Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
CYTK	CYTOKINETICS INC	259,300	$17.09M	2.7%	$40.28	+60.0%	CALL	23282W605
AZN	ASTRAZENECA PLC	62,530	$12.33M	2.0%	$190.39	0.0%	ORD	G0593M107
CLBT	CELLEBRITE DI LTD	631,521	$8.702M	1.4%	$15.55	0.0%	ORDINARY SHARES	M2197Q107
PANW	PALO ALTO NETWORKS INC	52,800	$8.465M	1.3%	$172.15	0.0%	COM	697435105
ORA	ORMAT TECHNOLOGIES INC	68,250	$7.639M	1.2%	$120.51	0.0%	COM	686688102
XENE	XENON PHARMACEUTICALS INC	127,000	$7.385M	1.2%	$41.98	0.0%	COM	98420N105
AMZN	AMAZON COM INC	31,940	$6.652M	1.1%	$226.83	0.0%	COM	023135106
AAOI	APPLIED OPTOELECTRONICS INC	73,400	$6.209M	1.0%	$41.81	0.0%	COM	03823U102
BHVN	BIOHAVEN LTD	594,000	$5.025M	0.8%	$11.75	0.0%	COM	G1110E107
ZBIO	ZENAS BIOPHARMA INC	214,334	$4.19M	0.7%	$21.89	0.0%	COM	98937L105
RLAY	RELAY THERAPEUTICS INC	408,436	$4.064M	0.6%	$8.30	0.0%	COM	75943R102
OVID	OVID THERAPEUTICS INC	1,622,828	$3.603M	0.6%	$1.60	0.0%	COM	690469101
IRON	DISC MEDICINE INC	53,538	$3.423M	0.5%	$74.04	0.0%	COM	254604101
UPB	UPSTREAM BIO INC	358,000	$3.222M	0.5%	$23.68	0.0%	COM	91678A107
MSLE	SATELLOS BIOSCIENCE INC	489,207	$2.754M	0.4%	$5.63	—	COM	80401L803
GENB	GENERATE BIOMEDICINES INC	185,000	$2.313M	0.4%	$12.50	—	COM SHS	370920100
OLMA	OLEMA PHARMACEUTICALS INC	100,000	$1.491M	0.2%	—	—	CALL	68062P106
ORGO	ORGANOGENESIS HLDGS INC	550,000	$1.304M	0.2%	$3.99	0.0%	COM	68621F102
CRIS	CURIS INC	1,994,937	$1.092M	0.2%	$0.98	0.0%	COM	231269309
CTMX	CYTOMX THERAPEUTICS INC.	220,000	$1.034M	0.2%	$5.23	0.0%	COM	23284F105
NICE	NICE LTD	5,611	$619K	0.1%	$110.26	—	SPONSORED ADR	653656108
FHTX	FOGHORN THERAPEUTICS INC	12,224	$58,431	0.0%	$5.69	0.0%	COM	344174107

Increased Positions (31)

MLYS MINERALYS THERAPEUTICS INC 5.8%

Value $36.3M (+122.8%) Shares 1,339,971 (+198.4%) Est. Cost $29.70 Unrealized +5.6%

XBI SPDR SERIES TRUST 4.1%

Value $25.55M (+199.3%) Shares 200,000 (+185.7%) Est. Cost — Unrealized —

TSEM TOWER SEMICONDUCTOR LTD 4.1%

Value $25.57M (+77.8%) Shares 145,735 (+19.0%) Est. Cost $54.51 Unrealized +136.4%

RARE ULTRAGENYX PHARMACEUTICAL IN 2.7%

Value $16.96M (+145.2%) Shares 809,333 (+169.2%) Est. Cost $27.53 Unrealized -15.2%

BBIO BRIDGEBIO PHARMA INC 2.9%

Value $18.21M (+121.0%) Shares 245,246 (+127.6%) Est. Cost $63.86 Unrealized +16.6%

NVMI NOVA LTD 3.7%

Value $23.18M (+47.5%) Shares 53,366 (+11.5%) Est. Cost $245.13 Unrealized +78.9%

PMN PROMIS NEUROSCIENCES INC 0.7%

Value $4.135M (+5031.2%) Shares 325,591 (+2657.6%) Est. Cost $12.08 Unrealized +0.7%

CAMT CAMTEK LTD 1.3%

Value $8.038M (+91.4%) Shares 53,020 (+34.2%) Est. Cost $107.76 Unrealized +35.4%

