SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

CIK: 0001496201 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value ($000): $434,314 (100.0% shares, 0.0% debt)

Holdings (115)

TEVA TEVA PHARMACEUTICAL INDS LTD 5.6%
Value ($000) $24,164 Shares 1,572,181 Est. Cost $15.07 Unrealized
TLT ISHARES TR 5.3%
Value ($000) $23,222 Shares 255,100 Est. Cost Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 4.7%
Value ($000) $20,442 Shares 1,663,974 Est. Cost $17.38 Unrealized -18.8%
SNY SANOFI 3.9%
Value ($000) $16,888 Shares 304,515 Est. Cost $46.09 Unrealized
NVMI NOVA LTD 3.8%
Value ($000) $16,718 Shares 90,697 Est. Cost $213.92 Unrealized +8.0%
AZN ASTRAZENECA PLC 3.0%
Value ($000) $12,867 Shares 175,060 Est. Cost $54.50 Unrealized
BBIO BRIDGEBIO PHARMA INC 2.9%
Value ($000) $12,674 Shares 366,608 Est. Cost $25.12 Unrealized +34.2%
SRPT SAREPTA THERAPEUTICS INC 2.3%
Value ($000) $10,079 Shares 157,931 Est. Cost $120.64 Unrealized -12.7%
RARE ULTRAGENYX PHARMACEUTICAL IN 2.2%
Value ($000) $9,682 Shares 267,385 Est. Cost $46.22 Unrealized -10.0%
LLY ELI LILLY & CO 2.2%
Value ($000) $9,655 Shares 11,690 Est. Cost $258.77 Unrealized +219.5%
CLDX CELLDEX THERAPEUTICS INC NEW 2.1%
Value ($000) $9,217 Shares 507,829 Est. Cost $32.36 Unrealized -31.0%
JNJ JOHNSON & JOHNSON 2.0%
Value ($000) $8,761 Shares 52,831 Est. Cost $136.97 Unrealized +11.3%
NVO NOVO-NORDISK A S 1.9%
Value ($000) $8,199 Shares 118,080 Est. Cost $94.01 Unrealized
ELDN ELEDON PHARMACEUTICALS INC 1.8%
Value ($000) $7,821 Shares 2,307,119 Est. Cost $3.15 Unrealized +30.6%
MLYS MINERALYS THERAPEUTICS INC 1.7%
Value ($000) $7,393 Shares 465,526 Est. Cost $12.09 Unrealized -4.8%
AMZN AMAZON COM INC 1.6%
Value ($000) $6,965 Shares 36,607 Est. Cost $141.58 Unrealized +53.3%
ABBV ABBVIE INC 1.5%
Value ($000) $6,339 Shares 30,256 Est. Cost $93.90 Unrealized +101.7%
PHVS PHARVARIS N V 1.4%
Value ($000) $6,027 Shares 383,856 Est. Cost $22.21 Unrealized -24.1%
ORA ORMAT TECHNOLOGIES INC 1.4%
Value ($000) $5,945 Shares 84,000 Est. Cost $76.19 Unrealized -11.5%
CYTK CYTOKINETICS INC 1.3%
Value ($000) $5,826 Shares 144,961 Est. Cost $47.18 Unrealized -2.6%
META META PLATFORMS INC 1.3%
Value ($000) $5,742 Shares 9,962 Est. Cost $353.49 Unrealized +82.0%
NVS NOVARTIS AG 1.3%
Value ($000) $5,574 Shares 50,000 Est. Cost $92.00 Unrealized
MRK MERCK & CO INC 1.2%
Value ($000) $5,350 Shares 59,600 Est. Cost $73.08 Unrealized +23.3%
PRAX PRAXIS PRECISION MEDICINES I 1.2%
Value ($000) $5,327 Shares 140,660 Est. Cost $51.58 Unrealized +21.1%
ORMAT TECHNOLOGIES INC 1.2%
Value ($000) $5,230 Shares 5,037,000 Est. Cost $1.04 Unrealized
NICE NICE LTD 1.2%
Value ($000) $5,134 Shares 33,303 Est. Cost $225.26 Unrealized
GSK GSK PLC 1.2%
Value ($000) $5,036 Shares 130,000 Est. Cost $35.22 Unrealized
SEDG SOLAREDGE TECHNOLOGIES INC 1.2%
