTICALS LTD	630,000	$5.834M	3.1%	$7.68	—	SHS	M46135105
—	CARA THERAPEUTICS INC	675,000	$5.636M	2.9%	$8.65	—	COM	140755109
CDXS	CODEXIS INC	1,170,000	$5.195M	2.7%	$1.98	+111.9%	COM	192005106
—	CYNAPSUS THERAPEUTICS INC	125,000	$5.029M	2.6%	$15.24	—	COM PAR NO PAR	23257Y859
—	HORIZON GLOBAL CORP	275,000	$4.986M	2.6%	$16.92	—	COM	G4617B105
EGRX	EAGLE PHARMACEUTICALS INC	70,000	$4.9M	2.6%	$67.25	-17.6%	COM	269796108
—	IMPRIMIS PHARMACEUTICALS INC	1,215,381	$4.631M	2.4%	$2946.31	—	COM NEW	45323A201
—	GLOBAL BLOOD THERAPEUTICS IN	200,000	$4.61M	2.4%	$18.14	—	COM	37890U108
—	PROTALIX BIOTHERAPEUTICS INC	8,070,000	$4.6M	2.4%	$1.32	—	COM	74365AAB7
MGNX	MACROGENICS INC	145,000	$4.337M	2.3%	$24.19	+23.0%	COM	556099109
—	CHIMERIX INC	780,000	$4.321M	2.3%	$5.17	—	COM	16934W106
—	AQUINOX PHARMACEUTICALS INC	310,000	$4.142M	2.2%	$6.95	—	COM	03842B101
—	ADAMAS PHARMACEUTICALS INC	250,000	$4.103M	2.1%	$18.87	—	COM	00548A106
—	IMMUNOMEDICS INC	1,200,000	$3.9M	2.0%	$2.62	—	COM	452907108
—	INOTEK PHARMACEUTICALS CORP	400,000	$3.792M	2.0%	$5.17	—	COM	45780VAA0
XENE	XENON PHARMACEUTICALS INC	410,000	$3.321M	1.7%	$8.69	-11.1%	COM	98420N105
PRTA	PROTHENA CORP PLC	50,000	$2.999M	1.6%	$53.65	0.0%	SHS	G72800108
—	EDGE THERAPEUTICS INC	280,000	$2.915M	1.5%	$9.54	—	COM	279870109
—	LOXO ONCOLOGY INC	110,000	$2.88M	1.5%	$26.18	—	COM	548862101
—	TRILLIUM THERAPEUTICS INC	175,000	$2.587M	1.4%	$9.00	—	COM NEW	89620X506
—	ZOGENIX INC	220,000	$2.515M	1.3%	$8.05	—	COM NEW	98978L105
CTMX	CYTOMX THERAPEUTICS INC	160,000	$2.509M	1.3%	$11.41	+6.1%	COM	23284F105
RARE	ULTRAGENYX PHARMACEUTICAL IN	35,000	$2.483M	1.3%	$45.89	+39.1%	COM	90400D108
—	PROTEOSTASIS THERAPEUTICS IN	152,000	$2.37M	1.2%	$13.20	—	COM	74373B109
—	LION BIOTECHNOLOGIES INC	280,000	$2.304M	1.2%	$8.11	—	COM	53619R102
—	CORIUM INTL INC	400,000	$2.252M	1.2%	$7.82	—	COM	21887L107
—	AMARIN CORP PLC	700,000	$2.233M	1.2%	$2.34	—	SPONS ADR NEW	023111206
—	NEURODERM LTD	98,500	$1.821M	1.0%	$16.47	—	ORD SHS	M74231107
—	NABRIVA THERAPEUTICS AG	239,500	$1.688M	0.9%	$9.49	—	SPONSORED ADR	62957M104
—	INNOCOLL HLDGS PLC	269,100	$1.563M	0.8%	$5.51	—	SHS	G4783X105
—	AFFIMED N V	430,000	$1.195M	0.6%	$13.23	—	COM	N01045108
—	INTEC PHARMA LTD JERUSALEM	175,000	$1.029M	0.5%	$5.56	—	COM	M53644106
—	TENAX THERAPEUTICS INC	390,000	$905K	0.5%	$3.68	—	COM	88032L100
—	PORTOLA PHARMACEUTICALS INC	35,000	$795K	0.4%	$22.71	—	COM	737010908
—	ABEONA THERAPEUTICS INC	100,000	$600K	0.3%	$6.00	—	COM	00289Y107
—	AMAG PHARMACEUTICALS INC	15,000	$368K	0.2%	$44.20	—	COM	00163U106
—	BIOLINERX LTD	250,000	$288K	0.2%	$1426.15	—	SPONSORED ADR	09071M106
—	DEPOMED INC	1,650	$41,000	0.0%	$24.85	—	COM	249908104