| 5AM Venture Management, LLC | 3,947,913 | $5,330 |
| RENAISSANCE TECHNOLOGIES LLC | 2,883,745 | $3,893 |
| VANGUARD GROUP INC | 2,855,590 | $3,855 |
| ACADIAN ASSET MANAGEMENT LLC | 2,849,294 | $4 |
| CITADEL ADVISORS LLC | 1,964,255 | $2,652 |
| D. E. Shaw & Co., Inc. | 1,660,378 | $2,242 |
| TWO SIGMA ADVISERS, LP | 1,483,500 | $2,003 |
| TWO SIGMA INVESTMENTS, LP | 1,471,414 | $1,986 |
| Opaleye Management Inc. | 1,400,906 | $1,891 |
| BANK OF AMERICA CORP /DE/ | 1,367,254 | $1,846 |
| Decheng Capital LLC | 1,323,327 | $1,786 |
| Ishara Investments LP | 1,320,000 | $1,782 |
| BlackRock, Inc. | 1,249,968 | $1,687 |
| GSA CAPITAL PARTNERS LLP | 1,169,573 | $2 |
| PRIMECAP MANAGEMENT CO/CA/ | 957,420 | $1,293 |
| Pfizer Inc | 953,834 | $1,288 |
| MORGAN STANLEY | 803,654 | $1,085 |
| Connor, Clark & Lunn Investment Management Ltd. | 787,055 | $1,063 |
| UBS Group AG | 674,598 | $911 |
| MILLENNIUM MANAGEMENT LLC | 673,129 | $909 |
| Almitas Capital LLC | 610,073 | $824 |
| GEODE CAPITAL MANAGEMENT, LLC | 589,105 | $796 |
| XTX Topco Ltd | 576,707 | $779 |
| BARCLAYS PLC | 568,443 | $767 |
| Woodline Partners LP | 530,582 | $716 |
| JANE STREET GROUP, LLC | 473,175 | $639 |
| Stonepine Capital Management, LLC | 463,700 | $626 |
| Peapod Lane Capital LLC | 448,861 | $606 |
| BNP PARIBAS ARBITRAGE, SA | 419,367 | $566 |
| STATE STREET CORP | 271,790 | $367 |
| Creative Planning | 260,000 | $351 |
| MARSHALL WACE, LLP | 247,788 | $335 |
| FMR LLC | 243,308 | $328 |
| Anfield Capital Management, LLC | 242,605 | $328 |
| Invesco Ltd. | 188,582 | $255 |
| JPMORGAN CHASE & CO | 185,007 | $250 |
| SEI INVESTMENTS CO | 167,100 | $226 |
| Quadrature Capital Ltd | 137,568 | $186 |
| Quarry LP | 132,000 | $178 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 130,407 | $232 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 124,525 | $168 |
| GOLDMAN SACHS GROUP INC | 118,212 | $160 |
| Walleye Capital LLC | 110,448 | $149 |
| Squarepoint Ops LLC | 107,734 | $145 |
| Point72 Asset Management, L.P. | 100,290 | $135 |
| DIMENSIONAL FUND ADVISORS LP | 96,263 | $130 |
| NORTHERN TRUST CORP | 92,871 | $125 |
| Graham Capital Management, L.P. | 90,910 | $123 |
| PANAGORA ASSET MANAGEMENT INC | 86,640 | $117 |
| RBF Capital, LLC | 80,000 | $108 |
| ADAR1 Capital Management, LLC | 80,000 | $108 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,300 | $104 |
| OPAL CAPITAL LLC | 72,251 | $173 |
| 49 WEALTH MANAGEMENT, LLC | 70,911 | $96 |
| COMMONWEALTH EQUITY SERVICES, LLC | 61,412 | $83 |
| BARR E S & CO | 57,500 | $78 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 51,061 | $69 |
| ALGERT GLOBAL LLC | 48,496 | $0 |
| AQR CAPITAL MANAGEMENT LLC | 45,995 | $62 |
| TUDOR INVESTMENT CORP ET AL | 34,849 | $47 |
| FEDERATED HERMES, INC. | 34,574 | $47 |
| Regency Capital Management Inc.\DE | 29,500 | $40 |
| PRUDENTIAL FINANCIAL INC | 24,550 | $33 |
| Carson Advisory Inc. | 23,470 | $32 |
| Acorn Wealth Advisors, LLC | 20,000 | $27 |
| Sivia Capital Partners, LLC | 20,000 | $27 |
| RAYMOND JAMES FINANCIAL INC | 19,895 | $27 |
| Qube Research & Technologies Ltd | 17,471 | $24 |
| Birchview Capital, LP | 17,000 | $23 |
| EVERGREEN CAPITAL MANAGEMENT LLC | 16,915 | $23 |
| AMERICAN CENTURY COMPANIES INC | 12,880 | $17 |
| ROYAL BANK OF CANADA | 12,740 | $17 |
| IEQ CAPITAL, LLC | 12,229 | $17 |
| Shay Capital LLC | 10,662 | $14 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,343 | $14 |
| CWM, LLC | 8,564 | $0 |
| HIGHLINE WEALTH PARTNERS LLC | 5,000 | $7 |
| EverSource Wealth Advisors, LLC | 1,644 | $2 |
| BRYN MAWR TRUST Co | 1,000 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 387 | $1 |
| HighMark Wealth Management LLC | 130 | $0 |
| Covestor Ltd | 51 | $0 |
| Optiver Holding B.V. | 44 | $0 |
| SBI Securities Co., Ltd. | 27 | $0 |
| Inspire Investing, LLC | 16 | $0 |
| Caitong International Asset Management Co., Ltd | 1 | $0 |