SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

CIK: 0001496201 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $474,069 (100.0% shares, 0.0% debt)

Holdings (114)

TEVA TEVA PHARMACEUTICAL INDS LTD 6.4%
Value ($000) $30,442 Shares 1,507,025 Est. Cost $15.12 Unrealized
NICE NICE LTD 4.8%
Value ($000) $22,788 Shares 157,400 Est. Cost $144.78 Unrealized
TSEM TOWER SEMICONDUCTOR LTD 4.8%
Value ($000) $22,543 Shares 311,802 Est. Cost $40.41 Unrealized +35.1%
MERUS N V 3.0%
Value ($000) $14,123 Shares 150,000 Est. Cost Unrealized
NVMI NOVA LTD 3.0%
Value ($000) $14,032 Shares 43,896 Est. Cost $213.92 Unrealized +29.1%
QQQ INVESCO QQQ TR 2.9%
Value ($000) $13,784 Shares 22,960 Est. Cost $600.37 Unrealized
BIIB BIOGEN INC 2.4%
Value ($000) $11,590 Shares 82,738 Est. Cost $158.50 Unrealized -14.7%
RARE ULTRAGENYX PHARMACEUTICAL IN 2.2%
Value ($000) $10,605 Shares 352,558 Est. Cost $34.60 Unrealized -13.3%
AZN ASTRAZENECA PLC 2.2%
Value ($000) $10,362 Shares 135,060 Est. Cost $54.50 Unrealized
SNY SANOFI SA 2.2%
Value ($000) $10,361 Shares 219,515 Est. Cost $46.09 Unrealized
CIDARA THERAPEUTICS INC 2.0%
Value ($000) $9,576 Shares 100,000 Est. Cost $45.34 Unrealized
CYTK CYTOKINETICS INC 1.9%
Value ($000) $8,877 Shares 161,517 Est. Cost $40.28 Unrealized +2.3%
MLYS MINERALYS THERAPEUTICS INC 1.8%
Value ($000) $8,339 Shares 219,910 Est. Cost $12.16 Unrealized +77.8%
FOLD AMICUS THERAPEUTICS INC 1.6%
Value ($000) $7,810 Shares 991,142 Est. Cost $6.45 Unrealized +10.3%
LLY ELI LILLY & CO 1.6%
Value ($000) $7,661 Shares 10,040 Est. Cost $258.77 Unrealized +186.8%
JNJ JOHNSON & JOHNSON 1.6%
Value ($000) $7,571 Shares 40,831 Est. Cost $136.97 Unrealized +23.8%
CIDARA THERAPEUTICS INC 1.5%
Value ($000) $7,253 Shares 75,743 Est. Cost $45.34 Unrealized
FBRX FORTE BIOSCIENCES INC 1.5%
Value ($000) $7,115 Shares 474,309 Est. Cost $8.61 Unrealized +33.8%
BBIO BRIDGEBIO PHARMA INC 1.4%
Value ($000) $6,752 Shares 130,000 Est. Cost $25.12 Unrealized +94.2%
SNDX SYNDAX PHARMACEUTICALS INC 1.3%
Value ($000) $5,965 Shares 387,716 Est. Cost $17.38 Unrealized -24.7%
TRVI TREVI THERAPEUTICS INC 1.2%
Value ($000) $5,892 Shares 643,957 Est. Cost $6.22 Unrealized +20.5%
NVO NOVO-NORDISK A S 1.2%
Value ($000) $5,864 Shares 105,677 Est. Cost $94.01 Unrealized
ABBV ABBVIE INC 1.2%
Value ($000) $5,848 Shares 25,256 Est. Cost $93.90 Unrealized +115.1%
CLBT CELLEBRITE DI LTD 1.2%
Value ($000) $5,540 Shares 298,948 Est. Cost $15.71 Unrealized 0.0%
ANNX ANNEXON INC 1.2%
Value ($000) $5,473 Shares 1,794,387 Est. Cost $5.27 Unrealized -52.9%
DYN DYNE THERAPEUTICS INC 1.1%
Value ($000) $5,395 Shares 426,518 Est. Cost $19.51 Unrealized -41.5%
CLDX CELLDEX THERAPEUTICS INC NEW 1.1%
Value ($000) $5,375 Shares 207,764 Est. Cost $32.36 Unrealized -28.4%
SOLAREDGE TECHNOLOGIES INC 1.1%