Value ($000) $5,003 Shares 309,216 Est. Cost $15.39 Unrealized +1.0%
89BIO INC 1.0%
Value ($000) $4,495 Shares 618,343 Est. Cost $13.61 Unrealized
MERUS N V 1.0%
Value ($000) $4,484 Shares 106,532 Est. Cost $22.47 Unrealized
IMTX IMMATICS N.V 1.0%
Value ($000) $4,154 Shares 921,111 Est. Cost $11.13 Unrealized -53.1%
APLS APELLIS PHARMACEUTICALS INC 0.9%
Value ($000) $3,966 Shares 181,346 Est. Cost $37.03 Unrealized -25.4%
MAZE MAZE THERAPEUTICS INC 0.9%
Value ($000) $3,915 Shares 355,554 Est. Cost $12.04 Unrealized 0.0%
PRAX PRAXIS PRECISION MEDICINES I 0.9%
Value ($000) $3,787 Shares 100,000 Est. Cost $51.58 Unrealized +21.1%
TVTX TRAVERE THERAPEUTICS INC 0.8%
Value ($000) $3,584 Shares 200,000 Est. Cost $17.69 Unrealized +14.7%
SVRA SAVARA INC 0.8%
Value ($000) $3,557 Shares 1,284,151 Est. Cost $3.87 Unrealized -28.6%
ARWR ARROWHEAD PHARMACEUTICALS IN 0.8%
Value ($000) $3,536 Shares 277,550 Est. Cost $19.90 Unrealized -8.6%
DYN DYNE THERAPEUTICS INC 0.8%
Value ($000) $3,444 Shares 329,262 Est. Cost $27.02 Unrealized -47.1%
ANNX ANNEXON INC 0.8%
Value ($000) $3,405 Shares 1,764,387 Est. Cost $5.32 Unrealized -37.4%
JANX JANUX THERAPEUTICS INC 0.8%
Value ($000) $3,398 Shares 125,840 Est. Cost $45.95 Unrealized -18.0%
HELP CYBIN INC 0.8%
Value ($000) $3,343 Shares 527,222 Est. Cost $9.89 Unrealized -12.5%
IMVT IMMUNOVANT INC 0.8%
Value ($000) $3,326 Shares 194,638 Est. Cost $20.92 Unrealized 0.0%
NVDA NVIDIA CORPORATION 0.7%
Value ($000) $3,209 Shares 29,605 Est. Cost $126.71 Unrealized 0.0%
RZLT REZOLUTE INC 0.7%
Value ($000) $3,136 Shares 1,081,447 Est. Cost $3.37 Unrealized +29.2%
RNAM AVIDITY BIOSCIENCES INC 0.7%
Value ($000) $3,129 Shares 106,000 Est. Cost $31.14 Unrealized 0.0%
AMGN AMGEN INC 0.7%
Value ($000) $3,116 Shares 10,000 Est. Cost $287.24 Unrealized 0.0%
BIIB BIOGEN INC 0.7%
Value ($000) $3,111 Shares 22,738 Est. Cost $247.93 Unrealized -42.3%
ACOG ALPHA COGNITION INC 0.7%
Value ($000) $3,021 Shares 596,992 Est. Cost $5.61 Unrealized +4.0%
VIGIL NEUROSCIENCE INC 0.7%
Value ($000) $2,856 Shares 1,604,429 Est. Cost $3.30 Unrealized
NTLA INTELLIA THERAPEUTICS INC 0.6%
Value ($000) $2,709 Shares 381,080 Est. Cost $20.48 Unrealized -50.7%
DAWN DAY ONE BIOPHARMACEUTICALS I 0.6%
Value ($000) $2,656 Shares 334,987 Est. Cost $13.06 Unrealized -17.5%
AMAT APPLIED MATLS INC 0.6%
Value ($000) $2,612 Shares 18,000 Est. Cost $166.66 Unrealized 0.0%
SRRK SCHOLAR ROCK HLDG CORP 0.6%
Value ($000) $2,514 Shares 78,193 Est. Cost $8.78 Unrealized +338.1%
CRM SALESFORCE INC 0.6%
Value ($000) $2,442 Shares 9,100 Est. Cost $309.01 Unrealized 0.0%
BHVN BIOHAVEN LTD 0.6%
Value ($000) $2,399 Shares 99,784 Est. Cost $40.05 Unrealized -12.0%
ENGN ENGENE HOLDINGS INC 0.5%
Value ($000) $2,367 Shares 528,365 Est. Cost $7.77 Unrealized -20.0%
SKYE SKYE BIOSCIENCE INC 0.5%