MAZE MAZE THERAPEUTICS INC 1.1%

Value $6.786M (+128.0%) Shares 227,343 (+216.4%) Est. Cost $33.93 Unrealized +29.8%

PFE PFIZER INC 0.8%

Value $5.223M (+143.9%) Shares 186,000 (+116.3%) Est. Cost $30.97 Unrealized -15.5%

WVE WAVE LIFE SCIENCES LTD 0.6%

Value $3.975M (-42.7%) Shares 548,272 (+34.3%) Est. Cost $10.89 Unrealized +26.3%

MDGL MADRIGAL PHARMACEUTICALS INC 0.8%

Value $4.732M (+146.2%) Shares 9,040 (+173.9%) Est. Cost $499.16 Unrealized -1.3%

PALI PALISADE BIO INC 0.5%

Value $3.034M (+601.2%) Shares 1,733,471 (+841.6%) Est. Cost $1.80 Unrealized -0.8%

COGT COGENT BIOSCIENCES INC 2.5%

Value $16.02M (+19.2%) Shares 416,340 (+10.0%) Est. Cost $24.16 Unrealized +54.7%

HELP CYBIN INC 0.8%

Value $4.738M (-29.8%) Shares 987,090 (+19.6%) Est. Cost $7.84 Unrealized -9.4%

BCRX BIOCRYST PHARMACEUTICALS INC 1.3%

Value $8.249M (+26.2%) Shares 866,464 (+3.4%) Est. Cost $7.22 Unrealized -3.1%

PRLD PRELUDE THERAPEUTICS INC 0.3%

Value $1.91M (+436.4%) Shares 558,339 (+354.9%) Est. Cost $2.17 Unrealized +6.2%

NVO NOVO-NORDISK A S 0.7%

Value $4.435M (-24.6%) Shares 120,677 (+4.3%) Est. Cost $88.07 Unrealized —

SNY SANOFI SA 2.1%

Value $12.99M (+11.9%) Shares 269,515 (+12.5%) Est. Cost $46.50 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 1.2%

Value $7.726M (+18.6%) Shares 243,575 (+1.6%) Est. Cost $31.46 Unrealized -19.2%

RVMD REVOLUTION MEDICINES INC 0.9%

Value $5.359M (+28.2%) Shares 55,110 (+5.0%) Est. Cost $42.18 Unrealized +144.2%

STTK SHATTUCK LABS INC 0.3%

Value $1.805M (+153.4%) Shares 280,786 (+43.8%) Est. Cost $2.92 Unrealized +42.0%

SLNO SOLENO THERAPEUTICS INC 1.1%

Value $7.241M (+14.7%) Shares 216,281 (+58.7%) Est. Cost $53.66 Unrealized -22.4%

