SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2017 (← Previous) (Next →)

Filing Date: Feb 12, 2018

Total Value: $852M (100.0% shares, 0.0% debt)

Holdings (136)

XBI SPDR SERIES TRUST 19.4%
Value $165M Shares 1,950,000 Est. Cost Unrealized
IBB ISHARES TR 6.3%
Value $53.38M Shares 500,000 Est. Cost Unrealized
CELGENE CORP 3.8%
Value $32.25M Shares 309,000 Est. Cost $116.87 Unrealized
MYLAN N V 3.8%
Value $32.01M Shares 756,449 Est. Cost $42.31 Unrealized
MRK MERCK & CO INC 2.8%
Value $23.91M Shares 425,000 Est. Cost $44.05 Unrealized -2.4%
BIIB BIOGEN INC 2.8%
Value $23.64M Shares 74,200 Est. Cost $282.04 Unrealized +13.7%
SRPT SAREPTA THERAPEUTICS INC 2.5%
Value $21.42M Shares 384,997 Est. Cost $33.13 Unrealized +59.9%
GLAXOSMITHKLINE PLC 1.9%
Value $15.96M Shares 450,000 Est. Cost $43.12 Unrealized
FOLD AMICUS THERAPEUTICS INC 1.9%
Value $15.83M Shares 1,100,000 Est. Cost $11.29 Unrealized +21.7%
ALEXION PHARMACEUTICALS INC 1.7%
Value $14.35M Shares 120,000 Est. Cost $119.59 Unrealized
PFE PFIZER INC 1.7%
Value $14.13M Shares 390,000 Est. Cost $21.41 Unrealized +11.2%
CELJF CELLCOM ISRAEL LTD 1.6%
Value $14.02M Shares 1,359,744 Est. Cost $9.17 Unrealized +5.8%
SHIRE PLC 1.6%
Value $13.42M Shares 86,500 Est. Cost $98.24 Unrealized
VRTX VERTEX PHARMACEUTICALS INC 1.5%
Value $12.86M Shares 85,823 Est. Cost $148.66 Unrealized -0.4%
CLOVIS ONCOLOGY INC 1.3%
Value $10.74M Shares 158,000 Est. Cost $89.01 Unrealized
PORTOLA PHARMACEUTICALS INC 1.2%
Value $10.22M Shares 210,000 Est. Cost $52.78 Unrealized
NICE NICE LTD 1.2%
Value $9.914M Shares 107,870 Est. Cost $72.68 Unrealized
CLLS CELLECTIS S A 1.2%
Value $9.893M Shares 339,367 Est. Cost $26.08 Unrealized
ALLERGAN PLC 1.2%
Value $9.815M Shares 60,000 Est. Cost $204.95 Unrealized
IGNYTA INC 1.1%
Value $9.193M Shares 344,300 Est. Cost $10.61 Unrealized
VKTX VIKING THERAPEUTICS INC 1.0%
Value $8.71M Shares 2,145,300 Est. Cost $2.67 Unrealized +9.0%
TESARO INC 0.9%
Value $7.873M Shares 95,000 Est. Cost $128.03 Unrealized
PRTA PROTHENA CORP PLC 0.9%
Value $7.685M Shares 205,000 Est. Cost $52.39 Unrealized -2.8%
LA JOLLA PHARMACEUTICAL CO 0.8%
Value $7.241M Shares 225,000 Est. Cost $28.39 Unrealized
EIGER BIOPHARMACEUTICALS INC 0.8%
Value $7.135M Shares 511,469 Est. Cost $13.73 Unrealized
ALDX ALDEYRA THERAPEUTICS INC 0.8%
Value $7.1M Shares 1,044,131 Est. Cost $6.06 Unrealized +8.8%
V VISA INC 0.8%
Value $6.887M Shares 60,401 Est. Cost $75.76 Unrealized +37.8%
REATA PHARMACEUTICALS INC 0.7%
Value $6.372M Shares 225,000 Est. Cost $30.86 Unrealized
GOOGL ALPHABET INC 0.7%
Value $6.075M Shares 5,767 Est. Cost $39.71 Unrealized +29.0%
PIERIS PHARMACEUTICALS INC 0.7%
Value $6.04M Shares 800,000 Est. Cost $2.93 Unrealized
META FACEBOOK INC 0.7%
Value $6.011M Shares 34,067 Est. Cost $137.15 Unrealized +28.0%
NOMD NOMAD FOODS LTD 0.7%
Value $5.752M Shares 340,162 Est. Cost $14.19 Unrealized +9.5%
FIBROGEN INC 0.7%
Value $5.678M Shares 119,779 Est. Cost $18.76 Unrealized
GLYCOMIMETICS INC 0.6%
