SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $517M (100.0% shares, 0.0% debt)

Holdings (99)

TEVA TEVA PHARMACEUTICAL INDS LTD 6.8%
Value $35.07M Shares 1,123,525 Est. Cost $15.12 Unrealized
BIIB BIOGEN INC 3.2%
Value $16.67M Shares 94,738 Est. Cost $159.11 Unrealized +2.7%
MLYS MINERALYS THERAPEUTICS INC 3.1%
Value $16.29M Shares 449,003 Est. Cost $26.42 Unrealized +51.8%
SNDX SYNDAX PHARMACEUTICALS INC 3.1%
Value $16.02M Shares 762,563 Est. Cost $17.41 Unrealized +0.2%
NVMI NOVA LTD 3.0%
Value $15.71M Shares 47,846 Est. Cost $222.80 Unrealized +44.3%
TSEM TOWER SEMICONDUCTOR LTD 2.8%
Value $14.39M Shares 122,513 Est. Cost $40.41 Unrealized +138.3%
COGT COGENT BIOSCIENCES INC 2.6%
Value $13.44M Shares 378,500 Est. Cost $22.83 Unrealized +23.1%
AZN ASTRAZENECA PLC 2.4%
Value $12.42M Shares 135,060 Est. Cost $54.50 Unrealized
PRAX PRAXIS PRECISION MEDICINES I 2.3%
Value $11.79M Shares 40,000 Est. Cost $51.58 Unrealized +261.0%
SNY SANOFI SA 2.2%
Value $11.61M Shares 239,515 Est. Cost $46.29 Unrealized
LLY ELI LILLY & CO 1.9%
Value $9.715M Shares 9,040 Est. Cost $258.77 Unrealized +269.3%
FOLD AMICUS THERAPEUTICS INC 1.8%
Value $9.375M Shares 658,377 Est. Cost $6.45 Unrealized +52.2%
IMTX IMMATICS N.V 1.7%
Value $9.042M Shares 861,105 Est. Cost $10.79 Unrealized -6.5%
BMRN BIOMARIN PHARMACEUTICAL INC 1.7%
Value $8.736M Shares 147,000 Est. Cost $54.44 Unrealized 0.0%
XBI SPDR SERIES TRUST 1.6%
Value $8.535M Shares 70,000 Est. Cost Unrealized
BBIO BRIDGEBIO PHARMA INC 1.6%
Value $8.241M Shares 107,746 Est. Cost $50.32 Unrealized +30.5%
ORIC ORIC PHARMACEUTICALS INC 1.6%
Value $8.216M Shares 1,004,378 Est. Cost $10.24 Unrealized +12.4%
RARE ULTRAGENYX PHARMACEUTICAL IN 1.6%
Value $8.05M Shares 350,000 Est. Cost $34.60 Unrealized -4.9%
DYN DYNE THERAPEUTICS INC 1.5%
Value $7.685M Shares 392,894 Est. Cost $19.51 Unrealized -2.9%
TRVI TREVI THERAPEUTICS INC 1.4%
Value $7.494M Shares 598,534 Est. Cost $6.22 Unrealized +85.8%
JNJ JOHNSON & JOHNSON 1.4%
Value $7.415M Shares 35,831 Est. Cost $136.97 Unrealized +43.8%
SVRA SAVARA INC 1.4%
Value $7.104M Shares 1,178,164 Est. Cost $3.82 Unrealized +28.3%
SRRK SCHOLAR ROCK HLDG CORP 1.3%
Value $6.972M Shares 158,265 Est. Cost $37.51 Unrealized 0.0%
WVE WAVE LIFE SCIENCES LTD 1.3%
Value $6.939M Shares 408,166 Est. Cost $9.91 Unrealized +2.6%
RARE ULTRAGENYX PHARMACEUTICAL IN 1.3%
Value $6.914M Shares 300,623 Est. Cost $34.60 Unrealized -4.9%
HELP CYBIN INC 1.3%
Value $6.753M Shares 825,576 Est. Cost $7.99 Unrealized -19.4%
ANNX ANNEXON INC 1.3%
Value $6.607M Shares 1,316,212 Est. Cost $5.27 Unrealized -27.5%
BCRX BIOCRYST PHARMACEUTICALS INC 1.3%
Value $6.536M Shares 837,889 Est. Cost $7.23 Unrealized 0.0%
CLDX CELLDEX THERAPEUTICS INC NEW 1.3%
Value $6.512M Shares 239,764 Est. Cost $31.56 Unrealized -16.5%
SLNO SOLENO THERAPEUTICS INC 1.2%
Value $6.311M Shares 136,314 Est. Cost $60.72 Unrealized -9.7%
APLS APELLIS PHARMACEUTICALS INC 1.2%
Value $6.304M Shares 250,961 Est. Cost $26.90 Unrealized -12.8%
NICE NICE LTD 1.2%
Value $6.296M Shares 55,700 Est. Cost $144.78 Unrealized