TEVA TEVA PHARMACEUTICAL INDS LTD 5.4%

Value $34.25M (-2.3%) Shares 1,136,975 (+1.2%) Est. Cost $15.30 Unrealized —

ABBV ABBVIE INC 1.0%

Value $6.58M (+14.0%) Shares 30,256 (+19.8%) Est. Cost $115.16 Unrealized +93.3%

IBIT ISHARES BITCOIN TRUST ETF 0.4%

Value $2.286M (+53.2%) Shares 59,505 (+98.0%) Est. Cost $46.29 Unrealized —

VYGR VOYAGER THERAPEUTICS INC 0.3%

Value $1.813M (+35.8%) Shares 469,761 (+38.3%) Est. Cost $4.23 Unrealized —

GPCR STRUCTURE THERAPEUTICS INC 0.4%

Value $2.449M (-14.1%) Shares 50,800 (+23.9%) Est. Cost $27.33 Unrealized —

MDWD MEDIWOUND LTD 0.7%

Value $4.401M (+3.5%) Shares 273,192 (+18.6%) Est. Cost $18.30 Unrealized -3.1%

SKYE SKYE BIOSCIENCE INC 0.1%

Value $417K (+16.2%) Shares 678,928 (+41.8%) Est. Cost $7.87 Unrealized -88.6%

ACAD ACADIA PHARMACEUTICALS INC 0.9%

Value $5.703M (+0.6%) Shares 256,202 (+20.7%) Est. Cost $21.04 Unrealized +19.8%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MLYS	MINERALYS THERAPEUTICS INC	1,339,971 (+198.4%)	$36.3M (+122.8%)	5.8%	$29.70	+5.6%	COM	603170101
XBI	SPDR SERIES TRUST	200,000 (+185.7%)	$25.55M (+199.3%)	4.1%	—	—	PUT	78464A870
TSEM	TOWER SEMICONDUCTOR LTD	145,735 (+19.0%)	$25.57M (+77.8%)	4.1%	$54.51	+136.4%	SHS NEW	M87915274
RARE	ULTRAGENYX PHARMACEUTICAL IN	809,333 (+169.2%)	$16.96M (+145.2%)	2.7%	$27.53	-15.2%	COM	90400D108
BBIO	BRIDGEBIO PHARMA INC	245,246 (+127.6%)	$18.21M (+121.0%)	2.9%	$63.86	+16.6%	COM	10806X102
NVMI	NOVA LTD	53,366 (+11.5%)	$23.18M (+47.5%)	3.7%	$245.13	+78.9%	COM	M7516K103
PMN	PROMIS NEUROSCIENCES INC	325,591 (+2657.6%)	$4.135M (+5031.2%)	0.7%	$12.08	+0.7%	COM SHS	74346M505
CAMT	CAMTEK LTD	53,020 (+34.2%)	$8.038M (+91.4%)	1.3%	$107.76	+35.4%	ORD	M20791105
MAZE	MAZE THERAPEUTICS INC	227,343 (+216.4%)	$6.786M (+128.0%)	1.1%	$33.93	+29.8%	COM	578784100
PFE	PFIZER INC	186,000 (+116.3%)	$5.223M (+143.9%)	0.8%	$30.97	-15.5%	COM	717081103
WVE	WAVE LIFE SCIENCES LTD	548,272 (+34.3%)	$3.975M (-42.7%)	0.6%	$10.89	+26.3%	SHS	Y95308105
MDGL	MADRIGAL PHARMACEUTICALS INC	9,040 (+173.9%)	$4.732M (+146.2%)	0.8%	$499.16	-1.3%	COM	558868105
PALI	PALISADE BIO INC	1,733,471 (+841.6%)	$3.034M (+601.2%)	0.5%	$1.80	-0.8%	COM	696389402
COGT	COGENT BIOSCIENCES INC	416,340 (+10.0%)	$16.02M (+19.2%)	2.5%	$24.16	+54.7%	COM	19240Q201
HELP	CYBIN INC	987,090 (+19.6%)	$4.738M (-29.8%)	0.8%	$7.84	-9.4%	COM NEW	23256X407
BCRX	BIOCRYST PHARMACEUTICALS INC	866,464 (+3.4%)	$8.249M (+26.2%)	1.3%	$7.22	-3.1%	COM	09058V103
PRLD	PRELUDE THERAPEUTICS INC	558,339 (+354.9%)	$1.91M (+436.4%)	0.3%	$2.17	+6.2%	COM	74065P101
NVO	NOVO-NORDISK A S	120,677 (+4.3%)	$4.435M (-24.6%)	0.7%	$88.07	—	ADR	670100205
SNY	SANOFI SA	269,515 (+12.5%)	$12.99M (+11.9%)	2.1%	$46.50	—	SPONSORED ADR	80105N105
CLDX	CELLDEX THERAPEUTICS INC NEW	243,575 (+1.6%)	$7.726M (+18.6%)	1.2%	$31.46	-19.2%	COM NEW	15117B202
RVMD	REVOLUTION MEDICINES INC	55,110 (+5.0%)	$5.359M (+28.2%)	0.9%	$42.18	+144.2%	COM	76155X100
STTK	SHATTUCK LABS INC	280,786 (+43.8%)	$1.805M (+153.4%)	0.3%	$2.92	+42.0%	COM	82024L103
SLNO	SOLENO THERAPEUTICS INC	216,281 (+58.7%)	$7.241M (+14.7%)	1.1%	$53.66	-22.4%	COM	834203309
TEVA	TEVA PHARMACEUTICAL INDS LTD	1,136,975 (+1.2%)	$34.25M (-2.3%)	5.4%	$15.30	—	SPONSORED ADS	881624209
ABBV	ABBVIE INC	30,256 (+19.8%)	$6.58M (+14.0%)	1.0%	$115.16	+93.3%	COM	00287Y109
IBIT	ISHARES BITCOIN TRUST ETF	59,505 (+98.0%)	$2.286M (+53.2%)	0.4%	$46.29	—	SHS BEN INT	46438F101
VYGR	VOYAGER THERAPEUTICS INC	469,761 (+38.3%)	$1.813M (+35.8%)	0.3%	$4.23	—	COM	92915B106
GPCR	STRUCTURE THERAPEUTICS INC	50,800 (+23.9%)	$2.449M (-14.1%)	0.4%	$27.33	—	SPONSORED ADS	86366E106
MDWD	MEDIWOUND LTD	273,192 (+18.6%)	$4.401M (+3.5%)	0.7%	$18.30	-3.1%	SHS NEW	M68830112
SKYE	SKYE BIOSCIENCE INC	678,928 (+41.8%)	$417K (+16.2%)	0.1%	$7.87	-88.6%	COM NEW	83086J200
ACAD	ACADIA PHARMACEUTICALS INC	256,202 (+20.7%)	$5.703M (+0.6%)	0.9%	$21.04	+19.8%	COM	004225108

