| VANGUARD GROUP INC | 13,649,250 | $984,520 |
| BlackRock, Inc. | 12,850,801 | $926,928 |
| RA CAPITAL MANAGEMENT, L.P. | 8,641,031 | $623,278 |
| JANUS HENDERSON GROUP PLC | 6,939,503 | $500,560 |
| BALYASNY ASSET MANAGEMENT L.P. | 6,040,590 | $435,708 |
| Pentwater Capital Management LP | 6,026,500 | $434,691 |
| Avoro Capital Advisors LLC | 5,455,000 | $393,469 |
| HBK INVESTMENTS L P | 4,365,000 | $314,847 |
| STATE STREET CORP | 4,097,885 | $295,580 |
| GOLDMAN SACHS GROUP INC | 3,776,785 | $272,420 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,120,780 | $225,145 |
| NORGES BANK | 3,046,388 | $219,736 |
| Bellevue Group AG | 2,630,969 | $189,772 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,630,966 | $189,772 |
| GLAZER CAPITAL, LLC | 2,467,139 | $178 |
| UBS Group AG | 2,356,812 | $169,997 |
| MILLENNIUM MANAGEMENT LLC | 2,157,270 | $155,604 |
| TIG Advisors, LLC | 1,801,683 | $129,955 |
| CITADEL ADVISORS LLC | 1,592,429 | $114,862 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,181,661 | $85,233 |
| Magnetar Financial LLC | 1,158,603 | $83,570 |
| FIL Ltd | 1,144,000 | $82,517 |
| Qube Research & Technologies Ltd | 1,105,830 | $79,764 |
| MORGAN STANLEY | 1,092,482 | $78,801 |
| ALLIANCEBERNSTEIN L.P. | 1,047,410 | $75,550 |
| KRYGER CAPITAL Ltd | 1,045,320 | $75,399 |
| NORTHERN TRUST CORP | 1,019,087 | $73,507 |
| Casdin Capital, LLC | 1,000,000 | $72,130 |
| Frazier Life Sciences Management, L.P. | 983,125 | $70,913 |
| Westchester Capital Management, LLC | 962,659 | $69,437 |
| NEXPOINT ASSET MANAGEMENT, L.P. | 923,950 | $66,645 |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | $64,917 |
| Man Group plc | 898,277 | $64,793 |
| Squarepoint Ops LLC | 868,200 | $62,623 |
| ALPINE ASSOCIATES MANAGEMENT INC. | 867,530 | $62,575 |
| SOROS FUND MANAGEMENT LLC | 840,976 | $60,660 |
| JPMORGAN CHASE & CO | 820,990 | $59,218 |
| Sofinnova Investments, Inc. | 745,116 | $53,745 |
| TUDOR INVESTMENT CORP ET AL | 733,010 | $52,872 |
| WELLINGTON MANAGEMENT GROUP LLP | 723,118 | $52,159 |
| Slotnik Capital, LLC | 715,000 | $51,573 |
| BANK OF AMERICA CORP /DE/ | 706,665 | $50,972 |
| Verition Fund Management LLC | 680,721 | $49,100 |
| Woodline Partners LP | 671,623 | $48,444 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 642,224 | $46,324 |
| NEUBERGER BERMAN GROUP LLC | 622,439 | $44,897 |
| ORBIMED ADVISORS LLC | 619,530 | $44,687 |
| BNP PARIBAS ARBITRAGE, SA | 610,547 | $44,039 |
| LMR Partners LLP | 598,525 | $43,172 |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 585,550 | $42,236 |
| Sculptor Capital LP | 566,000 | $40,826 |
| ADAR1 Capital Management, LLC | 546,534 | $39,421 |
| BARCLAYS PLC | 531,203 | $38,316 |
| Polar Asset Management Partners Inc. | 529,510 | $38,194 |
| EVENTIDE ASSET MANAGEMENT, LLC | 524,643 | $37,843 |
| Logos Global Management LP | 500,000 | $36,065 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 471,127 | $33,982 |
| CITIGROUP INC | 467,686 | $33,734 |
| ALETHEA CAPITAL MANAGEMENT, LLC | 446,127 | $32,179 |
| CAXTON ASSOCIATES LLP | 442,307 | $31,904 |
| Schonfeld Strategic Advisors LLC | 439,812 | $31,724 |
| PICTON MAHONEY ASSET MANAGEMENT | 425,000 | $30,655 |
| Bank of New York Mellon Corp | 417,539 | $30,117 |
| Capula Management Ltd | 389,566 | $28,099 |
| ODDO BHF ASSET MANAGEMENT SAS | 377,500 | $27,229 |
| Twin Securities, Inc. | 365,144 | $26,338 |
| Nearwater Capital Markets, Ltd | 360,200 | $25,981 |
| Melqart Asset Management (UK) Ltd | 355,691 | $25,656 |
| Sand Grove Capital Management LLP | 331,605 | $23,919 |
| HARVEST MANAGEMENT LLC | 329,300 | $23,752 |
| GABELLI FUNDS LLC | 328,616 | $23,703 |
| Boussard & Gavaudan Investment Management LLP | 328,204 | $23,680 |
| Allianz Asset Management GmbH | 309,887 | $22,352 |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 303,030 | $21,858 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 268,393 | $19,359 |
| Nuveen, LLC | 251,460 | $18,138 |
| Decagon Asset Management LLP | 242,436 | $17,487 |
| Hudson Bay Capital Management LP | 218,226 | $15,741 |
| Swiss National Bank | 215,800 | $15,566 |
| MARSHALL WACE, LLP | 212,581 | $15,333 |
| WELLS FARGO & COMPANY/MN | 210,604 | $15,191 |
| AQR Arbitrage LLC | 208,705 | $15,054 |
| CRCM LP | 202,370 | $14,597 |
| Vestcor Inc | 200,000 | $14 |
| UBS ASSET MANAGEMENT AMERICAS INC | 188,807 | $13,619 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 185,000 | $13,344 |
| Athos Capital Ltd | 184,564 | $13 |
| FMR LLC | 183,229 | $13,216 |
| Fort Baker Capital Management LP | 178,980 | $12,910 |
| PSquared Asset Management AG | 168,415 | $12,148 |
| WATER ISLAND CAPITAL LLC | 168,385 | $12,146 |
| CREDIT INDUSTRIEL ET COMMERCIAL | 168,000 | $12,118 |
| DEUTSCHE BANK AG\ | 166,841 | $12,034 |
| Versor Investments LP | 162,880 | $11,749 |
| Groupe la Francaise | 162,398 | $11,714 |
| GARDNER LEWIS ASSET MANAGEMENT L P | 158,959 | $11,466 |
| Grantham, Mayo, Van Otterloo & Co. LLC | 154,455 | $11,141 |
| RHUMBLINE ADVISERS | 152,511 | $11,001 |
| ExodusPoint Capital Management, LP | 148,731 | $10,728 |
| Empyrean Capital Partners, LP | 143,000 | $10,315 |
| 237 other institutions | 5,450,632 | $358,993 |