GSK GSK PLC 1.2%
Value $5.983M Shares 122,000 Est. Cost $35.22 Unrealized
ENPH ENPHASE ENERGY INC 1.2%
Value $5.977M Shares 186,500 Est. Cost $33.07 Unrealized -2.1%
NVO NOVO-NORDISK A S 1.1%
Value $5.886M Shares 115,677 Est. Cost $90.28 Unrealized
CYTK CYTOKINETICS INC 1.1%
Value $5.828M Shares 91,717 Est. Cost $40.28 Unrealized +54.4%
ABBV ABBVIE INC 1.1%
Value $5.771M Shares 25,256 Est. Cost $93.90 Unrealized +142.3%
SEDG SOLAREDGE TECHNOLOGIES INC 1.1%
Value $5.67M Shares 196,536 Est. Cost $21.86 Unrealized +59.5%
ACAD ACADIA PHARMACEUTICALS INC 1.1%
Value $5.668M Shares 212,202 Est. Cost $20.17 Unrealized +18.5%
VOR VOR BIOPHARMA INC 1.0%
Value $5.368M Shares 410,417 Est. Cost $18.62 Unrealized 0.0%
MRK MERCK & CO INC 1.0%
Value $5.116M Shares 48,600 Est. Cost $73.08 Unrealized +27.6%
NVS NOVARTIS AG 1.0%
Value $5.101M Shares 37,000 Est. Cost $92.00 Unrealized
FBRX FORTE BIOSCIENCES INC 1.0%
Value $5.069M Shares 185,869 Est. Cost $8.61 Unrealized +103.7%
KOD KODIAK SCIENCES INC 0.9%
Value $4.907M Shares 175,500 Est. Cost $20.48 Unrealized 0.0%
TNGX TANGO THERAPEUTICS INC 0.9%
Value $4.825M Shares 544,563 Est. Cost $8.62 Unrealized 0.0%
SOLAREDGE TECHNOLOGIES INC 0.9%
Value $4.699M Shares 4,000,000 Est. Cost $1.33 Unrealized
ASTRIA THERAPEUTICS INC 0.9%
Value $4.656M Shares 355,725 Est. Cost $9.38 Unrealized
MDWD MEDIWOUND LTD 0.8%
Value $4.252M Shares 230,347 Est. Cost $18.41 Unrealized -0.7%
CAMT CAMTEK LTD 0.8%
Value $4.2M Shares 39,498 Est. Cost $94.70 Unrealized +18.6%
RVMD REVOLUTION MEDICINES INC 0.8%
Value $4.182M Shares 52,500 Est. Cost $39.15 Unrealized +67.5%
TLT ISHARES TR 0.8%
Value $4.097M Shares 47,000 Est. Cost Unrealized
AMD ADVANCED MICRO DEVICES INC 0.7%
Value $3.863M Shares 18,040 Est. Cost $146.37 Unrealized +53.4%
CLYM CLIMB BIO INC 0.7%
Value $3.729M Shares 932,247 Est. Cost $3.04 Unrealized -20.9%
ACOG ALPHA COGNITION INC 0.7%
Value $3.69M Shares 567,616 Est. Cost $5.90 Unrealized +7.2%
ELVN ENLIVEN THERAPEUTICS INC 0.7%
Value $3.492M Shares 226,765 Est. Cost $20.68 Unrealized -3.6%
TARA PROTARA THERAPEUTICS INC 0.7%
Value $3.465M Shares 650,000 Est. Cost $5.56 Unrealized 0.0%
AVGO BROADCOM INC 0.7%
Value $3.376M Shares 9,755 Est. Cost $322.55 Unrealized +10.7%
ELDN ELEDON PHARMACEUTICALS INC 0.6%
Value $3.22M Shares 2,132,131 Est. Cost $2.84 Unrealized -16.4%
BIOA BIOAGE LABS INC 0.6%
Value $3.215M Shares 243,035 Est. Cost $8.86 Unrealized 0.0%
CRVS CORVUS PHARMACEUTICALS INC 0.6%
Value $3.139M Shares 407,709 Est. Cost $6.17 Unrealized +27.8%
ESLT ELBIT SYS LTD 0.6%
Value $3.085M Shares 5,340 Est. Cost $410.78 Unrealized +21.9%
KURA KURA ONCOLOGY INC 0.6%
Value $3.07M Shares 295,522 Est. Cost $16.72 Unrealized -37.2%
MAZE MAZE THERAPEUTICS INC 0.6%
Value $2.976M Shares 71,843 Est. Cost $12.04 Unrealized +185.5%
ZIM ZIM INTEGRATED SHIPPING SERV 0.6%
Value $2.887M Shares 136,005 Est. Cost $16.77 Unrealized 0.0%
GPCR STRUCTURE THERAPEUTICS INC 0.6%
Value $2.852M Shares 41,000 Est. Cost $22.34 Unrealized
EVMN EVOMMUNE INC 0.5%
Value $2.844M Shares 166,147 Est. Cost $18.78 Unrealized 0.0%