Exited Positions (25)

AZN ASTRAZENECA PLC 2.0%

Value $12.42M Shares 135,060 Est. Cost $54.50 Unrealized —

PRAX PRAXIS PRECISION MEDICINES I 1.9%

Value $11.79M Shares 40,000 Est. Cost — Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 1.3%

Value $8.05M Shares 350,000 Est. Cost $27.53 Unrealized -15.2%

ANNX ANNEXON INC 1.0%

Value $6.607M Shares 1,316,212 Est. Cost $5.27 Unrealized +9.0%

NICE NICE LTD 1.0%

Value $6.296M Shares 55,700 Est. Cost $110.26 Unrealized —

— ASTRIA THERAPEUTICS INC 0.7%

Value $4.656M Shares 355,725 Est. Cost $9.38 Unrealized —

AMD ADVANCED MICRO DEVICES INC 0.6%

Value $3.863M Shares 18,040 Est. Cost $146.37 Unrealized +51.5%

TARA PROTARA THERAPEUTICS INC 0.6%

Value $3.465M Shares 650,000 Est. Cost $5.56 Unrealized +11.2%

AVGO BROADCOM INC 0.5%

Value $3.376M Shares 9,755 Est. Cost $322.55 Unrealized +3.6%

ESLT ELBIT SYS LTD 0.5%

Value $3.085M Shares 5,340 Est. Cost $410.78 Unrealized +70.3%

NRIX NURIX THERAPEUTICS INC 0.4%

Value $2.352M Shares 124,000 Est. Cost $14.37 Unrealized +20.7%

JANX JANUX THERAPEUTICS INC 0.3%

Value $2.178M Shares 157,840 Est. Cost $35.72 Unrealized -61.8%

TSHA TAYSHA GENE THERAPIES INC 0.3%

Value $2.025M Shares 368,146 Est. Cost $2.17 Unrealized +119.1%

PHVS PHARVARIS N V 0.3%

Value $1.775M Shares 63,953 Est. Cost $22.21 Unrealized +20.4%

VRNS VARONIS SYS INC 0.3%

Value $1.722M Shares 52,500 Est. Cost $55.48 Unrealized -47.0%

VTYX VENTYX BIOSCIENCES INC 0.3%

Value $1.626M Shares 180,114 Est. Cost $5.44 Unrealized +148.5%

DAWN DAY ONE BIOPHARMACEUTICALS I 0.2%

Value $1.355M Shares 145,371 Est. Cost $13.06 Unrealized -15.6%

TRDA ENTRADA THERAPEUTICS INC 0.2%

Value $1.14M Shares 110,942 Est. Cost $10.28 Unrealized —

TNYA TENAYA THERAPEUTICS INC 0.2%

Value $1.067M Shares 1,500,000 Est. Cost $1.36 Unrealized -46.6%

CATX PERSPECTIVE THERAPEUTICS INC 0.2%

Value $962K Shares 349,973 Est. Cost $10.22 Unrealized -62.4%

JSPR JASPER THERAPEUTICS INC 0.1%

Value $888K Shares 485,401 Est. Cost $3.38 Unrealized -56.0%

PEPG PEPGEN INC 0.1%

Value $791K Shares 121,467 Est. Cost $1.43 Unrealized +307.4%

OKUR ONKURE THERAPEUTICS INC 0.0%

Value $175K Shares 60,454 Est. Cost $15.14 Unrealized -82.0%

MREO MEREO BIOPHARMA GROUP PLC 0.0%

Value $106K Shares 255,400 Est. Cost $0.42 Unrealized —

— APPLIED THERAPEUTICS INC 0.0%

