SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

CIK: 0001496201 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value ($000): $553,148 (100.0% shares, 0.0% debt)

Holdings (107)

TEVA TEVA PHARMACEUTICAL INDS LTD 6.3%
Value ($000) $34,585 Shares 1,569,181 Est. Cost $15.07 Unrealized
BBIO BRIDGEBIO PHARMA INC 4.5%
Value ($000) $24,841 Shares 905,279 Est. Cost $25.12 Unrealized +2.9%
SNY SANOFI 3.4%
Value ($000) $18,545 Shares 384,515 Est. Cost $46.09 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 3.3%
Value ($000) $18,260 Shares 1,381,241 Est. Cost $18.04 Unrealized -5.2%
AZN ASTRAZENECA PLC 2.7%
Value ($000) $14,746 Shares 225,060 Est. Cost $54.50 Unrealized
AMZN AMAZON COM INC 2.5%
Value ($000) $13,735 Shares 62,607 Est. Cost $141.58 Unrealized +44.5%
NVMI NOVA LTD 2.4%
Value ($000) $13,421 Shares 68,146 Est. Cost $208.29 Unrealized -7.7%
META META PLATFORMS INC 2.2%
Value ($000) $12,296 Shares 21,001 Est. Cost $353.49 Unrealized +65.4%
SRPT SAREPTA THERAPEUTICS INC 2.2%
Value ($000) $12,028 Shares 98,921 Est. Cost $129.81 Unrealized -5.6%
CLDX CELLDEX THERAPEUTICS INC NEW 2.2%
Value ($000) $11,981 Shares 474,103 Est. Cost $33.07 Unrealized -17.9%
ELDN ELEDON PHARMACEUTICALS INC 1.9%
Value ($000) $10,513 Shares 2,551,619 Est. Cost $3.15 Unrealized +25.1%
LLY ELI LILLY & CO 1.8%
Value ($000) $10,183 Shares 13,190 Est. Cost $258.77 Unrealized +217.3%
JNJ JOHNSON & JOHNSON 1.8%
Value ($000) $10,099 Shares 69,831 Est. Cost $136.97 Unrealized +9.2%
RARE ULTRAGENYX PHARMACEUTICAL IN 1.7%
Value ($000) $9,625 Shares 228,776 Est. Cost $47.00 Unrealized +5.6%
MSFT MICROSOFT CORP 1.7%
Value ($000) $9,411 Shares 22,327 Est. Cost $295.64 Unrealized +42.9%
MRVL MARVELL TECHNOLOGY INC 1.6%
Value ($000) $8,683 Shares 78,611 Est. Cost $68.96 Unrealized +34.1%
TSEM TOWER SEMICONDUCTOR LTD 1.5%
Value ($000) $8,558 Shares 166,149 Est. Cost $36.24 Unrealized +29.2%
NVO NOVO-NORDISK A S 1.5%
Value ($000) $8,437 Shares 98,080 Est. Cost $99.02 Unrealized
WIX WIX COM LTD 1.5%
Value ($000) $8,422 Shares 39,253 Est. Cost $123.41 Unrealized +54.9%
GOOG ALPHABET INC 1.5%
Value ($000) $8,284 Shares 43,500 Est. Cost $175.67 Unrealized 0.0%
PHVS PHARVARIS N V 1.3%
Value ($000) $7,441 Shares 388,183 Est. Cost $22.21 Unrealized -7.3%
NICE NICE LTD 1.3%
Value ($000) $7,218 Shares 42,500 Est. Cost $225.26 Unrealized
CYTK CYTOKINETICS INC 1.3%
Value ($000) $7,198 Shares 153,021 Est. Cost $47.18 Unrealized +10.1%
PRAX PRAXIS PRECISION MEDICINES I 1.3%
Value ($000) $7,048 Shares 91,583 Est. Cost $45.76 Unrealized +58.1%
CHKP CHECK POINT SOFTWARE TECH LT 1.2%
Value ($000) $6,653 Shares 35,635 Est. Cost $183.12 Unrealized +2.9%