VSTM VERASTEM INC 0.5%
Value $2.653M Shares 343,678 Est. Cost $8.31 Unrealized +7.3%
AMGN AMGEN INC 0.5%
Value $2.455M Shares 7,500 Est. Cost $287.24 Unrealized +10.0%
NRIX NURIX THERAPEUTICS INC 0.5%
Value $2.352M Shares 124,000 Est. Cost $14.37 Unrealized 0.0%
ASND ASCENDIS PHARMA A/S 0.5%
Value $2.346M Shares 11,000 Est. Cost $213.24 Unrealized
TENX TENAX THERAPEUTICS INC 0.4%
Value $2.317M Shares 190,111 Est. Cost $8.70 Unrealized 0.0%
JANX JANUX THERAPEUTICS INC 0.4%
Value $2.178M Shares 157,840 Est. Cost $35.72 Unrealized -34.2%
PFE PFIZER INC 0.4%
Value $2.141M Shares 86,000 Est. Cost $36.55 Unrealized -31.5%
TSHA TAYSHA GENE THERAPIES INC 0.4%
Value $2.025M Shares 368,146 Est. Cost $2.17 Unrealized +123.5%
CTNM CONTINEUM THERAPEUTICS INC 0.4%
Value $1.983M Shares 173,475 Est. Cost $11.41 Unrealized 0.0%
MDGL MADRIGAL PHARMACEUTICALS INC 0.4%
Value $1.922M Shares 3,300 Est. Cost $510.76 Unrealized 0.0%
PHVS PHARVARIS N V 0.3%
Value $1.775M Shares 63,953 Est. Cost $22.21 Unrealized +8.5%
VRNS VARONIS SYS INC 0.3%
Value $1.722M Shares 52,500 Est. Cost $55.48 Unrealized -24.3%
DTIL PRECISION BIOSCIENCES INC 0.3%
Value $1.648M Shares 396,116 Est. Cost $5.68 Unrealized 0.0%
VTYX VENTYX BIOSCIENCES INC 0.3%
Value $1.626M Shares 180,114 Est. Cost $5.44 Unrealized +37.4%
IBIT ISHARES BITCOIN TRUST ETF 0.3%
Value $1.492M Shares 30,055 Est. Cost $54.00 Unrealized
DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%
Value $1.355M Shares 145,371 Est. Cost $13.06 Unrealized -36.0%
VYGR VOYAGER THERAPEUTICS INC 0.3%
Value $1.335M Shares 339,761 Est. Cost $4.37 Unrealized
TRDA ENTRADA THERAPEUTICS INC 0.2%
Value $1.14M Shares 110,942 Est. Cost $10.28 Unrealized
TNYA TENAYA THERAPEUTICS INC 0.2%
Value $1.067M Shares 1,500,000 Est. Cost $1.36 Unrealized 0.0%
CATX PERSPECTIVE THERAPEUTICS INC 0.2%
Value $962K Shares 349,973 Est. Cost $10.22 Unrealized -72.1%
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value $944K Shares 17,500 Est. Cost $52.58 Unrealized -9.6%
JSPR JASPER THERAPEUTICS INC 0.2%
Value $888K Shares 485,401 Est. Cost $3.38 Unrealized -40.5%
PEPG PEPGEN INC 0.2%
Value $791K Shares 121,467 Est. Cost $1.43 Unrealized +262.6%
STTK SHATTUCK LABS INC 0.1%
Value $713K Shares 195,212 Est. Cost $2.39 Unrealized 0.0%
PALI PALISADE BIO INC 0.1%
Value $433K Shares 184,100 Est. Cost $1.92 Unrealized 0.0%
HOWL WEREWOLF THERAPEUTICS INC 0.1%
Value $397K Shares 626,810 Est. Cost $13.12 Unrealized -90.7%
SKYE SKYE BIOSCIENCE INC 0.1%
Value $359K Shares 478,928 Est. Cost $10.78 Unrealized -86.5%
PRLD PRELUDE THERAPEUTICS INC 0.1%
Value $356K Shares 122,752 Est. Cost $1.69 Unrealized 0.0%
APRE APREA THERAPEUTICS INC 0.0%
Value $230K Shares 270,000 Est. Cost $6.22 Unrealized -80.2%
OKUR ONKURE THERAPEUTICS INC 0.0%
Value $175K Shares 60,454 Est. Cost $15.14 Unrealized -80.2%
MREO MEREO BIOPHARMA GROUP PLC 0.0%
Value $106K Shares 255,400 Est. Cost $0.42 Unrealized
PMN PROMIS NEUROSCIENCES INC 0.0%
Value $80,586 Shares 11,807 Est. Cost $9.76 Unrealized 0.0%
APPLIED THERAPEUTICS INC 0.0%
Value $5,000 Shares 50,000 Est. Cost $6.63 Unrealized