Value $5,000 Shares 50,000 Est. Cost $6.63 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AZN	ASTRAZENECA PLC	135,060	$12.42M	2.0%	$54.50	—	—	046353108
PRAX	PRAXIS PRECISION MEDICINES I	40,000	$11.79M	1.9%	—	—	CALL	74006W207
RARE	ULTRAGENYX PHARMACEUTICAL IN	350,000	$8.05M	1.3%	$27.53	-15.2%	CALL	90400D108
ANNX	ANNEXON INC	1,316,212	$6.607M	1.0%	$5.27	+9.0%	—	03589W102
NICE	NICE LTD	55,700	$6.296M	1.0%	$110.26	—	CALL	653656108
—	ASTRIA THERAPEUTICS INC	355,725	$4.656M	0.7%	$9.38	—	—	04635X102
AMD	ADVANCED MICRO DEVICES INC	18,040	$3.863M	0.6%	$146.37	+51.5%	—	007903107
TARA	PROTARA THERAPEUTICS INC	650,000	$3.465M	0.6%	$5.56	+11.2%	—	74365U107
AVGO	BROADCOM INC	9,755	$3.376M	0.5%	$322.55	+3.6%	—	11135F101
ESLT	ELBIT SYS LTD	5,340	$3.085M	0.5%	$410.78	+70.3%	—	M3760D101
NRIX	NURIX THERAPEUTICS INC	124,000	$2.352M	0.4%	$14.37	+20.7%	—	67080M103
JANX	JANUX THERAPEUTICS INC	157,840	$2.178M	0.3%	$35.72	-61.8%	—	47103J105
TSHA	TAYSHA GENE THERAPIES INC	368,146	$2.025M	0.3%	$2.17	+119.1%	—	877619106
PHVS	PHARVARIS N V	63,953	$1.775M	0.3%	$22.21	+20.4%	—	N69605108
VRNS	VARONIS SYS INC	52,500	$1.722M	0.3%	$55.48	-47.0%	—	922280102
VTYX	VENTYX BIOSCIENCES INC	180,114	$1.626M	0.3%	$5.44	+148.5%	—	92332V107
DAWN	DAY ONE BIOPHARMACEUTICALS I	145,371	$1.355M	0.2%	$13.06	-15.6%	—	23954D109
TRDA	ENTRADA THERAPEUTICS INC	110,942	$1.14M	0.2%	$10.28	—	—	29384C108
TNYA	TENAYA THERAPEUTICS INC	1,500,000	$1.067M	0.2%	$1.36	-46.6%	—	87990A106
CATX	PERSPECTIVE THERAPEUTICS INC	349,973	$962K	0.2%	$10.22	-62.4%	—	46489V302
JSPR	JASPER THERAPEUTICS INC	485,401	$888K	0.1%	$3.38	-56.0%	—	471871202
PEPG	PEPGEN INC	121,467	$791K	0.1%	$1.43	+307.4%	—	713317105
OKUR	ONKURE THERAPEUTICS INC	60,454	$175K	0.0%	$15.14	-82.0%	—	68277Q105
MREO	MEREO BIOPHARMA GROUP PLC	255,400	$106K	0.0%	$0.42	—	—	589492107
—	APPLIED THERAPEUTICS INC	50,000	$5,000	0.0%	$6.63	—	—	03828A101

Decreased Positions (28)

DYN DYNE THERAPEUTICS INC 0.5%

Value $2.912M (-62.1%) Shares 160,594 (-59.1%) Est. Cost $19.51 Unrealized -12.3%

CYTK CYTOKINETICS INC 0.4%

Value $2.624M (-55.0%) Shares 39,817 (-56.6%) Est. Cost $40.28 Unrealized +60.0%

SVRA SAVARA INC 0.6%

Value $4.036M (-43.2%) Shares 739,164 (-37.3%) Est. Cost $3.82 Unrealized +49.1%

SEDG SOLAREDGE TECHNOLOGIES INC 0.4%

Value $2.697M (-52.4%) Shares 52,836 (-73.1%) Est. Cost $21.86 Unrealized +59.0%

ELVN ENLIVEN THERAPEUTICS INC 1.0%

Value $6.008M (+72.0%) Shares 153,265 (-32.4%) Est. Cost $20.68 Unrealized +23.8%