Value ($000) $5,333 Shares 4,000,000 Est. Cost $1.33 Unrealized
GSK GSK PLC 1.1%
Value ($000) $5,266 Shares 122,000 Est. Cost $35.22 Unrealized
SEDG SOLAREDGE TECHNOLOGIES INC 1.1%
Value ($000) $5,216 Shares 140,966 Est. Cost $16.73 Unrealized +78.5%
ORIC ORIC PHARMACEUTICALS INC 1.1%
Value ($000) $5,180 Shares 431,693 Est. Cost $8.56 Unrealized +22.9%
IMTX IMMATICS N.V 1.0%
Value ($000) $4,968 Shares 583,105 Est. Cost $11.13 Unrealized -44.7%
GPCR STRUCTURE THERAPEUTICS INC 1.0%
Value ($000) $4,870 Shares 173,931 Est. Cost $22.34 Unrealized
SVRA SAVARA INC 1.0%
Value ($000) $4,821 Shares 1,350,333 Est. Cost $3.82 Unrealized -22.6%
NVS NOVARTIS AG 1.0%
Value ($000) $4,745 Shares 37,000 Est. Cost $92.00 Unrealized
RAPP RAPPORT THERAPEUTICS INC 1.0%
Value ($000) $4,679 Shares 157,533 Est. Cost $17.84 Unrealized 0.0%
QURE UNIQURE NV 0.9%
Value ($000) $4,378 Shares 75,000 Est. Cost $18.16 Unrealized 0.0%
VRNS VARONIS SYS INC 0.9%
Value ($000) $4,247 Shares 73,900 Est. Cost $55.48 Unrealized 0.0%
TLT ISHARES TR 0.9%
Value ($000) $4,200 Shares 47,000 Est. Cost Unrealized
IMVT IMMUNOVANT INC 0.9%
Value ($000) $4,139 Shares 256,743 Est. Cost $19.52 Unrealized -17.0%
MRK MERCK & CO INC 0.9%
Value ($000) $4,079 Shares 48,600 Est. Cost $73.08 Unrealized +10.9%
MAZE MAZE THERAPEUTICS INC 0.8%
Value ($000) $4,002 Shares 154,343 Est. Cost $12.04 Unrealized +40.2%
ENGN ENGENE HOLDINGS INC 0.7%
Value ($000) $3,445 Shares 504,409 Est. Cost $7.77 Unrealized -41.3%
ESLT ELBIT SYS LTD 0.7%
Value ($000) $3,436 Shares 6,740 Est. Cost $410.78 Unrealized +13.7%
RZLT REZOLUTE INC 0.7%
Value ($000) $3,421 Shares 363,947 Est. Cost $3.37 Unrealized +97.5%
ELVN ENLIVEN THERAPEUTICS INC 0.7%
Value ($000) $3,414 Shares 166,765 Est. Cost $20.95 Unrealized -3.8%
MDWD MEDIWOUND LTD 0.7%
Value ($000) $3,339 Shares 185,270 Est. Cost $18.44 Unrealized 0.0%
ELDN ELEDON PHARMACEUTICALS INC 0.7%
Value ($000) $3,316 Shares 1,280,233 Est. Cost $3.15 Unrealized -7.2%
ACAD ACADIA PHARMACEUTICALS INC 0.7%
Value ($000) $3,178 Shares 148,900 Est. Cost $18.59 Unrealized +27.2%
PRAX PRAXIS PRECISION MEDICINES I 0.6%
Value ($000) $3,069 Shares 57,901 Est. Cost $51.58 Unrealized -6.0%
CAMT CAMTEK LTD 0.6%
Value ($000) $3,051 Shares 29,048 Est. Cost $88.36 Unrealized +1.4%
AMZN AMAZON COM INC 0.6%
Value ($000) $3,021 Shares 13,760 Est. Cost $141.58 Unrealized +59.9%
CRVS CORVUS PHARMACEUTICALS INC 0.6%
Value ($000) $3,005 Shares 407,709 Est. Cost $6.17 Unrealized -17.1%
PHVS PHARVARIS N V 0.6%
Value ($000) $2,979 Shares 119,406 Est. Cost $22.21 Unrealized -0.1%
SRPT SAREPTA THERAPEUTICS INC 0.6%
Value ($000) $2,891 Shares 150,000 Est. Cost $120.64 Unrealized -85.2%
META META PLATFORMS INC 0.6%
Value ($000) $2,882 Shares 3,924 Est. Cost $353.49 Unrealized +110.3%
SLNO SOLENO THERAPEUTICS INC 0.6%
Value ($000) $2,813 Shares 41,606 Est. Cost $74.14 Unrealized 0.0%