APLS APELLIS PHARMACEUTICALS INC 1.2%
Value ($000) $6,581 Shares 206,251 Est. Cost $37.03 Unrealized -18.8%
IMTX IMMATICS N.V 1.2%
Value ($000) $6,549 Shares 921,111 Est. Cost $11.13 Unrealized -22.8%
PRAX PRAXIS PRECISION MEDICINES I 1.2%
Value ($000) $6,388 Shares 83,000 Est. Cost $45.76 Unrealized +58.1%
ANNX ANNEXON INC 1.2%
Value ($000) $6,377 Shares 1,243,039 Est. Cost $6.15 Unrealized 0.0%
ABBV ABBVIE INC 1.1%
Value ($000) $6,087 Shares 34,256 Est. Cost $93.90 Unrealized +88.9%
MRK MERCK & CO INC 1.1%
Value ($000) $5,929 Shares 59,600 Est. Cost $73.08 Unrealized +35.1%
BHVN BIOHAVEN LTD 1.1%
Value ($000) $5,845 Shares 156,494 Est. Cost $40.05 Unrealized +16.5%
RZLT REZOLUTE INC 1.0%
Value ($000) $5,713 Shares 1,165,895 Est. Cost $3.37 Unrealized +49.5%
FROG JFROG LTD 1.0%
Value ($000) $5,599 Shares 190,381 Est. Cost $32.00 Unrealized -5.2%
DYN DYNE THERAPEUTICS INC 1.0%
Value ($000) $5,566 Shares 236,262 Est. Cost $32.02 Unrealized -7.6%
MERUS N V 1.0%
Value ($000) $5,489 Shares 130,532 Est. Cost $22.47 Unrealized
NTLA INTELLIA THERAPEUTICS INC 1.0%
Value ($000) $5,434 Shares 466,080 Est. Cost $20.48 Unrealized -23.8%
ORA ORMAT TECHNOLOGIES INC 1.0%
Value ($000) $5,350 Shares 79,000 Est. Cost $76.74 Unrealized 0.0%
KURA KURA ONCOLOGY INC 1.0%
Value ($000) $5,314 Shares 610,087 Est. Cost $18.44 Unrealized -22.0%
ACAD ACADIA PHARMACEUTICALS INC 1.0%
Value ($000) $5,295 Shares 288,539 Est. Cost $19.02 Unrealized -15.2%
SEDG SOLAREDGE TECHNOLOGIES INC 0.9%
Value ($000) $5,100 Shares 375,000 Est. Cost $15.39 Unrealized 0.0%
ORMAT TECHNOLOGIES INC 0.9%
Value ($000) $5,018 Shares 5,037,000 Est. Cost $1.04 Unrealized
NVS NOVARTIS AG 0.9%
Value ($000) $4,866 Shares 50,000 Est. Cost $92.00 Unrealized
HELP CYBIN INC 0.9%
Value ($000) $4,746 Shares 538,111 Est. Cost $9.89 Unrealized +2.6%
SKYE SKYE BIOSCIENCE INC 0.8%
Value ($000) $4,428 Shares 1,564,628 Est. Cost $10.78 Unrealized -61.3%
GSK GSK PLC 0.8%
Value ($000) $4,397 Shares 130,000 Est. Cost $35.22 Unrealized
89BIO INC 0.8%
Value ($000) $4,352 Shares 556,532 Est. Cost $14.31 Unrealized
VIR VIR BIOTECHNOLOGY INC 0.8%
Value ($000) $4,271 Shares 581,829 Est. Cost $8.16 Unrealized -3.3%
DAWN DAY ONE BIOPHARMACEUTICALS I 0.8%
Value ($000) $4,244 Shares 334,987 Est. Cost $13.06 Unrealized +6.5%
VKTX VIKING THERAPEUTICS INC 0.8%
Value ($000) $4,156 Shares 103,270 Est. Cost $58.67 Unrealized -2.8%
PLRX PLIANT THERAPEUTICS INC 0.7%
Value ($000) $3,916 Shares 297,362 Est. Cost $16.25 Unrealized -16.0%
AVGO BROADCOM INC 0.7%
Value ($000) $3,913 Shares 16,880 Est. Cost $135.31 Unrealized +35.1%
SRRK SCHOLAR ROCK HLDG CORP 0.7%