TNGX TANGO THERAPEUTICS INC 1.1%

Value $7.187M (+49.0%) Shares 343,563 (-36.9%) Est. Cost $8.62 Unrealized +38.2%

APLS APELLIS PHARMACEUTICALS INC 1.4%

Value $8.646M (+37.1%) Shares 214,914 (-14.4%) Est. Cost $26.90 Unrealized -15.7%

SRRK SCHOLAR ROCK HLDG CORP 0.7%

Value $4.634M (-33.5%) Shares 94,265 (-40.4%) Est. Cost $37.51 Unrealized +21.2%

ELDN ELEDON PHARMACEUTICALS INC 0.9%

Value $5.458M (+69.5%) Shares 1,772,131 (-16.9%) Est. Cost $2.84 Unrealized -26.6%

IMTX IMMATICS N.V 1.1%

Value $6.85M (-24.2%) Shares 696,105 (-19.2%) Est. Cost $10.79 Unrealized -9.1%

BIOA BIOAGE LABS INC 0.2%

Value $1.513M (-52.9%) Shares 86,518 (-64.4%) Est. Cost $8.86 Unrealized +116.6%

DTIL PRECISION BIOSCIENCES INC 0.0%

Value $220K (-86.6%) Shares 40,000 (-89.9%) Est. Cost $5.68 Unrealized -29.6%

ORIC ORIC PHARMACEUTICALS INC 1.1%

Value $6.812M (-17.1%) Shares 537,628 (-46.5%) Est. Cost $10.24 Unrealized +5.1%

EVMN EVOMMUNE INC 0.3%

Value $1.799M (-36.8%) Shares 78,234 (-52.9%) Est. Cost $18.78 Unrealized +17.1%

SNDX SYNDAX PHARMACEUTICALS INC 2.7%

Value $16.93M (+5.6%) Shares 724,563 (-5.0%) Est. Cost $17.41 Unrealized +19.2%

CLYM CLIMB BIO INC 0.5%

Value $2.872M (-23.0%) Shares 419,247 (-55.0%) Est. Cost $3.04 Unrealized +64.5%

BMRN BIOMARIN PHARMACEUTICAL INC 1.3%

Value $7.903M (-9.5%) Shares 139,900 (-4.8%) Est. Cost $54.44 Unrealized +7.9%

FOLD AMICUS THERAPEUTIC 1.4%

Value $8.725M (-6.9%) Shares 603,377 (-8.4%) Est. Cost $6.45 Unrealized +121.7%

TRVI TREVI THERAPEUTICS INC 1.1%

Value $6.848M (-8.6%) Shares 574,029 (-4.1%) Est. Cost $6.22 Unrealized +75.9%

ENPH ENPHASE ENERGY INC 0.9%

Value $5.385M (-9.9%) Shares 142,419 (-23.6%) Est. Cost $33.07 Unrealized +24.7%

KOD KODIAK SCIENCES INC 0.7%

Value $4.376M (-10.8%) Shares 114,796 (-34.6%) Est. Cost $20.48 Unrealized +24.1%

ASND ASCENDIS PHARMA A/S 0.3%

Value $1.83M (-22.0%) Shares 8,000 (-27.3%) Est. Cost $213.24 Unrealized —

CRVS CORVUS PHARMACEUTICALS INC 0.6%

Value $3.628M (+15.6%) Shares 247,961 (-39.2%) Est. Cost $6.17 Unrealized +163.9%