RVMD REVOLUTION MEDICINES INC 0.6%
Value ($000) $2,802 Shares 60,000 Est. Cost $39.15 Unrealized 0.0%
ORA ORMAT TECHNOLOGIES INC 0.6%
Value ($000) $2,791 Shares 29,000 Est. Cost $76.19 Unrealized +18.2%
IDYA IDEAYA BIOSCIENCES INC 0.6%
Value ($000) $2,721 Shares 100,000 Est. Cost $24.19 Unrealized 0.0%
AMGN AMGEN INC 0.6%
Value ($000) $2,681 Shares 9,500 Est. Cost $287.24 Unrealized -0.2%
PRAX PRAXIS PRECISION MEDICINES I 0.6%
Value ($000) $2,650 Shares 50,000 Est. Cost $51.58 Unrealized -6.0%
AMD ADVANCED MICRO DEVICES INC 0.5%
Value ($000) $2,503 Shares 15,470 Est. Cost $133.37 Unrealized +21.0%
TVTX TRAVERE THERAPEUTICS INC 0.5%
Value ($000) $2,433 Shares 101,800 Est. Cost $17.24 Unrealized +9.1%
ROIV ROIVANT SCIENCES LTD 0.5%
Value ($000) $2,294 Shares 151,600 Est. Cost $12.38 Unrealized 0.0%
ACOG ALPHA COGNITION INC 0.5%
Value ($000) $2,205 Shares 338,752 Est. Cost $5.61 Unrealized +62.4%
PFE PFIZER INC 0.5%
Value ($000) $2,191 Shares 86,000 Est. Cost $36.55 Unrealized -33.9%
HELP CYBIN INC 0.5%
Value ($000) $2,182 Shares 370,376 Est. Cost $9.89 Unrealized -28.4%
KURA KURA ONCOLOGY INC 0.5%
Value ($000) $2,173 Shares 245,522 Est. Cost $17.98 Unrealized -60.4%
AVGO BROADCOM INC 0.5%
Value ($000) $2,163 Shares 6,555 Est. Cost $305.74 Unrealized 0.0%
CEVA CEVA INC 0.5%
Value ($000) $2,141 Shares 81,085 Est. Cost $28.62 Unrealized -18.6%
BBIO BRIDGEBIO PHARMA INC 0.4%
Value ($000) $2,116 Shares 40,746 Est. Cost $25.12 Unrealized +94.2%
JANX JANUX THERAPEUTICS INC 0.4%
Value ($000) $2,098 Shares 85,840 Est. Cost $45.95 Unrealized -47.0%
SKYE SKYE BIOSCIENCE INC 0.4%
Value ($000) $1,882 Shares 478,928 Est. Cost $10.78 Unrealized -65.0%
ASTRIA THERAPEUTICS INC 0.4%
Value ($000) $1,829 Shares 251,225 Est. Cost $7.84 Unrealized
TECX TECTONIC THERAPEUTIC INC 0.4%
Value ($000) $1,819 Shares 115,908 Est. Cost $20.64 Unrealized 0.0%
PCVX VAXCYTE INC 0.4%
Value ($000) $1,801 Shares 50,000 Est. Cost $33.13 Unrealized 0.0%
CATX PERSPECTIVE THERAPEUTICS INC 0.4%
Value ($000) $1,750 Shares 510,343 Est. Cost $10.22 Unrealized -64.3%
IMNM IMMUNOME INC 0.4%
Value ($000) $1,724 Shares 147,200 Est. Cost $9.95 Unrealized 0.0%
MIST MILESTONE PHARMACEUTICALS IN 0.3%
Value ($000) $1,640 Shares 820,000 Est. Cost $1.76 Unrealized 0.0%
JSPR JASPER THERAPEUTICS INC 0.3%
Value ($000) $1,498 Shares 629,470 Est. Cost $3.38 Unrealized -10.2%
QURE UNIQURE NV 0.3%
Value ($000) $1,453 Shares 24,900 Est. Cost $18.16 Unrealized 0.0%
APLS APELLIS PHARMACEUTICALS INC 0.3%
Value ($000) $1,441 Shares 63,660 Est. Cost $37.03 Unrealized -37.0%
COGT COGENT BIOSCIENCES INC 0.3%
Value ($000) $1,415 Shares 98,526 Est. Cost $7.84 Unrealized +51.1%
GPCR STRUCTURE THERAPEUTICS INC 0.3%
Value ($000) $1,400 Shares 50,000 Est. Cost $22.34 Unrealized
IBIT ISHARES BITCOIN TRUST ETF 0.3%
Value ($000) $1,395 Shares 21,455 Est. Cost $55.74 Unrealized
