SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q3 2017 (← Previous) (Next →)

Filing Date: Nov 27, 2017

Total Value: $701M (100.0% shares, 0.0% debt)

Holdings (131)

XBI SPDR SERIES TRUST 17.3%
Value $121M Shares 1,400,000 Est. Cost Unrealized
CELGENE CORP 5.7%
Value $40.1M Shares 275,000 Est. Cost $118.41 Unrealized
BIIB BIOGEN INC 4.7%
Value $32.88M Shares 105,000 Est. Cost $282.04 Unrealized +5.0%
MRK MERCK & CO INC 3.9%
Value $27.21M Shares 425,000 Est. Cost $44.05 Unrealized +6.0%
GILD GILEAD SCIENCES INC 2.7%
Value $18.64M Shares 230,000 Est. Cost $48.32 Unrealized +15.8%
GLAXOSMITHKLINE PLC 2.6%
Value $18.27M Shares 450,000 Est. Cost $43.12 Unrealized
SRPT SAREPTA THERAPEUTICS INC 2.5%
Value $17.46M Shares 384,997 Est. Cost $33.13 Unrealized +20.6%
CELJF CELLCOM ISRAEL LTD 2.0%
Value $14.3M Shares 1,535,988 Est. Cost $9.17 Unrealized 0.0%
PFE PFIZER INC 2.0%
Value $13.92M Shares 390,000 Est. Cost $21.41 Unrealized +3.9%
SHIRE PLC 1.9%
Value $13.25M Shares 86,500 Est. Cost $98.24 Unrealized
CLOVIS ONCOLOGY INC 1.9%
Value $13.02M Shares 158,000 Est. Cost $89.01 Unrealized
ALLERGAN PLC 1.8%
Value $12.3M Shares 60,000 Est. Cost $204.95 Unrealized
TESARO INC 1.5%
Value $10.33M Shares 80,000 Est. Cost $136.49 Unrealized
CLLS CELLECTIS S A 1.4%
Value $9.922M Shares 348,736 Est. Cost $26.08 Unrealized
NICE NICE LTD 1.3%
Value $8.876M Shares 109,159 Est. Cost $72.68 Unrealized
ITRN ITURAN LOCATION AND CONTROL 1.2%
Value $8.266M Shares 229,283 Est. Cost $18.84 Unrealized +72.8%
BMRN BIOMARIN PHARMACEUTICAL INC 1.1%
Value $7.911M Shares 85,000 Est. Cost $90.67 Unrealized -2.5%
PORTOLA PHARMACEUTICALS INC 1.1%
Value $7.834M Shares 145,000 Est. Cost $54.62 Unrealized
ALDX ALDEYRA THERAPEUTICS INC 1.1%
Value $7.518M Shares 1,044,131 Est. Cost $6.06 Unrealized -13.8%
ORBOTECH LTD 1.1%
Value $7.397M Shares 175,243 Est. Cost $30.37 Unrealized
TEVA TEVA PHARMACEUTICAL INDS LTD 1.0%
Value $7.04M Shares 400,000 Est. Cost $17.60 Unrealized
FIBROGEN INC 1.0%
Value $6.982M Shares 129,779 Est. Cost $18.76 Unrealized
SRPT SAREPTA THERAPEUTICS INC 1.0%
Value $6.804M Shares 150,000 Est. Cost $33.13 Unrealized +20.6%
REATA PHARMACEUTICALS INC 0.9%
Value $6.376M Shares 205,000 Est. Cost $31.10 Unrealized
FOLD AMICUS THERAPEUTICS INC 0.9%
Value $6.334M Shares 420,000 Est. Cost $7.32 Unrealized +80.8%
IMMUNOMEDICS INC 0.9%
Value $6.291M Shares 450,000 Est. Cost $3.16 Unrealized
PIERIS PHARMACEUTICALS INC 0.8%
Value $5.76M Shares 1,000,000 Est. Cost $2.93 Unrealized
EIGER BIOPHARMACEUTICALS INC 0.8%
Value $5.723M Shares 520,269 Est. Cost $13.73 Unrealized
IGNYTA INC 0.8%
Value $5.672M Shares 459,300 Est. Cost $10.61 Unrealized
GOOGL ALPHABET INC 0.8%
Value $5.615M Shares 5,767 Est. Cost $39.71 Unrealized +18.5%
V VISA INC 0.8%
Value $5.573M Shares 52,951 Est. Cost $71.73 Unrealized +33.4%
META FACEBOOK INC 0.8%