Value ($000) $3,898 Shares 90,193 Est. Cost $8.78 Unrealized +270.8%
TVTX TRAVERE THERAPEUTICS INC 0.7%
Value ($000) $3,845 Shares 220,700 Est. Cost $17.69 Unrealized 0.0%
ENGN ENGENE HOLDINGS INC 0.7%
Value ($000) $3,724 Shares 560,000 Est. Cost $7.77 Unrealized 0.0%
SVRA SAVARA INC 0.7%
Value ($000) $3,719 Shares 1,211,533 Est. Cost $3.93 Unrealized -11.4%
ARWR ARROWHEAD PHARMACEUTICALS IN 0.7%
Value ($000) $3,714 Shares 197,550 Est. Cost $20.59 Unrealized 0.0%
JANX JANUX THERAPEUTICS INC 0.7%
Value ($000) $3,659 Shares 68,333 Est. Cost $52.89 Unrealized 0.0%
ACOG ALPHA COGNITION INC 0.7%
Value ($000) $3,652 Shares 620,000 Est. Cost $5.61 Unrealized 0.0%
SPRINGWORKS THERAPEUTICS INC 0.7%
Value ($000) $3,613 Shares 100,000 Est. Cost $36.13 Unrealized
BIIB BIOGEN INC 0.6%
Value ($000) $3,477 Shares 22,738 Est. Cost $247.93 Unrealized -32.0%
ENPH ENPHASE ENERGY INC 0.6%
Value ($000) $3,448 Shares 50,198 Est. Cost $110.32 Unrealized -28.1%
RCKT ROCKET PHARMACEUTICALS INC 0.6%
Value ($000) $3,416 Shares 271,792 Est. Cost $19.29 Unrealized -21.9%
INOZYME PHARMA INC 0.6%
Value ($000) $3,299 Shares 1,191,140 Est. Cost $4.03 Unrealized
CAMT CAMTEK LTD 0.5%
Value ($000) $2,931 Shares 36,287 Est. Cost $96.41 Unrealized -18.5%
JSPR JASPER THERAPEUTICS INC 0.5%
Value ($000) $2,902 Shares 135,720 Est. Cost $17.76 Unrealized +17.2%
CRVS CORVUS PHARMACEUTICALS INC 0.5%
Value ($000) $2,678 Shares 500,491 Est. Cost $7.47 Unrealized 0.0%
CARGO THERAPEUTICS INC 0.5%
Value ($000) $2,591 Shares 179,674 Est. Cost $19.44 Unrealized
WDAY WORKDAY INC 0.5%
Value ($000) $2,580 Shares 10,000 Est. Cost $241.00 Unrealized +6.0%
VIGIL NEUROSCIENCE INC 0.5%
Value ($000) $2,554 Shares 1,502,429 Est. Cost $3.40 Unrealized
NTR NUTRIEN LTD 0.5%
Value ($000) $2,501 Shares 55,894 Est. Cost $48.36 Unrealized -5.0%
CGEM CULLINAN THERAPEUTICS INC 0.5%
Value ($000) $2,497 Shares 205,000 Est. Cost $17.42 Unrealized -17.5%
PFE PFIZER INC 0.4%
Value ($000) $2,388 Shares 90,000 Est. Cost $36.55 Unrealized -31.3%
VTGN VISTAGEN THERAPEUTICS INC 0.4%
Value ($000) $2,385 Shares 808,550 Est. Cost $3.87 Unrealized -27.2%
CYTK CYTOKINETICS INC 0.4%
Value ($000) $2,352 Shares 50,000 Est. Cost $47.18 Unrealized +10.1%
MLYS MINERALYS THERAPEUTICS INC 0.4%
Value ($000) $2,347 Shares 190,672 Est. Cost $12.93 Unrealized +1.1%
IONS IONIS PHARMACEUTICALS INC 0.4%
Value ($000) $2,231 Shares 63,821 Est. Cost $41.01 Unrealized -8.9%
VTYX VENTYX BIOSCIENCES INC 0.4%
Value ($000) $2,218 Shares 1,012,749 Est. Cost $5.44 Unrealized -58.3%
ORIC ORIC PHARMACEUTICALS INC 0.4%
Value ($000) $2,205 Shares 273,213 Est. Cost $9.51 Unrealized -3.5%
CHEMOMAB THERAPEUTICS LTD 0.4%