Value $5.457M Shares 325,000 Est. Cost $16.79 Unrealized
OBSEVA SA 0.6%
Value $5.346M Shares 547,697 Est. Cost $9.88 Unrealized
ASND ASCENDIS PHARMA A S 0.6%
Value $5.187M Shares 129,474 Est. Cost $14.62 Unrealized
ARRAY BIOPHARMA INC 0.6%
Value $5.184M Shares 405,000 Est. Cost $6.75 Unrealized
SPARK THERAPEUTICS INC 0.6%
Value $5.142M Shares 100,000 Est. Cost $51.42 Unrealized
ACAD ACADIA PHARMACEUTICALS INC 0.6%
Value $5.119M Shares 170,000 Est. Cost $31.98 Unrealized 0.0%
DECIPHERA PHARMACEUTICALS IN 0.6%
Value $5.008M Shares 224,154 Est. Cost $21.22 Unrealized
SAGE THERAPEUTICS INC 0.6%
Value $4.941M Shares 30,000 Est. Cost $141.41 Unrealized
ADAMAS PHARMACEUTICALS INC 0.6%
Value $4.762M Shares 140,500 Est. Cost $24.25 Unrealized
MELLANOX TECHNOLOGIES LTD 0.6%
Value $4.752M Shares 73,446 Est. Cost $64.70 Unrealized
INCY INCYTE CORP 0.6%
Value $4.736M Shares 50,000 Est. Cost $104.52 Unrealized 0.0%
INCY INCYTE CORP 0.6%
Value $4.736M Shares 50,000 Est. Cost $104.52 Unrealized 0.0%
MINERVA NEUROSCIENCES INC 0.6%
Value $4.689M Shares 775,000 Est. Cost $8.06 Unrealized
STEMLINE THERAPEUTICS INC 0.5%
Value $4.68M Shares 300,000 Est. Cost $8.55 Unrealized
WIX WIX COM LTD 0.5%
Value $4.499M Shares 78,180 Est. Cost $61.89 Unrealized 0.0%
FLEX PHARMA INC 0.5%
Value $4.339M Shares 241,211 Est. Cost $17.16 Unrealized
XLF SELECT SECTOR SPDR TR 0.5%
Value $4.326M Shares 155,000 Est. Cost $27.91 Unrealized
HON HONEYWELL INTL INC 0.5%
Value $4.102M Shares 26,750 Est. Cost $113.37 Unrealized 0.0%
KADMON HLDGS INC 0.5%
Value $3.982M Shares 1,100,000 Est. Cost $3.35 Unrealized
GLOBAL BLOOD THERAPEUTICS IN 0.5%
Value $3.935M Shares 100,000 Est. Cost $27.35 Unrealized
CTSH COGNIZANT TECHNOLOGY SOLUTIO 0.5%
Value $3.912M Shares 55,086 Est. Cost $63.64 Unrealized +2.3%
CHTR CHARTER COMMUNICATIONS INC N 0.5%
Value $3.907M Shares 11,629 Est. Cost $227.34 Unrealized +49.4%
IMMUNOMEDICS INC 0.4%
Value $3.717M Shares 230,000 Est. Cost $3.16 Unrealized
AVEO PHARMACEUTICALS INC 0.4%
Value $3.627M Shares 1,300,000 Est. Cost $0.59 Unrealized
ANAB ANAPTYSBIO INC 0.4%
Value $3.525M Shares 35,000 Est. Cost $26.97 Unrealized +172.9%
PBYI PUMA BIOTECHNOLOGY INC 0.4%
Value $3.46M Shares 35,000 Est. Cost $111.90 Unrealized 0.0%
ARSANIS INC 0.4%
Value $3.436M Shares 269,268 Est. Cost $12.76 Unrealized
VBI VACCINES INC 0.4%
Value $3.416M Shares 800,000 Est. Cost $4.27 Unrealized
CTMX CYTOMX THERAPEUTICS INC 0.4%
Value $3.378M Shares 160,000 Est. Cost $13.73 Unrealized +51.0%
ABEONA THERAPEUTICS INC 0.4%
Value $3.329M Shares 210,000 Est. Cost $15.85 Unrealized
ALLENA PHARMACEUTICALS INC 0.4%
Value $3.27M Shares 325,000 Est. Cost $10.06 Unrealized
IMMUNOGEN INC 0.4%
Value $3.205M Shares 500,000 Est. Cost $6.41 Unrealized
MELINTA THERAPEUTICS INC 0.4%
Value $3.16M Shares 200,000 Est. Cost $15.80 Unrealized
CLEARSIDE BIOMEDICAL INC 0.4%
Value $3.15M Shares 450,000 Est. Cost $7.32 Unrealized
EDGE THERAPEUTICS INC 0.4%