Value ($000) $2,347 Shares 1,476,353 Est. Cost $10.78 Unrealized -74.7%
WDAY WORKDAY INC 0.5%
Value ($000) $2,335 Shares 10,000 Est. Cost $241.00 Unrealized +5.9%
SPRINGWORKS THERAPEUTICS INC 0.5%
Value ($000) $2,295 Shares 52,009 Est. Cost $36.13 Unrealized
PFE PFIZER INC 0.5%
Value ($000) $2,281 Shares 90,000 Est. Cost $36.55 Unrealized -32.4%
KURA KURA ONCOLOGY INC 0.5%
Value ($000) $2,267 Shares 343,522 Est. Cost $18.44 Unrealized -57.7%
ELVN ENLIVEN THERAPEUTICS INC 0.5%
Value ($000) $2,199 Shares 111,743 Est. Cost $21.52 Unrealized 0.0%
TSEM TOWER SEMICONDUCTOR LTD 0.5%
Value ($000) $2,195 Shares 61,549 Est. Cost $36.24 Unrealized +24.7%
UBER UBER TECHNOLOGIES INC 0.5%
Value ($000) $2,186 Shares 30,000 Est. Cost $71.41 Unrealized +0.9%
GOOG ALPHABET INC 0.5%
Value ($000) $2,109 Shares 13,500 Est. Cost $175.67 Unrealized +3.9%
VKTX VIKING THERAPEUTICS INC 0.5%
Value ($000) $2,011 Shares 83,270 Est. Cost $58.67 Unrealized -46.1%
COGT COGENT BIOSCIENCES INC 0.5%
Value ($000) $2,007 Shares 335,024 Est. Cost $7.84 Unrealized 0.0%
VTGN VISTAGEN THERAPEUTICS INC 0.5%
Value ($000) $1,976 Shares 790,550 Est. Cost $3.87 Unrealized -26.8%
AVGO BROADCOM INC 0.5%
Value ($000) $1,958 Shares 11,695 Est. Cost $135.31 Unrealized +55.1%
IONS IONIS PHARMACEUTICALS INC 0.4%
Value ($000) $1,925 Shares 63,821 Est. Cost $41.01 Unrealized -20.2%
NKE NIKE INC 0.4%
Value ($000) $1,908 Shares 30,050 Est. Cost $72.05 Unrealized 0.0%
CHKP CHECK POINT SOFTWARE TECH LT 0.4%
Value ($000) $1,899 Shares 8,334 Est. Cost $183.12 Unrealized +15.7%
RCKT ROCKET PHARMACEUTICALS INC 0.4%
Value ($000) $1,813 Shares 271,792 Est. Cost $19.29 Unrealized -48.8%
RARE ULTRAGENYX PHARMACEUTICAL IN 0.4%
Value ($000) $1,811 Shares 50,000 Est. Cost $46.22 Unrealized -10.0%
MSFT MICROSOFT CORP 0.4%
Value ($000) $1,724 Shares 4,592 Est. Cost $295.64 Unrealized +37.0%
NTR NUTRIEN LTD 0.4%
Value ($000) $1,535 Shares 30,894 Est. Cost $48.36 Unrealized +3.7%
GPCR STRUCTURE THERAPEUTICS INC 0.3%
Value ($000) $1,454 Shares 84,000 Est. Cost $17.31 Unrealized
WIX WIX COM LTD 0.3%
Value ($000) $1,438 Shares 8,800 Est. Cost $123.41 Unrealized +68.3%
FROG JFROG LTD 0.3%
Value ($000) $1,372 Shares 42,871 Est. Cost $32.00 Unrealized +8.8%
CAMT CAMTEK LTD 0.3%
Value ($000) $1,354 Shares 23,086 Est. Cost $96.41 Unrealized -16.5%
PROMIS NEUROSCIENCES INC 0.3%
Value ($000) $1,342 Shares 1,929,297 Est. Cost $1.96 Unrealized
SHL TELEMEDICINE LTD 0.3%
Value ($000) $1,311 Shares 632,456 Est. Cost $11.14 Unrealized
ORIC ORIC PHARMACEUTICALS INC 0.3%
Value ($000) $1,310 Shares 234,834 Est. Cost $9.51 Unrealized -8.1%
CEVA CEVA INC 0.3%
Value ($000) $1,253 Shares 48,920 Est. Cost $32.13 Unrealized 0.0%
BMY BRISTOL-MYERS SQUIBB CO 0.3%
Value ($000) $1,220 Shares 20,000 Est. Cost $52.58 Unrealized +5.5%
VTYX VENTYX BIOSCIENCES INC 0.3%