Value $5.496M Shares 32,167 Est. Cost $134.88 Unrealized +22.9%
NBIX NEUROCRINE BIOSCIENCES INC 0.8%
Value $5.331M Shares 87,000 Est. Cost $45.69 Unrealized +15.5%
LA JOLLA PHARMACEUTICAL CO 0.7%
Value $5.217M Shares 150,000 Est. Cost $26.50 Unrealized
AVEO PHARMACEUTICALS INC 0.7%
Value $5.11M Shares 1,400,000 Est. Cost $0.59 Unrealized
ZOGENIX INC 0.7%
Value $5.082M Shares 145,000 Est. Cost $35.05 Unrealized
ARRAY BIOPHARMA INC 0.7%
Value $4.982M Shares 405,000 Est. Cost $6.75 Unrealized
SVRA SAVARA INC 0.7%
Value $4.921M Shares 526,315 Est. Cost $5.87 Unrealized +10.8%
CHTR CHARTER COMMUNICATIONS INC N 0.7%
Value $4.856M Shares 13,362 Est. Cost $227.34 Unrealized +63.7%
MINERVA NEUROSCIENCES INC 0.7%
Value $4.75M Shares 625,000 Est. Cost $8.55 Unrealized
MYLAN N V 0.7%
Value $4.706M Shares 150,000 Est. Cost Unrealized
ASND ASCENDIS PHARMA A S 0.7%
Value $4.693M Shares 129,474 Est. Cost $14.62 Unrealized
SAPIENS INTL CORP N V 0.7%
Value $4.65M Shares 354,866 Est. Cost $12.92 Unrealized
RETROPHIN INC 0.6%
Value $4.334M Shares 174,131 Est. Cost $18.68 Unrealized
INSM INSMED INC 0.6%
Value $4.213M Shares 135,000 Est. Cost $19.05 Unrealized 0.0%
SELECTA BIOSCIENCES INC 0.6%
Value $4.171M Shares 228,534 Est. Cost $14.01 Unrealized
TEVA PHARMACEUTICAL FIN LLC 0.6%
Value $4.096M Shares 11,885 Est. Cost $617.35 Unrealized
GLD SPDR GOLD TRUST 0.6%
Value $4.035M Shares 33,190 Est. Cost $121.57 Unrealized
GLOBAL BLOOD THERAPEUTICS IN 0.6%
Value $3.943M Shares 127,000 Est. Cost $27.35 Unrealized
PRTA PROTHENA CORP PLC 0.6%
Value $3.886M Shares 60,000 Est. Cost $55.94 Unrealized +9.5%
MGNX MACROGENICS INC 0.6%
Value $3.857M Shares 208,700 Est. Cost $22.18 Unrealized -21.9%
CTMX CYTOMX THERAPEUTICS INC 0.5%
Value $3.816M Shares 210,000 Est. Cost $13.73 Unrealized +13.6%
KADMON HLDGS INC 0.5%
Value $3.685M Shares 1,100,000 Est. Cost $3.35 Unrealized
EDGE THERAPEUTICS INC 0.5%
Value $3.581M Shares 333,737 Est. Cost $11.53 Unrealized
CRVS CORVUS PHARMACEUTICALS INC 0.5%
Value $3.53M Shares 221,430 Est. Cost $13.79 Unrealized +0.3%
STEMLINE THERAPEUTICS INC 0.5%
Value $3.33M Shares 300,000 Est. Cost $8.55 Unrealized
CYTK CYTOKINETICS INC 0.5%
Value $3.306M Shares 227,990 Est. Cost $12.41 Unrealized +10.1%
VRTX VERTEX PHARMACEUTICALS INC 0.5%
Value $3.166M Shares 20,823 Est. Cost $150.51 Unrealized 0.0%
UNP UNION PAC CORP 0.4%
Value $3.149M Shares 27,156 Est. Cost $80.53 Unrealized +10.7%
PANW PALO ALTO NETWORKS INC 0.4%
Value $2.998M Shares 20,805 Est. Cost $22.77 Unrealized 0.0%
SEDG SOLAREDGE TECHNOLOGIES INC 0.4%
Value $2.912M Shares 102,003 Est. Cost $16.67 Unrealized +51.2%
SNDX SYNDAX PHARMACEUTICALS INC 0.4%
Value $2.907M Shares 248,472 Est. Cost $12.40 Unrealized -1.1%
ANAB ANAPTYSBIO INC 0.4%
Value $2.796M Shares 80,000 Est. Cost $26.97 Unrealized 0.0%
CASCADIAN THERAPEUTICS INC 0.4%
Value $2.786M Shares 681,210 Est. Cost $4.08 Unrealized
AXSM AXSOME THERAPEUTICS INC 0.4%