Value $3.127M Shares 333,737 Est. Cost $11.53 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.4%
Value $3.121M Shares 35,000 Est. Cost $90.67 Unrealized -4.1%
CLEMENTIA PHARMACEUTICALS IN 0.4%
Value $3.094M Shares 163,000 Est. Cost $16.89 Unrealized
LAM RESEARCH CORP 0.4%
Value $3.052M Shares 16,580 Est. Cost $184.08 Unrealized
AUDENTES THERAPEUTICS INC 0.3%
Value $2.969M Shares 95,000 Est. Cost $19.13 Unrealized
SVRA SAVARA INC 0.3%
Value $2.968M Shares 200,000 Est. Cost $5.87 Unrealized +95.5%
THERAPEUTICSMD INC 0.3%
Value $2.899M Shares 479,980 Est. Cost $6.96 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 0.3%
Value $2.871M Shares 37,000 Est. Cost $45.69 Unrealized +49.3%
ORLY O REILLY AUTOMOTIVE INC NEW 0.3%
Value $2.802M Shares 11,650 Est. Cost $14.64 Unrealized +1.7%
EXPE EXPEDIA INC DEL 0.3%
Value $2.749M Shares 22,950 Est. Cost $125.31 Unrealized 0.0%
CORBUS PHARMACEUTICALS HLDGS 0.3%
Value $2.663M Shares 375,000 Est. Cost $7.10 Unrealized
ERYTECH PHARMA 0.3%
Value $2.642M Shares 120,000 Est. Cost $22.02 Unrealized
MGNX MACROGENICS INC 0.3%
Value $2.635M Shares 138,700 Est. Cost $22.18 Unrealized -15.8%
CASCADIAN THERAPEUTICS INC 0.3%
Value $2.52M Shares 681,210 Est. Cost $4.08 Unrealized
SUMMIT THERAPEUTICS PLC 0.3%
Value $2.349M Shares 212,018 Est. Cost $12.31 Unrealized
PANW PALO ALTO NETWORKS INC 0.3%
Value $2.327M Shares 16,055 Est. Cost $22.77 Unrealized +6.8%
CRVS CORVUS PHARMACEUTICALS INC 0.3%
Value $2.294M Shares 221,430 Est. Cost $13.79 Unrealized -7.2%
ARDX ARDELYX INC 0.3%
Value $2.277M Shares 345,000 Est. Cost $11.98 Unrealized -50.5%
CPRX CATALYST PHARMACEUTICALS INC 0.3%
Value $2.255M Shares 576,825 Est. Cost $3.30 Unrealized 0.0%
TEVA TEVA PHARMACEUTICAL INDS LTD 0.3%
Value $2.25M Shares 118,750 Est. Cost $17.60 Unrealized
SELECTA BIOSCIENCES INC 0.3%
Value $2.242M Shares 228,534 Est. Cost $14.01 Unrealized
CTI BIOPHARMA CORP 0.3%
Value $2.234M Shares 833,633 Est. Cost $3.19 Unrealized
CYMABAY THERAPEUTICS INC 0.3%
Value $2.208M Shares 240,000 Est. Cost $9.20 Unrealized
ORBOTECH LTD 0.3%
Value $2.185M Shares 43,488 Est. Cost $30.37 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.3%
Value $2.177M Shares 248,472 Est. Cost $12.40 Unrealized -20.2%
GALMED PHARMACEUTICALS LTD 0.3%
Value $2.164M Shares 238,095 Est. Cost $9.09 Unrealized
MYLAN N V 0.2%
Value $2.116M Shares 50,000 Est. Cost $42.31 Unrealized
AAP ADVANCE AUTO PARTS INC 0.2%
Value $2.093M Shares 21,000 Est. Cost $83.31 Unrealized -3.0%
SIERRA ONCOLOGY INC 0.2%
Value $2.052M Shares 550,000 Est. Cost $3.73 Unrealized
CMCSA COMCAST CORP NEW 0.2%
Value $1.879M Shares 46,905 Est. Cost $32.02 Unrealized -4.2%
KALA PHARMACEUTICALS INC 0.2%
Value $1.849M Shares 100,000 Est. Cost $18.49 Unrealized
OVID OVID THERAPEUTICS INC 0.2%
Value $1.783M Shares 180,674 Est. Cost $13.06 Unrealized -29.7%
MA MASTERCARD INCORPORATED 0.2%
Value $1.744M Shares 11,525 Est. Cost $98.63 Unrealized +44.2%
EVOKE PHARMA INC 0.2%
Value $1.738M Shares 769,149 Est. Cost $2.91 Unrealized
