| Frazier Life Sciences Management, L.P. | 6,795,121 | $536,747 |
| JANUS HENDERSON GROUP PLC | 6,065,308 | $479,050 |
| BlackRock, Inc. | 3,645,286 | $287,941 |
| VANGUARD GROUP INC | 2,596,089 | $205,065 |
| STATE STREET CORP | 2,143,992 | $169,354 |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,093,582 | $165,370 |
| BVF INC/IL | 1,495,290 | $118,113 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,420,375 | $112 |
| Novo Holdings A/S | 1,264,028 | $99,846 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,237,830 | $97,776 |
| TANG CAPITAL MANAGEMENT LLC | 1,236,027 | $97,634 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,926 | $83,975 |
| D. E. Shaw & Co., Inc. | 948,161 | $74,895 |
| Clearbridge Investments, LLC | 865,967 | $68,403 |
| CITADEL ADVISORS LLC | 840,220 | $66,369 |
| Polar Capital Holdings Plc | 793,642 | $62,690 |
| Rock Springs Capital Management LP | 762,294 | $60,214 |
| GOLDMAN SACHS GROUP INC | 724,317 | $57,214 |
| BANK OF AMERICA CORP /DE/ | 713,452 | $56,356 |
| BNP PARIBAS ARBITRAGE, SA | 655,778 | $51,800 |
| FRANKLIN RESOURCES INC | 650,715 | $51,400 |
| FMR LLC | 646,466 | $51,064 |
| LORD, ABBETT & CO. LLC | 579,983 | $46 |
| Pictet Asset Management Holding SA | 577,274 | $45,599 |
| Soleus Capital Management, L.P. | 573,614 | $45,310 |
| Candriam S.C.A. | 569,590 | $44,994 |
| Woodline Partners LP | 567,894 | $44,858 |
| Bank of New York Mellon Corp | 565,579 | $44,675 |
| Connor, Clark & Lunn Investment Management Ltd. | 521,652 | $41,205 |
| LOOMIS SAYLES & CO L P | 514,981 | $40,678 |
| Nuveen, LLC | 503,045 | $39,736 |
| FEDERATED HERMES, INC. | 481,961 | $38,070 |
| First Turn Management, LLC | 481,564 | $38,039 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 467,468 | $36,925 |
| RENAISSANCE TECHNOLOGIES LLC | 439,085 | $34,683 |
| MORGAN STANLEY | 425,685 | $33,625 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 421,845 | $33,322 |
| BOONE CAPITAL MANAGEMENT LLC | 421,236 | $33,273 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,286 | $32,330 |
| TimesSquare Capital Management, LLC | 395,827 | $31,266 |
| TWO SIGMA INVESTMENTS, LP | 388,542 | $30,691 |
| NORTHERN TRUST CORP | 374,864 | $29,611 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 372,511 | $29,425 |
| NEXT CENTURY GROWTH INVESTORS LLC | 368,035 | $29,071 |
| EMERALD ADVISERS, LLC | 367,134 | $29,000 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 336,701 | $26,596 |
| UBS Group AG | 320,783 | $25,339 |
| Patient Square Capital LP | 298,682 | $23,593 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 297,950 | $23,535 |
| BALYASNY ASSET MANAGEMENT L.P. | 285,870 | $22,581 |
| Penn Capital Management Company, LLC | 281,918 | $22,322 |
| Hood River Capital Management LLC | 280,028 | $22,119 |
| AMERIPRISE FINANCIAL INC | 271,480 | $21,444 |
| NORGES BANK | 263,175 | $20,788 |
| PERCEPTIVE ADVISORS LLC | 259,545 | $20,501 |
| BNP Paribas Investment Partners S.A. | 257,228 | $20 |
| Erste Asset Management GmbH | 250,000 | $19,784 |
| RAYMOND JAMES FINANCIAL INC | 246,418 | $19,465 |
| MILLENNIUM MANAGEMENT LLC | 244,273 | $19,295 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 242,320 | $19,141 |
| TWO SIGMA ADVISERS, LP | 232,100 | $18,334 |
| NAN FUNG TRINITY (HK) LTD | 227,479 | $17,969 |
| Logos Global Management LP | 225,000 | $17,773 |
| NEW YORK STATE COMMON RETIREMENT FUND | 217,606 | $17,189 |
| Handelsbanken Fonder AB | 213,500 | $17 |
| Nicholas Investment Partners, LP | 213,391 | $16,856 |
| Russell Investments Group, Ltd. | 209,174 | $16,523 |
| Point72 Asset Management, L.P. | 190,638 | $15,058 |
| DEUTSCHE BANK AG\ | 186,712 | $14,748 |
| SEGALL BRYANT & HAMILL, LLC | 185,024 | $14,615 |
| ALGERT GLOBAL LLC | 174,189 | $14 |
| Voleon Capital Management LP | 173,067 | $13,671 |
| Squarepoint Ops LLC | 172,426 | $13,620 |
| Legal & General Group Plc | 168,393 | $13,301 |
| RICE HALL JAMES & ASSOCIATES, LLC | 164,449 | $12,990 |
| Palo Alto Investors LP | 156,421 | $12,356 |
| CITIGROUP INC | 145,992 | $11,532 |
| PDT Partners, LLC | 145,379 | $11,483 |
| BARCLAYS PLC | 142,144 | $11,228 |
| FIRST TRUST ADVISORS LP | 137,700 | $10,877 |
| Ensign Peak Advisors, Inc | 133,973 | $10,583 |
| Highlander Partners, L.P. | 122,980 | $9,714 |
| WELLS FARGO & COMPANY/MN | 115,437 | $9,118 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 111,310 | $8,792 |
| Qube Research & Technologies Ltd | 109,001 | $8,610 |
| Rhenman & Partners Asset Management AB | 106,255 | $8,393 |
| MARSHALL WACE, LLP | 102,703 | $8,113 |
| Hennion & Walsh Asset Management, Inc. | 98,294 | $7,764 |
| JPMORGAN CHASE & CO | 97,386 | $7,693 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 90,056 | $7,114 |
| HealthInvest Partners AB | 89,685 | $7,084 |
| Swiss National Bank | 74,300 | $5,869 |
| Rafferty Asset Management, LLC | 72,943 | $5,762 |
| VICTORY CAPITAL MANAGEMENT INC | 72,194 | $5,703 |
| Voya Investment Management LLC | 67,749 | $5,351 |
| Vestal Point Capital, LP | 66,000 | $5,213 |
| Invesco Ltd. | 64,951 | $5,130 |
| CAPITAL FUND MANAGEMENT S.A. | 62,313 | $4,922 |
| TCG Crossover Management, LLC | 62,049 | $4,901 |
| UBS ASSET MANAGEMENT AMERICAS INC | 59,201 | $4,676 |
| 179 other institutions | 1,980,297 | $147,203 |