Value $2.781M Shares 501,000 Est. Cost $4.66 Unrealized +15.1%
CLEMENTIA PHARMACEUTICALS IN 0.4%
Value $2.753M Shares 163,000 Est. Cost $16.89 Unrealized
SPRING BK PHARMACEUTICALS IN 0.4%
Value $2.685M Shares 159,417 Est. Cost $13.54 Unrealized
AUDENTES THERAPEUTICS INC 0.4%
Value $2.661M Shares 95,000 Est. Cost $19.13 Unrealized
CTI BIOPHARMA CORP 0.4%
Value $2.659M Shares 833,633 Est. Cost $3.19 Unrealized
SUMMIT THERAPEUTICS PLC 0.4%
Value $2.654M Shares 212,018 Est. Cost $12.31 Unrealized
CLEARSIDE BIOMEDICAL INC 0.4%
Value $2.622M Shares 300,000 Est. Cost $7.49 Unrealized
OVID OVID THERAPEUTICS INC 0.4%
Value $2.62M Shares 305,674 Est. Cost $13.06 Unrealized -36.2%
PRQR PROQR THRAPEUTICS N V 0.4%
Value $2.571M Shares 530,000 Est. Cost $4.98 Unrealized +4.2%
CMCSA COMCAST CORP NEW 0.4%
Value $2.554M Shares 66,360 Est. Cost $32.02 Unrealized 0.0%
ADAMAS PHARMACEUTICALS INC 0.3%
Value $2.445M Shares 115,500 Est. Cost $22.16 Unrealized
NOMD NOMAD FOODS LTD 0.3%
Value $2.428M Shares 166,662 Est. Cost $12.78 Unrealized +14.1%
FLEX PHARMA INC 0.3%
Value $2.341M Shares 141,300 Est. Cost $16.57 Unrealized
ORCL ORACLE CORP 0.3%
Value $2.285M Shares 47,250 Est. Cost $40.10 Unrealized +9.6%
ALBIREO PHARMA INC 0.3%
Value $2.274M Shares 108,526 Est. Cost $20.62 Unrealized
CTSH COGNIZANT TECHNOLOGY SOLUTIO 0.3%
Value $2.239M Shares 30,866 Est. Cost $62.47 Unrealized 0.0%
ORLY O REILLY AUTOMOTIVE INC NEW 0.3%
Value $2.154M Shares 10,000 Est. Cost $13.20 Unrealized 0.0%
OBSEVA SA 0.3%
Value $2.118M Shares 260,197 Est. Cost $10.01 Unrealized
AAP ADVANCE AUTO PARTS INC 0.3%
Value $2.083M Shares 21,000 Est. Cost $88.61 Unrealized 0.0%
AXOVANT SCIENCES LTD 0.3%
Value $2.064M Shares 300,000 Est. Cost Unrealized
THERAPEUTICSMD INC 0.3%
Value $2.01M Shares 380,000 Est. Cost $7.20 Unrealized
ARDX ARDELYX INC 0.3%
Value $1.932M Shares 345,000 Est. Cost $11.98 Unrealized -56.0%
EVOKE PHARMA INC 0.3%
Value $1.907M Shares 571,022 Est. Cost $3.13 Unrealized
DOVA PHARMACEUTICALS INC 0.3%
Value $1.901M Shares 78,284 Est. Cost $22.29 Unrealized
VTV THERAPEUTICS INC 0.3%
Value $1.794M Shares 300,000 Est. Cost $6.98 Unrealized
NIGHTSTAR THERAPEUTICS PLC 0.2%
Value $1.728M Shares 90,000 Est. Cost $19.20 Unrealized
VISTAGEN THERAPEUTICS INC 0.2%
Value $1.693M Shares 1,058,386 Est. Cost $2.84 Unrealized
AILERON THERAPEUTICS INC 0.2%
Value $1.673M Shares 125,000 Est. Cost $11.15 Unrealized
FIVE PRIME THERAPEUTICS INC 0.2%
Value $1.636M Shares 40,000 Est. Cost $40.90 Unrealized
MA MASTERCARD INCORPORATED 0.2%
Value $1.627M Shares 11,525 Est. Cost $98.63 Unrealized +28.1%
CYTK CYTOKINETICS INC 0.2%
Value $1.45M Shares 100,000 Est. Cost $12.41 Unrealized +10.1%
DECIPHERA PHARMACEUTICALS IN 0.2%
Value $1.424M Shares 75,000 Est. Cost $18.99 Unrealized
ACHILLION PHARMACEUTICALS IN 0.2%
Value $1.347M Shares 300,000 Est. Cost $4.49 Unrealized