VTYX VENTYX BIOSCIENCES INC 0.3%
Value ($000) $1,369 Shares 440,114 Est. Cost $5.44 Unrealized -51.3%
BHVN BIOHAVEN LTD 0.3%
Value ($000) $1,368 Shares 91,155 Est. Cost $33.08 Unrealized -56.0%
BCAX BICARA THERAPEUTICS INC 0.3%
Value ($000) $1,354 Shares 85,747 Est. Cost $11.75 Unrealized -4.7%
TSHA TAYSHA GENE THERAPIES INC 0.3%
Value ($000) $1,335 Shares 408,146 Est. Cost $2.17 Unrealized +30.3%
DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%
Value ($000) $1,236 Shares 175,371 Est. Cost $13.06 Unrealized -47.3%
HOWL WEREWOLF THERAPEUTICS INC 0.3%
Value ($000) $1,235 Shares 626,810 Est. Cost $13.12 Unrealized -89.6%
TRVI TREVI THERAPEUTICS INC 0.2%
Value ($000) $1,182 Shares 129,200 Est. Cost $6.22 Unrealized +20.5%
SABS SAB BIOTHERAPEUTICS INC 0.2%
Value ($000) $1,138 Shares 566,395 Est. Cost $2.26 Unrealized 0.0%
ENPH ENPHASE ENERGY INC 0.2%
Value ($000) $945 Shares 26,700 Est. Cost $37.15 Unrealized 0.0%
VYGR VOYAGER THERAPEUTICS INC 0.2%
Value ($000) $933 Shares 199,761 Est. Cost $4.67 Unrealized
CLYM CLIMB BIO INC 0.2%
Value ($000) $874 Shares 434,837 Est. Cost $3.77 Unrealized -50.7%
LRMR LARIMAR THERAPEUTICS INC 0.2%
Value ($000) $841 Shares 260,385 Est. Cost $6.69 Unrealized -44.0%
PEPG PEPGEN INC 0.2%
Value ($000) $792 Shares 171,467 Est. Cost $1.43 Unrealized +12.6%
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value ($000) $789 Shares 17,500 Est. Cost $52.58 Unrealized -13.4%
VSTM VERASTEM INC 0.1%
Value ($000) $691 Shares 78,307 Est. Cost $6.26 Unrealized +18.8%
ROIV ROIVANT SCIENCES LTD 0.1%
Value ($000) $644 Shares 42,571 Est. Cost $12.38 Unrealized 0.0%
89BIO INC 0.1%
Value ($000) $583 Shares 39,675 Est. Cost $13.61 Unrealized
ELDN ELEDON PHARMACEUTICALS INC 0.1%
Value ($000) $518 Shares 200,000 Est. Cost $3.15 Unrealized -7.2%
MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.1%
Value ($000) $509 Shares 71,010 Est. Cost $52.12 Unrealized 0.0%
CMMB CHEMOMAB THERAPEUTICS LTD 0.1%
Value ($000) $472 Shares 179,425 Est. Cost $2.63 Unrealized
ARWR ARROWHEAD PHARMACEUTICALS IN 0.1%
Value ($000) $431 Shares 12,496 Est. Cost $19.90 Unrealized +10.5%
APRE APREA THERAPEUTICS INC 0.1%
Value ($000) $398 Shares 270,000 Est. Cost $6.22 Unrealized -73.5%
WVE WAVE LIFE SCIENCES LTD 0.1%
Value ($000) $366 Shares 50,000 Est. Cost $8.09 Unrealized 0.0%
OKUR ONKURE THERAPEUTICS INC 0.0%
Value ($000) $166 Shares 60,454 Est. Cost $15.14 Unrealized -83.6%
DSGN DESIGN THERAPEUTICS INC 0.0%
Value ($000) $165 Shares 21,918 Est. Cost $5.01 Unrealized 0.0%
PROMIS NEUROSCIENCES INC 0.0%
Value ($000) $125 Shares 295,187 Est. Cost $1.96 Unrealized
MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.0%
Value ($000) $72 Shares 10,000 Est. Cost $52.12 Unrealized 0.0%
APPLIED THERAPEUTICS INC 0.0%
Value ($000) $30 Shares 50,000 Est. Cost $6.63 Unrealized