| FEDERATED HERMES, INC. | 16,534,712 | $39,022 |
| RA CAPITAL MANAGEMENT, L.P. | 9,180,000 | $21,665 |
| BlackRock, Inc. | 6,768,206 | $15,973 |
| Opaleye Management Inc. | 6,287,156 | $14,838 |
| VANGUARD GROUP INC | 4,788,511 | $11,301 |
| BALYASNY ASSET MANAGEMENT L.P. | 4,506,861 | $10,636 |
| BANK OF AMERICA CORP /DE/ | 4,325,248 | $10,208 |
| STATE STREET CORP | 3,981,708 | $9,397 |
| UBS Group AG | 2,816,291 | $6,646 |
| Affinity Asset Advisors, LLC | 2,351,144 | $5,549 |
| FMR LLC | 2,305,568 | $5,441 |
| Integral Health Asset Management, LLC | 2,000,000 | $4,720 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,954,733 | $4,614 |
| BARCLAYS PLC | 1,911,066 | $4,510 |
| MILLENNIUM MANAGEMENT LLC | 1,711,194 | $4,038 |
| Vestal Point Capital, LP | 1,686,000 | $3,979 |
| MORGAN STANLEY | 1,516,435 | $3,579 |
| JANE STREET GROUP, LLC | 1,407,699 | $3,322 |
| GOLDMAN SACHS GROUP INC | 1,304,782 | $3,079 |
| AMERIPRISE FINANCIAL INC | 1,093,925 | $2,582 |
| GREAT POINT PARTNERS LLC | 951,809 | $2,246 |
| 22NW, LP | 820,653 | $1,937 |
| Velan Capital Investment Management LP | 750,000 | $1,770 |
| NORTHERN TRUST CORP | 737,315 | $1,740 |
| KENNEDY CAPITAL MANAGEMENT LLC | 697,855 | $1,647 |
| Bank of New York Mellon Corp | 671,692 | $1,585 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 665,158 | $1,570 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 513,765 | $1,212 |
| XTX Topco Ltd | 481,949 | $1,137 |
| HRT FINANCIAL LP | 374,068 | $1 |
| Woodline Partners LP | 368,166 | $869 |
| Knott David M Jr | 340,000 | $802 |
| STATE OF WISCONSIN INVESTMENT BOARD | 296,843 | $701 |
| AQR CAPITAL MANAGEMENT LLC | 271,073 | $640 |
| D. E. Shaw & Co., Inc. | 249,390 | $589 |
| WELLINGTON MANAGEMENT GROUP LLP | 248,679 | $587 |
| Caitong International Asset Management Co., Ltd | 209,179 | $494 |
| PFM Health Sciences, LP | 206,265 | $487 |
| Virtu Financial LLC | 150,586 | $0 |
| Graham Capital Management, L.P. | 149,952 | $354 |
| Virtus Investment Advisers, LLC | 147,795 | $349 |
| DIMENSIONAL FUND ADVISORS LP | 141,883 | $335 |
| Rafferty Asset Management, LLC | 139,394 | $329 |
| Nuveen, LLC | 97,686 | $231 |
| RHUMBLINE ADVISERS | 95,968 | $226 |
| Engineers Gate Manager LP | 93,518 | $221 |
| RENAISSANCE TECHNOLOGIES LLC | 91,461 | $216 |
| WELLS FARGO & COMPANY/MN | 89,649 | $212 |
| Rangeley Capital, LLC | 78,200 | $185 |
| Scientech Research LLC | 77,848 | $184 |
| State of Alaska, Department of Revenue | 77,000 | $0 |
| ALPS ADVISORS INC | 76,143 | $180 |
| Persistent Asset Partners Ltd | 72,641 | $171 |
| CITADEL ADVISORS LLC | 69,373 | $164 |
| AlphaCentric Advisors LLC | 67,056 | $158 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 66,641 | $157 |
| DEUTSCHE BANK AG\ | 63,723 | $150 |
| SG Americas Securities, LLC | 63,622 | $0 |
| Decheng Capital LLC | 59,900 | $141 |
| PROFUND ADVISORS LLC | 51,821 | $122 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 46,413 | $110 |
| Invesco Ltd. | 45,425 | $107 |
| Qube Research & Technologies Ltd | 45,187 | $107 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,088 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,084 | $105 |
| ALLIANCEBERNSTEIN L.P. | 43,870 | $104 |
| INTECH INVESTMENT MANAGEMENT LLC | 43,819 | $103 |
| MetLife Investment Management, LLC | 42,229 | $100 |
| ADAR1 Capital Management, LLC | 38,679 | $91 |
| SEI INVESTMENTS CO | 37,897 | $89 |
| JPMORGAN CHASE & CO | 36,948 | $87 |
| ACADIAN ASSET MANAGEMENT LLC | 35,301 | $0 |
| Pale Fire Capital SE | 33,519 | $79 |
| CITIGROUP INC | 32,769 | $77 |
| GROUP ONE TRADING, L.P. | 27,676 | $65 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,831 | $61 |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,600 | $58 |
| PANAGORA ASSET MANAGEMENT INC | 22,680 | $54 |
| Police & Firemen's Retirement System of New Jersey | 21,800 | $51 |
| WINTON GROUP Ltd | 18,500 | $44 |
| FOX RUN MANAGEMENT, L.L.C. | 17,515 | $41 |
| Ikarian Capital, LLC | 16,479 | $39 |
| Jump Financial, LLC | 15,271 | $36 |
| Jefferies Financial Group Inc. | 15,000 | $35 |
| PFG Investments, LLC | 15,000 | $35 |
| ProShare Advisors LLC | 14,757 | $35 |
| PRUDENTIAL FINANCIAL INC | 14,630 | $35 |
| MML INVESTORS SERVICES, LLC | 14,625 | $35 |
| Voya Investment Management LLC | 12,776 | $30 |
| HSBC HOLDINGS PLC | 12,762 | $29 |
| Fifth Third Wealth Advisors LLC | 12,135 | $29 |
| HB Wealth Management, LLC | 11,073 | $26 |
| VICTORY CAPITAL MANAGEMENT INC | 10,588 | $25 |
| ExodusPoint Capital Management, LP | 10,510 | $25 |
| NIA IMPACT ADVISORS, LLC | 10,359 | $24 |
| Auxano Advisors, LLC | 10,000 | $24 |
| Tower Research Capital LLC (TRC) | 9,209 | $22 |
| BNP PARIBAS ARBITRAGE, SA | 8,264 | $20 |
| Legal & General Group Plc | 8,115 | $19 |
| Ameritas Investment Partners, Inc. | 6,834 | $16 |
| 20 other institutions | 41,418 | $86 |