TEVA TEVA PHARMACEUTICAL INDS LTD 0.2%
Value $1.267M Shares 72,000 Est. Cost $17.60 Unrealized
AXOVANT SCIENCES LTD 0.2%
Value $1.238M Shares 180,000 Est. Cost Unrealized
SNA SNAP ON INC 0.2%
Value $1.087M Shares 7,292 Est. Cost $127.56 Unrealized -4.7%
AQUINOX PHARMACEUTICALS INC 0.2%
Value $1.072M Shares 75,535 Est. Cost $14.10 Unrealized
KRNT KORNIT DIGITAL LTD 0.1%
Value $1.025M Shares 67,006 Est. Cost $19.16 Unrealized -4.8%
NUCANA PLC 0.1%
Value $919K Shares 50,000 Est. Cost $18.38 Unrealized
VERSARTIS INC 0.1%
Value $802K Shares 327,524 Est. Cost $14.87 Unrealized
VRSK VERISK ANALYTICS INC 0.1%
Value $782K Shares 9,400 Est. Cost $77.37 Unrealized +2.3%
INOTEK PHARMACEUTICALS CORP 0.1%
Value $715K Shares 401,764 Est. Cost $7.62 Unrealized
GENOCEA BIOSCIENCES INC 0.1%
Value $715K Shares 490,000 Est. Cost $6.64 Unrealized
XENE XENON PHARMACEUTICALS INC 0.1%
Value $673K Shares 228,029 Est. Cost $7.82 Unrealized -60.4%
CATABASIS PHARMACEUTICALS IN 0.1%
Value $611K Shares 288,030 Est. Cost $6.73 Unrealized
VKTX VIKING THERAPEUTICS INC 0.1%
Value $554K Shares 290,000 Est. Cost $1.14 Unrealized 0.0%
CSTE CAESARSTONE LTD 0.1%
Value $531K Shares 17,833 Est. Cost $31.04 Unrealized -6.9%
TJX TJX COS INC NEW 0.1%
Value $428K Shares 5,800 Est. Cost $33.96 Unrealized -6.7%
UNH UNITEDHEALTH GROUP INC 0.1%
Value $392K Shares 2,000 Est. Cost $123.75 Unrealized +36.5%
SAGE THERAPEUTICS INC 0.1%
Value $381K Shares 6,118 Est. Cost $50.48 Unrealized
SERVICEMASTER GLOBAL HLDGS I 0.1%
Value $374K Shares 8,000 Est. Cost $43.66 Unrealized
ORLY O REILLY AUTOMOTIVE INC NEW 0.1%
Value $366K Shares 1,700 Est. Cost $13.20 Unrealized 0.0%
WSO WATSCO INC 0.0%
Value $338K Shares 2,100 Est. Cost $142.89 Unrealized +5.7%
MHK MOHAWK INDS INC 0.0%
Value $272K Shares 1,100 Est. Cost $205.53 Unrealized +21.1%
AAP ADVANCE AUTO PARTS INC 0.0%
Value $266K Shares 2,686 Est. Cost $88.61 Unrealized 0.0%
ECL ECOLAB INC 0.0%
Value $257K Shares 2,000 Est. Cost $118.89 Unrealized +1.0%
SUNESIS PHARMACEUTICALS INC 0.0%
Value $217K Shares 111,762 Est. Cost $3.30 Unrealized
LOW LOWES COS INC 0.0%
Value $208K Shares 2,600 Est. Cost $65.42 Unrealized +0.3%
SEE SEALED AIR CORP NEW 0.0%
Value $192K Shares 4,500 Est. Cost $39.39 Unrealized -3.1%
LIBERTY INTERACTIVE CORP 0.0%
Value $173K Shares 3,000 Est. Cost $52.33 Unrealized
TRIP TRIPADVISOR INC 0.0%
Value $162K Shares 4,000 Est. Cost $42.17 Unrealized -14.3%
ULTIMATE SOFTWARE GROUP INC 0.0%
Value $152K Shares 800 Est. Cost $195.00 Unrealized
XRAY DENTSPLY SIRONA INC 0.0%
Value $150K Shares 2,500 Est. Cost $63.18 Unrealized -5.9%
SAGE THERAPEUTICS INC 0.0%
Value $150K Shares 2,400 Est. Cost $50.48 Unrealized
VISTA OUTDOOR INC 0.0%
Value $138K Shares 6,000 Est. Cost $22.50 Unrealized
CMG CHIPOTLE MEXICAN GRILL INC 0.0%
Value $123K Shares 400 Est. Cost $8.25 Unrealized -18.4%
ATHERSYS INC 0.0%
Value $2,000 Shares 773 Est. Cost $2.59 Unrealized