VOR VOR BIOPHARMA INC 0.9%

Value $5.743M (+7.0%) Shares 321,917 (-21.6%) Est. Cost $18.62 Unrealized -24.9%

JNJ JOHNSON & JOHNSON 1.1%

Value $7.047M (-5.0%) Shares 28,831 (-19.5%) Est. Cost $136.97 Unrealized +66.4%

BIIB BIOGEN INC 2.7%

Value $16.96M (+1.7%) Shares 92,526 (-2.3%) Est. Cost $159.11 Unrealized +15.2%

TENX TENAX THERAPEUTICS INC 0.3%

Value $2.175M (-6.2%) Shares 136,015 (-28.5%) Est. Cost $8.70 Unrealized +55.2%

ZIM ZIM INTEGRATED SHIPPING SERV 0.4%

Value $2.792M (-3.3%) Shares 105,950 (-22.1%) Est. Cost $16.77 Unrealized +39.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
DYN	DYNE THERAPEUTICS INC	160,594 (-59.1%)	$2.912M (-62.1%)	0.5%	$19.51	-12.3%	COM	26818M108
CYTK	CYTOKINETICS INC	39,817 (-56.6%)	$2.624M (-55.0%)	0.4%	$40.28	+60.0%	COM NEW	23282W605
SVRA	SAVARA INC	739,164 (-37.3%)	$4.036M (-43.2%)	0.6%	$3.82	+49.1%	COM	805111101
SEDG	SOLAREDGE TECHNOLOGIES INC	52,836 (-73.1%)	$2.697M (-52.4%)	0.4%	$21.86	+59.0%	COM	83417M104
ELVN	ENLIVEN THERAPEUTICS INC	153,265 (-32.4%)	$6.008M (+72.0%)	1.0%	$20.68	+23.8%	COM	29337E102
TNGX	TANGO THERAPEUTICS INC	343,563 (-36.9%)	$7.187M (+49.0%)	1.1%	$8.62	+38.2%	COM	87583X109
APLS	APELLIS PHARMACEUTICALS INC	214,914 (-14.4%)	$8.646M (+37.1%)	1.4%	$26.90	-15.7%	COM	03753U106
SRRK	SCHOLAR ROCK HLDG CORP	94,265 (-40.4%)	$4.634M (-33.5%)	0.7%	$37.51	+21.2%	COM	80706P103
ELDN	ELEDON PHARMACEUTICALS INC	1,772,131 (-16.9%)	$5.458M (+69.5%)	0.9%	$2.84	-26.6%	COM	28617K101
IMTX	IMMATICS N.V	696,105 (-19.2%)	$6.85M (-24.2%)	1.1%	$10.79	-9.1%	SHS	N44445109
BIOA	BIOAGE LABS INC	86,518 (-64.4%)	$1.513M (-52.9%)	0.2%	$8.86	+116.6%	COM	09077V100
DTIL	PRECISION BIOSCIENCES INC	40,000 (-89.9%)	$220K (-86.6%)	0.0%	$5.68	-29.6%	COM NEW	74019P207
ORIC	ORIC PHARMACEUTICALS INC	537,628 (-46.5%)	$6.812M (-17.1%)	1.1%	$10.24	+5.1%	COM	68622P109
EVMN	EVOMMUNE INC	78,234 (-52.9%)	$1.799M (-36.8%)	0.3%	$18.78	+17.1%	COM SHS	30054Y107
SNDX	SYNDAX PHARMACEUTICALS INC	724,563 (-5.0%)	$16.93M (+5.6%)	2.7%	$17.41	+19.2%	COM	87164F105
CLYM	CLIMB BIO INC	419,247 (-55.0%)	$2.872M (-23.0%)	0.5%	$3.04	+64.5%	COM	28658R106
BMRN	BIOMARIN PHARMACEUTICAL INC	139,900 (-4.8%)	$7.903M (-9.5%)	1.3%	$54.44	+7.9%	COM	09061G101
FOLD	AMICUS THERAPEUTIC	603,377 (-8.4%)	$8.725M (-6.9%)	1.4%	$6.45	+121.7%	COM	03152W109
TRVI	TREVI THERAPEUTICS INC	574,029 (-4.1%)	$6.848M (-8.6%)	1.1%	$6.22	+75.9%	COM	89532M101
ENPH	ENPHASE ENERGY INC	142,419 (-23.6%)	$5.385M (-9.9%)	0.9%	$33.07	+24.7%	COM	29355A107
KOD	KODIAK SCIENCES INC	114,796 (-34.6%)	$4.376M (-10.8%)	0.7%	$20.48	+24.1%	COM	50015M109
ASND	ASCENDIS PHARMA A/S	8,000 (-27.3%)	$1.83M (-22.0%)	0.3%	$213.24	—	SPONSORED ADR	04351P101
CRVS	CORVUS PHARMACEUTICALS INC	247,961 (-39.2%)	$3.628M (+15.6%)	0.6%	$6.17	+163.9%	COM	221015100
VOR	VOR BIOPHARMA INC	321,917 (-21.6%)	$5.743M (+7.0%)	0.9%	$18.62	-24.9%	COM NEW	929033207
JNJ	JOHNSON & JOHNSON	28,831 (-19.5%)	$7.047M (-5.0%)	1.1%	$136.97	+66.4%	COM	478160104
BIIB	BIOGEN INC	92,526 (-2.3%)	$16.96M (+1.7%)	2.7%	$159.11	+15.2%	COM	09062X103
TENX	TENAX THERAPEUTICS INC	136,015 (-28.5%)	$2.175M (-6.2%)	0.3%	$8.70	+55.2%	COM NEW	88032L605
ZIM	ZIM INTEGRATED SHIPPING SERV	105,950 (-22.1%)	$2.792M (-3.3%)	0.4%	$16.77	+39.7%	SHS	M9T951109