Value ($000) $2,198 Shares 1,214,575 Est. Cost $1.57 Unrealized
XENE XENON PHARMACEUTICALS INC 0.4%
Value ($000) $2,042 Shares 52,097 Est. Cost $41.35 Unrealized 0.0%
PROMIS NEUROSCIENCES INC 0.3%
Value ($000) $1,829 Shares 1,929,297 Est. Cost $1.96 Unrealized
UBER UBER TECHNOLOGIES INC 0.3%
Value ($000) $1,810 Shares 30,000 Est. Cost $71.41 Unrealized 0.0%
LRMR LARIMAR THERAPEUTICS INC 0.3%
Value ($000) $1,763 Shares 455,604 Est. Cost $7.65 Unrealized -13.7%
ZURA ZURA BIO LTD 0.3%
Value ($000) $1,727 Shares 690,718 Est. Cost $3.74 Unrealized -4.7%
SHL TELEMEDICINE LTD 0.3%
Value ($000) $1,676 Shares 632,456 Est. Cost $11.14 Unrealized
JSPR JASPER THERAPEUTICS INC 0.3%
Value ($000) $1,657 Shares 77,500 Est. Cost $17.76 Unrealized +17.2%
CATX PERSPECTIVE THERAPEUTICS INC 0.3%
Value ($000) $1,468 Shares 460,247 Est. Cost $14.46 Unrealized -43.5%
JSPR JASPER THERAPEUTICS INC 0.2%
Value ($000) $1,306 Shares 61,100 Est. Cost $17.76 Unrealized +17.2%
ASTRIA THERAPEUTICS INC 0.2%
Value ($000) $1,250 Shares 139,800 Est. Cost $9.93 Unrealized
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value ($000) $1,131 Shares 20,000 Est. Cost $52.58 Unrealized 0.0%
MERSANA THERAPEUTICS INC 0.2%
Value ($000) $987 Shares 690,272 Est. Cost $1.43 Unrealized
ALMS ALUMIS INC 0.2%
Value ($000) $983 Shares 125,000 Est. Cost $13.30 Unrealized -24.6%
HOWL WEREWOLF THERAPEUTICS INC 0.2%
Value ($000) $928 Shares 626,810 Est. Cost $13.12 Unrealized -84.5%
APRE APREA THERAPEUTICS INC 0.2%
Value ($000) $888 Shares 270,000 Est. Cost $6.22 Unrealized -46.2%
PERI PERION NETWORK LTD 0.2%
Value ($000) $869 Shares 102,612 Est. Cost $12.13 Unrealized -30.7%
OKUR ONKURE THERAPEUTICS INC 0.1%
Value ($000) $751 Shares 87,354 Est. Cost $15.14 Unrealized 0.0%
KZR KEZAR LIFE SCIENCES INC 0.1%
Value ($000) $729 Shares 108,473 Est. Cost $7.45 Unrealized 0.0%
FATE FATE THERAPEUTICS INC 0.1%
Value ($000) $655 Shares 397,177 Est. Cost $2.52 Unrealized 0.0%
ALEC ALECTOR INC 0.1%
Value ($000) $614 Shares 324,639 Est. Cost $6.41 Unrealized -41.3%
ELEVATION ONCOLOGY INC 0.1%
Value ($000) $573 Shares 1,018,562 Est. Cost $0.88 Unrealized
CLYM CLIMB BIO INC 0.1%
Value ($000) $453 Shares 251,935 Est. Cost $5.81 Unrealized -37.8%
KYTX KYVERNA THERAPEUTICS INC 0.1%
Value ($000) $444 Shares 118,758 Est. Cost $14.89 Unrealized -67.8%
CGEN COMPUGEN LTD 0.0%
Value ($000) $271 Shares 177,094 Est. Cost $0.89 Unrealized +83.3%
LAVA THERAPEUTICS NV 0.0%
Value ($000) $120 Shares 126,328 Est. Cost $3.33 Unrealized
APPLIED THERAPEUTICS INC 0.0%
Value ($000) $43 Shares 50,000 Est. Cost $6.63 Unrealized
IMMATICS N.V 0.0%
Value ($000) $25 Shares 100,000 Est. Cost $3.50 Unrealized