NEOS THERAPEUTICS INC 0.2%
Value $1.734M Shares 170,032 Est. Cost $10.20 Unrealized
CYTK CYTOKINETICS INC 0.2%
Value $1.712M Shares 210,000 Est. Cost $12.41 Unrealized -8.5%
PRQR PROQR THRAPEUTICS N V 0.2%
Value $1.709M Shares 530,000 Est. Cost $4.98 Unrealized -27.9%
VTV THERAPEUTICS INC 0.2%
Value $1.693M Shares 281,679 Est. Cost $6.98 Unrealized
AXSM AXSOME THERAPEUTICS INC 0.2%
Value $1.686M Shares 301,000 Est. Cost $4.66 Unrealized +8.3%
VISTAGEN THERAPEUTICS INC 0.2%
Value $1.384M Shares 1,247,251 Est. Cost $2.58 Unrealized
AILERON THERAPEUTICS INC 0.2%
Value $1.318M Shares 125,000 Est. Cost $11.15 Unrealized
RDCM RADCOM LTD 0.2%
Value $1.305M Shares 65,760 Est. Cost $20.37 Unrealized 0.0%
SNA SNAP ON INC 0.1%
Value $1.271M Shares 7,292 Est. Cost $127.56 Unrealized +3.1%
ACORDA THERAPEUTICS INC 0.1%
Value $1.073M Shares 50,000 Est. Cost $21.46 Unrealized
INOTEK PHARMACEUTICALS CORP 0.1%
Value $1.049M Shares 100,441 Est. Cost $7.62 Unrealized
SPRING BK PHARMACEUTICALS IN 0.1%
Value $999K Shares 74,309 Est. Cost $13.54 Unrealized
ALBIREO PHARMA INC 0.1%
Value $907K Shares 35,431 Est. Cost $20.62 Unrealized
AQUINOX PHARMACEUTICALS INC 0.1%
Value $888K Shares 75,535 Est. Cost $14.10 Unrealized
AAP ADVANCE AUTO PARTS INC 0.1%
Value $831K Shares 8,336 Est. Cost $83.31 Unrealized -3.0%
TEVA PHARMACEUTICAL FIN LLC 0.1%
Value $758K Shares 2,135 Est. Cost $617.35 Unrealized
RGNX REGENXBIO INC 0.1%
Value $735K Shares 22,107 Est. Cost $30.13 Unrealized 0.0%
CATABASIS PHARMACEUTICALS IN 0.1%
Value $489K Shares 328,030 Est. Cost $6.09 Unrealized
TJX TJX COS INC NEW 0.1%
Value $443K Shares 5,800 Est. Cost $33.96 Unrealized -4.6%
UNH UNITEDHEALTH GROUP INC 0.1%
Value $441K Shares 2,000 Est. Cost $123.75 Unrealized +50.3%
SERVICEMASTER GLOBAL HLDGS I 0.0%
Value $410K Shares 8,000 Est. Cost $43.66 Unrealized
SAGE THERAPEUTICS INC 0.0%
Value $395K Shares 2,400 Est. Cost $141.41 Unrealized
WSO WATSCO INC 0.0%
Value $357K Shares 2,100 Est. Cost $142.89 Unrealized +15.6%
MHK MOHAWK INDS INC 0.0%
Value $303K Shares 1,100 Est. Cost $205.53 Unrealized +30.5%
ECL ECOLAB INC 0.0%
Value $268K Shares 2,000 Est. Cost $118.89 Unrealized +2.5%
LOW LOWES COS INC 0.0%
Value $242K Shares 2,600 Est. Cost $65.42 Unrealized +8.9%
SEE SEALED AIR CORP NEW 0.0%
Value $222K Shares 4,500 Est. Cost $39.39 Unrealized +0.8%
ULTIMATE SOFTWARE GROUP INC 0.0%
Value $175K Shares 800 Est. Cost $195.00 Unrealized
XRAY DENTSPLY SIRONA INC 0.0%
Value $165K Shares 2,500 Est. Cost $63.18 Unrealized +0.7%
LIBERTY INTERACTIVE CORP 0.0%
Value $163K Shares 3,000 Est. Cost $52.33 Unrealized
TRIP TRIPADVISOR INC 0.0%
Value $138K Shares 4,000 Est. Cost $42.17 Unrealized -23.8%
CMG CHIPOTLE MEXICAN GRILL INC 0.0%
Value $116K Shares 400 Est. Cost $8.25 Unrealized -27.7%
VISTA OUTDOOR INC 0.0%
Value $87,000 Shares 6,000 Est. Cost $22.50 Unrealized
CIDARA THERAPEUTICS INC 0.0%
Value $5,000 Shares 800 Est. Cost $6.25 Unrealized
ATHERSYS INC 0.0%
Value $1,000 Shares 773 Est. Cost $2.59 Unrealized