Unchanged Positions (15)

— SOLAREDGE TECHNOLOGIES INC 1.1%

Value $6.91M Shares 4,000,000 Est. Cost $1.33 Unrealized —

LLY ELI LILLY & CO 1.3%

Value $8.315M Shares 9,040 Est. Cost $258.77 Unrealized +304.6%

VSTM VERASTEM INC 0.3%

Value $1.821M Shares 343,678 Est. Cost $8.31 Unrealized -22.1%

GSK GSK PLC 1.1%

Value $6.733M Shares 122,000 Est. Cost $35.22 Unrealized —

MRK MERCK & CO INC 0.9%

Value $5.846M Shares 48,600 Est. Cost $73.08 Unrealized +56.4%

KURA KURA ONCOLOGY INC 0.4%

Value $2.403M Shares 295,522 Est. Cost $16.72 Unrealized -48.5%

ACOG ALPHA COGNITION INC 0.5%

Value $3.116M Shares 567,616 Est. Cost $5.90 Unrealized -3.9%

NVS NOVARTIS AG 0.9%

Value $5.652M Shares 37,000 Est. Cost $92.00 Unrealized —

CTNM CONTINEUM THERAPEUTICS INC 0.4%

Value $2.266M Shares 173,475 Est. Cost $11.41 Unrealized +17.0%

FBRX FORTE BIOSCIENCES INC 0.8%

Value $4.791M Shares 184,984 Est. Cost $8.61 Unrealized +244.8%

AMGN AMGEN INC 0.4%

Value $2.639M Shares 7,500 Est. Cost $287.24 Unrealized +21.7%

HOWL WEREWOLF THERAPEUTICS INC 0.1%

Value $522K Shares 626,810 Est. Cost $13.12 Unrealized -95.1%

BMY BRISTOL-MYERS SQUIBB CO 0.2%

Value $1.061M Shares 17,500 Est. Cost $52.58 Unrealized +9.2%

APRE APREA THERAPEUTICS INC 0.0%

Value $206K Shares 270,000 Est. Cost $6.22 Unrealized -87.4%

TLT ISHARES TR 0.6%

Value $4.074M Shares 47,000 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	SOLAREDGE TECHNOLOGIES INC	4,000,000	$6.91M	1.1%	$1.33	—	NOTE 2.250% 7/0	83417MAE4
LLY	ELI LILLY & CO	9,040	$8.315M	1.3%	$258.77	+304.6%	COM	532457108
VSTM	VERASTEM INC	343,678	$1.821M	0.3%	$8.31	-22.1%	COM NEW	92337C203
GSK	GSK PLC	122,000	$6.733M	1.1%	$35.22	—	SPONSORED ADR	37733W204
MRK	MERCK & CO INC	48,600	$5.846M	0.9%	$73.08	+56.4%	COM	58933Y105
KURA	KURA ONCOLOGY INC	295,522	$2.403M	0.4%	$16.72	-48.5%	COM	50127T109
ACOG	ALPHA COGNITION INC	567,616	$3.116M	0.5%	$5.90	-3.9%	COM NEW	02074J501
NVS	NOVARTIS AG	37,000	$5.652M	0.9%	$92.00	—	SPONSORED ADR	66987V109
CTNM	CONTINEUM THERAPEUTICS INC	173,475	$2.266M	0.4%	$11.41	+17.0%	CL A	21217B100
FBRX	FORTE BIOSCIENCES INC	184,984	$4.791M	0.8%	$8.61	+244.8%	COM NEW	34962G208
AMGN	AMGEN INC	7,500	$2.639M	0.4%	$287.24	+21.7%	COM	031162100
HOWL	WEREWOLF THERAPEUTICS INC	626,810	$522K	0.1%	$13.12	-95.1%	COM	95075A107
BMY	BRISTOL-MYERS SQUIBB CO	17,500	$1.061M	0.2%	$52.58	+9.2%	COM	110122108
APRE	APREA THERAPEUTICS INC	270,000	$206K	0.0%	$6.22	-87.4%	COM NEW	03836J201
TLT	ISHARES TR	47,000	$4.074M	0.6%	—	—	CALL	464287432