Value ($000) $1,165 Shares 1,012,749 Est. Cost $5.44 Unrealized -68.4%
NNDM NANO DIMENSION LTD 0.3%
Value ($000) $1,141 Shares 717,518 Est. Cost $1.59 Unrealized
INOZYME PHARMA INC 0.2%
Value ($000) $1,084 Shares 1,191,140 Est. Cost $4.03 Unrealized
OTLK OUTLOOK THERAPEUTICS INC 0.2%
Value ($000) $1,046 Shares 857,142 Est. Cost $1.75 Unrealized 0.0%
ASTRIA THERAPEUTICS INC 0.2%
Value ($000) $1,014 Shares 189,800 Est. Cost $8.72 Unrealized
CHEMOMAB THERAPEUTICS LTD 0.2%
Value ($000) $981 Shares 900,428 Est. Cost $1.57 Unrealized
CATX PERSPECTIVE THERAPEUTICS INC 0.2%
Value ($000) $980 Shares 460,247 Est. Cost $14.46 Unrealized -79.2%
MRVL MARVELL TECHNOLOGY INC 0.2%
Value ($000) $928 Shares 15,070 Est. Cost $68.96 Unrealized +40.2%
ARVN ARVINAS INC 0.2%
Value ($000) $878 Shares 125,000 Est. Cost $15.67 Unrealized 0.0%
XENE XENON PHARMACEUTICALS INC 0.2%
Value ($000) $876 Shares 26,097 Est. Cost $41.35 Unrealized -8.2%
PERI PERION NETWORK LTD 0.2%
Value ($000) $835 Shares 102,612 Est. Cost $12.13 Unrealized -28.0%
REGULUS THERAPEUTICS INC 0.2%
Value ($000) $792 Shares 452,845 Est. Cost $1.75 Unrealized
LRMR LARIMAR THERAPEUTICS INC 0.2%
Value ($000) $788 Shares 366,304 Est. Cost $7.65 Unrealized -58.7%
CRVS CORVUS PHARMACEUTICALS INC 0.2%
Value ($000) $655 Shares 205,859 Est. Cost $7.47 Unrealized -36.9%
HOWL WEREWOLF THERAPEUTICS INC 0.1%
Value ($000) $609 Shares 626,810 Est. Cost $13.12 Unrealized -90.0%
VIR VIR BIOTECHNOLOGY INC 0.1%
Value ($000) $589 Shares 90,855 Est. Cost $8.16 Unrealized +9.0%
APRE APREA THERAPEUTICS INC 0.1%
Value ($000) $551 Shares 270,000 Est. Cost $6.22 Unrealized -49.6%
ZURA ZURA BIO LTD 0.1%
Value ($000) $543 Shares 421,229 Est. Cost $3.74 Unrealized -57.8%
KZR KEZAR LIFE SCIENCES INC 0.1%
Value ($000) $529 Shares 108,473 Est. Cost $7.45 Unrealized -18.5%
JSPR JASPER THERAPEUTICS INC 0.1%
Value ($000) $525 Shares 122,017 Est. Cost $17.76 Unrealized -62.5%
IBIT ISHARES BITCOIN TRUST ETF 0.1%
Value ($000) $382 Shares 8,150 Est. Cost $46.81 Unrealized
CIDARA THERAPEUTICS INC 0.1%
Value ($000) $369 Shares 17,128 Est. Cost $21.54 Unrealized
OKUR ONKURE THERAPEUTICS INC 0.1%
Value ($000) $346 Shares 80,454 Est. Cost $15.14 Unrealized -62.9%
FATE FATE THERAPEUTICS INC 0.1%
Value ($000) $314 Shares 397,177 Est. Cost $2.52 Unrealized -51.4%
CLYM CLIMB BIO INC 0.1%
Value ($000) $295 Shares 241,935 Est. Cost $5.81 Unrealized -72.1%
ALEC ALECTOR INC 0.0%
Value ($000) $134 Shares 109,208 Est. Cost $6.41 Unrealized -74.6%
ELEVATION ONCOLOGY INC 0.0%
Value ($000) $93 Shares 358,562 Est. Cost $0.88 Unrealized
LAVA THERAPEUTICS NV 0.0%
Value ($000) $61 Shares 48,420 Est. Cost $3.33 Unrealized
APPLIED THERAPEUTICS INC 0.0%
Value ($000) $24 Shares 50,000 Est. Cost $6.63 Unrealized
IMMATICS N.V 0.0%
Value ($000) $2 Shares 100,000 Est. Cost $3.50 Unrealized